Health & Fitness

Cholesterol levels are declining sharply in Western nations, but rising in low- and middle-income nations - particularly in Asia, suggests the largest ever study of global cholesterol levels.

from Diet and Weight Loss News -- ScienceDaily https://ift.tt/3dRU7Qp

Italian researchers have been able to identify the genetic basis of susceptibility to Covid-19 infection, and also to the possibility of contracting a more severe form of the disease. This has important implications for treatment and drug development.

from Top Health News -- ScienceDaily https://ift.tt/2BA7nKV

Vitamin C, a water-soluble vitamin found in abundance in fruits and vegetables, is an essential nutrient that humans must get from their diet or supplements. Also known as ascorbic acid, vitamin C is perhaps most well-known for its antioxidant properties — properties it maintains because of an ability to donate electrons to oxidized molecules.

In the video above, Rhonda Patrick, Ph.D., discusses vitamin C in-depth, covering everything from its effects on immune function and viral infections to the bioavailability of different vitamin C forms and administrations, such as oral or intravenous — plus much more. If you have any interest in learning how vitamin C can benefit your health, this video is a must-see.

Vitamin C’s Many Roles in Your Health

Vitamin C, even in small quantities, protects proteins, lipids and even DNA and RNA in your body from reactive oxygen species that are generated during normal metabolism as well as due to toxin exposure (such as to cigarette smoke and air pollution).

Vitamin C is also involved in the biosynthesis of collagen, carnitine and catecholamines, according to Patrick, and as such, “vitamin C participates in immune function, wound healing, fatty acid metabolism, neurotransmitter production, and blood vessel formation, as well as other key processes and pathways.”¹

Intravenous (IV) vitamin C has also shown promise in helping to treat viral infections and cancer, while vitamin C is also involved in the way your body processes other vitamins, such as vitamin E, which it regenerates from its oxidized form. Vitamin C also makes iron from dietary sources more bioavailable because it enhances gut absorption of nonheme iron.²

Vitamin C and Immune Function

Vitamin C’s role in immune function is worthy of attention. “It stimulates the production of white blood cells, especially neutrophils, lymphocytes and phagocytes, and promotes the cells' normal functions, such as their ability to detect, move toward and engulf pathogens,” according to Patrick.³

Vitamin C also acts as an antioxidant within your cells, helping to protect immune cells from incurring damage, and may promote the production of interferon, which helps defend against viruses.

There’s also evidence that vitamin C may help in some cases of exercise-induced immune dysfunction. While exercise is generally beneficial for immune function, over-exercise or repeated high-intensity training can take a toll on the immune system. In the case of marathon runners, skiers and soldiers, for instance, those who used supplemental vitamin C had 50% fewer colds.⁴

Vitamin C’s anti-cold effects are among its most-studied uses, and research suggests that using vitamin C prophylactically as well as therapeutically at the onset of cold symptoms may reduce symptoms and cold duration.⁵ It may also be useful against COVID-19.

In my March 17, 2020 interview with Dr. Andrew Saul, editor-in-chief of the Orthomolecular Medicine News Service, he mentions being in contact with a South Korean medical doctor who is giving patients and medical staff an injection of 100,000 IUs of vitamin D along with as much as 24,000 mg (24 grams) of IV vitamin C. "He's reporting that these people are getting well in a matter of days," Saul says.

As explained by Saul, vitamin C at extremely high doses acts as an antiviral drug, actually killing viruses. While it does have anti-inflammatory activity, which helps prevent the massive cytokine cascade associated with severe SARS-CoV-2 infection, its antiviral capacity likely has more to do with it being a non-rate-limited free radical scavenger.

Patrick also noted that vitamin C may be protective against respiratory diseases. In one study, people with the highest vitamin C levels were 15% less likely to develop respiratory conditions and 46% less likely to die of lung cancer compared to those with the lowest levels.⁶

Further, vitamin C is well known for helping with lung defense, which takes on renewed meaning in the midst of the COVID-19 pandemic. According to Patrick:⁷

“The innate immune system of the lungs is an integral component of the body's defense system, protecting the body against exposure to inhaled oxidants and pathogens … Vitamin C's lung defense capacity is evidenced by robust data suggesting that vitamin C intake protects against chronic obstructive pulmonary disease, pulmonary fibrosis, and other respiratory illnesses, including lung cancer.

But this characteristic takes on special relevance in light of recent concerns about complications associated with COVID-19, such as pneumonia and acute lung injury, which often necessitate mechanical ventilation support.

