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06/27/21

Researchers have discovered a crucial protein involved in the communication and coordination between astrocytes as they build synapses in the brain. Lacking this molecule, called hepaCAM, astrocytes aren't as sticky as they should be, and tend to stick to themselves rather than forming connections with their fellow astrocytes.

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By Dr. Mercola

Reaching puberty is a rite of passage that we've all been through, but children are now reaching it earlier than ever before, and while precocious puberty in girls has received most of the attention, we now know the trend applies to boys as well.

In the 19th century, the onset of menstruation in girls occurred around the age of 15. Now the average age of the first period is around 12. Some girls develop breasts as early as age seven1 .

According to a recent study in the journal Pediatrics2, boys are now beginning sexual development anywhere from six months to two years earlier than the medically accepted standard based on previous studies.

African-American boys were found to hit the onset of puberty the soonest, starting around the age of nine. Caucasian and Hispanic boys begin developing around the age of 10.

"The causes and public health implications of this apparent shift in US boys to a lower age of onset for the development of secondary sexual characteristics in US boys needs further exploration," the authors write.

Indeed, while some may shrug off the trend of earlier maturation, it's actually pretty significant, as it can affect both physical and psychological health in a number of ways, including raising the future risk for hormone-related cancers. Girls who enter puberty earlier are at an increased risk of breast cancer, for example, due to the early rise in estrogen.

The trend also raises serious questions about environmental factors spurring this development. Lead researcher Marcia Herman-Giddens told CNN Health3:

"The changes are too fast. Genetics take maybe hundreds, thousands of years. You have to look at something in the environment. That would include everything from (a lack of) exercise to junk food to TV to chemicals."

Environmental Chemicals a Likely Factor

Scientists have brought forth a number of potential explanations for the rising rates of early puberty, but one that deserves special attention is environmental chemicals, and particularly xeno-estrogens, i.e. estrogen-mimicking chemicals. These compounds behave like steroid hormones and can alter the timing of puberty, and affect disease risk throughout life.

In adults, xeno-estrogens have been linked to decreased sperm quality, stimulation of mammary gland development in men, disrupted reproductive cycles and ovarian dysfunction, obesity, cancer and heart disease, among numerous other health problems.

We're surrounded by hormone-disrupting chemicals these days, many of which are plasticizers. Bisphenol A (BPA) for example, is an industrial petrochemical that acts as a synthetic estrogen, and can be found plastics and tin can linings, in dental sealants, and on cash-register receipts. Three years ago, laboratory tests commissioned by the Environmental Working Group (EWG) detected BPA in the umbilical cord blood of 90 percent of newborn infants tested -- along with more than 230 other chemicals!

In September 2010, Canada declared BPA a toxic substance, but to date no other country has followed suit, although BPA has been banned in baby bottles in Canada, Europe and the United States. Frustratingly, the US FDA has denied the request to ban BPA, however many American companies have voluntarily removed the chemical from their products, in response to consumer demand. So, if you check around, you can find a lot of BPA-free products.

However, buyer beware, as it recently came to light that some companies are simply replacing the offending BPA with another less known but equally toxic chemical called bisphenol-S (BPS)! Not only does BPS appear to have similar hormone-mimicking characteristics to BPA, but research suggests it is actually significantly less biodegradable, and more heat-stable and photo-resistant, than BPA.

10 Top Offenders that Can Disrupt Your Hormones

Beside BPA and BPS, other top offenders you should be aware of, and watch out for, include:

Phthalates, a group of industrial chemicals used to make plastics like polyvinyl chloride (PVC) more flexible and resilient. They're also one of the most pervasive of the endocrine disrupters, found in everything from processed food packaging and shower curtains to detergents, toys and beauty products like nail polish, hair spray, shampoo, deodorants, and fragrances. Exposure to phthalates can lead to incomplete testicular descent in fetuses, reduced sperm counts, testicular atrophy or structural abnormality and inflammation in newborns. Fluoride, which is added to the majority of public water supplies in the United States. Research has shown that animals treated with fluoride had lower levels of circulating melatonin, as reflected by reduced levels of melatonin metabolites in the animals' urine. This reduced level of circulating melatonin was accompanied -- as might be expected -- by an earlier onset of puberty in the fluoride-treated female animals.
Perfluorooctanoic acid (PFOA), a likely carcinogen found in grease- and water-resistant coatings and non-stick cookware. Methoxychlor and Vinclozin, an insecticide and a fungicide respectively, have been found to cause changes to male mice born for as many as four subsequent generations after the initial exposure.
Nonylphenol ethoxylates (NPEs). Known to be potent endocrine disrupters, these chemicals affect gene expression by turning on or off certain genes, and interfere with the way your glandular system works. Bovine growth hormones (rBGH) commonly added to commercial dairy have been implicated as a contributor to premature adolescence.
MSG, a food additive that's been linked to reduced fertility. Non-fermented soy products, which are loaded with hormone-like substances.
DDE (a breakdown product of the pesticide DDT) PCBs

New Concern: Metalloestrogens

Recent research has also confirmed the existence of a previously unknown class of cancer-causing estrogen-mimicking compounds: "metalloestrogens." The following metals, which are added to thousands of consumer products, including vaccines, have been identified as being capable of binding to cellular estrogen receptors and then mimicking the actions of physiological estrogens:4

Aluminum Antimony Arsenite Barium Cadmium Chromium Cobalt
Copper Lead Mercury Nickel Selenite Tin Vanadate

Tips to Reduce Exposure to Hormone-Disrupting Substances

While young girls and boys may show obvious signs of exposure to hormone-disrupting substances via early puberty, other signals are more insidious and may not show up until a disease is already present. You can cut back on your family's exposure to these dangerous chemicals by following these 12 guidelines. Pregnant women and women who may become pregnant should pay particular attention to reducing their exposure as much as possible to protect the health of their unborn baby:

  1. Eat whole, preferably organic, produce and free-range, organic meats to reduce your exposure to added hormones, pesticides and fertilizers. Also avoid milk and other dairy products that contain the genetically engineered recombinant bovine growth hormone (rBGH or rBST)
  2. Eat mostly raw, fresh foods. Processed, prepackaged foods (of all kinds) are a major source of soy and chemicals such as BPA and phthalates.
  3. Store your food and beverages in glass rather than plastic, and avoid using plastic wrap and canned foods (which are often lined with BPA-containing liners).
  4. Use glass baby bottles and BPA-free sippy cups for your little ones.
  5. Make sure your baby's toys are BPA-free, such as pacifiers, teething rings and anything your child may be prone to suck on.
  6. Only use natural cleaning products in your home to avoid phthalates.
  7. Switch over to natural brands of toiletries such as shampoo, toothpaste, antiperspirants and cosmetics. The Environmental Working Group's Skin Deep Database5 is a great resource for finding personal care products that are free of phthalates, parabens and other potentially dangerous chemicals.
  8. Avoid using artificial air fresheners, dryer sheets, fabric softeners or other synthetic fragrances.
  9. Replace your non-stick pots and pans with ceramic or glass cookware.
  10. When redoing your home, look for "green," toxin-free alternatives in lieu of regular paint and vinyl floor coverings.
  11. Replace your vinyl shower curtain with one made of fabric.
  12. Avoid non-fermented soy, especially if you're pregnant. Also, never use soy-based infant formula.


