Researchers have identified how specific brain cells interacting during development could be related to neurological and neuropsychiatric diseases, including some that occur later in life.
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On a gram for gram basis, animal proteins are more effective than plant proteins in supporting the maintenance of skeletal muscle mass with advancing age, shows new research.
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Ricki-Lee Coulter talks to Body+Soul about getting out of iso and back in the studio, being tired of tabloid headlines and why dance empowers her to feel confident, sexy and sensual.
Biologists have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish. They studies the Mauthner cells, which are solely responsible for the escape behavior of the fish, and previously regarded as incapable of regeneration. However, their ability to regenerate crucially depends on the location of the injury.
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Strains of a common subtype of influenza virus, H3N2, have almost universally acquired a mutation that effectively blocks antibodies from binding to a key viral protein.
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New research from Wuhan, China shows that, in patients with COVID-19 but without a previous diagnosis of diabetes, abnormally high blood sugar is associated with more than double the risk of death and also an increased risk of severe complications.
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A new study highlights the critical role that working memory capacity plays in social distancing compliance during the early stages of the COVID-19 pandemic.
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Based on their experience treating COVID-19, physicians have assembled critical information about the coronavirus's effects on organs outside the lungs.
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Climate change will leave some farmers with a difficult conundrum, according to a new study by researchers from Cornell University and Washington State University: Either risk more revenue volatility, or live with a more predictable decrease in crop yields.
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Each year, wind turbines are responsible for the death of hundreds of thousands of airborne animals such as bats. To find a constructive way out of this ''green-green'' dilemma, companies building and running wind turbines might have to work together with environmental experts and conservationists. Yet lack of trust between them can hinder effective collaboration. Scientists show: shared values are not sufficient to build trust, as beliefs and emotions have stronger influence.
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New research has identified for the first time the specific brain cells that control how much sugar you eat and how much you crave sweet tasting food. The study specifically identifies the brain cells that respond to the hormone FGF21 to regulate sugar intake and sweet taste preference.
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Researchers report the results of a study using artificial intelligence and human brain studies to compare brain areas involved in mental imagery and vision. Their findings suggest that mental imagery and vision are similar, but that low-level visual areas are activated in a less precise manner with mental imagery. This suggests that the brain is more tuned and sensitive to what it sees than what it imagines.
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In the video podcast above, Dr. Paul Saladino and science journalist and author, Nina Teicholz — who is also an adjunct professor at NYU's Wagner Graduate School of Public Service and the executive director of The Nutrition Coalition — review the evidence against chicken, and why saturated fat really qualifies as a health food.
Teicholz' book, "The Big Fat Surprise," challenged the conventional wisdom on dietary fats, especially saturated fat. Saladino, meanwhile, is releasing the second edition of his book, "The Carnivore Code," August 4, 2020.
Why Conventional Chicken May Contribute to Poor Health
As noted by Saladino, while consumption of red meat is on the decline, thanks to the vilification of red meat and saturated fat, people are eating more and more chicken.
Long thought of as a healthier type of meat, primarily because it's leaner than red meat, the problem with conventional chicken is that they're fed corn — typically GMO varieties that are farmed with glyphosate.
Increasingly, we're finding that trans fats and polyunsaturated fat from vegetable oils are far worse for your health, and a greater contributor to chronic disease, than added sugar even. And what happens when chicken is fed corn? The meat becomes high in omega-6 linoleic acid, as corn is high in this type of fat.1
As Saladino points out, high chicken consumption actually adds to your vegetable oil consumption. While you need some omega-6, the amounts obtained from a standard American diet high in processed foods are far too high for health. High omega-6 intake also skews your omega-3 to omega-6 ratio, which ideally would be close to 1-to-1.
As noted by Saladino and Teicholz, 60% of the U.S. population has chronic disease, nearly 70% are overweight or obese, and recent NHANES data2 reveal 87.8% of Americans are metabolically unhealthy, based on five parameters. That data is over four years old now, so the figure is clearly greater than 90% of the population today.
That means virtually everyone is at risk for Type 2 diabetes and all the chronic diseases associated with insulin resistance, which run the gamut from cancer to Alzheimer's. Simply assuming you are one of the 12.2% (from the 4-year-old figures) that are metabolically healthy would be risky business.
Will Saturated Fat Myth Soon Be Upended?