Epidemiological and observational data indicate that higher vitamin C intake is associated with a lower risk of developing pneumonia, and the vitamin has also proven to be effective at decreasing the duration for which patients are kept on mechanical ventilation, especially among patients who require more than 24 hours of breathing support.”

Vitamin C and Cancer

Another exciting area of vitamin C research involves cancer. Research suggests that IV vitamin C may extend survival compared to chemotherapy alone, even for pancreatic and ovarian cancers, which are among the deadliest. Patrick mentions two studies in patients with pancreatic cancer, which found intravenous vitamin C helped reduce tumor size and promote longer progression-free survival.⁸

Vitamin C also leads to improved quality of life for cancer patients. In one study of 39 patients diagnosed with terminal cancer, IV vitamin C led to improvements in physical, emotional and cognitive status as well as reductions in fatigue, nausea, vomiting, pain and appetite loss.⁹

Since conventional cancer therapies often lead to significant side effects, including physical, emotional, cognitive and sexual impairments, using vitamin C as an adjunct to improve quality of life can be a significant improvement.

Vitamin C for Heart and Brain Health

Patrick’s video also goes into the role vitamin C plays as a cardioprotective agent, as well as a mediator of brain health. For starters, vitamin C is known to protect against high blood pressure, as well as reduce blood pressure in people with high blood pressure or prehypertension.¹⁰

Vitamin C also shows promise as a treatment for ischemia and perfusion injury, which can occur following a heart attack or stroke, leading to increased inflammation and oxidative damage. “Vitamin C might be effective at reducing myocardial injury in part by mitigating oxidative stress,” Patrick explained.¹¹ In your brain, vitamin C is also essential. According to Patrick:¹²

“Vitamin C is found in high concentrations in the brain, especially in the hippocampus and frontal cortex regions – areas involved in memory consolidation, learning, and aspects of executive function.

In fact, in a classic example of the body triaging resources based on needs, the brain retains vitamin C during times of deficiency at the expense of other tissues. This is critical to our survival: Evidence suggests that vitamin C plays roles in the brain throughout the lifespan from development through older age.”

Due to vitamin C’s antioxidant properties, it may help decrease the risk of neurodegenerative conditions like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and multiple sclerosis because it reduces oxidative damage. “Vitamin C is also important for the regulation of neurotransmitters, the formation of neural circuits, and many other key brain functions,” Patrick says.¹³

Vitamin C as a ‘Cure-All’

Patrick describes double Nobel Prize laureate Dr. Linus Pauling’s 1970 publication on vitamin C and the common cold as the impetus that brought vitamin C into the realm of a cure-all in the minds of the general public. While this is an exaggeration — vitamin C can’t cure everything — it’s truly remarkable how many different conditions appear to be benefited by vitamin C. Aside from being an antioxidant and anti-infective agent, Patrick describes vitamin C’s benefits for:

Pneumonia	Asthma	Exercise-induced bronchoconstriction
Fatty acid oxidation	Sepsis	Myocarditis in children
Herpes	Epstein-Barr virus infection	Fertility and reproduction
Inflammation	Lung cancer	Common cold and other respiratory diseases

Vitamin C Bioavailability Varies by Form

There are differences in the bioavailability of vitamin C depending on its form. Both frequency and dose of vitamin C will affect your levels, but so too will taking it in oral or IV form.

“For example, oral vitamin C is absorbed in the small intestine via specialized transporters that are subject to saturation, but intravenous vitamin C bypasses the gut, achieving blood and tissue concentrations that are markedly higher than those achieved with the oral form,” Patrick explains.¹⁴

IV vitamin C may lead to blood concentrations up to 70 times higher than an equivalent oral dose.¹⁵ That being said, liposomal vitamin C, in which vitamin C is encapsulated in a lipid particle, may increase bioavailability of oral vitamin C considerably.

“A few studies suggest that oral bioavailability of vitamin C can be increased when consumed in liposomal form, which exerts a unique profile of oral bioavailability,” Patrick says, citing a study of 20 people who were given a 10-gram dose of free oral vitamin C or liposomal vitamin C.¹⁶

“The average peak plasma concentration of vitamin C in the participants who took the free form was approximately 180 micromoles per liter of blood. However, among those who took the liposomal form, the average peak plasma concentration was 300 micromoles per liter of blood, a 70 percent difference,” she said.¹⁷

I strongly believe that liposomal vitamin C is a must for your medicine kit to be pulled out for acute viral illnesses. If I were to become acutely ill, I would take 4 grams of liposomal vitamin C every hour until feeling better, then start decreasing the dosage slowly over a few days once symptoms improve.

