Health & Fitness

I've previously discussed the synergy between magnesium and vitamin D, and the importance of vitamin D for optimal immune function and overall health — especially as it pertains to lowering your risk of COVID-19. Previous studies have also highlighted the role this duo plays in cognitive function among older adults, as well as overall mortality.

Vitamin D and Magnesium Protect Cognitive Health

One such study,¹ "Association of Vitamin D and Magnesium Status with Cognitive Function in Older Adults: Results from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014," points out that vitamin D not only protects neuronal structures and plays a role in neuronal calcium regulation, but also appears to impact your risk for neurodegeneration as you grow older.

Magnesium, meanwhile, aside from being required for converting vitamin D to its active form,^2,3,4 also plays a role in cognitive health, and magnesium deficiency has been implicated in several neurological disorders.

Using NHANES data from 2,984 participants over the age of 60, the researchers compared serum vitamin D status and dietary magnesium intake against cognitive function scores.

After adjusting for confounding factors, including total calorie consumption and magnesium intake, higher blood levels of vitamin D positively correlated with decreased odds of having a low cognitive function score on the Digit Symbol Substitution Test.

The same trend was found when they looked at vitamin D intake, rather than blood level. The correlation of higher vitamin D levels and better cognitive function was particularly strong among those whose magnesium intake was equal to or greater than 375 mg per day. According to the authors:⁵

"We found that higher serum 25(OH)D levels were associated with reduced risk of low cognitive function in older adults, and this association appeared to be modified by the intake level of magnesium."

Magnesium Improves Brain Plasticity

While magnesium intake by itself did not appear to have an impact on cognitive function in the study above, other research has highlighted its role in healthy cognition.

Memory impairment occurs when the connections (synapses) between brain cells diminish. While many factors can come into play, magnesium is an important one. As noted by Dr. David Perlmutter, a neurologist and fellow of the American College of Nutrition:⁶

"It has now been discovered that magnesium is a critical player in the activation of nerve channels that are involved in synaptic plasticity. That means that magnesium is critical for the physiological events that are fundamental to the processes of learning and memory."

A specific form of magnesium called magnesium threonate was in 2010 found to enhance "learning abilities, working memory, and short- and long-term memory in rats."⁷ According to the authors, "Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions."

COVID-19 Can Deprive Brain of Oxygen

While we're on the topic of the brain, a July 1, 2020, article⁸ in The Washington Post reviewed findings from autopsies of COVID-19 patients. Surprisingly, Chinese researchers have reported⁹ that COVID-19 patients can exhibit a range of neurological manifestations.

A June 12, 2020, letter to the editor¹⁰ published in The New England Journal of Medicine also discusses the neuropathological features of COVID-19. As reported by The Washington Post:¹¹

"Patients have reported a host of neurological impairments, including reduced ability to smell or taste, altered mental status, stroke, seizures — even delirium … In June, researchers in France reported that 84% of patients in intensive care had neurological problems, and a third were confused or disoriented at discharge.

… Also this month, those in the United Kingdom found that 57 of 125 coronavirus patients with a new neurological or psychiatric diagnosis had experienced a stroke due to a blood clot in the brain, and 39 had an altered mental state.

Based on such data and anecdotal reports, Isaac Solomon, a neuropathologist at Brigham and Women's Hospital in Boston, set out to systematically investigate where the virus might be embedding itself in the brain.

He conducted autopsies of 18 consecutive deaths, taking slices of key areas: the cerebral cortex (the gray matter responsible for information processing), thalamus (modulates sensory inputs), basal ganglia (responsible for motor control) and others …"

Interestingly, while doctors and researchers initially suspected that brain inflammation was causing the neurological problems seen in some patients, Solomon's autopsies found very little inflammation. Instead, these neurological manifestations appear to be the result of brain damage caused by oxygen deprivation.

Signs of oxygen deprivation were present both in patients who had spent a significant amount of time in intensive care, and those who died suddenly after a short but severe bout of illness. I believe this is likely due to increases in clotting in the brain microvasculature.

Solomon told The Washington Post he was "very surprised," by the finding. It makes sense, though, considering COVID-19 patients have been found to be starved for oxygen. As reported by The Washington Post:¹²

"When the brain does not get enough oxygen, individual neurons die … To a certain extent, people's brains can compensate, but at some point, the damage is so extensive that different functions start to degrade … The findings underscore the importance of getting people on supplementary oxygen quickly to prevent irreversible damage."

Magnesium and Vitamin D Impact Mortality

Getting back to magnesium and vitamin D, previous research¹³ using NHANES data from 2001 through 2006 found the duo has a positive impact on overall mortality rates. This study also pointed out that magnesium "substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent vitamin-D-resistant rickets."

The researchers hypothesized that magnesium supplementation increases your vitamin D level by activating more of it, and that your mortality risk might therefore be lowered by increasing magnesium intake. That is indeed what they found. According to the authors:

"High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively. Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency.

Additionally, the inverse association between total magnesium intake and vitamin D insufficiency primarily appeared among populations at high risk of vitamin insufficiency.

Furthermore, the associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease (CVD) and colorectal cancer, were modified by magnesium intake, and the inverse associations were primarily present among those with magnesium intake above the median.

Our preliminary findings indicate it is possible that magnesium intake alone or its interaction with vitamin D intake may contribute to vitamin D status. The associations between serum 25(OH)D and risk of mortality may be modified by the intake level of magnesium."

Magnesium Lowers Vitamin D Requirement by 146%

According to a scientific review^14,15 published in 2018, as many as 50% of Americans taking vitamin D supplements may not get significant benefit as the vitamin D simply gets stored in its inactive form, and the reason for this is because they have insufficient magnesium levels.

Research published in 2013 also highlighted this issue, concluding that higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it. As noted by the authors:¹⁶

"High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively.

Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency … Our preliminary findings indicate it is possible that magnesium intake alone or its interaction with vitamin D intake may contribute to vitamin D status."

More recently, GrassrootsHealth concluded¹⁷ you need 146% more vitamin D to achieve a blood level of 40 ng/ml (100 nmol/L) if you do not take supplemental magnesium, compared to taking your vitamin D with at least 400 mg of magnesium per day.

The interplay between magnesium and vitamin D isn't a one-way street, though. It goes both ways. Interestingly, while vitamin D improves magnesium absorption,¹⁸ taking large doses of vitamin D can also deplete magnesium.¹⁹ Again, the reason for that is because magnesium is required in the conversion of vitamin D into its active form.

Magnesium + Vitamin K Lowers Vitamin D Requirement Even More

Magnesium isn't the only nutrient that can have a significant impact on your vitamin D status. GrassrootsHealth data further reveal you can lower your oral vitamin D requirement by a whopping 244% simply by adding magnesium and vitamin K2. As reported by GrassrootsHealth:²⁰

"… 244% more supplemental vitamin D was needed for 50% of the population to achieve 40 ng/ml (100 nmol/L) for those not taking supplemental magnesium or vitamin K2 compared to those who usually took both supplemental magnesium and vitamin K2."

How to Boost Your Magnesium Level

The recommended daily allowance for magnesium is around 310 mg to 420 mg per day depending on your age and sex,²¹ but many experts believe you may need anywhere from 600 mg to 900 mg per day.²²

Personally, I believe many may benefit from amounts as high as 1 to 2 grams (1,000 to 2,000 mg) of elemental magnesium per day, as most of us have EMF exposures that simply cannot be mitigated, and the extra magnesium may help lower the damage from that exposure.