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By Dr. Mercola

If you think your birth control pill is the best pregnancy prevention tool there is, you may be surprised by new research looking into its failure rates.

Compared to other forms of protection, the Pill failed miserably, which only adds to the myriad of reasons why you should heavily question its use.

The Pill Fails 20 Times More Often

About 99 percent of sexually active women use at least one method of birth control, the most common of which is the birth control pill (oral contraceptives). The Pill was used by nearly 11 million U.S. women from 2006-2008.i

Meanwhile, nearly half of all pregnancies in the United States are unintended.ii Certainly not all of these are due to a birth control failure, but some of them -- estimates suggest about half -- undoubtedly are. Which brings me to a recent study published in the New England Journal of Medicine.iii Out of the 7,500 women in the study, who used various forms of birth control including an intrauterine device (IUD), implant, birth control pills, patch, ring and contraceptive injection, 334 became pregnant, 156 of which were due to birth control failure.

The contraceptive failure rate among pills, patch or ring was 4.55 percent, compared to 0.27 percent among participants using reversible contraception such as intrauterine devices. The effectiveness—or non-effectiveness—was no different in adolescents or young women. The implications—that birth control pills are 20 times more likely to fail than IUDs—should give some women a pause to think about the method of contraception they want to use.

As for the varying degrees of effectiveness, the Pill must be taken daily, preferably around the same time for it to work its best. Study author Dr. Jeffrey Peipert, a professor of obstetrics and gynecology at Washington University School of Medicine in St. Louis, noted:iv

"This study is the best evidence we have that long-acting reversible methods are far superior to the birth control pill, patch and ring. IUDs and implants are more effective because women can forget about them after clinicians put the devices in place ... If there were a drug for cancer, heart disease or diabetes that was 20 times more effective, we would recommend it first."

Hormone-Based Contraceptives Have Steep Risks

Unintended pregnancy is clearly a big one, but artificially manipulating your hormones using oral contraceptives, the patch or ring, or an injection like Depo-Provera is also a very risky proposition. Most birth control pills are a combination of the derivatives of the hormones estrogen and a synthetic progesterone(progestin). They work by disrupting the hormones in your body, essentially fooling your intricate hormonal reproductive system into producing the following effects:

  • Preventing your ovaries from releasing eggs
  • Thickening your cervical mucus to help block sperm from fertilizing an egg
  • Thinning the lining of your uterus, which would make it difficult for an egg to implant, should it become fertilized

However, it is naive to believe that these are the only impacts the synthetic hormones are having. Your reproductive system does not exist in a bubble ... it is connected to all of your other bodily systems as well. The Pill, too, does not only influence your reproductive status; it's capable of altering much more.

Ten years ago, in 2002, one of the largest and best-designed federal studies of hormone replacement therapy was halted because women taking these synthetic hormones had a such a higher risk of breast cancer, heart attack, stroke and blood clots that continuing forward with the study would have been unethical. The news made headlines because millions of women were already taking these synthetic hormones, but fortunately it prompted many of them to quit. And what do you think happened a year after millions of women quit taking hormone replacement therapy? Incidents of breast cancer fell dramatically -- by 7 percent!

What does this have to do with the Pill? Birth control pills contain the SAME type of synthetic hormones -- estrogen and progestin -- that were used in the ill-fated study!

That's just one risk. Oral contraceptives have been linked to more than two dozen conditions, including heart disease, liver cancer, deep vein thrombosis and inflammatory bowel disease.v Research suggests they are not only carcinogenic (cancer-causing) but also cardiotoxic (toxic to your heart) and endocrine disrupting.

Why I Advise Most Women to Stop Hormonal Contraceptives

Birth control pills are rarely, if ever, necessary or beneficial. In exchange for the convenience of preventing pregnancy (which you can do naturally perhaps even more effectively, and I'll explain how below), you are putting yourself at risk of a myriad of health issues.

A new study in the New England Journal of Medicine revealed that several types of hormone-based birth control methods increased women's risk of heart attack and stroke.vi The link was found between oral contraceptives as well as contraceptive patches and the vaginal ring. Women using the ring were found to have a 2.5 times greater risk of stroke compared to those not using hormonal contraceptives, whereas the other methods increased the risk to varying degrees.

Other known health risks of hormone-based birth control include:

Cancer: Women who take birth control pills increase their risk of cervical and breast cancers, and possibly liver cancer as well. Fatal blood clots: All birth control pills increase your risk of blood clots and subsequent stroke. Thinner bones: Women who take birth control pills have lower bone mineral density (BMD) than women who have never used oral contraceptives. Impaired muscle gains: A study found that oral contraceptive use impairs muscle gains from resistance exercise training in women.vii
Long-term sexual dysfunction: The Pill may limit the availability and/or action of testosterone, leading to long-term sexual dysfunction, including decreased desire and arousal. Heart disease: Long-term use of birth control pills may increase the buildup of arterial plaque, which may raise your risk of heart disease and cardiac mortality.viii Migraines and nausea Weight gain and mood changes
Irregular bleeding or spotting Breast tenderness Yeast overgrowth Yeast infection

The other hormonal-based options are not much better. Birth control patches (Ortho Evra) have resulted in an avalanche of lawsuits over the past several years due to the overwhelming health problems women have experienced from using them. One of the reasons the patch is so risky is that you absorb up to 60 percent more synthetic estrogen than if you were taking an oral contraceptive. Side effects of the patch include:

Raised risk of heart attack and stroke Irregular bleeding Problems wearing contact lenses Fluid retention or raised blood pressure
Nausea Headache Breast tenderness Mood changes
Menstrual cramps Abdominal pain Skin irritation or rashes at site of patch  

As far as injections like Depo-Provera, or depo medroxyprogesterone (DMPA), go, this synthetic analogue of natural progesterone known as a progestin interferes with hormone signaling to prevent your ovaries from releasing eggs. Progestins carry with them a vast array of negative side effects, including:

Side Effects of Depo-Provera
  • Weight gain
  • Headaches
  • Breast swelling and tenderness
  • Decreased sexual desire
  • Depression
  • Bloating
  • Swelling of the hands and feet
  • Nervousness
  • Abdominal cramps
  • Dizziness
  • Weakness of fatigue
  • Leg cramps
  • Nausea
  • Vaginal discharge or irritation
  • Backache
  • Insomnia
  • Acne
  • Pelvic pain
  • Lack of hair growth or excessive hair loss
  • Rashes
  • Hot flashes
  • Joint pain
  • Convulsions
  • Jaundice
  • Urinary tract infections
  • Allergic reactions
  • Fainting
  • Paralysis
  • Osteoporosis
  • Lack of return to fertility
  • Deep vein thrombosis
  • Pulmonary embolus
  • Breast and cervical cancers
  • Abnormal menstrual bleeding
  • Increased risk for STDs
  • Unexpected breast milk production
  • Changes in speech, coordination, or vision
  • Swelling of face, ankles or feet
  • Mood changes
  • Unusual fatigue

Is an IUD a Better Option?

Intrauterine devices are small, plastic, T-shaped sticks with a string attached to the end. The IUD is placed inside the uterus and prevents pregnancy by rendering the sperm unable to fertilize an egg, and by changing the lining of the uterus so that it is less supportive for an embryo. It also works by releasing hormones into your body, specifically a progestin hormone called levonorgestrel, which is often used in birth control pills.