Best Food Sources of Vitamin C

I personally only take 100 milligrams (mg) of vitamin C supplement and only when I don’t have regular access to fresh acerola cherries. I have several trees on my property that usually have a harvest every few weeks for nine months of the year. Each cherry has 80 mg of vitamin C, so I can easily get up to 10 grams on days that I eat the cherries.

A wide variety of foods are high in vitamin C, including red pepper, parsley, broccoli, kiwi, strawberries, guava, tomato and all citrus fruits. You can get significant amounts of vitamin C from your diet if you eat these foods on a daily basis.

Keep in mind, however, that cooking destroys about 25% of the vitamin C present in foods.¹⁸ Fortunately, many vitamin C-rich foods are commonly eaten raw. If you're healthy, or have only mild illness, you can certainly use these types of whole foods, and they may even be preferable, but if you want to treat illness, your best bet is to use vitamin C in supplement form, either liposomal or IV. Further, according to Patrick:¹⁹

“It is noteworthy that some scientists believe that compelling evidence supports increasing the RDA for vitamin C to 200 milligrams per day for adults. Whereas the goal of the current recommendations is to reduce the risk of scurvy, higher intake could saturate tissue levels, potentially reducing the risk of chronic conditions such as heart disease, stroke, cancer, and metabolic dysfunction.”

Certain populations, including people who smoke, consume alcohol or have inflammatory bowel disease, may need increased intake of vitamin C, but some research suggests vitamin C deficiency may be more common than realized.

“Interestingly, a population-based cross-sectional study of nearly 150 patients admitted to a large teaching hospital in Canada found that 60 percent of the patients had suboptimal plasma vitamin C levels and 19 percent were deficient, with levels approaching those associated with scurvy,” Patrick noted.²⁰ It’s clear that vitamin C is one nutrient everyone should be sure to get enough of, but if you’re acutely ill, vitamin C becomes even more important.

“Vitamin C might be especially beneficial for critically ill people, particularly those with viral infections, who commonly have lower blood levels of vitamin C compared to healthy people,” Patrick says. So in addition to eating plenty of vitamin C-rich foods daily, keep vitamin C in mind during times of illness. Fortunately, Patrick adds, “With some exceptions, oral and intravenous vitamin C supplementation have been shown to be safe, well-tolerated, and have low toxicity.”²¹

from Articles https://ift.tt/3cFGBOd
via IFTTT

During an organ transplant, physicians use the healthy organs and tissues from one individual and transplant them into another. In 2018, there were 36,527 organ transplants in the U.S., which set a record for the sixth straight year in a row.¹ The total number has exceeded 750,000 since 1988, when the first transplant data were collected.

Organ donation can be done in one of two ways. The first occurs when the donor is living and chooses to give an organ or tissue to another individual. Living donors can offer a kidney or part of a liver or lung.²

The second type happens when the organ donor has died and left instructions for donation. More than 155 million people are registered as organ donors, yet only three out of 1,000 will qualify after they die. There are several different organs and tissues that can be transplanted from a deceased person, including:^3,4

Heart and heart valves	Lung	Cornea
Bone or bone marrow	Liver	Kidney
Pancreas	Intestine	Skin
Middle ear	Connective tissue

As of March 2020, there were 112,000 men, women and children on the waiting list. According to the Health Resources and services Administration,⁵ 20 people die every day waiting for an organ transplant, while another person is added to the list every 10 minutes.

Advances in technology and medicine have made it possible to successfully transplant more organs and tissue than ever before. Yet, each year the number of people waiting for a transplant grows faster than the number of people willing to donate, whether living or deceased. One individual who dies can donate up to eight lifesaving organs and impact the lives of many others.

Organ Donation and Transplant Numbers Down

When the shelter-in-place orders went into effect across the country, many states saw a decline in traffic accidents and fatalities. An April report from the University of California Davis⁶ noted that the number in California had been reduced by half in the first three weeks.

By comparison, in Minnesota, the number of fatalities from January to April in 2019 and 2020 were actually close.⁷ Preliminary data showed there were 81 people killed in car crashes in 2020 as compared to 78 the previous year during the same time of year.

Deaths from accidents account for nearly 33% of all organ donations,⁸ which were down 23% nationwide from March 8 to April 11. Spring break, outdoor activities and travel often signal a greater number of accidents. April is usually when organ donations surge. However, the United Network for Organ Sharing (UNOS) has found that numbers were consistently lower across the board during the pandemic.

