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12/20/20

Although they sound the same, and some people use the terms interchangeably, flavonoids and flavanols are different. Flavonoids are a family of plant compounds, of which flavanols are one subclass. You can find flavonoids in fruits, vegetables, tea, chocolate and wine. Evidence shows it’s flavanol-rich dark chocolate that improves cognitive performance and mood.

The chemical properties of flavanols impact the bioavailability of the compounds and help determine their biological activity. As a family, flavonoids have antidiabetic, anti-inflammatory, anticancer and neuroprotective properties.

Oregon State University reports there is evidence that some flavonoids can improve cognitive function, but it is not known if they can help lower risk for those who are at risk for cognitive decline and dementia.1

For at least 4,000 years, chocolate has been a symbol of luxury, wealth and power.2 Of all the treats available, chocolate remains one of the most popular in the world. However, while dark chocolate has known health benefits, the same cannot be said for milk chocolate.

Flavanols Raise Brain Oxygenation and Cognitive Performance

In 2017, a meta-analysis was published in Frontiers in Nutrition evaluating the association between cocoa flavonoids and cognitive performance.3 Cocoa and cocoa products are a substantial source of flavanols. Scientists suggest cocoa can help counteract cognitive decline, especially in people at risk.

They speculated that the administration of cocoa flavanols may improve cognitive function and protect performance that occurs during sleep loss in healthy people. A study published in Scientific Reports delved further into this hypothesis.4

Using a randomized double-blind study design with young healthy adults, the researchers showed that cocoa flavanols increased the speed and capacity of brain oxygenation in response to the administration of carbon dioxide.

The participants also exhibited 11% faster performance than baseline when the demand was high.5 ZME Science spoke with Catarina Rendeiro from the University of Birmingham, who led the study. She described what the researchers were looking for, saying:6

“I have been for the last 10-12 years interested in the health benefits of plant-derived flavonoids, particularly their effects on brain and cognitive function. We have known for many years that flavanols from cocoa (in particular) can improve vascular function in humans by improving vessel/arterial function.

These benefits are apparent even after one single dose. However, the extent to which some of these benefits could translate into the brain vasculature was less clear.”

The researchers engaged 18 healthy people whom they tested in two trials. During the first, the participants consumed cocoa rich in flavanols and in the second processed cocoa with low levels of flavanols. Neither the participants nor the researchers were aware of which type had been consumed during the trials.

Two hours later the participants breathed 5% carbon dioxide (CO2) to increase blood flow to the brain. Normally, the air you breathe is composed of 0.04% CO2.7 CO2 causes vasodilation and vascular changes in the brain, including raising blood flow.8 The air delivered to the participants was just over 100 times greater than the normal concentration of CO2 in the air.

The researchers then measured the increased blood flow and oxygenation to the brain using customized helmets. They found the participants who ate high flavanol cocoa showed three times more oxygenated hemoglobin than those who ate the low flavanol cocoa.

Interestingly, the researchers also found a few participants did not show any benefits from flavanols and had the healthiest oxygenation responses. While speaking to ZME Science, Rendeiro said:9

“It is currently unclear why these subjects had higher responses but it might be related to higher levels of fitness, but we did not measure this in the study.

Consuming foods rich in flavanols, such as grapes, green tea, apples, berries can provide levels of flavanols that are beneficial for brain function. The fact that we can see benefits even in a perfectly healthy brain it is good news for all of us. There shouldn’t be any downsides from consuming flavanols from fresh fruits and vegetables …”

Chocolate Improves Taste of Natural Triterpenes

In a second study of cocoa, researchers used 70% cocoa chocolate as a delivery mechanism for ursolic acid and oleanolic acid.10 These are triterpenoid compounds with known pharmacological effects, including liver protection after chemically-induced injury in laboratory animals11 and antimicrobial activity in the fight against human pathogens.12

Oleanolic acid is sold in China for liver disorders and both are recognized as having anti-inflammatory and antihyperlipidemic properties when tested in lab animals.13 Researchers have found the health benefits of ursolic acid may include "anti-inflammatory, antioxidant, antiapoptotic, and anticarcinogenic effects."14

An animal study found ursolic acid increased calorie burn, skeletal muscle and brown fat development associated with weight loss, and increased strength. It also improved glucose tolerance.15

The objective of the study was to evaluate the effect of consuming 70% chocolate infused with ursolic and oleanolic acids that had been isolated from the Mansoa hirsuta DC plant.16 Initially, the researchers sought a combination with microbiological and sensory properties that were well accepted. There were 100 volunteers who participated in the “acceptance analysis.”