One of its major advantages, and what contributes to its increased effectiveness rate, is that it essentially eliminates the compliance failure issue as all you do is insert it once. There is no daily task to remember to do. However, it, too, carries significant risks, including some that are unique to a foreign body being placed inside your uterus. Among them:

  • Pelvic infection: IUDs may lead to pelvic inflammatory disease, a serious infection
  • The device may attach to or go through the wall of the uterus
  • Pregnancy while using an IUD can be life threatening, and may result in loss of the pregnancy or fertility
  • Ovarian cysts may occur
  • Bleeding and spotting

Take Charge of Your Body Using Natural Birth Control Methods

You may not be aware that there are many effective and safe methods for preventing pregnancy. Some of the more common, barrier methods are:

  • Male condoms: Condoms have a 98 percent effectiveness rate when used correctly. A water-based lubricant will increase the effectiveness; do not use an oil-based lubricant, however, as they break the latex and usually are petrochemical in origin.
  • Female condoms: These thin, soft polyurethane pouches fitted inside the vagina before sex are 95 percent effective. Female condoms are less likely to tear than male condoms.
  • Diaphragm: Diaphragms, which must be fitted by a doctor, act as a barrier to sperm. When used correctly with spermicidal jellies, they are 92 to 98 percent effective.
  • Cervical cap: This heavy rubber cap fits tightly against the cervix and can be left in place for 48 hours. Like the diaphragm, a doctor must fit the cap. Proper fitting enhances the effectiveness above 91 percent.
  • Cervical sponges: The sponge, made of polyurethane foam, is moistened with water and inserted into the vagina prior to sex. It works as a barrier between sperm and the cervix, both trapping and absorbing sperm and releasing a spermicide to kill them. It can be left in for up to 24 hours at a time. When used correctly, the sponge is about 89-91 percent effective.

Many people are familiar with these barrier methods, and less familiar with natural family planning (NFP) tools, which a woman uses to track when she is ovulating, and then avoid sex during that time (or does so only using a back-up barrier method). Many women feel empowered by NFP because it allows them to get in touch with their fertility cycle.

Some of the most popular methods include:

  • Calendar Method: Abstention from sex during the week the woman is ovulating. This technique works best when a woman's menstrual cycle is very regular. The calendar method doesn't work very well for couples who use it by itself (about a 75 percent success rate), but it can be effective when combined with the temperature and mucus methods described below.
  • The Temperature Method: This is a way to pinpoint the day of ovulation so that sex can be avoided for a few days before and after. It involves taking your basal body temperature (your temperature upon first waking) each morning with an accurate "basal" thermometer, and noting the rise in temperature that occurs after ovulation.

    Illness or lack of sleep can change your body temperature and make this method unreliable by itself, but when it is combined with the mucus method, it can be an accurate way of assessing fertility. The two methods combined can have a success rate as high as 98 percent.
  • The Mucus Method: This involves tracking changes in the amount and texture of vaginal discharge, which reflect rising levels of estrogen in your body. For the first few days after your period, there is often no discharge, but there will be a cloudy, tacky mucus as estrogen starts to rise. When the discharge starts to increase in volume and becomes clear and stringy, ovulation is near. A return to the tacky, cloudy mucus or no discharge means that ovulation has passed.

I encourage you to become actively involved in fertility awareness, and embrace natural family planning or barrier methods that will not interfere with your hormones and health. Some excellent reading to get you started on this path include:

  1. The Ovulation Method: Natural Family Planning, by John J. Billings
  2. Taking Charge of Your Fertility: The Definitive Guide to Natural Birth Control, Pregnancy Achievement, and Reproductive Health, by Toni Weschler
  3. Honoring Our Cycles: A Natural Family Planning Workbook, by Katie Singer

References:




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By Dr. Mercola

New research examining parabens found in cancerous human breast tissue points the finger at antiperspirants and other cosmetics for increasing your risk of breast canceri.

The research, which is also reviewed in an editorial published in the Journal of Applied Toxicology, looked at where breast tumors were appearing, and determined that higher concentrations of parabens were found in the upper quadrants of the breast and axillary area, where antiperspirants are usually appliedii.

Parabens are chemicals that serve as preservatives in antiperspirants and many cosmetics, as well as sun lotions. Previous studies have shown that all parabens have estrogenic activity in human breast cancer cells.

Another component of antiperspirants, aluminum chloride, has been found to act similarly to the way oncogenes work to provide molecular transformations in cancer cells. According to the authors of the editorial review, the research shows "signals of concern that such compounds are not as safe as previously generally considered, and further research is warranted." Furthermore:

"The data from this latest study, the most extensive examination of parabens in human breast so far published, confirms previous work and raises a number of questions on the entire parabens, personal care product and human health debate, particularly relating to the source and toxicological significance of the paraben esters."

Ninety-nine Percent of Breast Cancer Tissue Samples Contain Parabens

The featured study by Barr et.al. discovered one or more paraben esters in 99 percent of the 160 tissue samples collected from 40 mastectomiesiii. In 60 percent of the samples, all five paraben esters were present. There were no correlations between paraben concentrations and age, length of breast feeding, tumor location, or tumor estrogen receptor content. The median values in nanograms per tissue for the five chemicals were:

  1. n-propylparaben 16.8
  2. methylparaben 16.6
  3. n-butylparaben 5.8
  4. ethylparaben 3.4
  5. isobutylparaben 2.1

While antiperspirants are a common source of parabens, the authors note that the source of the parabens cannot be established, and that 7 of the 40 patients reportedly never used deodorants or antiperspirants in their lifetime. What this tells us is that parabens, regardless of the source, can bioaccumulate in breast tissue.

And the sources are many. Parabens can be found in a wide variety of personal care products, cosmetics, as well as drugs. That said, it appears the dermal route is the most significant form of exposure. In the featured editorial, Philip Harvey and David Everett explain why:

"... [T]he dermal route of exposure is considered more plausible when intact esters are detected, and other authors reporting human exposures and body fluid concentrations of paraben esters consider cosmetics of some form or another as the likely sources... This is because the metabolic esterase activity of the gut and liver (relevant to oral exposure) is considered to greatly exceed that of the skin, and oral exposures would result in rapid liver metabolism of the esters to produce the common metabolite p-hydroxybenzoic acid... Paraben esters typically used in cosmetics pass through human skin in vitro/ex vivo, and Ishiwatrai et.al. (2007) has shown persistence of unmetabolized methylparaben in the skin"

Safety of Parabens has NEVER Been Established...

As incredible as it sounds, despite the fact that parabens are used in such a wide variety of products, the toxicology of these chemicals has barely been investigated. There is a complete lack of modern toxicology studies on these ingredients, and according to the featured review, not a single study on the chemicals' carcinogenity follows acceptable regulatory standard carcinogenity study protocols.

The authors point out that one rat study from 1956 is still used as "the pivotal evaluation upon which human safety is judged!"

"This may be acceptable for certain chemicals for which there is limited human exposure but not for chemicals such as parabens for which such a large population is exposed, and which show significant tissue concentrations," they write.

Furthermore, virtually all toxicology studies are based on the oral route of exposure, which means that risk assessment, according to Harvey and Everett, is "largely based on assumption, opinion and the technical regulatory instrument of GRAS (Generally Regarded as Safe)."