My personal recommendation is that unless you have kidney disease and are on dialysis, continually increase your magnesium dose until you have loose stools and then cut it back. You want the highest dose you can tolerate and still have normal bowel movements.

When it comes to oral supplementation, my personal preference is magnesium threonate, as it appears to be the most efficient at penetrating cell membranes, including your mitochondria and blood-brain barrier. But I am also fond of magnesium malate, magnesium citrate, and ionic magnesium from molecular hydrogen as each tablet has 80 mg of elemental magnesium.

Eat More Magnesium-Rich Foods

Last but not least, while you may still need magnesium supplementation (due to denatured soils), it would certainly be wise to try to get as much magnesium from your diet as possible. Dark-green leafy vegetables lead the pack when it comes to magnesium content, and juicing your greens is an excellent way to boost your intake. Foods with high magnesium levels include:²³

Avocados	Swiss chard
Turnip greens	Beet greens
Herbs and spices such as coriander, chives, cumin seed, parsley, mustard seeds, fennel, basil and cloves	Broccoli
Brussel sprouts	Organic, raw grass fed yogurt and natto
Bok Choy	Romaine lettuce

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The older you get, the more important your muscle mass becomes. Not only are strong muscles a requirement for mobility, balance and the ability to live independently, but having reserve muscle mass will also increase your chances of survival¹ when sick or hospitalized.

Muscle is lost far more easily and quicker than it’s built, so finding ways to continuously promote and maintain your muscle mass is really crucial, especially as you get older.

Age-related loss of muscle mass is known as sarcopenia, and if you don’t do anything to stop it you can expect to lose about 15% of your muscle mass between your 30s and your 80s.² An estimated 10% to 25% of seniors under the age of 70 have sarcopenia and as many as half those over the age of 80 are impaired with it.³

In the lecture above, Brendan Egan, Ph.D., associate professor of sport and exercise physiology at the School of Health and Human Performance and the National Institute for Cellular Biotechnology at Dublin City University in Ireland, reviews the latest research on exercise training for aging adults, which places a significant focus on building and maintaining muscle, and the nutritional components that can help optimize training results.

Muscle Strength and Function in Relation to Muscle Size

While it’s true that larger muscle is indicative of stronger, more functional muscle, it’s not a true 1-to-1 relationship. As noted by Egan, “you can have situations where you can gain back function without necessarily gaining muscle size.” To illustrate this point, Egan presents data from the Baltimore Longitudinal Study of Aging, which looked at leg strength and lean muscle mass.

While declines in muscle mass and strength are relatively well-synchronized in the 35- to 40-year-old group, strength dramatically drops off as you get into the 75-year-old and over groups, with 85-year-olds seeing dramatic declines in strength and function relative to the decline in muscles size.

Speed as a Measure of Functional Muscle Capacity

One way to measure functional capacity in older adults is gait (walking) speed, which is a strong predictor of life expectancy. Data suggest that if you have a walking speed of 1.6 meters (about 5.2 feet) per second (approximately 3.5 mph) at the age of 65, your life expectancy is another 32 years, meaning you may live into your late 90s.

Having a walking speed at or below the cutoff for sarcopenia, which is 0.8 meters (about 2.6 feet) per second, your life expectancy would be another 15 years, which means you’d be predicted to live to 80. At this speed, you would not be able to make it safely across a typical pedestrian crossing before the light changes to red.

Strength as a Predictor of Survival

Strength can also tell us a lot about an individual’s chances of survival. Egan presents data from a study in which people’s chest and leg press strength were measured to arrive at a composite score of whole body strength. The pattern is quite revealing, showing the strongest one-third of the population over 60 had a 50% lower death rate than the weakest.

Exercise guidelines recommend getting 150 minutes of aerobics exercise and two strength training sessions per week. As noted by Egan, you need both. It’s not just one or the other.

Research shows aerobic exercise in isolation reduces your all-cause mortality by 16% and strength training-only reduces it by 21%, whereas if you do both, you reduce your all-cause mortality by 29%.⁴ Disturbingly, U.K. data suggest only 36.2% of adults over the age of 30 meet aerobic guidelines, and a minuscule 3.4% meet strength training guidelines.

Part of the problem may be that many don’t want to go to the gym. But there’s little difference between doing gym-based strength training and doing bodyweight resistance training at home.

The Danger of Bedrest and Disuse Atrophy

As noted by Egan, enforced bedrest, such as acute hospitalization, can have a dramatic impact on your muscle mass. For example, a 2015 review⁵ in Extreme Physiology & Medicine notes you can lose 2.5% of your muscle mass in the first two weeks of bedrest. By Day 23, you can have lost up to 10% of your quadriceps muscle mass. As explained in this review:⁶

“Skeletal muscle mass is regulated by a balance between MPS [muscle protein synthesis] and MPB [muscle protein breakdown]. In a 70-kg human, approximately 280 g of protein is synthesized and degraded each day.

The two processes are linked … as facilitative or adaptive processes, whereby MPS facilitates (allows modulation of muscle mass) and MPB adapts (limiting said modulation).

When exposed to an anabolic stimulus, MPS rises. MPB rises too, but to a lesser amount, resulting in a net synthetic balance. In response to an anti-anabolic stimulus, MPS decreases and MPB decreases to a lesser degree, resulting in a net breakdown.

The interaction between critical illness and bed rest may result in greater muscle loss compared to bed rest alone. The musculoskeletal system is a highly plastic and adaptive system, responding quickly to changing demands. Relatively short periods of immobilization decrease MPS, with no effect on MPB.

Furthermore, this altered balance is relatively resistant to high dose amino acid delivery … Immobilization has significant effects on peripheral muscle aerobic capacity, contractility, insulin resistance and architecture.

Microvascular dysfunction occurring in severe sepsis is associated with immobilization and may have an additive effect on reducing MPS. In critically ill patients, MPS is reduced even with nutritional delivery, with increased MPB seen, leading to a net catabolic state and thus muscle wasting.”

Research⁷ has shown even healthy young subjects in their 20s can lose 3.1 pounds of muscle mass in a single week of bedrest. This is why it is so important to have a reserve in case you wind up in the hospital and lose this much muscle mass. It may take you the better part of a year to regain that muscle, as gaining muscle mass is hard work and many elderly fail to do so.

The loss of muscle mass also significantly decreases your insulin sensitivity. One of the reasons for this has to do with the fact that muscle tissue is a significant reservoir for the disposal of glucose. Your muscle tissue also produces cytokines and anti-inflammatory myokines that play an important role in health.

Concurrent Exercise Training

While three to five sessions of aerobic exercise and two or more strength sessions per week may sound like a lot, for many, the lack of time is a restricting factor. However, some of these sessions can be done together. “That’s called concurrent exercise training,” Egan says.

He goes on to cite research looking at time matched concurrent exercise in the elderly, 65 and older, where an aerobic training group and a strength training group were compared to a group that spent half of their session doing aerobic exercise and the other half doing resistance training. All groups spent the same overall time exercising (30 minutes, three times a week for 12 weeks).

In terms of leg strength, the concurrent training group had better responses to training than aerobic or strength training alone. There was little difference in lean body mass, meaning they didn’t necessarily bulk up, but they had a 50% increase in strength nonetheless. They also lost more body fat around the trunk area. In short, concurrent training appears to give you more bang for your buck.

Blood Flow Restriction Training

One of the reasons I’m so passionate about blood flow restriction (BFR) training is because it has the ability to prevent and widely treat sarcopenia like no other type of training.

There are several reasons why BFR is far superior to conventional types of resistance training in the elderly. Importantly, it allows you to use very light weights, which makes it suitable for the elderly and those who are already frail or recovering from an injury. And, since you’re using very light weights, you don’t damage the muscle and therefore don’t need to recover as long.

