Health & Fitness

Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome. A team examining the colon identified the presence of Piezo2, the subject of the 2021 Nobel Prize in Physiology or Medicine, now known to be responsible for sensing light touch on our skin.

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The artificial intelligence algorithms behind the chatbot program ChatGPT -- which has drawn attention for its ability to generate humanlike written responses to some of the most creative queries -- might one day be able to help doctors detect Alzheimer's Disease in its early stages. Research recently demonstrated that OpenAI's GPT-3 program can identify clues from spontaneous speech that are 80% accurate in predicting the early stages of dementia.

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Researchers have shown that changes in gene expression happen almost entirely during the transcription stage while the cells are growing. The researchers have provided a simple quantitative formula linking regulatory control to mRNA and protein levels.

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A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers. The drug stalled the growth of tumors in the five people in the trial with neuroendocrine cancers and reduced tumor size in two of those patients. It also showed some therapeutic activity against sarcomas, scientists and clinicians report.

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Researchers have made an advancement in genetic testing that allows for more accurate prediction of which parent's genes led to an individual's increased cancer risk. This improves the efficiency of familial testing strategies and could eliminate concern for patients at high risk of cancer caused by genes inherited from a parent.

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A new study has identified that Talarozole, a drug that is known to increase retinoic acid, was able to prevent osteoarthritis (OA) in disease models.

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