Janice Whaley, CEO of Donor Network West, told a reporter from Kaiser Health News, “Spring break accidents are almost nonexistent because there’s no spring break — beach accidents, motorcycle accidents, hunting accidents.”⁹

Another factor limiting the number of available donor organs is a decline in emergency room visits. George Rutherford, infectious disease specialist at the University of California San Francisco, remarked:¹⁰

“Where are all the people with heart attacks? Where are all the people with strokes? Are those patients staying away from the ERs for fear of COVID? Clearly, the census is way down in ERs.”

Transplant Teams Balancing Risk Against Need

Individuals who die from a stroke or a heart attack are the second and third largest sources of organ donation. When individuals die at home, the organs can't be used for transplant since they are not kept viable after death.

For an organ to be usable, a person must die or be declared brain-dead while they're on a ventilator, which keeps the heart, lungs, liver and kidneys viable. Although transplants are considered essential, teams have been making decisions as each case is presented.

The criteria for surgery are based on the recipient's risk of death without receiving a transplant and the hospital’s current census, staffing and number of ventilators available.¹¹

With the uncertainty of how many ventilators the hospital may need for patients with COVID-19, clinicians have been reluctant to take on transplants. For the organs to remain viable, the donor must remain on a ventilator until a transplant team can be assembled and recipients identified. The organ recipients also need to be on ventilators during surgery.¹²

Although many of those who died in the hospital from COVID-19 were willing to donate their organs, they were declined since they could potentially infect the recipient. Living donations have also been canceled at many hospitals because it doubles the risk by bringing in two patients — the donor and the recipient — for the procedure.

Transplant procedures have a complex logistical process. Once a person is declared brain-dead, a medical provider from the organ procurement organization will evaluate them to be sure they're suitable for donation.¹³

Authorization must be received from the patient’s family before their information can be added to the national computer database to find a match. Once this is completed, the hospital must organize transportation, transplantation and recovery for the recipients.

Paired Organ Donation Program

Living donors have a second option if they find they're not a good medical match for the intended recipient. The kidney paired donation pilot project¹⁴ is managed by the United Network for Organ Sharing through the Health Resources and Services Administration. This is the program a kidney transplant patient featured in The Wall Street Journal used when his sister found she wasn’t a match for him.¹⁵

The program involves multiple institutions, candidates and donors. The sister agreed to donate her kidney to a stranger with whom she was a match, in exchange for the understanding that another individual who is a match for her brother would donate to him. Experts believe nearly 16% of paired kidney transplants occur each year.

The Wall Street Journal¹⁶ reported on May 25, 2020 that their featured subjects were still waiting for the transplant teams to agree to do the surgeries, as the procedures were put on hold during the pandemic. In the meantime, the kidney patient is on dialysis 17 hours a day as he waits for the surgery.

How Organ Donation Works

When a person needs to be placed on the organ transplant waiting list, they must have a referral from their physician to be evaluated for the program. A team of people, including a transplant coordinator, social worker and surgeon, work with the patient and family to organize the process.¹⁷

The patient undergoes specific tests to gauge medical necessity as well as their social support and psychological readiness.¹⁸ This helps determine if the person is a candidate. Once accepted, their medical information is entered into the national database. Patients are encouraged to seek living donors when appropriate.

Kidney transplants are crucial for those with end-stage kidney disease. One factor that can raise the rate of success is ensuring viability of the organ. Researchers from the University of Cincinnati have discovered a gene that may predict the potential risk of a donor having kidney disease later in life.¹⁹

The test may help identify individuals whose kidneys may not remain viable for the recipient, and who may need to keep their kidneys long-term. This can assist with expanding the living kidney transplant program because it identifies potential challenges for donors and recipients.

Myths About Organ Donation

There are several myths about organ donation that may have stopped you from considering becoming an organ donor. Many of these have been perpetuated in the movies. It’s important to know the facts to make an informed decision. These are some of the more common questions and concerns:^20,21,22

How to Become an Organ Donor

There are several ways of indicating your interest to become an organ donor. It’s also important that even after registering and adding the information to your driver's license, that you also share your decision with your family. During times of crisis, it's important for your family to know and understand your wishes so they can be carried out.²³

A donor registry, such as the National Donate Life Registry,²⁴ is one way to indicate your interest.²⁵ Each time you renew your driver’s license, you're asked if you want to make an anatomical gift or become an organ donor. When you say yes, the indication is added to your license.

You can also pick up a form at the Bureau of Motor Vehicles. It's important to sign and carry an organ donor card; this can be downloaded from OrganDonor.gov.²⁶ It’s used to communicate your wishes to emergency personnel after an accident or catastrophic event.

from Articles https://ift.tt/2YaT5YO
via IFTTT