Health & Fitness

A study of tuberculosis drug therapy found that a two-drug, four-month regimen can be used to treat TB as effectively as the standard regimen that lasts six months and consists of four drugs.

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Researchers have found that the inclusion of a third drug to commonly used dual-drug inhalers can reduce asthma exacerbations and improve control over the disease in children, adolescents, and adults with moderate-to-severe asthma.

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The yeast Candida albicans can cause itchy, painful urinary tract and vaginal yeast infections. For women in low-resource settings who lack access to healthcare facilities, these infections create substantial social and economic burdens. Now, researchers have developed color-changing threads that turn bright pink in the presence of C. albicans. When embedded in tampons or sanitary napkins, they could allow women to quickly and discreetly self-diagnose vulvovaginal yeast infections, the researchers say.

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Scientists have revealed a layer of genetic material involved in controlling the production of tau; a protein which plays a critical role in serious degenerative conditions, such as Parkinson's and Alzheimer's disease.

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The latest findings show that with clever science, a single fingerprint left at a crime scene could be used to determine whether someone has touched or ingested class A drugs.

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Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team has succeeded in sustainably lowering high LDL cholesterol levels in the blood of mice and macaques. This opens up the possibility of curing patients with inherited metabolic liver diseases.

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Scientists have successfully treated flies displaying behavioral problems linked to newly discovered schizophrenia-associated genes in humans, using common anti-psychotics.

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The APP protein is known for its role in Alzheimer's disease, but its contribution to healthy brain function remains largely unexplored. Using a mouse model, a research team gained new insights on the physiological functions of the APP protein family. The absence of APP during brain development was shown to result in malformations of brain regions implicated in learning and memory, severely impairing learning in the mice and causing autistic-like behavior.

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A new study describes multiple ways to achieve the same health benefits from exercise -- as long as your exercise 'cocktail' includes plenty of light physical activity.

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Researchers have unveiled important new insights into how hormones known as androgens act on our cells - and the discovery could boost efforts to develop better treatments for prostate, ovarian and breast cancers.

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Researchers have identified a potential new approach to better controlling epileptic seizures.

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A new article from ocular researchers demonstrates that small uveal (intraocular) melanomas are not always harmless, as the current paradigm suggests. Instead, a reasonable proportion of them have molecular genetic alterations, which categorizes them as highly metastatic tumors. The article recommends that they should not be observed but rather treated immediately, to improve patients' chances of survival.

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An international research team has discovered a new molecule with potential to revolutionize the biosurfactant market.

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We enlist the help of Dr Sam Hay to help us bust some of the craziest gum myths making it around the rumour mill.

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It's the international day to praise tea! So, here are some fun tea facts for you to marvel at while you sip on your favourite leaf.

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A study reveals new insights about a protein called CRTC3, a genetic switch that could potentially be targeted to develop new treatments for melanoma by keeping the switch turned off.

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With pandemic lockdowns still in place last summer, The Ohio State University couldn't host its in-person Summer Success Program to help preschoolers from low-income families prepare for kindergarten. Staff and teachers quickly pivoted to a fully virtual program, but they were worried: Could this really work with 4- and 5-year-olds who had no previous experience with preschool? A new study suggested it did.

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An artificial intelligence program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a new study.

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Within the next decade, the novel coronavirus responsible for COVID-19 could become little more than a nuisance, causing no more than common cold-like coughs and sniffles. That possible future is predicted by mathematical models that incorporate lessons learned from the current pandemic on how our body's immunity changes over time.

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By Dr. Mercola

If you think your birth control pill is the best pregnancy prevention tool there is, you may be surprised by new research looking into its failure rates.

Compared to other forms of protection, the Pill failed miserably, which only adds to the myriad of reasons why you should heavily question its use.

The Pill Fails 20 Times More Often

About 99 percent of sexually active women use at least one method of birth control, the most common of which is the birth control pill (oral contraceptives). The Pill was used by nearly 11 million U.S. women from 2006-2008.ⁱ

Meanwhile, nearly half of all pregnancies in the United States are unintended.ⁱⁱ Certainly not all of these are due to a birth control failure, but some of them -- estimates suggest about half -- undoubtedly are. Which brings me to a recent study published in the New England Journal of Medicine.ⁱⁱⁱ Out of the 7,500 women in the study, who used various forms of birth control including an intrauterine device (IUD), implant, birth control pills, patch, ring and contraceptive injection, 334 became pregnant, 156 of which were due to birth control failure.

The contraceptive failure rate among pills, patch or ring was 4.55 percent, compared to 0.27 percent among participants using reversible contraception such as intrauterine devices. The effectiveness—or non-effectiveness—was no different in adolescents or young women. The implications—that birth control pills are 20 times more likely to fail than IUDs—should give some women a pause to think about the method of contraception they want to use.