To evaluate the health effect, the researchers engaged 45 volunteers who were divided into a test group, a control group and a placebo group. The test group received a chocolate formulation containing the triterpenes; the placebo group received chocolate without the triterpenes; and the control group was instructed not to eat any chocolate of any kind during the course of the study.

The test group received 25 grams (g) of 70% cocoa chocolate with the added triterpenes over a four-week period. All were asked to maintain their regular activities and diet. Before and after the intervention the participants had their weight, height and waist circumference measured. Lipid profile and fasting blood sugar tests were also done.

In the control group in which no one consumed chocolate, there were no significant changes in the anthropometric measurements or lab tests. In the test group, after eating the chocolate with the ursolic and oleanolic acids, 50% lost approximately 2 kilograms (kg) (4.4 pounds) and 73.3% had reduced waist circumference. In the placebo group, which ate the regular chocolate, 86.6% gained weight.

In Moderation, Dark Chocolate Has Health Benefits

As demonstrated by the research discussed above, dark chocolate in moderation may have health benefits, but too much can raise your risk of weight gain and subsequent insulin resistance. Cocoa beans are rich in fat (54%), fiber (16%), protein (11%) and carbohydrates (31%).17

The largest source of bioactive compounds comes from flavonoids, which can improve central and peripheral vascular function. When consumed in moderation, flavanol-rich dark chocolate may improve insulin sensitivity by reducing your body's oxidative stress and improving endothelial function. This indicates that dark chocolate rich in flavanols may be a beneficial addition to your diet.

However, while dark chocolate has health benefits, milk chocolate does not. Unfortunately, the vast majority of chocolate sold and eaten is in the form of milk chocolate candy, which is loaded with sugar and has minute amounts of healthy cocoa. Additionally, one study found that the added milk proteins can reduce the bioavailability of epicatechin, a flavonoid important to antioxidant activity, in chocolate candies.18

In addition to the flavonoids, researchers have also found theobromine and other methylxanthines in dark chocolate that may affect health.19 For instance, theobromine improved memory in an animal study. But, as with most foods found in nature, the likelihood is the health effects come from the combination of polyphenols found in the food and not from a single ingredient.

There is some evidence that hearing loss may be inversely associated with chocolate consumption, yet it has no effect on tinnitus.20 Another review of the literature analyzed 13 clinical trials and found athletes experienced a reduction in oxidative stress linked to cocoa ingestion, but no clear conclusion could be drawn on the impact it had on exercise performance or recovery.21

A 2013 paper in The Netherlands Journal of Medicine also reviewed the health benefits of cacao, noting that some consider it a "complete food," as it contains:22

  • Healthy fats
  • Antioxidants
  • Nitrogenous compounds, including proteins, methylxanthines theobromine and caffeine
  • Minerals, including potassium, phosphorus, copper, iron, zinc and magnesium
  • Valeric acid, which acts as a stress reducer despite the presence of stimulants

Bitter Chocolate May Help Improve Your Mood

Human trial data from Loma Linda University, presented at the Experimental Biology 2018 annual meeting in San Diego, revealed chocolate helps improve stress levels, inflammation, mood, memory and immune function. The caveat? It must contain at least 70% cacao and be sweetened with organic cane sugar. According to the scientists:23

"While it is well-known that cacao is a major source of flavonoids, this is the first time the effect has been studied in human subjects to determine how it can support cognitive, endocrine and cardiovascular health … These studies show us that the higher the concentration of cacao, the more positive the impact on cognition, memory, mood, immunity and other beneficial effects."

A number of other studies have confirmed cacao can benefit your heart, blood vessels, brain and nervous system, and helps combat diabetes and other conditions rooted in inflammation.

As noted in a paper published in the journal Oxidative Medicine and Cellular Longevity,24 "Cocoa contains about 380 known chemicals, 10 of which are psychoactive compounds” and it “has more phenolics and higher antioxidant capacity than green tea, black tea, or red wine …”

“The antioxidant properties of cocoa or cocoa-derived products enriched in flavonoids may help protect against diseases in which oxidative stress is implicated as a causal or contributing factor.

The phenolics from cocoa may thus protect against diseases in which oxidative stress is implicated as a causal or contributing factor, such as cancer. They also have antiproliferative, antimutagenic, and chemoprotective effects, in addition to their anticariogenic effects.”

