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10/05/21

To understand the biological underpinnings of skin and hair pigmentation and related diseases such as albinism or melanoma, scientists and doctors need quantitative, three-dimensional information about the architecture, content and location of pigment cells. Researchers have developed a new technique that allows scientists to visualize every cell containing melanin pigment in 3D, in whole zebrafish.

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Living with a food allergy can greatly impact a child's everyday life -- from limiting participation in social activities to being treated differently by peers. While previous research indicates many kids experience food allergy-related bullying, a new study found that offering kids with food allergies a multi-question assessment gives a more accurate picture of the size and scope of the problem.

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It is still elusive to what extent interactions between different cell types of the heart influence the normal heart rhythm and possibly trigger life-threatening arrhythmias. A new measurement method combines optical and electrical recording of cardiac ventricular activation which, in conjunction with optogenetics, will permit finding comprehensive answers to these questions.

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The period after hospital discharge is a high-risk time for people who use illicit opioids such as heroin, according to new research. Fatal opioid overdoses are four times more likely in the first two days after hospital discharge than at other times, and people who use illicit drugs need extra support when being discharged from hospital.

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As far back as ancient Rome, spider silk has been used as a remedy to treat everything from skin lesions to warts. In the past, doctors have covered open wounds in cobwebs or advised patients to place cocoons on infected teeth. In modern times, however, the literature contains conflicting reports of whether or not spider silk has antimicrobial properties. Researchers have now revisited these old experiments and debunk the myth of antibiotic spider silk.

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Researchers identified a small RNA molecule called miR-766-5p that reduces expression of MYC, a critical cancer-promoting gene. This microRNA reduces levels of proteins CBP and BRD4, which are both involved in super-enhancer (SE) formation. SEs form in areas of DNA that can fuel MYC expression and tumor progression. This study provides strong evidence for developing miR-766-5p as a novel therapeutic to treat MYC-driven cancers.

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A drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's disease, new research has found. The drug, Axitinib, inhibits growth of new blood vessels in the brain -- a feature shared by both cancer tumors and Alzheimer's disease. This hallmark represents a new target for Alzheimer's therapies. Mice that underwent the therapy not only exhibited a reduction in blood vessels and other Alzheimer's markers in their brains, they also performed remarkably well in tests designed to measure learning and memory.

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