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06/22/21

Years before they are diagnosed, persons with multiple sclerosis (MS) make significantly more visits to doctors and hospitals than others. Specialists have recently discussed whether this might represent a preliminary phase of MS - known as a prodrome. A new study suggests that, in many cases, the complaints may relate to unrecognized early clinical MS events.

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A research team recently published the results of a three-year study of cognitive changes in older adults who complained that their cognitive ability was worsening though clinical assessments showed no impairments. The MRI studies showed significant changes in functional connectivity in two areas of the brain.

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Pancreatic cancer cells typically rely on a mutant version of the KRAS protein to proliferate. These cancer cells can also survive losing KRAS by activating alternative growth pathways. Scientists discovered a new interaction between mutant KRAS and a protein complex called RSK1/NF1 that may be the source of this adaptive resistance.

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A new study shows inherited risk of early-onset cancer is significantly higher among Latino and African American families for solid tumors, and Asian/Pacific Islander families for blood-based cancers, compared to non-Latino white families in California. Researchers used California population-based health registries to evaluate the relative cancer risk among first-degree relatives of patients diagnosed with cancer by the age of 26. This study demonstrates the need for increased scrutiny on familial cancer clustering in minority populations.

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To understand what role an individual gene plays, biologists have, for 100 years, been using a trick of nature: While in principle, the genome in all cells of an organism is the same, mutations arise in individual cells. These mutations differentiate a cell from its neighbors, forming a 'genetic mosaic.' Now, researchers have advanced genetic mosaic analysis, making almost all genes in the mouse genome accessible to single-cell genetic mosaic analysis.

from Top Health News -- ScienceDaily https://ift.tt/3d6xd9w

Without an audience, men run slower and women faster: The lack of spectators during the coronavirus pandemic appears to have had a noticeable effect on the performance of athletes at the 2020 Biathlon World Cup, a new study shows. According to the new analysis, women also performed better in complex tasks, such as shooting, when an audience was present while men did not.

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