Health & Fitness

In a study that followed hundreds of mice over their lifespans, calorie restriction combined with time-restricted eating boosted longevity.

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Whether it's making rash decisions or feeling grumpy, hunger can make us think and act differently -- 'hangry,' even. But little is known about how hunger signals in the gut communicate with the brain to change behavior. Now, scientists are using worms as a model to examine the molecular underpinnings and help explain how hunger makes an organism sacrifice comfort and make risky decisions to get a meal.

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In a prospective study of young, lean adults, PET/CT imaging revealed that higher levels of active brown adipose tissue (also known as 'brown fat') are more prevalent in individuals who exhibit very early indications of metabolic disorders. The study suggests that active brown fat is recruited to counteract 'pre-prediabetic' states, potentially serving as a first-line protective mechanism against very early metabolic or hormonal abnormalities.

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The human body consists of trillions of cells that constantly communicate with each other. A central role in this communication process is played by receptor proteins on the cell surface. Since they often serve as drug targets, they have been the subject of intensive research. Often there are whole families of receptors. The signal messengers as well as the receptors are very similar to each other, so it is not clear how the signals are distinguished from each other at the molecular level. Now, scientists have succeeded in determining high-resolution structures for three related signalling complexes that occur naturally in the body for the neuropeptide Y (NPY) receptor family, thus shedding light on the 'small but essential differences'.

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Researchers have uncovered how signals from a group of neurons in the brain's frontal lobe simultaneously give humans the flexibility to learn new tasks -- and the focus to develop highly specific skills.

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