Hidden mitochondrial DNA damage may be a missing link in disease

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate stress-response pathways. Simulations show the damage makes mtDNA more rigid, possibly marking it for removal. The finding offers fresh clues to inflammation, aging, and diseases such as diabetes and neurodegeneration.

from Top Health News -- ScienceDaily https://ift.tt/GbqWm7O