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03/26/20

Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively -- allowing the nanoparticles to diffuse into tumors and become held in place, or actively -- adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice suggests the question is even more complicated.

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The pediatric brain cancer known as diffuse intrinsic pontine glioma (DIPG) is almost uniformly fatal. In part, this is due to where and how it grows, forming as a diffuse net of cells in a part of the brainstem called the pons, which controls essential functions like breathing and swallowing. Another factor that makes DIPG especially dangerous is a lack of treatments - currently, there are no targeted therapies or immunotherapies proven effective to treat the condition, and the many chemotherapy clinical trials seeking to treat DIPG have been uniformly unsuccessful.

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Right now, many people are hoping for a vaccine to protect against the new coronavirus. While that’s still on the horizon, new research suggests that families who do vaccinate their children may not be following the recommended schedule.

Vaccines are given on a schedule for a reason: to protect children from vaccine-preventable disease. Experts designed the schedule so that children get protection when they need it — and the doses are timed so the vaccine itself can have the best effect. When parents don’t follow the schedule, their children may not be protected.

And yet, many parents do not follow the schedule.

A third of families change vaccine schedule

In a study recently published in the journal Pediatrics, researchers looked at data from the National Immunization Survey from 2014 and found that only 63% of families followed the recommended vaccination schedule for their children. The majority of those who didn’t followed an alternate schedule, spacing vaccines out, skipping some, or doing a combination of both.

The study did not include the influenza vaccine, one that many parents choose not to give. The vaccines in this study were routine vaccines, given to all children and required for many schools and daycare programs.

Not surprisingly, children whose parents used an alternate vaccine schedule were four times as likely to be behind in their immunizations or missing vaccines entirely. This can be very dangerous.

In the first two years of life, vaccines protect babies and toddlers against:

  • pneumococcus and Haemophilus Influenzae, bacteria that can cause serious infections
  • pertussis (whooping cough), which can be fatal in infants
  • polio, which can cause a paralysis that can be fatal
  • diphtheria, a serious respiratory illness
  • rotavirus, a diarrhea that can lead to serious dehydration in young infants
  • measles, which can cause pneumonia and neurological problems
  • mumps, which causes swollen glands in the neck and can sometimes lead to complications
  • rubella, or German measles. If women catch it during pregnancy, it can lead to miscarriage or birth defects.
  • varicella (chicken pox). While most infections are mild, the rash caused by chicken pox can get infected and the virus itself can affect the lungs or brain.
  • hepatitis B and hepatitis A, both infections of the liver. Hepatitis B infections can be chronic and lead to liver damage.

Having vaccines on schedule protects babies and children vulnerable to disease

Parents sometimes worry about giving several vaccines at once, something that the schedule calls for, especially at the 2, 4, and 6-month visits. Not only is it safe, but when parents spread out the schedule it takes longer before the child is protected, leaving babies vulnerable to these diseases. It also means more visits to the doctor: the study found that babies whose parents used an alternate schedule had three more vaccination visits than babies whose parents followed the recommended schedule.

Parents also worry about side effects of vaccines, and other risks, often fueled by information they get on social media. Not every person who gets these infections has a serious case or complications. But the risk of a complication of the disease is always higher than the risk of the vaccine, an important fact that sometimes gets lost in the vaccine discussion.

Another important fact is that when children get behind on vaccines, it can put others at risk as well. When enough of the community is vaccinated, it makes disease less likely to spread. This is particularly important for those who aren’t fully vaccinated, such as newborns, and those who can’t be vaccinated, such as children who are taking medications that suppress the immune system. Parents often forget that the decisions they make about immunization affect more people than just their child.

It’s normal for parents to have questions and worry about medical treatments given to their children. After all, it’s a parent’s job to worry. But as parents question and worry, it’s really important that they get reliable medical information from expert sources. The Centers for Disease Control and Prevention, as well as immunize.org and the American Academy of Pediatrics, have lots of accurate and useful information, and parents should always talk to their child’s doctor if they have concerns.

The bottom line for parents

Think long and hard, and get information from reliable sources, before you change your child’s vaccine schedule. The schedule is there to protect your child — and everyone around your child.

Follow me on Twitter @drClaire

The post Why follow a vaccine schedule? appeared first on Harvard Health Blog.



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Weedy rice is a feral form of rice that infests paddies worldwide and aggressively outcompetes cultivated varieties. A new study led by biologists at Washington University in St. Louis shows that weed populations have evolved multiple times from cultivated rice, and a strikingly high proportion of contemporary Asian weed strains can be traced to a few Green Revolution cultivars that were widely grown in the late 20th century.

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Researchers have used an ultrasound technique they pioneered a decade ago -- electromechanical wave imaging (EWI) -- to accurately localize atrial and ventricular cardiac arrhythmias in adult patients in a double-blinded clinical study. They evaluated the accuracy of EWI for localization of various arrhythmias in all four chambers of the heart prior to catheter ablation: the results showed that EWI correctly predicted 96% of arrhythmia locations as compared with 71% for 12-lead ECGs.

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Researchers have developed the first computational model of a human cell and simulated its behavior for 15 minutes -- the longest time achieved for a biological system of this complexity. In a new study, simulations reveal the effects of spatial organization within cells on some of the genetic processes that control the regulation and development of human traits and some human diseases.

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