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11/16/21

Using a new model of brain activity, computational neuroscientists are exploring striking bursts of activity in the human brain that have not been examined before. These bursts may have potential to serve as biomarkers for brain disease and conditions such as depression, schizophrenia, dementia, and ADHD.

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Researchers have revealed a striking pattern following a functional screen of extracts from plants collected in Muir Woods National Monument, in coastal redwood forest land in California. They found plants with a long history of use by Native Americans as topical analgesics, were often also used as gastrointestinal aids.

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In 2020, an untreated HIV patient was identified with no intact copies of HIV genomes in more than 1.5 billion blood cells analyzed, suggesting the virus had been cleared from the patient's body. Researchers now report a second untreated person living with HIV who had no evidence of intact HIV genomes in more than 1.5 billion blood and tissue cells analyzed.

from Top Health News -- ScienceDaily https://ift.tt/3clFBAY

The most common pharmaceuticals on the market are made by chaining together rings of molecules to create the drugs that treat conditions including pain, depression and leukemia. But creating those rings and forming them in a way that is tailored to each individual disease has always been a cumbersome and expensive process in medicinal chemistry. New research proposes a way to simplify that transformation. The discovery will likely make it easier to produce new drug candidates, the researchers say.

from Top Health News -- ScienceDaily https://ift.tt/3cziPpH

Immunotherapies, which harness the body's natural defenses to combat disease, have revolutionized the treatment of aggressive and deadly cancers. But often, these therapies -- especially those based on immune cells -- must be tailored to the individual patient, costing valuable time and pushing their price into the hundreds of thousands of dollars.

from Top Health News -- ScienceDaily https://ift.tt/3CoavDF

In brain scans of almost 1500 people throughout Europe, researchers found that people with 'older-looking' brains had both lower birth weight and genes for smaller brains, compared with those with normal aging brains. Both these factors are present early in life, indicating that your 'brain age' is mostly related to early life influences and not so much on events that happen later in life.

from Top Health News -- ScienceDaily https://ift.tt/2YXIrcA

A recent study provides evidence that CD4+ T lymphocytes -- immune system cells also known as helper T cells -- produced by people who received either of the two available messenger RNA (mRNA) vaccines for COVID-19 persist six months after vaccination at only slightly reduced levels from two weeks after vaccination and are at significantly higher levels than for those who are unvaccinated.

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Amid the COVID-19 pandemic and rising air pollution levels, incidence of idiopathic pulmonary fibrosis is anticipated to rise, urgently increasing the need for strong model systems. Researchers describe a 3D cell culturing platform that allows study of lung fibroblasts and their microenvironment. The platform enables measurement of cell behaviors and microenvironment changes involved in the disease progression of IPF, and the platform's size and simplicity make it suitable for use in high-throughput drug screening protocols.

from Top Health News -- ScienceDaily https://ift.tt/3FpONkC

Scientists are turning to genomics to better understand the epidemiology of malaria and to inform control and elimination interventions and strategies. In the Lake Victoria region of Kenya, malaria burden remains very high despite more than a decade of intense control activities. A team of researchers generated whole Plasmodium falciparum genome sequences from the lake region. Their analyses revealed that malaria parasites from this region appear distinct from other parasites from East Africa, while frequencies of known drug resistance markers were similar to those in other East African parasite populations.

from Top Health News -- ScienceDaily https://ift.tt/3ciwSQ5

Observational data shows air pollution in India decreased drastically in the first COVID-19 lockdown when emissions from vehicles naturally declined, but researchers say those numbers only tell part of the story -- blue skies and an absence of visible smog can be deceiving and hide pollutants that could potentially cause health issues.

from Top Health News -- ScienceDaily https://ift.tt/3Ckhj51

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