As for the varying degrees of effectiveness, the Pill must be taken daily, preferably around the same time for it to work its best. Study author Dr. Jeffrey Peipert, a professor of obstetrics and gynecology at Washington University School of Medicine in St. Louis, noted:^iv

"This study is the best evidence we have that long-acting reversible methods are far superior to the birth control pill, patch and ring. IUDs and implants are more effective because women can forget about them after clinicians put the devices in place ... If there were a drug for cancer, heart disease or diabetes that was 20 times more effective, we would recommend it first."

Hormone-Based Contraceptives Have Steep Risks

Unintended pregnancy is clearly a big one, but artificially manipulating your hormones using oral contraceptives, the patch or ring, or an injection like Depo-Provera is also a very risky proposition. Most birth control pills are a combination of the derivatives of the hormones estrogen and a synthetic progesterone(progestin). They work by disrupting the hormones in your body, essentially fooling your intricate hormonal reproductive system into producing the following effects:

• Preventing your ovaries from releasing eggs
• Thickening your cervical mucus to help block sperm from fertilizing an egg
• Thinning the lining of your uterus, which would make it difficult for an egg to implant, should it become fertilized

However, it is naive to believe that these are the only impacts the synthetic hormones are having. Your reproductive system does not exist in a bubble ... it is connected to all of your other bodily systems as well. The Pill, too, does not only influence your reproductive status; it's capable of altering much more.

Ten years ago, in 2002, one of the largest and best-designed federal studies of hormone replacement therapy was halted because women taking these synthetic hormones had a such a higher risk of breast cancer, heart attack, stroke and blood clots that continuing forward with the study would have been unethical. The news made headlines because millions of women were already taking these synthetic hormones, but fortunately it prompted many of them to quit. And what do you think happened a year after millions of women quit taking hormone replacement therapy? Incidents of breast cancer fell dramatically -- by 7 percent!

What does this have to do with the Pill? Birth control pills contain the SAME type of synthetic hormones -- estrogen and progestin -- that were used in the ill-fated study!

That's just one risk. Oral contraceptives have been linked to more than two dozen conditions, including heart disease, liver cancer, deep vein thrombosis and inflammatory bowel disease.^v Research suggests they are not only carcinogenic (cancer-causing) but also cardiotoxic (toxic to your heart) and endocrine disrupting.

Why I Advise Most Women to Stop Hormonal Contraceptives

Birth control pills are rarely, if ever, necessary or beneficial. In exchange for the convenience of preventing pregnancy (which you can do naturally perhaps even more effectively, and I'll explain how below), you are putting yourself at risk of a myriad of health issues.

A new study in the New England Journal of Medicine revealed that several types of hormone-based birth control methods increased women's risk of heart attack and stroke.^vi The link was found between oral contraceptives as well as contraceptive patches and the vaginal ring. Women using the ring were found to have a 2.5 times greater risk of stroke compared to those not using hormonal contraceptives, whereas the other methods increased the risk to varying degrees.

Other known health risks of hormone-based birth control include:

Cancer: Women who take birth control pills increase their risk of cervical and breast cancers, and possibly liver cancer as well.	Fatal blood clots: All birth control pills increase your risk of blood clots and subsequent stroke.	Thinner bones: Women who take birth control pills have lower bone mineral density (BMD) than women who have never used oral contraceptives.	Impaired muscle gains: A study found that oral contraceptive use impairs muscle gains from resistance exercise training in women.vii
Long-term sexual dysfunction: The Pill may limit the availability and/or action of testosterone, leading to long-term sexual dysfunction, including decreased desire and arousal.	Heart disease: Long-term use of birth control pills may increase the buildup of arterial plaque, which may raise your risk of heart disease and cardiac mortality.viii	Migraines and nausea	Weight gain and mood changes
Irregular bleeding or spotting	Breast tenderness	Yeast overgrowth	Yeast infection

The other hormonal-based options are not much better. Birth control patches (Ortho Evra) have resulted in an avalanche of lawsuits over the past several years due to the overwhelming health problems women have experienced from using them. One of the reasons the patch is so risky is that you absorb up to 60 percent more synthetic estrogen than if you were taking an oral contraceptive. Side effects of the patch include:

Raised risk of heart attack and stroke	Irregular bleeding	Problems wearing contact lenses	Fluid retention or raised blood pressure
Nausea	Headache	Breast tenderness	Mood changes
Menstrual cramps	Abdominal pain	Skin irritation or rashes at site of patch