While most elderly cannot engage in high-intensity exercise or heavy weightlifting, even extraordinarily fit individuals in their 60s, 70s and 80s who can do conventional training will be limited in terms of the benefits they can achieve, thanks to decreased microcirculation. This is because your microcirculation tends to decrease with age.

With age, your capillary growth diminishes, and capillary blood flow is essential to supply blood to your muscle stem cells, specifically the fast twitch Type II muscle fiber stem cells. If they don’t have enough blood flow — even though they’re getting the signal from the conventional strength training — they’re not going to grow and you’re not going to get muscle hypertrophy and strength.

BFR, because of the local hypoxia that is created, stimulates hypoxia-inducible factor-1 alpha (HIF1a) and, secondarily, vascular endothelial growth factor (VEGF), which acts as “fertilizer” for your blood vessels. VEGF allows your stem cells to function the way they were designed to when they were younger.

What’s more, the hypoxia also triggers vascular endothelial growth factor, which enhances the capillarization of the muscle and likely the veins in the arteries as well. Building muscle and improving blood vessel function are related, which is why BFR offers such powerful stimulus for reversing sarcopenia.

In short, BFR has a systemic or crossover training effect. While you’re only restricting blood flow to your extremities, once you release the bands, the metabolic variables created by the hypoxia flow into your blood — lactate and VEGF being two of them — thereby spreading this “metabolic magic” throughout your entire system. To learn more, please see my special report, “What You Need to Know About BFR,” and “BFR Training for Muscle Mass Maintenance.”

Nutrition for Muscle Maintenance

It should come as no surprise that there is an important synergy between nutrition and exercise. When it comes to muscle building and maintenance, amino acids, the building blocks of protein, are of particular importance.

In the podcast above, Megan Hall, scientific director at Nourish Balance Thrive delves into this topic at greater depth and reviews the current recommended daily allowances of protein compared to the optimal levels needed to support muscle mass and strength in at various life stages.⁸

Research⁹ looking at post-prandial protein handling and amino acid absorption shows 55.3% of the dietary protein of a given meal is in circulation within five hours after eating, which significantly increases muscle protein synthesis.

Research¹⁰ suggests healthy young adult men “max out the protein synthesis signal from a given meal” at a dose of 0.24 grams of protein per kilogram of total bodyweight, or 0.25 grams of protein per kilogram of lean body mass.

The current U.S.-Canadian recommended dietary protein allowance is 0.8 g/kg/d (0,36/grams/pound/day), but healthy older adults may actually require about 1.20 g/kg/d or .55 grams/pound/day. According to this study:¹¹

“Our data suggest that healthy older men are less sensitive to low protein intakes and require a greater relative protein intake, in a single meal, than young men to maximally stimulate postprandial rates of MPS [myofibrillar protein synthesis].

These results should be considered when developing nutritional solutions to maximize MPS for the maintenance or enhancement of muscle mass with advancing age.”

Amino acids also act as signaling molecules that trigger muscle growth. Leucine is a particularly potent signaling agent, although all of the amino acids are required to actually build the muscle. The richest source of leucine (which helps regulate the turnover of protein in your muscle), by far, is whey protein. In fact, it can be difficult to obtain sufficient amounts of leucine from other sources.

The typical requirement for leucine to maintain body protein is 1 to 3 grams daily. However, to optimize its anabolic pathway, research shows¹² you need somewhere between 8 and 16 grams of leucine per day, in divided doses.^13,14

To reach the 8-gram minimum, you’d have to eat nearly 15 eggs.¹⁵ Whey, on the other hand, contains about 10% leucine (10 grams of leucine per 100 grams of protein).¹⁶ So, 80 grams of whey protein will give you 8 grams of leucine.

Time-Restricted Eating Adds Benefits

One of the problems with Egan is that he’s not very literate on time-restricted eating. During the question and answer portion, an audience member asks him about it and he admits he hasn’t studied it.

This is important because restricting your eating window to six to eight hours, which means you’re fasting 14 to 18 hours each day, would make it far easier for each of the meals to be over the leucine threshold. It will also activate autophagy, which is another factor essential for optimal muscle growth.

Autophagy is a self-cleaning process in which your body digests damaged cells, which in turn encourages the proliferation of new, healthy cells. The harder your workout, the more autophagy you will activate.

So, I recommend fasting for as long as you can before your morning workout, and then, shortly thereafter, have your largest meal of the day with plenty of high-quality protein, making sure you get several grams of leucine and arginine, both of which are potent mTOR stimulators.

The mTOR pathway is an important key for protein synthesis and muscle building. As explained in David Sabatini’s excellent review paper “mTOR at the Nexus of Nutrition, Growth, Ageing and Disease,” published in Nature Reviews Molecular Cell Biology:¹⁷

“Over the past two and a half decades, mapping of the mTOR signaling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy.

Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signaling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing.”

In summary, fasting activates autophagy, allowing your body to clean out damaged subcellular parts. Exercising while fasted maximizes autophagy even further. In fact, exercising while you are fasting for more than 14 to 18 hours likely activates as much autophagy as if you were fasting for two to three days. It does this by increasing AMPK, increasing NAD+ and inhibiting mTOR.

Refeeding with protein after your fasted workout then activates mTOR, thus shutting down autophagy and starting the rebuilding process. These two processes need to be cyclically activated to optimize your health and avoid problems.

Muscle Health Is Central to an Active Lifestyle

As noted by Egan, “Hopefully I've convinced you that muscle health is central to active lifestyles. There's been this increased awareness of muscle size, but I think we need to emphasize the idea about strength and function. These are the things that are easiest to change with the right type of training.”

In short, if you want to increase muscle size and strength, then there’s no getting around resistance training. It simply must be part of your exercise prescription, and concurrent training, where you’re combining aerobic and strength training in a given session is a time-efficient model.

BFR is also a particularly excellent way to ensure you’re getting effective strength training without the risks of conventional strength training using heavy weights, and is easy to combine with exercises such as walking and swimming. You simply wear the BFR bands while walking or exercising as normal.

Defy Aging by Improving Your Muscle Mass

In my February 2020 interview with Ben Greenfield, author of “Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging,” we discuss the importance of strength training and getting the appropriate amount of protein to build and maintain your muscle mass and optimize mitochondrial density and biogenesis.

In summary, Greenfield recommends a fitness program that includes the following types of exercise in order to target the main pathways involved in health and aging:

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The ketogenic diet is beneficial for many people as it helps with weight control and management and offers protection against a number of health ailments. Approached incorrectly, however, it can actually be harmful.

In this short video Dr. Eric Berg warns, "The last thing you want to do is get the benefits of the ketogenic diet but then have deficiencies of omega-3 fatty acids." If you're following a standard ketogenic nutrition plan I recommend you focus on eating healthy fats and 1 gram of protein for every kilogram of body mass. You should also keep your net carbohydrates to not more than 10% of your daily calories.

However, if you're not getting enough omega-3 fat it can be detrimental to your health. As Berg describes, your body uses fat for many reasons, including the lining and protection of cell membranes, the processing of fat soluble vitamins, the catalyzation of chemical reactions, and the production of hormones and bile. Without enough healthy fat, and the right kinds of fat, you may increase your risk for negative health conditions.

Omega-3 fats are one type of polyunsaturated fats (PUFAs) you must get from your food since your body doesn't make them.¹ The second type of PUFAs are omega-6 fats. Your body needs both in a balanced ratio for optimal health.