Part of why chronic ill health is so widespread is this persistent idea that saturated animal fats are unhealthy, and should be replaced with industrial vegetable oils.3
On the upside, Teicholz reviews a recent paper4 in the Journal of the American College of Cardiology, published online June 17, 2020, which actually admits the long-standing nutritional guideline to limit saturated fat has been incorrect. This is a rather stunning admission, and a huge step forward. As noted in the abstract:
"The recommendation to limit dietary saturated fatty acid (SFA) intake has persisted despite mounting evidence to the contrary. Most recent meta-analyses of randomized trials and observational studies found no beneficial effects of reducing SFA intake on cardiovascular disease (CVD) and total mortality, and instead found protective effects against stroke.
Although SFAs increase low-density lipoprotein (LDL)-cholesterol, in most individuals, this is not due to increasing levels of small, dense LDL particles, but rather larger LDL which are much less strongly related to CVD risk.
It is also apparent that the health effects of foods cannot be predicted by their content in any nutrient group, without considering the overall macronutrient distribution.
Whole-fat dairy, unprocessed meat, eggs and dark chocolate are SFA-rich foods with a complex matrix that are not associated with increased risk of CVD. The totality of available evidence does not support further limiting the intake of such foods."
How Did We Go so Wrong?
In the podcast, Saladino and Teicholz review the history of the demonization of saturated fat and cholesterol, starting with Ancel Keys' flawed hypothesis5 that saturated fat causes heart disease in 1960-1961, and how the introduction of the first Dietary Guidelines for Americans in 1980 (which recommended limiting saturated fat and cholesterol) coincided with a rapid rise in obesity and chronic diseases such as heart disease.
They also discuss the reasons why this myth has been allowed to persist, despite the scientific evidence against it. In short, the low-fat, low-cholesterol myths promulgated by Keys in the '60s rapidly led to dramatic changes in the food and drug industries, and these behemoths are incredibly reluctant to relinquish what have become highly profitable businesses.
Acknowledging that saturated animal fats are healthy, and processed industrial vegetable oils and grains are not, would decimate the processed food industry, as it relies on vegetable oils and grains. The healthy alternative is real food, and there's no big industry profits to be made from that.
Vegetable Oils Undermine Your Health
Saladino and Knobbe are both equally convinced that the massive increase in linoleic acid (omega-6 polyunsaturated fat found in industrial vegetable oils) is a key metabolic driver of obesity, heart disease, cancer and other chronic disease. They review several studies6,7,8,9,10,11,12 demonstrating the truth of this.
Historically, humans got an estimated 2% polyunsaturated fat from their diet. Today, that percentage is between 10% and 20% — and conventional poultry is a hidden source of harmful polyunsaturated fat as well.
Importantly, they also review the incorrect belief that high LDL is a risk factor for heart disease, and that by lowering your LDL, you lower your risk of a heart attack. The science simply doesn't bear this out, and the reason for this is because not all LDL particles are the same.
By cutting down on red meat and saturated fat and eating more vegetable oil and chicken for example (which again will count toward your vegetable oil or polyunsaturated fat intake), your LDL may go down, but those LDLs are now going to be oxidized, and no one is testing for oxidation. Oxidized LDL, Saladino explains, will in turn trigger insulin resistance and related problems, including heart disease.
Eating saturated fat, on the other hand, may raise your LDL, but those LDL particles will be large and "fluffy," and do not cause any arterial damage. Many studies have demonstrated that high LDL has nothing to do with heart disease. High LDL does not raise your risk of heart disease per se, but oxidized LDL do.
Teicholz also makes another important point, in that the saturated fat myth has been one of the most thoroughly and comprehensive hypotheses in the history of nutritional science, and it has failed miserably.
She also details how avoiding saturated animal fats causes you to end up with nutritional deficiencies, as animal foods and fats are also rich in micronutrients. Industrially processed vegetable oils are not. As noted by Teicholz, "foods high in saturated fats are the most nutrient-dense foods on the planet." These nutrients are also highly bioavailable.
Meanwhile, the diet recommended by our Dietary Guidelines for Americans do not actually meet nutritional goals. As a result, the most disadvantaged among us — impoverished school children who rely on school meals, hospital patients and the elderly who are in long-term care facilities for example — are being disproportionally harmed, as they have few if any options to make healthier food choices.
The Benefits of Carnosine
In addition to saturated fat and the vitamins and minerals it contains, red meat is also an important source of carnosine, a dipeptide (two amino acids put together) made up of beta-alanine and histidine. Carnosine is only found animal products. It serves as a scavenger or sink for reactive carbonyl groups — intermediaries that go on to form advanced lipoxidation end-products.
If you can grab these carbonyls before they attack proteins and fats, you can essentially stop the vicious cycle resulting in catastrophic peroxidation. Diets that exclude animal products and meat will lower your carnosine level, and carnosine is a really important nutrient to limit the damage from oxidation products. It's also important for mitochondrial function.