Another compound found in cacao is phenylethylamine, which has been shown to boost mood in a way similar to that of tryptophan, which your body converts to serotonin. Cocoa also contains chemical compounds shown to boost mood. One study found the polyphenols in a dark chocolate drink mix helped reduce anxiety and induce a sense of calm when consumed daily for one month.25

There were 72 participants who completed the trial, in which they drank a chocolate drink standardized to 500 milligrams (mg), 250 mg or zero mg of polyphenols. The researchers found those taking the high-dose polyphenol chocolate drink increased their self-assessed calmness and contentedness in relation to those drinking the placebo chocolate drink.

When colorectal cell lines were incubated with cocoa extract for 24 hours in the lab, the researchers found the chocolate had an impact on genetic up and down regulation.26 They believe the results suggest "valuable clues for future clinical studies of cocoa health benefits are highlighted as [an] anticancer agent in this study once validation studies are carried out."

Cacao to Chocolate — Raw Dark Chocolate Is What You Want

The results of these studies demonstrate the importance of consuming dark chocolate rich in flavanols to experience the health benefits. As I show in this short video above, you can create your own delectable and healthy chocolate treat at home that satisfies your sweet tooth.

Although some people use the terms interchangeably, there is a difference between cocoa and cacao. Many of the studies discussed used a cocoa-based product, but it’s helpful to understand the differences. Cacao is the term used for the evergreen plant and the dried seeds, which ultimately become chocolate. Raw cacao nibs have the highest levels of polyphenols.

Ideally, you’ll want to buy them whole and grind them at home. You can use a coffee grinder for this. You can also nibble on them like you would chocolate chips. A healthy amount would be around one-half to 1 ounce per day. I personally grind 1 tablespoon of raw cacao nibs twice a day and put them into my smoothies.

Cacao becomes cocoa when the beans are roasted and ground into a powder from which most of the fat is removed. Cocoa butter, which you can purchase from health food stores and some grocers, is the yellow fat that’s extracted from the beans.

The cacao beans go through 14 steps in processing before resulting in the chocolate that is ready for distribution to your local store. If the chocolate is processed from cacao seeds that are not roasted, then you’re buying “raw chocolate.”

When you are selecting your chocolate, the evidence shows health benefits are greatest in products with a higher percentage of cacao and lower percentage of sugar. Since cacao has a bitter taste, you’ll also find the higher percentage chocolates are more bitter.

It’s the polyphenols that make the chocolate bitter, so some manufacturers remove them, but it’s also the polyphenols that are responsible for many of the health benefits. That’s why, for health benefits, it’s best to choose 70% or higher cacao chocolate.

On the other hand, “white chocolate” contains only the butter extracted from the beans and none of the cocoa, which is the ingredient chocolate gets its name from. Instead, white chocolate is a health-zapping mix of pasteurized milk, vanilla flavoring and processed sugar.



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While lockdowns were supposed to be temporary — initially just a couple of weeks to “flatten the curve” — nine months into the COVID-19 pandemic, there’s still no end in sight. Thanksgiving was canceled in many parts of the U.S., and many government leaders are now urging residents to cancel their Christmas celebrations too.

What many still don’t realize is that the global response to the COVID-19 pandemic has little to do with the spread of an actual virus, and everything to do with the planned global takeover and implementation of a technocratic agenda known as the Great Reset.

Universal mask mandates, social distancing, business shutdowns, online shopping, working and learning, CRP testing and quarantining of asymptomatic individuals are all forms of “soft indoctrination” to get us used to an entirely new, and unfathomably inhumane, way of life devoid of our usual rights and freedoms.

The Other Klaus

Klaus Schwab is the founder and executive chairman of the World Economic Forum. Schwab announced the World Economic Forum’s Great Reset Initiative in June 2020, which includes stripping people of their privately owned assets.

In addition to being a poster boy for technocracy, Schwab also has a strong transhumanist bend, and wrote the book on the Fourth Industrial Revolution, a hallmark of which is the merger of man and machine, biology and digital technology.1

According to Winter Oak — a British nonprofit social justice organization — Schwab and his globalist accomplices are using the COVID-19 pandemic “to bypass democratic accountability, to override opposition, to accelerate their agenda and to impose it on the rest of humankind against our will.”

Indeed, Schwab’s book,2,3 “COVID-19: The Great Reset” urges industry leaders and decision makers to “make good use of the pandemic” and “not letting the crisis go to waste.”

Greatest Wealth Transfer in History Is Underway

While the Great Reset plan is being sold as a way to make life fair and equitable for all, the required sacrifices do not apply to the technocrats running the system.

On the contrary, as noted by Patrick Wood in his recent interview with James Delingpole, featured in “Technocracy and the Great Reset,” the wealth distribution and circular economies promoted by the technocratic elite will never benefit the people, because what they’re really referring to is the redistribution of wealth from the people, to themselves.

