Health & Fitness

In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later.

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Viruses use the molecular repertoire of the host cell to replicate. Researchers want to exploit this for the treatment of influenza. The team identified a compound that inhibits the body's own methyltransferase MTr1, thereby limiting the replication of influenza viruses. The compound proved effective in lung tissue preparations and mouse studies and showed synergistic effects with already approved influenza drugs.

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Scientists have demonstrated that personalizing CAR-T cell stimulation during manufacturing can significantly enhance the consistency and potency of the resulting CAR-T cell products. By using artificial antigen-presenting cell mimicking scaffolds (APC-ms), the team was able to fine-tune the levels of T cell stimulation to match the phenotype of T cells obtained from leukemia patients, and significantly enhanced their ex vivo and in vivo tumor-clearing abilities.

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Using a new method 'Terahertz (THz) calorimetry', a research team shed new light on the spontaneous phase separation into a protein-rich and a protein-poor phase in a solution. It is assumed that the protein-rich droplets promote the formation of neurotoxic protein aggregates -- a hot spot for neurodegenerative diseases.

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DNA can help to stimulate bone healing in a localized and targeted manner, for example after a complicated fracture or after severe tissue loss following surgery. Scientists have developed a new process in which they coat implant materials with a gene-activated biomaterial that induces stem cells to produce bone tissue.

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Over 600 CTE cases have been published in the literature from multiple international research groups. And of those over 600 cases, 97 percent have confirmed exposure to RHI, primarily through contact and collision sports. CTE has been diagnosed in amateur and professional athletes, including athletes from American, Canadian, and Australian football, rugby union, rugby league, soccer, ice hockey, bull-riding, wrestling, mixed-martial arts, and boxing.

from Top Health News -- ScienceDaily https://ift.tt/n2uR4sp