Summary of Why Saturated Fats Are so Crucial
Toward the end of his podcast, around one hour and 44 minutes in, Saladino offers a comprehensive summary of the entire discussion. Here's a quick review of his key points:
The insulin sensitivity of your adipose fat cells is inverse to the rest of your body. In other words, you want your fat cells to be insulin resistant, because this makes the rest of your body insulin sensitive (i.e., not insulin resistant). If your adipose fat cells are insulin sensitive, the rest of your body will be insulin resistant. The factor that determines the insulin sensitivity of your adipocytes is the fats you eat.
Linoleic acid "breaks the sensitivity for insulin at the level of your fat cells" — it makes them more insulin sensitive — and, since your fat cells control the insulin sensitivity of the rest of your body by releasing free fatty acids, you end up with insulin resistance.
Conversely, when you eat saturated fat, because of the way it's beta-oxidized in your mitochondria, your fat cells become insulin resistant. As a result, they do not grow and they do not release free fatty acids. Thus, the insulin sensitivity in the rest of your body improves, and insulin resistance goes down.
Vegetable Oils Are Toxic
As discussed in my recent interview with Knobbe (above), the polyunsaturated fats from vegetable oils, seed oils and trans fats are mostly stored in your fat cells (opposed to being used for fuel), and have a half-life of 600 to 680 days.13
They also get incorporated into tissues, including your heart and brain. Who in their right mind would want a highly oxidizable oil saturating their organs for years? One result of this could be memory impairment and increased risk of Alzheimer's disease, which is exactly what they found with canola oil.14 As reported in one 2017 study:15
"Our findings do not support a beneficial effect of chronic canola oil consumption on two important aspects of AD pathophysiology which includes memory impairments as well as synaptic integrity. While more studies are needed, our data do not justify the current trend aimed at replacing olive oil with canola oil."
In the interview above, Knobbe explains the harms of vegetable oils and, like Saladino and Teicholz, reviews why they are a root cause behind virtually all chronic diseases.
According to the featured BBC Documentary “The Power of Meditation,”1,2 originally aired in 2008, more than 10 million Westerners practice daily meditation. More recent statistics3 suggest people are turning to meditation in droves, with the number of practitioners tripling since 2012. As of 2019, an estimated 200 million to 500 million people meditate regularly around the globe.
Considering its many psychological and physical benefits, this is good news, especially in light on the pandemic we are all going through. There is a large body of evidence demonstrating the mind-body connection is real, and that your mind has a direct impact on your physical health.
Meditation Changes Your Brain and Body for the Better
For example, brain imaging has revealed meditation alters your brain in a number of beneficial ways — such as increasing gray matter volume in brain regions involved in the regulation of emotions, memory, learning and self-referential processes4 — and studies show meditative practices even alter your genetic expression.5,6,7,8
Indeed, one study9 found meditation practice altered the expression of no less than 2,209 different genes. Examples of genetic effects include the down-regulation of genes involved in inflammation and stress.10,11
According to a study in PLOS ONE,12 many of these genetic changes — such as reduced oxidative stress and increased antioxidant production and telomerase stability — are the result of activating the body’s relaxation response. The relaxation response also influences your energy metabolism, which can have bodywide benefits. As explained by the authors:13
“Upregulating ATP synthase — with its central role in mitochondrial energy mechanics, oxidative phosphorylation and cell aging — RR [the relaxation response] may act to buffer against cellular overactivation with overexpenditure of mitochondrial energy that results in excess reactive oxygen species production.
We thus postulate that upregulation of the ATP synthase pathway may play an important role in translating the beneficial effects of the RR.”
Meditation Improves Wellness by Promoting Balance
Findings such as these prove you cannot separate your health from your emotional well-being, and if you want to prevent chronic illness, you’d be wise to incorporate this knowledge.
Clinically, mindfulness-based meditation practice has been demonstrated in randomized trials to improve depressive symptoms in women with fibromyalgia14 and to have lasting anti-anxiety effects after only eight weeks of group practice.15
In “The Power of Meditation,” professor Kathy Sykes begins her investigation of meditation by visiting a Buddhist monk in Nepal, who teaches her basic Buddhist meditation, which involves sitting comfortably, with your spine straight, concentrating on a single focal point, such as your breath.
When a thought arises, you simply refocus your attention on your breath. Over time, this kind of meditation fosters inner calm, happiness, relaxation and emotional equanimity, although results can often be felt rather quickly. “Meditation is not just a hobby,” the monk says. “It’s something that is going to change the very way you experience every moment of your life.”