Evidence of this can be seen in the decision to allow big box stores to remain open during the pandemic while forcing small businesses to close, no matter how small the infection risk.

There’s really no rhyme or reason for such a decision, other than to shift wealth away from small, private business owners to multinational corporations. Walmart and Target, for example, report record sales this year4 while more than half of all small business owners fear their businesses won’t survive.5

Yelp’s September 2020 economic impact report showed that, as of August 31, 2020, 163,735 U.S. businesses had closed and 60% of them are permanent closures.6 Similarly, while working-class Americans filed for unemployment by the tens of millions, the five richest men in the U.S. — Jeff Bezos, Bill Gates, Mark Zuckerberg, Warren Buffett and Larry Ellison — grew their wealth by a total of $101.7 billion (26%), between March 18 and June 17, 2020, alone.7

Since the beginning of the pandemic, the collective wealth of 651 billionaires in the U.S. rose by more than $1 trillion (36%).8 To put their current wealth in perspective, the assets of these 651 billionaires is nearly double that of the combined wealth of the least wealthy 165 million Americans. As noted by Frank Clemente, executive director of Americans for Tax Fairness, “Never before has America seen such an accumulation of wealth in so few hands.”9

That’s technocratic wealth redistribution for you. Ultimately, the Great Reset will result in two tiers or people: the technocratic elite, who have all the power and rule over all assets, and the rest of humanity, who have no power, no assets and no voice.

That the COVID-19 pandemic is a form of class war is also evident in the way rules are enforced. While citizens are threatened with fines and arrest if they don’t do as they’re told, those who lay down the rules repeatedly break them without repercussions.

The PCR Test Hoax

The reason technocratic world leaders and their loyal minions are now calling for the cancellation of Christmas is — as illustrated in our Christmas parody above — because of PCR testing. The number of positive tests are reportedly on the rise, which is said to be proof that the infection is spreading out of control.

However, evidence shows there’s no relationship between positive tests and deaths, and the reason for this is because the false positive rate for the PCR test is extraordinarily high. We’re simply quarantining and preventing healthy people who pose no risk to anyone from living their lives.

A September 28, 2020, study10 in Clinical Infectious Diseases revealed that when you run a PCR test at a cycle threshold (CT, i.e., the amplification rate) of 35 cycles or higher, the accuracy drops to 3%, resulting in a 97% false positive rate.

According to an April 2020 study11 in the European Journal of Clinical Microbiology & Infectious Diseases, to get 100% confirmed real positives, the PCR test must be run at no more than 17 amplification cycles.

Meanwhile, the U.S. Food and Drug Administration and the U.S. Centers for Disease Control and Prevention recommend running PCR tests at a CT of 40,12 and Drosten tests and tests recommended by the World Health Organization are set to a CT of 45.

By using CTs known to result in false positives, you end up with the appearance of widespread infection, which is then used to keep the pandemic measures going. In reality, COVID-19 has not resulted in excess deaths13,14,15 and were it not for the fact that it’s being used as a cover for the Great Reset, life would have returned to normal months ago.

According to Dr. Roger Hodkinson, one of Canada’s top pathologists and an expert in virology, the COVID-19 pandemic is the “greatest hoax ever perpetrated on an unsuspecting public.”16 Hodkinson is the CEO of Western Medical Assessments, a biotech company that manufactures COVID-19 PCR tests.

Michael Yeadon, Ph.D., a former vice-president and chief scientific adviser of the drug company Pfizer and founder/CEO of the biotech company Ziarco, is also speaking out about how fraudulent PCR testing is being used to manufacture the appearance of a pandemic that doesn’t really exist, as are Dr. Lee Merritt, members of the German Corona Extra-Parliamentary Inquiry Committee17,18 and many others.

What Vaccines Have to Do With It

If you need more evidence that we’re in the middle of a technocratic takeover, look no further than the mass vaccination agenda and the promotion of fake, lab-grown meat. Bill Gates, another frontline technocrat, has repeatedly stated that we have no choice but to vaccinate everyone against COVID-19.

Naturally, he’s heavily invested in said vaccine and stands to gain handsomely from a global mass vaccination campaign. Technocrats are nothing if not self-serving, all while pretending to be do-gooders — much like COVID Claus in our little video.

But the vaccine program isn’t just about selling vaccines. It’s also a way to implement a global biological surveillance network (which is also why 5G is being rolled out across the globe).

The Bill & Melinda Gates Foundation has funded and promoted a new delivery method for the COVID-19 vaccine that uses a microneedle array rather than conventional injection.19 The microneedles are equipped with fluorescent quantum dot tags. The resulting invisible mark can then be read by a smartphone equipped with a special sensor. This mark will also allow government to track you.