As the National Institutes of Health describes,² "The three main omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA is found mainly in plant oils such as flaxseed, soybean and canola oils. DHA and EPA are found in fish and other seafood."

Omega-3 Fats Are Crucial to Heart Health

EPA, DHA and ALA each have unique functions. DHA is particularly important for your brain,³ as about 90 percent of the fat in your brain is DHA, while EPA appears to be of particular importance for heart health.⁴ ALA, found in plants, is the "parent fatty acid" and is used as a source of energy.

However, while some may be converted to EPA and DHA in the body, conversion to EPA is restricted and unreliable, and conversion to DHA is severely restricted.⁵ Making lifestyle changes, such as exercising, stopping smoking and improving your diet, have a significant impact on your heart health.

The authors of one study published in the New England Journal of Medicine⁶ analyzed the risk of a cardiovascular event while taking icosapent ethyl. The medication is a "highly purified eicosapentaenoic acid ethyl ester" that is "a synthetic derivative of omega-3 fatty acid."⁷

The data⁸ were based on information gathered from 8,179 participants who were followed over a period of 4.9 years. The researchers identified end points of the study as death from a cardiac event, or a nonfatal heart attack or stroke.

The participants either had heart disease or risk factors for it and were taking statins. They were given either a placebo or 2 grams of icosapent ethyl twice a day. Those who took the medication had a significantly lower number of ischemic events than those taking the placebo.

Although the drug had previously been approved in 2012 for people with high triglycerides, in December 2019 the FDA approved it for use alongside statins.⁹ Its mechanism of action has not been completely identified, but the American Heart Association lists the following reasons natural omega-3 may have an impact on lowering the risk of heart disease:¹⁰

Lowers triglyceride levels and increases HDLs	Decreases platelet aggregation and prevents blockage of coronary artery
Lowers resting blood pressure	Increases compliance of arteries
Decreases atherosclerosis	Reduces inflammatory markers
Decreases risk of abnormal heart rhythms

As explained in a meta-analysis published in Circulation,¹¹ scientists concluded there was a growing body of evidence that omega-3 fats can prevent sudden cardiac death by "modulating ion channels so as to stabilize the cardiomyocytes electrically."

EPA and DHA Lowers Inflammation, Pain and Depression

EPA and DHA have been shown to improve blood pressure,¹² reduce overall inflammation, reduce the effects of rheumatoid arthritis¹³ and depression¹⁴ and help to slow the progression of Alzheimer's disease.¹⁵

Other conditions linked to inflammation that are positively affected by omega-3 fatty acids are Hashimoto's disease and inflammatory bowel disease. Nutritionist Steph Lowe spoke with Starts at 60 about omega-3 fats, saying:¹⁶

"Fish oil is a natural alternative to non-steroidal anti-inflammatory drugs (NSAID), without the side effects but with the potential to reduce the inflammatory response and thereby reduces joint stiffness and pain."

Your Body Needs Cholesterol for Vital Functions

For decades you've been told that high cholesterol levels will increase your risk for heart disease. In fact, some in the health community continue to stress your level of cholesterol as a biomarker for heart risk, when in fact it's smarter to take a global view of cholesterol — how it affects your body and what you can do to reduce your risk of heart disease beyond the simple narrative which focuses on cholesterol as some kind of culprit.

Cholesterol is vital to your overall health, as it helps with the manufacturing of hormones and vitamin D. About 80% of the cholesterol in your body is made in your liver and intestines, while the rest has to come from your food.¹⁷

There are two categories of cholesterol: The first is high density lipoprotein (HDL), which many know as the "good" type that moves cholesterol out of your arteries.¹⁸

The second is low-density lipoprotein (LDL) or what many know as the "bad" type that may build up and form plaque in the arteries. The American Heart Association focuses on your total cholesterol number, which they recommend you keep at 150 milligrams per deciliter (mg/dL).¹⁹

In the 2015-2020 Dietary Guidelines for Americans, it's noted that the Institute of Medicine recommends²⁰ "… individuals should eat as little dietary cholesterol as possible while consuming a healthy eating pattern." However, in the Scientific Report of the 2015 Dietary Guidelines Advisory Committee, it was acknowledged that "… cholesterol is not considered a nutrient of concern for overconsumption."²¹

It's troubling to know that the public hears one thing and something completely different is discussed at a medical advisory meeting.

Using cholesterol as a sole marker for the risk of heart disease is inaccurate because, like most things related to your body, its mechanisms are complex and interrelated. Increasing amounts of evidence show that people with higher levels of cholesterol live longer lives.²² As summarized by the authors of one study:

"Overall, an inverse trend is found between all-cause mortality and total (or low density lipoprotein [LDL]) cholesterol levels: mortality is highest in the lowest cholesterol group without exception … elderly people with the highest cholesterol levels have the highest survival rates irrespective of where they live in the world."

While evaluating your heart disease risk, consider your fasting insulin and blood sugar levels, waist circumference and iron levels. I discuss the relationships of these factors to your heart health and the importance of differentiating the types of LDL in "Important Facts About Cholesterol and Heart Disease."

There are a number of ways higher levels of cholesterol may have a protective effect on your health; these are discussed in "Higher Cholesterol is Associated With Longer Life." Instead of looking at simple levels, there are two indicators that are important: your HDL/total cholesterol ratio and your triglyceride/HDL ratio.

Why Testing Your Omega-3 Level Is so Important

An omega-3 deficiency leaves you vulnerable to several chronic diseases and lifelong challenges. Optimizing your levels is truly a foundational strategy to attaining and maintaining good health. The best way to determine if you're eating enough food with omega-3 is to get tested.

In fact, research²³ supported by the National Institutes of Health suggests that an omega-3 test is a good predictor of overall health and all-cause mortality.²⁴

Leaders of the study measured the omega-3 index in 2,500 participants; they found that those with the highest omega-3 index had lower risks of heart problems. The omega-3 Index is a measure of the amount of EPA and DHA in the membranes of your red blood cells (RBCs). As Berg mentioned, fat is a component of cell membranes.

Your index is expressed as a percent of your total RBC fatty acids. The omega-3 index has been validated as a stable, long-term marker of your omega-3 status, and it reflects your tissue levels of EPA and DHA. I just had my omega-3 index done last week from GrassrootsHealth and it was 11.1% and my 6:3 ratio was 2.7.

An omega-3 index over 8% is associated with the lowest risk of death from heart disease, while an index below 4% places you at the highest risk of heart disease-related mortality. Given its importance to your health, it is absolutely worth your time to complete the simple blood test required to determine your omega-3 index.

I firmly believe an omega-3 index test is one of the most important annual health screens that everyone needs. Please note I make no profit from these tests. I merely supply them as a convenience for my readers. It's the same price whether you buy it from me or directly from GrassrootsHealth.²⁵

Protect Your Heart and Brain With Animal-Based Omega-3

You can get all three types of omega-3 fats from your food, but EPA and DHA come mostly from fatty fish, seafood and grass fed beef and dairy products. Grass fed beef and dairy products, incidentally, offer a nearly 1-to-1 ratio of omega-3 to omega-6 fatty acids.²⁶ Lowe points out the importance of where you source your fish:²⁷

"As a nutritionist, my preference is always food, but one of the biggest challenges we face at the moment is that most of our oily fish is farmed and grain-fed."

Your best sources of fatty fish are wild-caught Alaskan salmon, herring, mackerel and anchovies. The larger predatory fish, such as tuna, have much higher amounts of toxins such as mercury. As Berg stated in the video, steer clear of grain-finished beef as the omega-3 fatty acids are significantly reduced.