As far as injections like Depo-Provera, or depo medroxyprogesterone (DMPA), go, this synthetic analogue of natural progesterone known as a progestin interferes with hormone signaling to prevent your ovaries from releasing eggs. Progestins carry with them a vast array of negative side effects, including:

Side Effects of Depo-Provera
Weight gain Headaches Breast swelling and tenderness Decreased sexual desire Depression Bloating Swelling of the hands and feet Nervousness Abdominal cramps Dizziness Weakness of fatigue Leg cramps Nausea Vaginal discharge or irritation	Backache Insomnia Acne Pelvic pain Lack of hair growth or excessive hair loss Rashes Hot flashes Joint pain Convulsions Jaundice Urinary tract infections Allergic reactions Fainting Paralysis Osteoporosis	Lack of return to fertility Deep vein thrombosis Pulmonary embolus Breast and cervical cancers Abnormal menstrual bleeding Increased risk for STDs Unexpected breast milk production Changes in speech, coordination, or vision Swelling of face, ankles or feet Mood changes Unusual fatigue

Is an IUD a Better Option?

Intrauterine devices are small, plastic, T-shaped sticks with a string attached to the end. The IUD is placed inside the uterus and prevents pregnancy by rendering the sperm unable to fertilize an egg, and by changing the lining of the uterus so that it is less supportive for an embryo. It also works by releasing hormones into your body, specifically a progestin hormone called levonorgestrel, which is often used in birth control pills.

One of its major advantages, and what contributes to its increased effectiveness rate, is that it essentially eliminates the compliance failure issue as all you do is insert it once. There is no daily task to remember to do. However, it, too, carries significant risks, including some that are unique to a foreign body being placed inside your uterus. Among them:

• Pelvic infection: IUDs may lead to pelvic inflammatory disease, a serious infection
• The device may attach to or go through the wall of the uterus
• Pregnancy while using an IUD can be life threatening, and may result in loss of the pregnancy or fertility
• Ovarian cysts may occur
• Bleeding and spotting

Take Charge of Your Body Using Natural Birth Control Methods

You may not be aware that there are many effective and safe methods for preventing pregnancy. Some of the more common, barrier methods are:

• Male condoms: Condoms have a 98 percent effectiveness rate when used correctly. A water-based lubricant will increase the effectiveness; do not use an oil-based lubricant, however, as they break the latex and usually are petrochemical in origin.
• Female condoms: These thin, soft polyurethane pouches fitted inside the vagina before sex are 95 percent effective. Female condoms are less likely to tear than male condoms.
• Diaphragm: Diaphragms, which must be fitted by a doctor, act as a barrier to sperm. When used correctly with spermicidal jellies, they are 92 to 98 percent effective.
• Cervical cap: This heavy rubber cap fits tightly against the cervix and can be left in place for 48 hours. Like the diaphragm, a doctor must fit the cap. Proper fitting enhances the effectiveness above 91 percent.
• Cervical sponges: The sponge, made of polyurethane foam, is moistened with water and inserted into the vagina prior to sex. It works as a barrier between sperm and the cervix, both trapping and absorbing sperm and releasing a spermicide to kill them. It can be left in for up to 24 hours at a time. When used correctly, the sponge is about 89-91 percent effective.

Many people are familiar with these barrier methods, and less familiar with natural family planning (NFP) tools, which a woman uses to track when she is ovulating, and then avoid sex during that time (or does so only using a back-up barrier method). Many women feel empowered by NFP because it allows them to get in touch with their fertility cycle.

Some of the most popular methods include:

• Calendar Method: Abstention from sex during the week the woman is ovulating. This technique works best when a woman's menstrual cycle is very regular. The calendar method doesn't work very well for couples who use it by itself (about a 75 percent success rate), but it can be effective when combined with the temperature and mucus methods described below.
• The Temperature Method: This is a way to pinpoint the day of ovulation so that sex can be avoided for a few days before and after. It involves taking your basal body temperature (your temperature upon first waking) each morning with an accurate "basal" thermometer, and noting the rise in temperature that occurs after ovulation.
  
  Illness or lack of sleep can change your body temperature and make this method unreliable by itself, but when it is combined with the mucus method, it can be an accurate way of assessing fertility. The two methods combined can have a success rate as high as 98 percent.
• The Mucus Method: This involves tracking changes in the amount and texture of vaginal discharge, which reflect rising levels of estrogen in your body. For the first few days after your period, there is often no discharge, but there will be a cloudy, tacky mucus as estrogen starts to rise. When the discharge starts to increase in volume and becomes clear and stringy, ovulation is near. A return to the tacky, cloudy mucus or no discharge means that ovulation has passed.