The Science of Meditation
I’ve already mentioned a number of studies demonstrating the benefits of meditation. “The Power of Meditation” cites16 additional evidence showing it can help a wide range of health problems, including cardiac arrhythmias, bronchial asthma, cold sores, cough, ulcers, diabetes, constipation, infertility, high blood pressure, psoriasis, pain and much more.
Research17 even suggests total medical costs for primary care could be drastically reduced simply by practicing meditation and other relaxation techniques.
To reach this conclusion, the researchers analyzed data from 4,452 people who received eight weeks of relaxation response training and 13,149 controls who did not meditate. The intervention group also worked on building resiliency using social support, cognitive skills training and positive psychology. Results showed:
“At one year, total [health care] utilization for the intervention group decreased by 43%. Clinical encounters decreased by 41.9%, imaging by 50.3%, lab encounters by 43.5%, and procedures by 21.4% … The intervention group’s Emergency department (ED) visits decreased from 3.6 to 1.7/year and Hospital and Urgent care visits converged with the controls.
Subgroup analysis (identically matched initial utilization rates—Intervention group: high utilizing controls) showed the intervention group significantly reduced utilization relative to the control group by: 18.3% across all functional categories, 24.7% across all site categories and 25.3% across all clinical categories.
Conclusion: Mind body interventions such as 3RP [relaxation response resiliency program] have the potential to substantially reduce healthcare utilization at relatively low cost and thus can serve as key components in any population health and health care delivery system.”
The researchers estimate the average patient could save between $640 and $25,500 a year in health care costs by implementing this kind of relaxation response training.
Meditation Guidelines for Heart Disease
While the mind-body connection has long been ignored by conventional medicine, the American Heart Association in 2017 issued its first scientific statement and guidelines on seated meditation,18 suggesting it can be a valuable adjunctive intervention for cardiovascular disease. As noted in the AHA’s scientific statement:19
“Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have reported on the benefits of meditation.
Meditation instruction and practice is widely accessible and inexpensive and may thus be a potential attractive cost‐effective adjunct to more traditional medical therapies …
Neurophysiological and neuroanatomical studies demonstrate that meditation can have long-standing effects on the brain, which provide some biological plausibility for beneficial consequences on the physiological basal state and on cardiovascular risk …
Overall, studies of meditation suggest a possible benefit on cardiovascular risk … Given the low costs and low risks of this intervention, meditation may be considered as an adjunct to guideline‐directed cardiovascular risk reduction by those interested in this lifestyle modification …”
There Are Many Types of Meditation
As noted in “The Power of Meditation,” there are many different kinds of meditation techniques. Common forms of seated meditation suggested in the AHA’s guidelines include:20
Samatha (focused attention technique)
Vipassana (insight meditation; an “open monitoring” technique that encourages a broader awareness of your environment or train of thought, allowing feelings you might normally suppress to rise to the surface)
Mindful meditation
Zazen (Zen meditation)
Raja yoga
Metta (loving-kindness meditation)
Transcendental meditation (TM)
Relaxation response practice
“The Power of Meditation” interviews Dr. Robert Schneider, a medical doctor who conducts research on the health benefits of Transcendental Meditation.21 According to Schneider, there are several hundred studies showing TM “evokes a deep state of rest and an orderliness of the brain and nervous system, and this results in improved mental health, physical health and even improved social health.”
He goes on to discuss the scientifically demonstrated benefits of TM on cardiovascular diseases specifically. This includes lowering high blood pressure and reducing death rates from heart attacks and strokes.
Meditation Relaxes Yet Invigorates
In the 2014 Talks at Google video above, meditation expert Emily Fletcher22 explains the differences between two popular styles of meditation, directed attention (mindfulness) meditation and nondirected attention meditation (which she refers to as “self-induced transcendence” meditation), and explains how each meditation style affects your brain.
She also discusses the similarities between meditation and caffeine. Both have the effect of energizing you and boosting your productivity, but meditation accomplishes this without any adverse effects.
Caffeine stimulates neural activity in your brain that triggers the release adrenaline, a stress chemical involved in the fight-or-flight state. Meditation, on the other hand, energizes you and makes you more productive without triggering an adrenaline rush.
The reason for this is because meditation de-excites your nervous system rather than exciting it further. This makes it more orderly, thereby making it easier for your system to release pent-up stress. It also makes you more productive. In fact, she notes that many are now starting to recognize meditation as a powerful productivity tool.
Contrary to popular belief, taking the time to meditate can actually help you gain more time through boosted productivity than what you put into it.23 According to Fletcher, meditating for just 20 minutes equates to taking a 1.5-hour nap, and provides your body with rest that is two to five times deeper than sleep. This is why even a short period of meditation each day can help you feel more refreshed and awake.