As I touched on above, it's important to realize your body doesn't convert enough plant-based omega-3 to meet your needs. This means that if you're vegan, you must figure out a way to compensate for the lack of marine or grass fed animal products in your diet.

While the authors of some studies²⁸ suggest that algae products may be an effective alternative, the only way to know if you're on the right track is to test. If you are pregnant I urge you to check your vitamin D and omega-3 levels, as these two nutrients are vital for healthy fetal development and can dramatically reduce your risk of complications during pregnancy and delivery.

If your test results are low, and you are considering a supplement, compare the advantages and disadvantages of fish oil and krill oil as you'll see in the infographic below. Krill are wild-caught and sustainable; krill oil is also more potent than fish oil and is less prone to oxidation.

Embed this infographic on your website:

<img src="https://ift.tt/2P2BPzy" alt="krill oil vs fish oil infographics" border="0" style="max-width:100%; min-width:300px; margin: 0 auto 20px auto; display:block;" /><p style="max-width:800px; min-width:300px; margin:0 auto; text-align:center;">Learn why krill oil is a safer and smarter choice than fish oil through the <a href="https://www.mercola.com/infographics/fish-oil-vs-krill-oil.htm"><strong>Fish Oil versus Krill Oil: The Cold, Hard Facts</strong></a> infographic. Use the embed code to share it on your website or visit our infographic page for the high-res version.</p> <pre style="max-width:800px; min-width:300px; margin: 20px auto 0 auto; padding:10px; border:solid 1px #999999; background: #ffffff; white-space: pre-wrap; word-wrap:break-word;"><code>&lt;img src="https://ift.tt/2P2BPzy" alt="krill oil vs fish oil infographics" border="0" style="max-width:100%; min-width:300px; margin: 0 auto 20px auto; display:block;"&gt;&lt;p style="max-width:800px; min-width:300px; margin:0 auto; text-align:center;"&gt;Learn why krill oil is a safer and smarter choice than fish oil through the &lt;a href="https://www.mercola.com/infographics/fish-oil-vs-krill-oil.htm"&gt;&lt;strong&gt;Fish Oil versus Krill Oil: The Cold, Hard Facts&lt;/strong&gt;&lt;/a&gt; infographic. Visit our infographic page for the high-res version.&lt;/p&gt;</code></pre>

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Youthfulness, vitality and a long, prosperous life have been sought after throughout human history. And now, it seems scientists may have discovered one of the keys to turning back the hands of time.

Researchers from Arizona State University and Texas A&M University have made a breakthrough discovery in plant DNA that could lead to stopping cancer cold and slowing the aging process, ABC affiliate News 15 Arizona reports.¹

The research involves telomerase, an enzyme that produces the DNA of telomeres, which have been shown to play a role in the aging process. As your telomeres lengthen, they protect your cells from aging.

Take It From the Experts: Centenarians Share Their Secrets

While direct applications from the study to human health are distant, there are a number of things you can do now to improve your health span, according to one of the co-authors. In interviews and surveys with centenarians, certain themes came up time and time again when they explained why they've lived so long. The 10 most common reasons they gave for their long lives were:

Keeping a positive attitude	Eating good food
Participating in moderate exercise like walking, gardening swimming, etc.	Living clean (not smoking or drinking excessively)
Living independently	Having family to interact with
Having a circle of friends	Being born with "good" genes
Having faith/spirituality	Staying mentally active and continually learning

Centenarians are the fastest growing segment of the U.S population, with numbers doubling every decade; by the year 2050, the number of people who will have reached the century mark is expected to pass 1 million.

Centenarians have 60% lower rates of heart disease, stroke and high blood pressure, yet scientific explanations for their health and longevity remain elusive. As a group, they are happy and optimistic and have extremely low rates of depression and other psychiatric problems, suggesting you may live longer by maintaining the right attitude.

Hopefulness and Positivity Affect the Heart

There are compelling links between cardiac health and mental health. For example, having untreated depression or anxiety disorder increases your odds of having a heart attack or developing heart disease. Stress hormones are again a primary culprit.

According to Julia Boehm, author of earlier Harvard studies looking at optimism and cardiovascular disease (CVD):²

"The absence of the negative is not the same thing as the presence of the positive. We found that factors such as optimism, life satisfaction and happiness are associated with reduced risk of CVD regardless of such factors as a person's age, socioeconomic status, smoking status or body weight."

With a later study,³ author Eric Kim told The Harvard Gazette:

"While most medical and public health efforts today focus on reducing risk factors for diseases, evidence has been mounting that enhancing psychological resilience may also make a difference.

Our new findings suggest that we should make efforts to boost optimism, which has been shown to be associated with healthier behaviors and healthier ways of coping with life challenges."

The Significance of Sound Sleep

Getting adequate sleep is an important part of both mental and physical health. Too much or too little can lead to metabolic issues, as well as changes in mood and your ability to focus. Your circadian rhythm, which affects your sleep/wake cycle, holds implications for your brain, body temperature, hormones and cell regeneration among other things.⁴

"Irregular rhythms have been linked to various chronic health conditions, such as sleep disorders, obesity, diabetes, depression, bipolar disorder and seasonal affective disorder," say scientists from the National Institute of General Medical Sciences.⁵

Italian researchers found that deletion of a specific gene related to aging also affects glucose homeostasis. According to their article, published in the journal Glia, "Disruption of the circadian cycle is strongly associated with metabolic imbalance and reduced longevity in humans."⁶

Telomeres and telomerase activity are also controlled by your circadian rhythm,⁷ making proper sleep an important part of longevity. In a 2007 study involving 21,268 adult twins, Finnish researchers found that adults who slept more than eight hours per night, or less than seven, showed increased risk of death.⁸

Of course, the quality of your sleep is also important, not just the quantity. Good quality sleep, in the appropriate amount, can improve how you think and adapt to the demands on your time and changes throughout your day. There is evidence suggesting that a calm mind and active body are two important ingredients for longevity.

The meditative technique known as "mindfulness" has even been shown to have a beneficial effect on genetic expression. According to a 2018 article in Brain, Behavior, and Immunity,⁹ meditation has also been found to affect the enzyme telomerase, which some researchers believe is actively involved with the process of aging.

After Resting, Be Sure to Refuel

Additionally, there are many other strategies you can implement to improve your health and extend your life span. To live longer, you need to counteract the progressive loss of muscle mass by increasing your protein intake as you age. The elderly, bodybuilders and endurance athletes typically have higher than normal protein requirements for their age group.

It's also important to cycle high and low protein intake. Ideally, combine protein restriction with time-restricted eating, followed by increased protein intake on strength training days.

Fasting 16 to 20 hours each day is likely ideal, as this allows your body to more thoroughly deplete the glycogen stores in your liver. Benefits of fasting include the suppression of mammalian target of rapamycin (mTOR) and the activation of autophagy, both of which play decisive roles in disease prevention and longevity.

You'd also be wise to avoid eating two to three hours before bed, as late-night eating will decrease your nicotinamide adenine dinucleotide (NAD+) level, which is crucial for health and longevity. Late-night eating will also make you pack on unwanted pounds, as the excess calories will not be burned but stored as fat.