The Estrogenic Activity of Parabens

Estrogens, whether synthetic or natural are a primary risk factor for breast cancer. Approximately 20 different studies have established that parabens have estrogenic activity, which makes them relevant when it comes to estrogen-sensitive cancers. A common excuse used to defend the absence of toxicological studies is that parabens are weak in terms of potency. For example, propylparaben and butylparaben are approximately 30,000 and 10,000 less potent than estradiol, respectively.

"However, estradiol occurs in breast tissue in the pictogram per gram of tissue range... but the results reported by Barr et.al. [the featured study] show tissue concentrations of parabens, in the worst cases, in the microgram per gram of breast tissue range, which is one million-fold higher than that of estradiol. Clearly, the magnitude of exposure would seem to more than compensate for the reduction in potency," Harvey and Everett write.

But that's not all. A 2011 study reported that methylparaben promotes cell cycling and makes human breast cells more resistant to apoptosis, which, according to the authors can provide the molecular basis for malignant tumor proliferation. Harvey and Everett also cite another study from 2007, which found that propylparaben and butylparaben cause detectable DNA damage.

Rise in Breast Cancer Likely Linked to Chemical Exposures

Harvey and Everett point out that the hypothesis that chemicals in personal care products might be harmful to your health and contribute to breast cancer has a basis in two key observations:

  1. Breast cancer rates have increased in recent decades, which correlates with many lifestyle factors that have undergone significant change during that same time, such as diet, obesity, and use of personal care products containing untested chemicals
  2. Tumors are disproportionately located in the upper, outer quadrant of the breast, and more tumors are found in the left breast than the right, suggesting it may be related to products applied topically to those areas (most people are right-handed, which could make you a bit more heavy-handed when applying products under your left arm than your right)

In my view, one of the key observations by Harvey and Everett is that:

"The tenet that there "is no evidence that personal care products (antiperspirants or deodorants) are related to breast cancer" is technically correct, but only because studies have not been conducted to investigate any relationships. Such arguments provide false assurance by masking the inadequacies of empirical evidence and knowledge."

Aluminum—Another Cancer-Promoting Ingredient in Antiperspirants

Antiperspirants work by clogging, closing, or blocking the pores that release sweat under your arms—with the active ingredient being aluminum. (If you are using a deodorant-only product it is unlikely to contain aluminum but might contain other chemicals that could be a concern, such as parabens.) Not only does this block one of your body's routes for detoxification (releasing toxins via your underarm sweat), but it raises concerns about where these metals are going once you roll them (or spray them) on.

Like parabens, aluminum salts can also mimic estrogen, and, just like the featured study, previous research has shown that aluminum is also absorbed and deposited into breast tissueiv. The researchers suggested raised levels of aluminum could even be used as a biomarker for identification of women at increased risk of developing breast cancer.

Aluminum salts can account for 25 percent of the volume of some antiperspirants, and a review of the common sources of aluminum exposure for humans found that antiperspirant use can significantly increase the amount of aluminum absorbed by your body. According to the review, after a single underarm application of antiperspirant, about .012 percent of the aluminum may be absorbedv. This may not sound like much until you multiply it by one or more times a day for a lifetime, which adds up to massive exposure to aluminum—a poison that is not supposed to be in your body, and may be more toxic than mercury. Aside from vaccinations, your antiperspirant may be your largest source of exposure to this poisonous metal!

Be Cautious with Natural Deodorants, Too

There are many brands of aluminum-free deodorants on the market, and many of these are safe alternatives. "Crystal" deodorant stones, which are a popular natural deodorant alternative often used by health-conscious shoppers looking to avoid aluminum, often claim to be aluminum-free, but some actually contain a different type of compound known as an alum, the most common form being potassium alum, also known as potassium aluminum sulfate.

Potassium Alum or Ammonium Alum are natural mineral salts made up of molecules that are too large to be absorbed by your skin. They form a protective layer on your skin that inhibits the growth of odor-causing bacteria. These deodorants are recommended by many cancer treatment centers, but while this may be a better alternative to most antiperspirants and deodorants on the market, it is not completely aluminum-free. Also remember to check the remaining ingredients, keeping a watchful eye out for parabens.

For the last few decades I have not used antiperspirants or deodorants--even natural ones. I noticed that they would cause a yellow stain in the armpit of my shirts. At first I thought the stain was due to my sweat but I quickly realized it was the chemicals in the antiperspirants. I routinely substitute soap and water in my armpits and that seems to work. Although last year I noticed that if I sunbathe my axilla regularly, the UV light actually sterilized my armpits in addition to raising my levels of vitamin D. There is no odor even without using soap and water. Essentially you tan your armpits. The effect is not long lasting and the bacteria repopulate in a day or so unless you expose your armpits to sunlight.

What Can You Do to Prevent Breast Cancer?

Aside from skin cancer, breast cancer is the most common cancer among U.S. women. Unfortunately, while the American Cancer Society widely encourages women to get mammograms, they do not do nearly enough to spread the word about the many ways women can help prevent breast cancer in the first place. The following lifestyle strategies will help to lower your risk of breast cancer:

  • Radically reduce your sugar/fructose intake. Normalizing your insulin levels by avoiding sugar and fructose is one of the most powerful physical actions you can take to lower your risk of cancer. Unfortunately, very few oncologists appreciate or apply this knowledge today. The Cancer Centers of America is one of the few exceptions, where strict dietary measures are included in their cancer treatment program. Fructose is especially dangerous, as research shows it actually speeds up cancer growth.
  • Optimize your vitamin D level. Ideally it should be over 50 ng/ml, but levels from 70-100 ng/ml will radically reduce your cancer risk. Safe sun exposure is the most effective way to increase your levels, followed by safe tanning beds and then oral vitamin D3 supplementation as a last resort if no other option is available.
  • Maintain a healthy body weight. This will come naturally when you begin eating right for your nutritional type and exercising using high-intensity burst-type activities, which are part of my Peak Fitness program. It's important to lose excess weight because estrogen is produced in fat tissue.
  • Get plenty of high quality animal-based omega-3 fats, such as those from krill oil. Omega-3 deficiency is a common underlying factor for cancer.
  • Avoid drinking alcohol, or limit your drinks to one a day for women.
  • Breastfeed exclusively for up to six months. Research shows this will reduce your breast cancer risk.
  • Watch out for excessive iron levels. This is actually very common once women stop menstruating. The extra iron actually works as a powerful oxidant, increasing free radicals and raising your risk of cancer. So if you are a post-menopausal woman or have breast cancer you will certainly want to have your Ferritin level drawn. Ferritin is the iron transport protein and should not be above 80. If it is elevated you can simply donate your blood to reduce it.

References:




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By Dr. Mercola

Reaching puberty is a rite of passage that we've all been through, but children nowadays are reaching it earlier than ever before -- a trend that has both health experts and parents alarmed.

Precocious puberty, which is the appearance of secondary sex characteristics like pubic hair or breast growth before age 8, or the onset of menarche before age 9, impacts at least 1 in 5,000 U.S. children, and the rate is on the rise.1

Even in the last three decades, children (particularly girls) are maturing at younger and younger ages (precocious puberty is 10 times more common in girls than in boys).

Puberty, Once the Norm at Age 15, Now Occurring in 7-, 8- and 9-Year-Olds

In the 19th century the onset of menstruation occurred around the age of 15. Now the average age of the first period, or menarche, is around 12. The time during and before puberty is one of rapid development and change, which is why even months matter when it comes to first menstruation. Before menstruation, girls will show beginning signs of development, such as breast "budding" and growth of pubic hair.

