Improved chemokine homing enhances CAR T--cell therapy for osteosarcoma
Investigators identified a chemokine/chemokine receptor mismatch for osteosarcoma (i.e., osteosarcomas secrete chemokines for which CAR T cells do not express receptors). The researchers modified CAR T cells targeting the osteosarcoma antigen B7-H3 to express CXCR2 or CXCR6 receptors, which recognize chemokines (CXCL8 or CXCL16) secreted by osteosarcoma.
from Top Health News -- ScienceDaily https://ift.tt/eECPTSo
from Top Health News -- ScienceDaily https://ift.tt/eECPTSo