Preventing Cognitive Decline

Naturally, if you're going to live longer, you'll want to be healthy for the remainder, and that includes maintaining your cognitive function. Specific nutrients that can help prevent dementia and cognitive decline include vitamin D, DHA, folate and magnesium. Additional nutrients of notable interest, which are readily available in supplement form, include:

• Astaxanthin — Commonly called "king of the carotenoids," is a potent anti-inflammatory from specific types of microalgae and may be useful for treating joint and muscle pain. It also supports healthy vision and can be used as an "internal sunscreen."
• Ergothioneine — Found in porcini mushrooms, ergothioneine appears to play a specific role in protecting your DNA from oxidative damage. Along with glutathione, it may offer protection against age-related conditions such as Alzheimer's disease, cancer and heart disease.
• PQQ — Particularly important for the health and protection of your mitochondria, PQQ has been shown to help protect against Alzheimer's and Parkinson's disease. It also works synergistically with CoQ10, producing better results than when either one is used alone. Celery, parsley and kiwi are dietary sources of PQQ.

Kick the Chemicals to the Curb

Naturally, there's also the issue of toxic exposures, which can take a toll on your health, so avoiding toxins is a given, right along with eating a wholesome diet of organic, unprocessed foods.

This includes tossing out your toxic household cleaners, soaps, personal hygiene products, air fresheners, bug sprays, lawn pesticides and insecticides, just to name a few, and replacing them with nontoxic alternatives.

A group of scientists from Southeast University and Changzhou No. 7 People's Hospital in China recently published a study¹⁰ about the role of plastics in our environment and how long-term exposure affects our health. They found that high concentrations of nanoplastic particles reduced the life span of roundworms.

They believe that different levels of exposure may have effects on locomotion and immune response, indicating that nanopolystyrene is likely toxic to all types of organisms.

"Our results highlight the potential of long-term nanopolystyrene exposure in reducing longevity and in affecting health state during the aging process in environmental organisms," they wrote. Next week I will post my interview with leading researcher James Clement on his book, "The Switch," that will go into far more fascinating details on this topic.

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The celery juice phenomenon is often attributed to Anthony William, who considers himself the originator of the Global Celery Juice Movement.¹ The movement has received both social media and major media attention in The New York Times² and LA Times³ among others.

You can easily grow your own organic celery at home when you keep it cool, give it an unfailing supply of water and plant it in good soil.⁴ It’s important to choose organically grown celery as it’s one of the more contaminated vegetables available at the grocery store.

Choose Organic Celery for Your Table

Each year the Environmental Working Group (EWG),⁵ a nonprofit organization aimed at protecting health and the environment, publishes a guide to pesticides in produce. This document is called “The Dirty Dozen;” celery usually makes an appearance on the list.

In 2012, it was No. 2 on the list and the one most likely to contain multiple pesticides, with 96% of the samples testing positive and nearly 90% retaining more than one pesticide.⁶ By 2019, celery had dropped to number 11, having been overtaken by strawberries, spinach and kale.⁷

Before testing the fruits and vegetables, the produce was washed and peeled as consumers may be expected to at home.⁸ The Shopper’s Guide, which the EWG has published since 2004, ranks contamination in 47 fruits and vegetables based on more than 40,900 samples.⁹ Carla Burns, EWG Research Analyst, commented:¹⁰

“The main route of pesticide exposure for most Americans who do not live or work on or near farms is through their diet. Studies have shown that eating fruits and vegetables free of pesticides benefits health, and this is especially important for pregnant women and children.”

The American Academy of Pediatrics¹¹ emphasizes children's exposure should be limited. Pesticide exposure is linked with poor mental development, pervasive developmental disorders and attention deficit hyperactivity disorder. Their data also suggest an association with physical birth defects, fetal death and neurodevelopmental effects.

The EWG evaluated the U.S. Department of Agriculture's tests, which found 225 different pesticides on fruits and vegetables.¹² Dr. Philip Landrigan is director of the Global Public Health Initiative at Boston College and one of the writers of the 1993 National Academy of Sciences study, “Pesticides in the Diets of Infants and Children.”¹³

He underscores the implications of pesticide exposure and stresses that when possible, steps should be taken to lower a child's exposure while continuing to offer a diet full of fresh produce.¹⁴

The dangers of pesticide exposure continue into adulthood. The Pesticide Action Network reports long-term toxicity at low doses has been associated with Parkinson's disease, depression, anxiety, asthma and certain cancers.¹⁵

Celery Juice Trending: Rising Cost Is a Perfect Storm

Michael Karsch is the CEO of a New York chain of juice bars, Juice Press,^16,17 and he tracks juice trends. In 2018 he noticed a rise in celery juice interest and decided to offer a 12-ounce, one ingredient drink for $7. Karsch spoke to The New York Times about the shortage and his take on the future, saying:¹⁸

“Within a few days, it was our third best selling beverage, which is astonishing for a one-ingredient offering. I have been historically unimpressed by celery. It’s not vibrant. It’s got a ton of water and a ton of a fiber … Three months ago where we couldn’t provide enough celery juice for about 4 days … Five years ago it was organic almonds, there was kale maybe 7 years ago. Usually what happens is it corrects.”

Vandana Sheth,¹⁹ spokesperson for the Academy of Nutrition and Dietetics, finds these trends are often driven by social media and may be enticing because she believes many people are looking for a quick fix for their health.

She noted moving back and forth between different trending eating plans may be dangerous, and said:²⁰ “I'm seeing a lot more of a disordered way of eating in my practice. It's not sustainable long-term.”

Sammy Duda,²¹ senior vice president of Duda Farm Fresh Foods, one of the largest celery growers in the world, spoke to The New York Times about his family’s familiarity with the supply and demand issue when celebrities endorse a specific type of vegetable juice. Out of 10 items listed on their products page, three of those are packaged celery and one is fresh celery.²²

The cost not only is affected by demand from the juice trend, but also by the weather. The New York Times²³ reports a warm, dry fall in Palm Beach, Florida, where some of the crop is grown, and a cold, wet winter on the west coast where other fields are located, have affected growth and harvest.

The crop on Duda Farm was also impacted by a soil-borne disease, which together added up to a shorter than normal supply in an environment with a greater than normal demand.

Phytonutrients Promote Health Benefits

Although there’s been a push to promote celery as a cure for many different health conditions, scientific evidence supports a more limited number. One cup of raw celery contains 40% of your daily value of vitamin K.²⁴ In addition to this it contains 11% of your daily value of molybdenum,²⁵ a trace mineral your body uses for the detoxification of heavy metals.

Some of the larger threats from heavy metal are associated with cadmium, mercury, arsenic and lead.²⁶ Long-term exposure may result in neurological damage, skin cancers, kidney damage and bone fractures.

Toxicity will depend on several factors including the route of exposure and duration.²⁷ You can read more about how molybdenum functions in heavy metal detoxification in my past article, “The Three Pillars of Heavy Metal Detoxification.”

Celery also contains measurable amounts of folate, potassium and vitamin B2. Celery stalks are a great source of antioxidants, phytosterols, flavanols and flavones, many of which provide anti-inflammatory benefits.²⁸ But, one of the more advantageous compounds found in celery may be apigenin, gaining interest for its potential to fight cancer.²⁹

Apigenin is a flavonoid found in several fruits and vegetables and some Chinese medicinal herbs. It has strong anti-inflammatory, antibacterial and antiviral properties and is now being reported as subduing different forms of cancer. This has been found in vitro and in vivo by initiating apoptosis and autophagy, as well as stimulating an immune response.³⁰

Apigenin is associated with stimulating the growth of nerve cells. One animal study demonstrated learning and memory improvements when apigenin was injected or taken orally.³¹ Studies have also linked apigenin with activating AMP-activated protein kinase (AMPK) in human skin cells.

The results suggest that “one of the mechanisms by which apigenin exerts its chemoprotective action may be through activation of AMPK and induction of autophagy in human keratinocytes.”³² In another published study, scientists looked at the anticarcinogenic properties on the regulation of oxidative stress and DNA damage. They wrote:³³

“One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines.”