These signs are now becoming unsettlingly common among 7-, 8- and 9-year-old girls, to the extent that many health care providers, rather than labeling these children with a diagnosis that something is wrong, have simply changed the definition of what's normal... but is it really "normal" for girls to mature at such a young age?

There are more questions than answers in the case of precocious puberty, but what is certain is that girls are developing earlier than they have even 10, 20 or 30 years ago.

One study in the journal Pediatrics revealed that by age 7, 10 percent of white girls, 23 percent of black girls, 15 percent of Hispanic girls and 2 percent of Asian girls had started developing breasts, with researchers noting:2

"The proportion of girls who had breast development at ages 7 and 8 years, particularly among white girls, is greater than that reported from studies of girls who were born 10 to 30 years earlier."

Early puberty can set the stage for emotional and behavioral problems, and is linked to lower self-esteem, depression, eating disorders, alcohol use, earlier loss of virginity, more sexual partners and increased risk of sexually transmitted diseases. There is also evidence that suggests these girls are at increased risk of diabetes, heart disease and other cardiovascular diseases, as well as cancer, later in life.

Environmental Chemicals a Likely Factor

Scientists have brought forth a number of potential explanations for the rising rates of early puberty, but one that deserves special attention is environmental chemicals, and particularly estrogen-mimicking, "gender-bending" chemicals that easily leach out of the products that contain them, contaminating everything they touch, including food and beverages.

As the featured New York Times article reported:

" ...animal studies show that the exposure to some environmental chemicals can cause bodies to mature early. Of particular concern are endocrine-disrupters, like "xeno-estrogens" or estrogen mimics. These compounds behave like steroid hormones and can alter puberty timing.

For obvious ethical reasons, scientists cannot perform controlled studies proving the direct impact of these chemicals on children, so researchers instead look for so-called "natural experiments," one of which occurred in 1973 in Michigan, when cattle were accidentally fed grain contaminated with an estrogen-mimicking chemical, the flame retardant PBB.

The daughters born to the pregnant women who ate the PBB-laced meat and drank the PBB-laced milk started menstruating significantly earlier than their peers."

This is an extreme case, but the truth is we are all part of a "secret experiment" of sorts, because hormone-disrupting chemicals are all around us. Bisphenol A (BPA), an industrial petrochemical that acts as a synthetic estrogen, is found in our plastics and our tin can linings, in dental sealants and on cash-register receipts. Laboratory tests commissioned by the Environmental Working Group (EWG) detected BPA in the umbilical cord blood of 90 percent of newborn infants tested -- along with more than 230 other chemicals. As written in the New York Times:

"One concern, among parents and researchers, is the effect of simultaneous exposures to many estrogen-mimics, including the compound BPA, which is ubiquitous."

No one knows what happens when a developing fetus or young child is exposed to hundreds of chemicals, many of which mimic your body's natural hormones and can trigger major changes in your body even as an adult, let along during the most rapid and vulnerable periods of development (in utero and as a young child).

BPA is, unfortunately, but one example. Others include phthalates, a group of industrial chemicals used to make plastics like polyvinyl chloride (PVC) more flexible and resilient. They're also one of the most pervasive of the endocrine disrupters, found in everything from processed food packaging and shower curtains to detergents, toys and beauty products like nail polish, hair spray, shampoo, deodorants, and fragrances.

Other environmental chemicals like PCBs and DDE (a breakdown product of the pesticide DDT) may also be associated with early sexual development in girls. Both DDE and PCBs are known to mimic, or interfere with, sex hormones.

Perfluorooctanoic acid (PFOA), found in non-stick cookware, also falls into this dangerous category, as does fluoride, which is added to the majority of public water supplies in the United States. Research showed that animals treated with fluoride had lower levels of circulating melatonin, as reflected by reduced levels of melatonin metabolites in the animals' urine. This reduced level of circulating melatonin was accompanied -- as might be expected -- by an earlier onset of puberty in the fluoride-treated female animals.

These Chemicals Also Increase Your Risk of Cancer and Heart Disease

If a chemical is capable of influencing the rate of your reproductive development, it stands to reason that it would be capable of influencing other hormone-sensitive growth processes as well, and this is indeed the case.

For instance, new research has detected the presence of paraben esters in 99 percent of breast cancer tissues sampled.3 Parabens are chemicals with estrogen-like properties, and estrogen is one of the hormones involved in not only puberty but also the development of breast cancer. They are widely used in household products such as:

Deodorants and antiperspirants

Shampoos and conditioners

Shaving gel

Toothpaste

Lotions and sunscreens

Make-up / cosmetics

Pharmaceutical drugs

Food additives

Recent research has also confirmed the existence of a previously unknown class of cancer-causing estrogen-mimicking compounds: metals. Yes, a broad range of metals have been shown to act as "metalloestrogens" with the potential to add to the estrogenic burden of the human body, thereby increasing the risk of breast cancer and also possibly early puberty. The following metals, which are added to thousands of consumer products, including vaccines, have been identified as being capable of binding to cellular estrogen receptors and then mimicking the actions of physiological estrogens:4

Aluminum

Antimony

Arsenite

Barium

Cadmium

Chromium

Cobalt

Copper

Lead

Mercury

Nickel

Selenite

Tin

Vanadate

Data from a long-running British health survey, meanwhile, has shown that if you have high levels of the chemical BPA in your urine, you may be at an increased risk of heart disease. Some of the greatest concern surrounds early-life, in utero exposure to BPA, which can lead to chromosomal errors in your developing fetus, causing spontaneous miscarriages and genetic damage. But evidence is also very strong showing these chemicals are influencing adults and children, too, and leading to decreased sperm quality, early puberty, stimulation of mammary gland development, disrupted reproductive cycles and ovarian dysfunction, obesity, cancer and heart disease, among numerous other health problems.

Avoiding Hormone-Disrupting Substances is Crucial for Children and Adults Alike

While young girls may show obvious signs of exposure to hormone-disrupting substances via early puberty, other signals are more insidious and may not show up until a disease is already present. Here are 11 measures you can implement right away to help protect yourself and your children from common toxic substances that could cause precocious puberty and other long-term health problems:

  1. As much as possible, buy and eat organic produce and free-range, organic meats to reduce your exposure to added hormones, pesticides and fertilizers. Also avoid milk and other dairy products that contain the genetically engineered recombinant bovine growth hormone (rBGH or rBST)
  2. Eat mostly raw, fresh foods. Processed, prepackaged foods (of all kinds) are a major source of soy and chemicals such as BPA and phthalates.
  3. Store your food and beverages in glass rather than plastic, and avoid using plastic wrap and canned foods (which are often lined with BPA-containing liners).
  4. Use glass baby bottles and BPA-free sippy cups for your little ones.
  5. Make sure your baby's toys are BPA-free, such as pacifiers, teething rings and anything your child may be prone to suck on.
  6. Only use natural cleaning products in your home to avoid phthalates.
  7. Switch over to natural brands of toiletries such as shampoo, toothpaste, antiperspirants and cosmetics. The Environmental Working Group has a great safety guide to help you find personal care products that are free of phthalates, parabens and other potentially dangerous chemicals.
  8. Avoid using artificial air fresheners, dryer sheets, fabric softeners or other synthetic fragrances, many of which can also disrupt your hormone balance.
  9. Replace your non-stick pots and pans with ceramic or glass cookware.
  10. When redoing your home, look for "green," toxin-free alternatives in lieu of regular paint and vinyl floor coverings.
  11. Replace your vinyl shower curtain with one made of fabric.
  12. Avoid non-fermented soy, especially if you're pregnant and in infant formula.