Eventually, your personal identification, medical records, finances and who knows what else, will all be tied together and embedded somewhere on or in your body. Every possible aspect of your biology and life activities will be trackable 24/7. You will also be digitally tied into the internet of things, which eventually will include smart cities.

All the different parts of this giant population control grid fit together like pieces of a jigsaw puzzle. The global vaccination agenda ties into the biometric identity agenda, which ties into the cashless society agenda, which ties into the social credit system agenda, which ties into the social engineering agenda and so on.

When you follow this experiment to its ultimate conclusion, you find all of humanity enslaved within a digitized prison with no way out. Those who rebel will simply have their digital-everything restricted or shut down.

Fake Meat Is Part of the Reset Too

The rise of fake, lab-grown meat is a puzzle piece of the Great Reset agenda too. According to the World Economic Forum, lab-grown, cultured meat is a more sustainable alternative to conventional livestock, and in the future, we’ll all be eating a lot less meat. As noted on its website:20

“As the world looks to reset its economy, along with food systems, in a cleaner way post-pandemic, one more sustainable solution coming to fruition is cultured meat … Cultured meat takes much less time to grow, uses fewer of the planet’s resources, and no animals are slaughtered.”

But don’t think for a second that this has anything to do with environmental protection. No, it’s about controlling the food supply and preventing food independence. 

Already, multinational corporations have taken over a majority of the global food supply with their patented genetically engineered seeds. Patented cultured meats and seafood will allow private companies to control the food supply in its entirety, and by controlling the food supply, they will control countries and entire populations.

Public health will undoubtedly suffer from this dietary switch, as canola and safflower oil are primary sources of fat in these fake meat concoctions. Vegetable oils are loaded with linoleic acid (LA), an omega-6 fat that, in excess, acts as a metabolic poison, causing severe mitochondrial dysfunction, insulin resistance, decreased NAD+ levels, obesity and a radical decrease in your ability to generate cellular energy.

Our LA consumption 150 years ago was between 2 and 3 grams per day. Today it is 10 to 20 times higher. If fake meat becomes a staple, the average LA intake is bound to increase even further.

Make a Christmas Vow to Undo the Great Reset

The Great Reset is well underway, but it’s not yet too late to stop it. Enough people have to see it and understand it, though. And then they must act. If we want to prevent the Great Reset from destroying life as we know it, we must view civil disobedience as a duty. We must resist it from every angle.

We must reclaim our sovereignty, our right to live free, to open our businesses and move about freely. We must communicate with our elected leaders and demand they not infringe on our constitutional rights. We have to engage in political processes and help educate our local sheriffs of their role as defenders of the constitution. We may also need to support legal challenges.

A small step in the right direction that you can take right now would be to celebrate Christmas like you normally would this week, and not allow the Klaus Schwabs and Bill Gateses of the world rob you of valuable time with family and friends.

There are no guarantees in this life, and for many, this will be their last Christmas. So, spend it well. Cherish life by actually living it and spending it with those you love. Refusing to give up our humanity is how we resist the Great Reset.



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1 If you are injured by a pandemic vaccine, such as the COVID-19 vaccine, your only recourse is to:

  • File an injury claim with the National Vaccine Injury Compensation Program (NVICP) within four years from the date of the first manifestation of symptoms
  • Sue the vaccine manufacturer for damages
  • Sue the doctor and/or health care facility that administered the vaccine for damages, but not the manufacturer or distributors
  • File an injury claim with the Countermeasures Injury Compensation Program (CICP), run by the Department of Health and Human Services, within one year of vaccination

    If you are injured by a pandemic vaccine, you cannot sue any of the parties involved in getting the vaccine to you. Within one year of vaccination, you would have to file a claim with the Countermeasures Injury Compensation Program (CICP), run by the DHHS. The maximum payout is $250,000 per person; however, you'd have to exhaust your private insurance policy first. CICP will only pay the difference between what your insurance covers and the total CICP payout amount established for your case. Learn more.

2 Which of the following vaccine makers are using a fetal cell line in the production of their COVID-19 vaccines?

  • AstraZeneca and Jansen Research and Development/Johnson & Johnson

    Vaccine makers using a fetal cell line in the development of their COVID-19 vaccines include AstraZeneca, which is using the HEK293 cell line, and Jansen Research and Development (owned by Johnson & Johnson), which is using the PER.C6 cell line. Learn more.