Large Amounts May Interfere With Kidney Function

Although not high in oxalates, celery has between 11 and 20 mg for every 3 1/2 ounces of the vegetable. Oxalates are found in plant and animal foods with some of the more concentrated sources including spinach, almonds and beet greens.³⁴ Oxalates are related to kidney stone formation and calcium absorption.

Your gut bacteria play a role in how available oxalate will be for absorption. A combination of oxalate and nonoxalate-containing foods will also impact how much soluble oxalate gets absorbed from the digestive tract.³⁵

Calcium oxalate kidney stones are among the more common types of stones. However, it's not high amounts of calcium that cause the stones but, rather, oxalate.³⁶ Oxalates are compounds that protect plants from predators.³⁷ The oxalic acid binds with calcium to make it less bioavailable and insoluble, increasing the risk of kidney stones.

Oxalates are broken down by gut bacteria, but when your microbiota are compromised the compounds enter the bloodstream and get stored in the kidneys. While 11 to 20 mg of oxalate in one 3 1/2-ounce serving of celery is minor, drinking 16 ounces of celery juice each day may not be.

One 16-ounce glass of celery juice requires one large bunch of celery,³⁸ which often contains 10 stalks³⁹ and weighs about 16 ounces or more.⁴⁰ Drinking this much celery juice is roughly equivalent to 90 mg of oxalates every day. In addition to other foods, including chocolate, berries, nuts, legumes and grains,⁴¹ this may increase your risk for kidney stones. 

Soothing Chamomile Tea — An Option With Similar Benefits

Herbal teas are a rich source of polyphenols and flavonoids with antioxidant and anti-inflammatory properties. One of the most soothing is chamomile tea, belonging to the Asteraceae family⁴² containing a large number of herbs, shrubs and trees.⁴³

In addition to being used as a tea, chamomile has been praised for many health benefits, including those in the volatile oils found in the flowers. One of the major constituents in the flower is apigenin, primarily found as a glycoside.⁴⁴

Adults can use the volatile oils from the flower in a bath, as a cream for flaky skin, as an inhalant or tincture to relieve menstrual cramps and to improve sleep. For more information about the benefits of chamomile and how to make a tincture at home, see my past article, “What Are the Benefits of Chamomile?”

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For the past six decades, the U.S. dietary advice has warned against eating cholesterol-rich foods, claiming dietary cholesterol promotes arterial plaque formation that leads to heart disease. We now have overwhelming evidence to the contrary, yet dogmatic thinking can be persistent, to say the least.

After decades’ worth of research failed to demonstrate a correlation between dietary cholesterol and heart disease, the 2015-2020 Dietary Guidelines for Americans^1,2 finally addressed this scientific shortcoming, announcing “cholesterol is not considered a nutrient of concern for overconsumption.”

To this day, the evidence keeps mounting, showing there’s no link between the two. Similarly, the evidence supporting the use of cholesterol-lowering statin drugs to lower your risk of heart disease is slim to none, and is likely little more than the manufactured work of statin makers — at least that’s the implied conclusion of a scientific review³ published in the Expert Review of Clinical Pharmacology in 2018.

Cholesterol myth kept alive by statin advocates?

The 2018 review⁴ identified significant flaws in three recent studies “published by statin advocates” attempting “to validate the current dogma.” The paper presents substantial evidence that total cholesterol and low-density lipoprotein (LDL) cholesterol levels are not an indication of heart disease risk, and that statin treatment is of “doubtful benefit” as a form of primary prevention for this reason. According to the authors:⁵

“According to the British-Austrian philosopher Karl Popper, a theory in the empirical sciences can never be proven, but it can be shown to be false. If it cannot be falsified, it is not a scientific hypothesis. In the following, we have followed Popper’s principle to see whether it is possible to falsify the cholesterol hypothesis.

We have also assessed whether the conclusions from three recent reviews by its supporters are based on an accurate and comprehensive review of the research on lipids and cardiovascular disease (CVD) …

Our search for falsifications of the cholesterol hypothesis confirms that it is unable to satisfy any of the Bradford Hill criteria for causality and that the conclusions of the authors of the three reviews are based on misleading statistics, exclusion of unsuccessful trials and by ignoring numerous contradictory observations.”

As reported by Reason.com:⁶

“A comprehensive new study on cholesterol, based on results from more than a million patients, could help upend decades of government advice about diet, nutrition, health, prevention, and medication …

The study … centers on statins, a class of drugs used to lower levels of LDL-C, the so-called ‘bad’ cholesterol, in the human body. According to the study, statins are pointless for most people …

The study also reports that ‘heart attack patients were shown to have lower than normal cholesterol levels of LDL-C’ and that older people with higher levels of bad cholesterol tend to live longer than those with lower levels.”

No evidence cholesterol influences heart disease risk

Indeed, the authors of the Expert Review of Clinical Pharmacology analysis point out that were high total cholesterol in fact a major cause of atherosclerosis, “there should be exposure-response in cholesterol-lowering drug trials.”⁷ In other words, patients whose total cholesterol is lowered the most should also see the greatest benefit. Alas, that’s not the case.

A review of 16 relevant cholesterol-lowering trials (studies in which exposure-response was actually calculated), showed this kind of exposure-response was not detected in 15 of them. What’s more, the researchers point out that the only study⁸ showing a positive exposure-response to lowered cholesterol used exercise-only as the treatment.

Patients with high total cholesterol should also be at increased risk of death from CVD, but the researchers found no evidence of this either, not-so-subtly pointing out that this is “an idea supported by fraudulent reviews of the literature.” They provide the following example of how research has been misrepresented:⁹

“The hypothesis that high TC [total cholesterol] causes CVD was introduced in the 1960s by the authors of the Framingham Heart Study. However, in their 30-year follow-up study published in 1987, the authors reported that ‘For each 1 mg/dl drop in TC per year, there was an eleven percent increase in coronary and total mortality’.

Three years later, the American Heart Association and the U.S. National Heart, Lung and Blood Institute published a joint summary concluding, ‘a one percent reduction in an individual’s TC results in an approximate two percent reduction in CHD risk’. The authors fraudulently referred to the Framingham publication to support this widely quoted false conclusion.”

Contradictory findings routinely ignored or misrepresented

To determine whether the three reviews under analysis had misrepresented previous findings, they scoured the three papers for quotations from 12 studies reporting results “discordant with the cholesterol hypothesis.” Only one of the three reviews had quoted articles correctly, and even then, only two of the dozen studies were quoted correctly.¹⁰

“About half of the contradictory articles were ignored. In the rest, statistically nonsignificant findings in favor of the cholesterol hypothesis were inflated, and unsupportive results were quoted as if they were supportive. Only one of the six randomized cholesterol-lowering trials with a negative outcome was cited and only in one of the reviews.”

The researchers also highlight a large meta-analysis that simply ignored “at least a dozen studies” in which no or inverse association was shown. Overall, the Expert Review of Clinical Pharmacology analysis found that “the association between total cholesterol and CVD is weak, absent or inverse in many studies.”

No link between LDL and heart disease either

The Expert Review of Clinical Pharmacology paper¹¹ also tears apart claims that high LDL causes atherosclerosis and/or CVD. Just as with total cholesterol, if high LDL was in fact responsible for atherosclerosis, then patients with high LDL would be diagnosed with atherosclerosis more frequently, yet they’re not, and those with the highest levels would have the greatest severity of atherosclerosis, yet they don’t.

The researchers cite studies showing “no association” between LDL and coronary calcification or degree of atherosclerosis. Ditto for LDL and CVD. In fact, a study looking at nearly 140,000 patients with acute myocardial infarction found them to have lower than normal LDL at the time of admission.