I encourage you to become actively involved in fertility awareness, and embrace natural family planning or barrier methods that will not interfere with your hormones and health. Some excellent reading to get you started on this path include:

1. The Ovulation Method: Natural Family Planning, by John J. Billings
2. Taking Charge of Your Fertility: The Definitive Guide to Natural Birth Control, Pregnancy Achievement, and Reproductive Health, by Toni Weschler
3. Honoring Our Cycles: A Natural Family Planning Workbook, by Katie Singer

References:

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• ⁱ See All References

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Despite widespread publicity, the 2002 landmark study on the potential dangers of hormone therapy for postmenopausal women is completely unknown to most women. 

New research from the Stanford University School of Medicine discovered that only 29 percent of the women surveyed knew anything about the study two years later. Additionally, only 40 percent of the women were able to identify possible risks and benefits linked to hormone therapy. 

Hormone therapy is used to ease your symptoms of menopause, but has also been widely prescribed for preventive purposes, based in part on earlier observational studies that had suggested it could help protect women against heart disease, weak bones, and dementia. 

In July 2002, the Women's Health Initiative (WHI) abruptly ended its combination of estrogen and progestin therapy study, as their data discovered higher rates of breast cancer, heart attacks, strokes, and blood clots in the population taking the hormones, compared to those taking placebos. 

Later, in April 2004, WHI also halted the portion of the study for estrogen-only therapy, after finding the hormone did not offer any protective heart disease prevention, but rather increased your risk of stroke and blood clots. 

The WHI findings triggered enormous changes in the use of hormone therapy, and prescriptions had dropped 38 percent by 2003. 

Senior author Randall Stafford, MD, PhD, said their latest survey indicates there's a huge problem in communicating crucial health information to patients effectively, which in turn is indicative of an even larger problem – ensuring that people can make informed decisions about their medical care. 

Menopause April 10, 2007

Women's Health Initiative June 21, 2007

WHI March 2, 2007 (The Estrogen-Alone Study Links)

Women's Health Initiative (The Estrogen-Plus-Progestin Study Links)

Eurekalert September 18, 2007

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The chemical bisphenol F (found in plastics) can induce changes in a gene that is vital for neurological development. The mechanism could explain why exposure to this chemical during the fetal stage may be connected with a lower IQ at seven years of age -- an association previously seen by the same research group.

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The amount of nutrients people get from the crops that they eat is a type of 'postcode lottery', according to new research that has analysed thousands of cereal grains and soils as part of a project to tackle hidden hunger in Malawi and Ethiopia.

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Mutations associated with autism can inhibit the release of the bonding hormone oxytocin and cause abnormal social behavior in mice, researchers report.

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A microchip technology test kit may facilitate point-of-care testing in remote locations, clinics, and airports while providing similar accuracy to the tube-based real-time PCR tests, investigators report.

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Monoclonal antibodies, a COVID-19 treatment given early after coronavirus infection, cut the risk of hospitalization and death by 60 percent in those most likely to suffer complications of the disease, according to an analysis of UPMC patients who received the medication compared to similar patients who did not.

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A new technology enables the body to produce therapeutic agents on demand at the exact location where they are needed. The innovation could reduce the side effects of cancer therapy and may hold the solution to better delivery of COVID-related therapies directly to the lungs.

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Using a robotic 'Third Thumb' can impact how the hand is represented in the brain, finds a new study.

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The most populous boroughs in New York City, Queens and Brooklyn, likely served as the major hub of COVID-19 spread in the spring of 2020, a new study finds.

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Biologists have used human pluripotent stem cells to grow sesame-seed-sized heart models, called cardioids, that spontaneously self-organize to develop a hollow chamber without the need of experimental scaffolds. This advance allows for the creation of some of the most realistic heart organoids to date.

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A common factor called 'decision acuity' underpins diverse decision-making abilities in adolescents and young adults, suggests a new study. A large set of behavioral and neuroimaging data revealed that decision acuity is stable over time, distinct from IQ, and reduced in individuals with low general social functioning.

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Australia has successfully suppressed any serious, widespread damage caused by COVID. But the nation can’t be a fortress for much longer, says peak medical bodies.

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The brain-computer interface user was able to transfer objects with a robotic arm at twice the speed of doing it without the tactile feedback.

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Blocked blood vessels in the brains of stroke patients prevent oxygen-rich blood from getting to cells, causing severe damage. Plants and some microbes produce oxygen through photosynthesis. What if there was a way to make photosynthesis happen in the brains of patients? Now, researchers have done just that in cells and in mice, using blue-green algae and special nanoparticles, in a proof-of-concept demonstration.

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