  • Moderna and Merck
  • Novavax and Sanofi Pasteur
  • Pfizer and GlaxoSmithKline

3 Who is the president of the EcoHealth Alliance, who is now also leading The Lancet's COVID-19 Commission charged with getting to the bottom of SARS-CoV-2's origin?

  • Andrew Cuomo
  • Peter Daszak

    Peter Daszak is heading The Lancet's COVID-19 Commission. He is also the president of the EcoHealth Alliance, an organization that has received many millions in funding for coronavirus research that was then contracted to the Wuhan Institute of Virology. Emails now prove Daszak was behind the plot to obscure the lab origin of SARS-CoV-2 by issuing a scientific statement condemning such inquiries as "conspiracy theory." Learn more.

  • Rita Colwell
  • William Karesh

4 The so-called "Great Reset" will benefit:

  • Everyone
  • Primarily the poor
  • Wealthy, unelected powerbrokers

    As reckless government overreach has destroyed many small businesses and engineered catastrophic unemployment around the world, world leaders are joining the World Economic Forum in calling for a Great Reset of the global economy that will benefit wealthy powerbrokers while enslaving and impoverishing everyone else. Learn more.

  • The middle-class

5 What can the SARS-CoV-2 PCR test tell you?

  • Whether you have an active SARS-CoV-2 infection
  • How serious your infection is
  • Whether you're infectious or not
  • Whether you have viral RNA in your body, but not whether it's from live virus or inactive/noninfectious RNA

    PCR tests cannot distinguish between "live" viruses and inactive (noninfectious) viral particles and therefore cannot be used as a diagnostic tool. They also cannot confirm that 2019-nCoV is the causative agent for clinical symptoms as the test cannot rule out diseases caused by other bacterial or viral pathogens. Learn more.

6 Which of the following most aptly describes the OPPOSITE of technocracy?

  • Freedom

    The goal of all technocratic agendas is to capture all the world's resources for a small global elite so that they can dictate the lives of everyone. It's the ultimate form of totalitarianism: total enslavement of mind and body, the opposite of which is freedom. Learn more.

  • Totalitarianism
  • Wealth redistribution
  • Enslavement

7 Which of the following conditions is closely related to Alzheimer's disease and is often predictive of a future Alzheimer's diagnosis?

  • Cataracts
  • Glaucoma

    Glaucoma and Alzheimer's disease frequently follow each other. Glaucoma can be viewed as "Alzheimer's disease of the eye," and Alzheimer's as "glaucoma of the brain." Learn more.

  • Lyme disease
  • COVID-19


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Through utilization of genetically modified high-risk atherosclerotic mice, researchers have identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease.

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In urban environments, allergic diseases are more common among dogs and their owners compared to those living in rural areas. Simultaneous allergic traits appear to be associated with the microbes found in the environment, but microbes relevant to health differ between dogs and humans.

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Dr. Mercola Interviews the Experts

This article is part of a weekly series in which Dr. Mercola interviews various experts on a variety of health issues. To see more expert interviews, click here.

The Immunity Fix: Strengthen Your Immune System, Fight Off Infections, Reverse Chronic Disease and Live a Healthier Life” is a new book written by James DiNicolantonio, Pharm.D., with whom I co-wrote “Super Fuel,” and Siim Land, an esteemed biohacker and author of “Metabolic Autophagy.”

In it, they review how to improve and regulate your immunity — a topic that should be high on anybody’s list these days. The catalyst for this collaboration was a number of academic papers written by DiNicolantonio on the underlying reasons for why some people suffer worse COVID-19 outcomes.

Many who end up with severe illness produce low amounts of Type 1 interferon. There's also a reduction in their adaptive immune system. As a result, they don't clear the virus quickly and end up having to rely on a more proinflammatory killing of the virus inside their cells instead.

Immune System Basics

As a refresher, your immune system consists of two primary “arms”:

  • The innate immune system, which is your first line defense made up of natural killer (NK) cells, macrophages and white blood cells like neutrophils
  • The adaptive immune system — T cells, and B cells that produce antibodies

As explained by DiNicolantonio:

“We used to think that the adaptive immune system was this system that takes a while to kick in, and once you have immunity from your adaptive immune system, then you have a longer-term protection, which is true. However, the adaptive immune system also seems to have cross sensitivity, meaning if you've been exposed to previous coronaviruses, your T cells seem to have some cross sensitivity to SARS-COV-2.

So, essentially, what we see is a reduction in T cells, in the cytotoxicity of these CD8 T-killer cells, which kill viruses in a nice, apoptotic, controlled way.

When you have a reduction in those types of immune cells, you have to rely more on your proinflammatory innate immune system for clearing viruses — things like neutrophils, white blood cells, macrophages. They kill in a much more pro-inflammatory, non-specific way, and they end up killing healthy bystander cells.