Theo Colburn's book Our Stolen Future is a great source for further investigation as it identifies the numerous ways in which environmental pollutants are disrupting human reproductive patterns. I believe it is one of the best resources on this topic and highly recommend it.

Vitamin D Also Linked to Early Puberty

It has been suggested that girls who live closer to the equator start puberty at a later age than girls who live in Northern regions. Since this indicates a potential connection with sun exposure, researchers decided to investigate whether vitamin D was, in fact, related. Upon measuring vitamin D levels in 242 girls aged 5-12, researchers from the University of Michigan School of Public Health found that those who were deficient were twice as likely to start menstruation during the study period as those with higher levels.5

Specifically, among the vitamin-D-deficient girls, 57 percent started their period during the study, compared to 23 percent with adequate vitamin D. However, researchers defined adequate vitamin D as ≥ 30 ng/mL, which is actually still a deficiency state! For optimal health, vitamin D levels should be a minimum of 50 ng/mL, which means the number of vitamin-D-deficient girls with early puberty was probably much higher than the study reported.

The earlier you enter puberty, the longer you're exposed to elevated levels of the female hormone estrogen, which is a risk factor for certain cancers such as breast cancer. This has been the primary "link" between early puberty and cancer that has been explored, but it's important to understand that vitamin D deficiency is also a major risk factor for cancer, heart disease and many other diseases. So it could be that some of the increased risks that come from early puberty are linked to low vitamin D levels.

What You Should Know About Obesity, Stress and Exercise

Obesity (which exposes girls to more estrogen because estrogen is both stored and produced in fat tissue) is another likely factor in early puberty. The New York Times reported:

"As Robert Lustig, a professor of clinical pediatrics at the University of California, San Francisco's Benioff Children's Hospital, explains, fatter girls have higher levels of the hormone leptin, which can lead to early puberty, which leads to higher estrogen levels, which leads to greater insulin resistance, causing girls to have yet more fat tissue, more leptin and more estrogen, the cycle feeding on itself, until their bodies physically mature."

As for stress, this, too, has been linked to early puberty, with girls whose parents divorced when they were between 3- and 8-years-old significantly more likely to experience precocious puberty. "Evolutionary psychology offers a theory," the New York Times reports. "A stressful childhood inclines a body toward early reproduction; if life is hard, best to mature young. But such theories are tough to prove." Interestingly, in addition to avoiding environmental chemicals, obesity and stress, and optimizing your vitamin D, regular exercise appears to be one of the best known ways to help prevent early puberty.



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By Dr. Mercola

You may be aware, and possibly have experienced firsthand, that antibiotics can cause diarrhea.

This is because antibiotics, by design, disrupt the balance of good and bad bacteria in your gastrointestinal tract, often killing off both beneficial and harmful microorganisms without distinction.

It is through this same mechanism that antibiotics may also be causing you to pack on extra pounds.

In fact, Dr. Martin Blaser, a professor of microbiology at New York University Langone Medical Center, suggests that antibiotics may permanently alter your gut bacteria and interfere with important hunger hormones secreted by your stomach, leading to increased appetite and body mass index (BMI).

Antibiotics Lead to Increases in Body Fat and Hunger Hormones

Research by Dr. Blaser has shown that 18 months after antibiotics are used to eradicate H. pylori bacteria, there is a:

  • 6-fold increase in the release of ghrelin (the "hunger hormone") after a meal
  • 20 percent increase in leptin levels (leptin is a hormone produced by fat tissue)
  • 5 percent increase in BMI

Levels of ghrelin should ordinarily fall after a meal to signal your brain that you're full and ready to stop eating; an increase would therefore essentially tell your brain to continue eating, leading to weight gain. Further, the increase in leptin levels is concerning because overexposure to high levels of the hormone can lead to leptin resistance, which means your body is unable to properly hear leptin's signals.

The way your body stores fat is a highly regulated process that is controlled, primarily, by leptin. If you gain excess weight, the additional fat produces extra leptin that should alert your brain that your body is storing too much fat and needs to burn off the excess.

To do this, signals are sent to your brain to stop being hungry and to stop eating. When you become leptin-resistant, your body can no longer hear these messages -- so it remains hungry and stores more fat.

Interestingly, you can easily become leptin resistant by eating the typical American diet full of sugar (particularly fructose), refined grains and processed foods … which, like antibiotics, will upset the balance of bacteria in your gut.

Farmers Use Antibiotics to Fatten Up Livestock Quickly

About 70 percent of all the antibiotics produced are used in agriculture -- not necessarily to fight disease, but rather to promote weight gain.

As stated by the Ontario Ministry of Agriculture, Food and Rural Affairs:

"Continuous, low-dose administration of an antibiotic can increase the rate and efficiency of weight gain in healthy livestock. The presence of antibiotics likely changes the composition of the gut flora to favor growth. Debate is ongoing as to how gut flora are changed; change may simply be a reduction in numbers, a change in species composition or a combination of the two.

… Some antibiotics may also enhance feed consumption and growth by stimulating metabolic processes within the animal."

Unfortunately, this practice is also contributing to the alarming spread of antibiotic-resistant disease. As it pertains to your weight, there's ample reason to believe that this same phenomenon occurs in humans as well, figuratively turning Americans into fatted calves.

Your Gut Bacteria and Your Waistline Go Hand-in-Hand

Research by Dr. Blaser, for instance, found that mice fed antibiotics (in dosages similar to those given to children for throat or ear infections) had significant increases in body fat despite their diets remaining unchanged.

Multiple studies have actually shown that obese people have different intestinal bacteria than slim people, and that altering the microbial balance in your gut can influence your weight. Here are six such studies:

  1. When rats were given lactic acid bacteria while in utero through adulthood, they put on significantly less weight than other rats eating the same high-calorie diet. They also had lower levels of minor inflammation, which has been associated with obesity.
  2. Babies with high numbers of Bifidobacteria and low numbers of Staphylococcus aureus -- which may cause low-grade inflammation in your body, contributing to obesity -- appeared to be protected from excess weight gain. This may be one reason why breast-fed babies have a lower risk of obesity, as Bifidobacteria flourish in the guts of breast-fed babies.
  3. Two studies found that obese individuals had about 20 percent more of a family of bacteria known as Firmicutes, and almost 90 percent less of a bacteria called Bacteroidetes than lean people. Firmicutes help your body to extract calories from complex sugars and deposit those calories in fat. When these microbes were transplanted into normal-weight mice, those mice started to gain twice as much fat.
  4. Obese people were able to reduce their abdominal fat by nearly 5 percent, and their subcutaneous fat by over 3 percent, just be drinking a probiotic-rich fermented milk beverage for 12 weeks.
  5. Probiotics (good bacteria) have been found to benefit metabolic syndrome, which often goes hand-in-hand with obesity.
  6. Probiotics may also be beneficial in helping women lose weight after childbirth when taken from the first trimester through breastfeeding.