How Different Types of Meditation Affect Your Brain
So, just how does different types of meditation styles impact your brain? Here’s a summary of some of the neuroplastic changes induced by three popular sitting meditation practices:
•Transcendental meditation24 causes your brain to switch into primarily alpha frequency, corresponding to a relaxed yet aware state akin to daydreaming.
As the left and right hemisphere of your brain enter into coherence, endorphin production increases, inducing a sense of happiness and bliss. Over time, this kind of meditation expands your sense of self beyond bodily limitations, resulting in a more integrated personality.
•Mindful meditation25 and samatha — focused attention techniques in which you concentrate on your breath or a single object, thought, mantra, sound or visualization — activate the executive mode of your brain.
The idea behind mindfulness is to remain in the present moment by focusing your attention in the now. The brainwave frequency here typically responds to the gamma range.
Long-term, this type of meditation tends to enlarge your hippocampus, which is where your memories are stored, while shrinking the amygdala, the emotional center and the site of your fight-or-flight instinct. This is in part why mindfulness training tends to be helpful for depression and anxiety, as it helps improve the regulation of emotions.
•Self-induced transcendence (discussed by Fletcher in the video above) is a nondirected style of meditation in which you access a fourth state of consciousness that is different from waking, sleeping and dreaming. Transcendence style meditation strengthens your corpus callosum, the bridge between your two brain hemispheres.
Your left brain is in charge of the past and the future, language, math and critical thought, while your right brain is in charge of “right now,” intuition, inspiration, connectedness, creativity and problem-solving.
By strengthening the connection between your right and left hemispheres, you gain access to more creative problem-solving and increase your productivity without adding stress.
Mindfulness-Based Cognitive Therapy for Depression
Sykes also investigates the benefits of meditation on mental health, for which there is perhaps even more evidence. She visits a woman named Carol, who struggled with severe depression after the death of her husband.
Her psychiatrist suggested meditation, in which you focus on your breathing — similar to the Buddhist meditation described earlier. “It stopped me from living in my head with my thoughts,” Carol says, “and it’s given me a better picture of what it’s like to be alive, really.”
The program Carol enrolled in, called MBCT, which stands for mindfulness-based cognitive therapy, was developed by professor Mark Williams, described as a leader in the field of clinical depression. MBCT is a mix of about 80% mindfulness meditation and 20% cognitive therapy, which is a widely used psychological technique.
As explained by Williams, mindfulness meditation teaches you to see your problems or thoughts clearly, without trying to change or fix anything. In other words, you learn to view your thoughts as “just thoughts,” be they positive, negative or neutral, rather than something with intrinsic meaning or something that you need to do anything about.
According to Sykes, four different trials have demonstrated that MBCT reduces the risk of recurrent depression by 50% in people who have had three or more depressive episodes.
Williams also points out that mindfulness meditation can really benefit everyone, as it helps us deal with expectations, judgments (of self and others), paralyzing self-analysis and the feeling that we’re just not good enough.
“All of these things are just thoughts,” he says. “They will come up in meditation, and learning to recognize what they are — thoughts — and let them go, can be enormously empowering.”
Beginner’s Guide to Meditation
While it's not unusual for the most experienced meditators to have spent decades, even a lifetime, perfecting the art of meditation, you can gain benefits just from meditating in your home for 20 minutes a day.
If you'd like to give meditation a try, there are many classes and group sessions available if you want a structured group setting, and free guided meditation apps you can use on your own wherever you are.
The UCLA’s Mindful Awareness Research Center26 is a helpful resource where you can download free guided meditations in English and Spanish. The following suggestions can also help you get started:
• Set aside 20 to 30 minutes to meditate each day. Choose a quiet place where you can sit comfortably without being disturbed or interrupted. Simply close your eyes and focus on your breath. You don’t need to control your mind or breathe in any unnatural way. When thoughts arise — and they will — simply let them pass through without judgment and return your attention to the breath.
• As you meditate, you will notice thoughts, sensations and sounds. The next step is to take note of the presence or “witness” that is doing the actual noticing. You’ll find that this presence cannot be pinned down to any particular place inside you. As you continue, simply abide in this presence and be the witness.
In the book, “The Untethered Soul, the Journey Beyond Yourself,”27 Michael Singer asserts that happiness and freedom are the result of cultivating “witness consciousness,” a state of willfully observing your mind, emotions and behaviors, rather than feeling that you actually are these things.
• The more you meditate, the easier it will become to quickly enter into a state of calm and relaxed yet focused awareness. It will also become easier to remain in meditation for longer periods of time. The after-effects will also last longer the more you meditate, allowing you to go through your day in a calmer more focused state.