What we think is going on is, essentially, you have this reduction in Type 1 interferons … which interfere with the virus. And at the same token, you have a reduction in B cells and T cells. So, what ends up happening is you don't clear the virus as quickly, and you end up having this proinflammatory killing.

Siim and I collaborated because these things are complex. We need to get this in layman's terms. What our book boils down to is that your diet and your lifestyle control those types of things, and there's things that you can do to support your own immune system.”

Your T cell function tends to decline with age. It’s also reduced in those with chronic disease. Reduced T cell function appears to be a primary cause of severe COVID-19, seeing how those with the worst COVID-19 outcomes are the elderly and/or those with comorbidities such as diabetes, hypertension, metabolic syndrome and cardiovascular disease.

These factors worsen the proinflammatory response that you get from SARS-CoV-2, but they also weaken your immunity in general. “The Immunity Fix” reviews lifestyle strategies that help you sidestep and prevent this proinflammatory response. “It's a very holistic approach to looking at the immune system,” Land notes.

Top Two Nutrient Deficiencies to Address

Diet and nutritional supplementation are two key strategies that can help boost your immune function. According to Land and DiNicolantonio, vitamin D may be the most important nutrient in this respect.

Vitamin D activates more than 2,000 genes, DiNicolantonio notes, including vitamin K-dependent proteins and repair genes. It also helps your body produce powerful antimicrobial and antiviral peptides.

Those over the age of 60 have a ninefold greater risk of dying from COVID-19 than that of younger individuals. If you’re severely vitamin D deficient, your risk can be 15fold greater. So, while you cannot change your age, you can certainly alter your vitamin D status, thereby potentially minimizing your risk.

However, in order to convert the vitamin D into its active form, you need magnesium, so magnesium would probably be the second-most important nutrient deficiency to address. Magnesium is also required for immune cell function, so if your magnesium level is low, your immune function could be impaired. 

“People who have genetically low magnesium in their natural killer (NK) cells and their CD8 T-killer cells … their immune system is down. They have chronic activation of Epstein-Barr, which 95% of us are infected with, and they're at a much higher risk of lymphoma,” DiNicolantonio says.

“And that's just one nutrient. Being deficient in one nutrient can potentially cause this immunodeficiency essentially. So, in the book, we go through how nutrients and your immune system interact and why nutrient deficiencies are probably leading to a lot of these poor COVID-19 outcomes.”

Zinc and Selenium Are Also Important

In terms of importance, zinc would probably nab the third spot. Taking zinc lozenges at the first onset of cold symptoms has been shown to cut the duration of the common cold by six to seven days, but you have to take it correctly.

“If you're using lozenges, you have to take it every two hours,” DiNicolantonio explains. “You got to take it within 24 hours of symptom onset. You have to take about 18 milligrams per dose, and you have to get the total daily dose over 75 milligrams.”

Fourth on the list would be selenium. Not only is selenium deficiency associated with a fivefold higher risk of dying from COVID-19 and a threefold higher risk of having a poor COVID-19 outcome, but it is also associated with coxsackievirus-induced cardiomyopathy (Keshan disease).

So, if you're deficient in selenium, a nonvirulent RNA virus called coxsackievirus, which typically only causes hand, foot and mouth syndrome in certain children, can become much more virulent, leading to virally induced cardiomyopathy. Patients with this cardiomyopathy, known as Keshan disease, are typically given selenium. Selenium is also important for the production of glutathione, which appears to play a significant role in COVID-19.

The Importance of Melatonin

Another thing that is associated with improved COVID-19 outcomes is melatonin. DiNicolantonio explains:

“Melatonin is interesting. I kind of view it like molecular hydrogen but with some additional advantages. Melatonin can freely pass into any cell membrane, so that's very key. If you want to get to the oxidative stress, you have to be able to access it and get into the mitochondria. Melatonin and molecular hydrogen are two molecules that can do that and really do that well …

Melatonin is not just this hormone we secrete in the brain. We synthesize it from serotonin, and it can be produced in many cells. So, it's active throughout the entire day. What's interesting is that it's one of the only molecules that seems to increase the transcription of Nrf2.

Most plant polyphenols and all these other Nrf2 boosters only inhibit the inhibitor of Nrf2, which is KEAP1. Essentially, they're making the current Nrf2 levels more active. When you add melatonin, that increases the transcription of Nrf2. Very few molecules can actually do that.

And Nrf2 is how we boost our endogenous antioxidant enzymes. Really, that's the key. If you have acute respiratory distress, you want to boost your overall endogenous antioxidant systems, and the best way to do tha is through Nrf2 activators, particularly melatonin.”