Healthy Gut Bacteria Cannot Coexist With Antibiotics

Antibiotics can save your life if you develop a serious bacterial infection, but it's important that you resist the urge to ask your physician for a prescription for every ear, nose, or throat infection you come down with. Likewise for a cold or the flu. Antibiotics are useless against viral infections like these, and when used for this purpose will only harm your health by wiping out the good bacteria in your gut.

Antibiotic use has become so routine in the United States that one round of the drugs may seem like no big deal, but remember that using them drastically alters the makeup of bacteria in your gut, which will need to be rebuilt in order for you to stay in good health. Whenever you use an antibiotic, you're also increasing your susceptibility to developing infections with resistance to that antibiotic -- and you can become the carrier of this resistant bug and even spread it to others.

Ultimately the problem of antibiotic-overuse needs to be stemmed through public policy on a nationwide level, especially in the agricultural community, but I urge you to also take personal responsibility and evaluate your own use of antibiotics, and avoid taking them -- or giving them to your children -- unless absolutely necessary.

Remember that the foods you eat are also a major source of exposure to antibiotics, so to protect your gut bacteria you should buy primarily antibiotic-free, organically raised meat and produce. Keep in mind that conventionally farmed food is often grown in fertilizer derived from factory-farmed animal waste and human sewage, which may be a source of contamination with antibiotic-resistant bacteria.

The Recipe for Healthy Gut Bacteria

Your gut bacteria are vulnerable to your lifestyle. If you eat a lot of processed foods, for instance, your gut bacteria are going to be compromised because processed foods in general will destroy healthy microflora and feed bad bacteria and yeast.

In addition to antibiotics, your gut bacteria are also very sensitive to:

  • Chlorinated water
  • Antibacterial soap
  • Agricultural chemicals
  • Pollution

Because virtually all of us are exposed to these at least occasionally, ensuring your gut bacteria remain balanced should be considered an ongoing process, and consuming fermented foods is one of the best ways to do this.

One of the reasons why fermented foods are so beneficial is because they contain lactic acid bacteria -- a type of beneficial gut bacteria that research shows can help you stay slim.

I have long stated that it's generally a wise choice to "reseed" your body with good bacteria from time to time by taking a high-quality probiotic supplement or eating non-pasteurized, traditionally fermented foods such as:

  • Lassi (an Indian yoghurt drink, traditionally enjoyed before dinner)
  • Fermented  organic grass-fed raw milk, such as kefir
  • Various pickled fermentations of cabbage, turnips, eggplant, cucumbers, onions, squash and carrots
  • Natto (fermented soy)

If you do not eat fermented foods on a regular basis, a high-quality probiotic supplement can be incredibly useful to help maintain healthy gut bacteria when you stray from your healthy diet and consume excess grains or sugar, or if you have to take antibiotics.

Also please remember that it is vital to eliminate ALL sugars. They will sabotage any beneficial effects of the fermented foods, as they will act as nutrients for the pathogenic yeast, fungi and bacteria that are in your gut.



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By Dr. Mercola

Bioidentical hormone therapy has become widely adopted as a useful method of normalizing hormone levels. While it is far safer than synthetic or animal based hormones like Premarin, there are clearly some dangers associated with its use and the purpose of this article is to highlight some of the major ones.

This article is in no way meant to be a comprehensive review of the topic, but merely to point out some of the major concerns and approaches as I see them from having practiced medicine for nearly three decades.

If you have any interest. I would strongly recommend purchasing Dr. Wright's new book Stay Young and Sexy. It is under $10 and simply the best book I have reviewed on the topic. If the book were $100 it would be worth the price. This book is a classic and should be in everyone's natural medicine library. The publisher has also created a web site with a free hormone self assessment and sample chapters at www.stayyoungandsexy.com.

Natural Progesterone

I will focus much of this article on natural progesterone cream as it is one of the most popular and useful ones for women.Typically, women find rapid improvement in two of the most common premenopausal challenges which are PMS and painful cramps.  It can be also extraordinarily useful to prevent miscarriages but dosing would be continuous after conception.

Dr. John Lee was my original mentor in this area but he passed away a number of years ago and did not fully appreciate the challenges that are associated with using the creams on your skin.

Dr. Jonathon Wright, along with Dr. Lee, are considered the pioneers in introducing bioidentical hormone therapy in the United States. Dr. Wright is still alive and I believe has successfully resolved the challenge associated with using the creams. Before I discuss that though, let's first do a brief review of why progesterone is important.

Natural progesterone is the identical hormone that is produced by a woman's ovary. It is made from naturally occurring plant steroids found in the wild yam. It is NOT the synthetic version that is commonly purchased as tablets with a prescription such as Provera.

Synthetic progesterones, like Provera or medroxyprogesterone, can produce severe side effects including increased risk of cancer, abnormal menstrual flow, fluid retention, nausea, depression and can even increase risk of heart disease and stroke.

Side effects are extremely rare with natural progesterone. The only one of concern is that it can potentially alter the timing of your menstrual cycle.

Reasons Why Natural Progesterone Made by Your Body Is Good

Progesterone is a steroid hormone made by a woman's ovaries when she ovulates and in smaller amounts by the adrenal gland. A menstruating woman will typically produce about 20 to 30 mg of progesterone a day during the luteal or last phase of her menstrual cycle.

While menopause doesn't typically occur until age 50 or later, many women can start going out of balance in their 30s or even earlier. This decline in progesterone is not trivial for as women age into their fourth, fifth, and sixth decade, their progesterone levels continue to fall.  By the time they reach perimenopause as much as 75% or more of their youthful progesterone secretion may already be missing.

Natural progesterone is very useful to balance excess estrogen which can be a major risk for breast cancer. Natural progesterone is also different from estrogen in that your body can use it as a precursor or starting material to make other hormones such as adrenal hormones. It can even convert it into estrogen or testosterone if your body needs it.

Natural progesterone is made from a substance called diosgenin which is commonly extracted from wild yams or soybeans.  Even though it may be extracted from soy it is a highly purified hormone and there are absolutely no remnants of soy substances that would lead to any problem.

Estrogen Dominance

Many if not most women in our culture are estrogen dominant, so using the progesterone goes a long way towards balancing hormones which usually:

  • Decreases a woman's risk for breast cancer,
  • Improves her PMS and breast tenderness and

The table below lists the properties of estrogen relative to progesterone. Some of the reasons that estrogen is frequently in excess in many women are:

  • Overproduction of estrogen. Ovarian cysts or tumors can lead to excess estrogen production. Stress also increases production, but probably the most common cause is obesity. All body fat has an enzyme which converts adrenal steroids to estrogen, so the more fat you have, the more estrogen is present.
  • Inability to breakdown estrogen. Excess estrogen is generally removed by the liver. Diseases of the liver like cirrhosis or decreased enzyme activity can lead to increased estrogen levels. Vitamin B6 and magnesium are necessary for the liver to neutralize estrogen. Increased sugar intake will also excrete magnesium and interfere with its ability to breakdown estrogen.
  • Exposure to pesticides in foods. Most of us eat foods that have pesticides on them. These and many other unnatural chemicals share a common structure with estrogen and serve as "false" estrogens which further stimulates the body's estrogen receptors.
  • Estrogen supplementation. Clearly any additional estrogen given by prescription will increase the level unless it is properly balanced with natural progesterone.
  • Decreased production of progesterone. Progesterone is necessary to counterbalance estrogen. If women do not ovulate during their cycle they will not produce any progesterone that cycle. This happens commonly and worsens the already disturbed progesterone/estrogen balance. Decreased progesterone levels are one of the most common reasons for miscarriages.