Even more telling, another study, which had originally reported similar findings, still went ahead and lowered the patients’ LDL even more. At follow-up three years later, they discovered that patients with an LDL level below 105 mg/dl (2 mmol/L) had double the mortality rate of those with higher LDL.¹²

Interestingly, the authors suggest this inverse relationship may be due to low LDL increasing your risk for infectious diseases and cancer, both of which are common killers.

They also review evidence showing older people with high LDL do not die prematurely — they actually live the longest, outliving both those with untreated low LDL and those on statin treatment. One such study^13,14 — a meta-analysis of 19 studies — found 92% of individuals with high cholesterol lived longer.

Benefits of statin treatment are overblown

Lastly, the Expert Review of Clinical Pharmacology paper analyzes statin claims, showing how studies exaggerate benefits through a variety of different tactics. Again, in some cases, by simply excluding unsuccessful trials.

“Furthermore, the most important outcome — an increase of life expectancy — has never been mentioned in any cholesterol-lowering trial, but as calculated recently by Kristensen et al.,¹⁵ statin treatment does not prolong lifespan by more than an average of a few days,” the authors state.¹⁶

Indeed, the study they’re referring to, published in BMJ Open in 2015, which looked at 11 studies with a follow-up between two and 6.1 years, found “Death was postponed between -5 and 19 days in primary prevention trials and between -10 and 27 days in secondary prevention trials.” The median postponement of death in primary prevention trials was 3.2 days, and in secondary prevention trials 4.1 days!

Considering the well-documented health risks associated with statins, this is a mind-bending finding that really should upend the dogma. And yet, the dogma remains, and may even strengthen in coming days.

JAMA editorial calls for end to ‘fake news’ about statins

The cholesterol myth has been a boon to the pharmaceutical industry, as cholesterol-lowering statins — often prescribed as a primary prevention against heart attack and stroke — have become one of the most frequently used drugs on the market. In 2012-2013, 27.8% of American adults over the age of 40 reported using a statin, up from 17.9% a decade earlier.^17,18 But that was six years ago, I suspect over a third of adults over the age of 40 are now using statins.

In addition to the BMJ Open study cited above, an evidence report¹⁹ by the U.S. Preventive Services Task Force, published November 2016 in JAMA, found 250 people need to take a statin for one to six years to prevent a single death from any cause; 233 had to take a statin for two to six years to prevent a single cardiovascular death specifically. To prevent a single cardiovascular event in people younger than 70, 94 individuals would have to take a statin.

As noted in a 2015 report,²⁰ “statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease.” The paper points out that by using a statistical tool known as relative risk reduction, the trivial benefits of statins appear greatly amplified.

Scientific findings such as these are the core reason why statins are given negative press. However, we may soon see a reversal in the news cycle, with negative statin articles being tagged as “fake news.”

According to a June 2019 editorial²¹ in JAMA Cardiology, written by cardiologist Ann Marie Navar,²² statins are the victim of “fear-based medical information,” just like vaccines, and this is what’s driving patient nonadherence. Cardiovascular Business reported:²³

“We know that what people read influences their actions, Navar said, and indeed, one 2016 study in the European Heart Journal found that on a population level, statin discontinuation increased after negative news stories about statins surfaced in those communities.

In another study, more than one in three heart patients said they declined a statin prescription solely for fears of adverse effects. ‘Measles outbreaks are highly visible: a rash appears, public health agencies respond, headlines are made and the medical community responds vocally,’ Navar wrote.

‘In contrast, when a patient who has refused a statin because of concerns stoked by false information has an MI, the result is less visible. Nevertheless, cardiologists and primary care physicians observe the smoldering outbreak of statin refusal daily.’”

Cardiovascular Business summarizes Navar’s suggestions for how doctors can fight back against false information about statins and build adherence, such as handing out yearlong prescriptions with automatic refills.²⁴

When I first wrote about the censorship of anti-vaccine material occurring on every single online platform, I warned that this censorship would not stop at vaccines. And here we’re already seeing the call for censoring anti-statin information by glibly labeling it all “fake news.”

Chances are, the censoring of anti-statin information is already underway. A quick Google search for “statin side effects” garnered pages worth of links talking about minor risks, the benefits of statins, comparison articles, looking at two different brands — in other words, mostly positive news.

The scientific fact is, aside from being a “waste of time” and not doing anything to reduce mortality, statins also come with a long list of potential side effects and clinical challenges, including:

An increased risk for diabetes

Decreased heart function25

Nutrient depletions — Including CoQ10 and vitamin K2, both of which are important for cardiovascular and heart health

Impaired fertility — Importantly, statins are a Category X medication,26 meaning they cause serious birth defects,27 so they should never be used by a pregnant woman or women planning a pregnancy

Increased risk of cancer — Long-term statin use (10 years or longer) more than doubles women's risk of two major types of breast cancer: invasive ductal carcinoma and invasive lobular carcinoma28

Nerve damage — Research has shown statin treatment lasting longer than two years causes “definite damage to peripheral nerves”29

How to assess your heart disease risk

>>>>> Click Here <<<<<

As a general rule, cholesterol-lowering drugs are not required or prudent for the majority of people — especially if both high cholesterol and longevity run in your family. Remember, the evidence overwhelmingly suggests your overall cholesterol level has little to nothing to do with your risk for heart disease.

For more information about cholesterol and what the different levels mean, take a look at the infographic above. You can also learn more about the benefits of cholesterol, and why you don’t want your level to be too low, in “Cholesterol Plays Key Role in Cell Signaling.” As for evaluating your heart disease risk, the following tests will provide you with a more accurate picture of your risk:

HDL/Cholesterol ratio — HDL percentage is a very potent heart disease risk factor. Just divide your HDL level by your total cholesterol. That percentage should ideally be above 24%.

Triglyceride/HDL ratio — You can also do the same thing with your triglycerides and HDL ratio. That percentage should be below 2.

NMR LipoProfile — Large LDL particles do not appear to be harmful. Only small dense LDL particles can potentially be a problem, as they can squeeze through the lining of your arteries. If they oxidize, they can cause damage and inflammation. Some groups, such as the National Lipid Association, are now starting to shift the focus toward LDL particle number instead of total and LDL cholesterol to better assess your heart disease risk. Once you know your particle size numbers, you and your doctor can develop a more customized program to help manage your risk.

Your fasting insulin level — Heart disease is primarily rooted in insulin resistance,30 which is the result of a high-sugar diet. Sugar, not cholesterol or saturated fat, is the primary driver. Clinical trials have shown high fructose corn syrup can trigger risk factors for cardiovascular disease within as little as two weeks.31 Any meal or snack high in carbohydrates like fructose and refined grains generates a rapid rise in blood glucose and then insulin to compensate for the rise in blood sugar. The insulin released from eating too many carbs promotes fat accumulation and makes it more difficult for your body to shed excess weight. Excess fat, particularly around your belly, is one of the major contributors to heart disease.

Your fasting blood sugar level — Research has shown people with a fasting blood sugar level of 100 to 125 mg/dl have a nearly 300% increased higher risk of coronary heart disease than people with a level below 79 mg/dl.32,33

Your iron level — Iron can be a very potent oxidative stress, so if you have excess iron levels you can damage your blood vessels and increase your risk of heart disease. Ideally, you should monitor your ferritin levels and make sure they are not much above 80 ng/ml. The simplest way to lower them if they are elevated is to donate your blood. If that is not possible you can have a therapeutic phlebotomy and that will effectively eliminate the excess iron from your body.

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