To minimize your risk of cancer it is very important to understand that you should never take any supplemental estrogen without taking natural progesterone. Note that I use the term "natural' progesterone, or the real hormone. Taking synthetic versions like Provera will actually increase your risk of cancers and heart disease.

Estrogen Effects Progesterone Effects
Stimulates breasts cysts Protects against breast cysts
Increases body fat storage Helps use fat for energy and keep it off hips
Salt and fluid retention Natural diuretic (water pill)
Depression and headaches Natural anti-depressant
Interferes with thyroid hormone Facilitates thyroid hormone action
Increases blood clotting and risk of stroke Normalizes blood clotting
Decreases libido (sex drive) Increases libido
Impairs blood sugar control Normalizes blood sugar levels
Loss of zinc and retention of copper Normalizes zinc and copper levels
Reduced oxygen level in all cells Restores proper cell oxygen levels
Increased risk of endometrial cancer Helps prevent endometrial cancer
Increased risk of breast cancer Helps prevent breast cancer
Helps decrease bone loss slightly Increases bone building

Why You Should AVOID All Oral Hormone Preparations

There are many ways to "naturally" address bioidentical hormone replacement but one of the most common mistakes is to use oral hormones.

If nature had intended to locate your ovaries in your stomach or somewhere else in your GI tract it might make sense for women to swallow progesterone. If your ovaries were in your GI tract, your body would certainly have been equipped with a way to process them safely and efficiently so that everything worked in perfect synchrony.

Of course your ovaries are not in your GI tract but in your pelvis outside your GI tract and connected to your uterus and vagina through your fallopian tubes. Your ovaries have direct access to your blood stream through a pelvic plexus of veins, which delivers their hormone secretions to your heart which in turn pumps them, unchanged to hormone sensitive cells throughout your entire body.

If you swallow steroid hormones you will seriously distort their natural metabolism  When you swallow them they will encounter potent stomach acids. The hormones that survive this assault then go to your liver where they will be further broken down. Your liver screens all molecules that enter your blood stream, passing some onward, modifying or detoxifying others, and rejecting a few. 

This routing of orally swallowed hormones is in sharp contrast to the way nature intended them to be distributed to your tissues.  If you swallow hormones only 10-15% will eventually reach the target tissues and you will need to take an oral dose that is 500% higher than you need. Over 30 different metabolites are created in your liver when you swallow the progesterone and any of these can then have unwanted side effects.

So if you or anyone you know currently use oral hormones like progesterone or DHEA or any hormone, I encourage you to strongly consider phasing them out. 

Like most good things in life if you use too much of the hormone cream, complications can develop and disrupt your hormone balance.

The Key to Safely and Effectively Using Progesterone Cream

If you want to copy nature and reproduce a hormonal environment that most closely resembles a normal premenopausal woman the first logical step would be to get the hormones directly into your blood stream, just the way your ovary does.

Hormones carefully measured and formulated in an appropriate cream or gel need only be rubbed once or twice a day into your mucous (epithelial) membranes. Since there are no destructive detours through your GI tract when administered this way, your tissues are exposed to the appropriate concentrations of the hormone without the side effects of 30 different liver metabolites.

I first started using these creams in the early 1990s be became gradually disenchanted with them after I noticed that they typically worked wonderfully initially but then invariably stopped working. This is now known as "dermal fatigue". 

What happens, not only for progesterone cream, but for ANY hormone preparation you use by applying as a cream to your skin is that within a few weeks to a few months you will saturate the fat tissue with the hormones and they will actually stop working or can even make your symptoms worse.

The problem relates to the fact that progesterone is highly fat soluble and once applied to your skin will store itself in your fat tissue. When one initially uses the cream, there aren't any problems as the fat stores are very low. But as time goes on, the cream accumulates and contributes to disruptions in your adrenal hormones such as DHEA, cortisol, and testosterone. I have learned that although progesterone cream is an enormously useful tool, it needs to be used very cautiously.

I found that many of the women who were on the cream have terribly elevated levels of this hormone. Progesterone is normally a cyclical hormone and the body really needs to see a change in the concentration to affect a proper physiological response. If the level is constantly above the concentration that it recognizes as "off" or low, this is not possible.

Fortunately, this is repairable. But it may involve going off the cream for as long as two years to wash the progesterone out of your system.

Best Way to Use Progesterone Cream

The key mistake that many well intentioned knowledgeable doctors, including myself made is to advise to use the cream on your skin. While this certainly provides better results than swallowing the hormones, it can still be improved.

There is a relatively minor tweak you can make with the creams which avoids nearly all of the side effects of applying the cream on your skin.

If you apply the cream to your mucous epithelial membranes that line your uterus and vagina you obtain a virtually ideal administration system. Not only is absorption through these membranes more complete than through your skin, but hormones absorbed through your vaginal membranes enter the very same pelvic plexus of veins that your ovaries normally empty into.

From here the hormones are carried to your heart and lungs and distributed to your tissues just as if your ovary had actually produced them.

Men also require hormones. Obviously men don't have a vagina to use but we do have a rectum that has a similar mucosal epithelial surface and can be used to administer the hormones in a near ideal fashion without any of the complications previously described.

Timing and Dose of Progesterone Cream

For most premenopausal women the usual dose is 15-24 mg/day for 14 days before expected menses, stopping the day or so before menses.  So you would use the cream for twelve days and then stop. Typically this would mean you would start on day 12 of your cycle and stop on day 26.

The abrupt lowering of your progesterone level is the primary stimulus for your period to start.  Hopefully when it starts any PMS and painful periods will be dramatically reduced.

When a women is in menopause she may only need 15 mg but taken for the first 25 days of the month, then take 5 or 6 days off and restart on the first of the month.

For most women a single daily application will work. However, because the half-life is relatively short, some women find that they get a more satisfactory response by splitting the daily dose in two, half in the morning and half in the evening. If you are only taking the hormones in the morning and begin to feel symptoms later in the day, splitting the dose in two should solve this problem.

Testing of Your Natural Hormones

This is somewhat of a controversial area but basically involves three different types.

  • Blood
  • Saliva
  • Urine

I have never been a fan of blood testing as many of the hormones are secreted in a pulsatile fashion and it is difficult to get an accurate idea of the levels in this way.

Saliva testing is easier than urine but is not as accurate.

My current belief is that a 24 hour urine test is the preferred method and the one I use for myself and family. This is the one that Dr. Wright advocates in his own clinic. Dr. Wright has trained many hundreds of physicians in this system and if you are seeking further guidance in this area it would be wise to seek one of them to help you in this area.



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soy not effective for bone loss and hot flashesSoy supplements are reputed to stave off hot flashes, night sweats, and other uncomfortable menopausal symptoms.  But the latest in a series of disappointing studies finds that soy supplements do not actually have any such effect, they do not reduce the aging-related bone loss that can lead to osteoporosis.

During menopause, a woman's body produces less estrogen and progesterone. Soy protein has been considered a possible treatment ever since researchers observed that women in Asia tend to have lower rates of bone loss and osteoporosis.

According to CNN:

"So if soy isn't beneficial, what options are women left with? To prevent bone loss, women should stick with the basics ... That means getting enough calcium and vitamin D, [and] exercising regularly".



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