High-Dose Melatonin Reduces COVID-19 Mortality

As for dosage, a recent case series involving 10 patients with COVID-19-related pneumonia used 36 to 72 mg of oral melatonin per day in four divided doses, which is far higher than recommended for sleep. DiNicolantonio comments:

“It's so safe. Doses of melatonin up to 1,000 mg per day in humans have shown virtually no side effects besides grogginess and sleepiness … Melatonin use is associated with an 83% reduction in mortality from COVID-19, a 30 to 50% reduction in testing positive for SARS-COV-2, and in a case series of 10 COVID pneumonia patients, it cut the duration of hospital stay by five days.

And none of those patients who got melatonin ended up on a mechanical ventilator or died whereas in similar severe COVID-19 cases that were hospitalized at the same time, 25% to 40% of those individuals ended up on mechanical ventilators or died.”

As explained by DiNicolantonio, melatonin is actively produced throughout the day and is a master antioxidant, meaning it scavenges free radicals. It also binds to melatonin receptors that upregulate your innate antioxidant defense systems.

“Melatonin actually seems to concentrate in the bone marrow and that's important because your immune system comes from stem cells produced from your bone marrow,” DiNicolantonio explains.

“From those stem cells, you get your immune cells. Some of your immune cells can even produce melatonin. We think it's being concentrated in the bone marrow to protect immature stem cells and immune cells from oxidative damage, which actually makes a lot of sense.”

Nebulized Hydrogen Peroxide

While Land and DiNicolantonio hypothesized that inhaled molecular hydrogen at 2% or 3% would be a potential important strategy in COVID-19 patients requiring ventilation in a hospital, this can be significantly expensive. A better alternative, in my opinion, would be nebulized hydrogen peroxide, which you can do at home. This is my personal go-to strategy, and I’ve seen many recover from COVID-19 using this strategy. You can review my video below for more detailed in formation.

Nebulizing hydrogen peroxide into your sinuses, throat and lungs is a simple, straightforward way to augment your body’s natural expression of hydrogen peroxide to combat infections and can be used to support the immune system.

All you need is a desktop nebulizer, food-grade hydrogen peroxide and some saline. That way, you have everything you need and can begin treatment at home at the first signs of a respiratory infection. Keep in mind food grade hydrogen peroxide must be diluted down to a 0.1% dilution before use.

hydrogen peroxide dilution chart

I believe the hydrogen peroxide works like a signaling molecule, and may even have some direct viricidal effect on the cells in the lining of the lungs and the sinuses where the virus takes hold initially. So, you're potentially killing it directly, plus supporting your immune responses.

Address Your Metabolic Health

In addition to addressing nutrient deficiencies, in particular vitamin D, magnesium, zinc and selenium, Land stresses the importance of optimizing your metabolic health.

“Research [has found] that metabolic syndrome, obesity and diabetes, all those things, worsen the outcomes of COVID-19 as well as other infections like influenza. Obesity also increases the duration that you can carry the virus and share it for longer. So, it's especially negative in a society that tends to be in poor metabolic health.

One interesting thing that we discovered during the writing of the book is that one of the molecules that gets activated during an infection is called HMGB1, which stands for High Mobility Box-1.

That gets activated during an infection, and it's one of the key molecules that kind of offsets the cytokine storm by activating NFKB and NLRP3 inflammasome and eventually causes this massive pro-inflammatory cytokine response …

What we theorized based on this research, is that hyperglycemia, insulin resistance, elevated blood sugar will make it more likely that HMGB1 is going to get into the cell and turn on NFKB and these other pro-inflammatory cytokines that will eventually lead to the cytokine storm.”

The Case for a Low Linoleic Acid Diet

DiNicolantonio and I discussed the importance of avoiding seed oils in our book, “Superfuel.” In it, we dove deep into the importance of healthy fats for metabolic health, and the destructive nature of linoleic acid-rich vegetable oils.

Linoleic acid (LA) is one of the most perishable molecules in food, meaning it’s highly susceptible to damage. When it oxidizes, it turns into oxidative metabolites called oxidative linoleic acid metabolites or oxylipids or OXLAMs that damage proteins, DNA and cell membranes and are likely the primary culprit of chronic disease.

OXLAMs also activate pathways that destroy your immune response. What we didn’t fully appreciate at the time was that even healthy oils, such as olive oil, can have a negative impact, thanks to their LA content. LA is also high in conventionally raised chicken, as these animals are typically fed LA-rich grains.

If you exceed 10 grams of LA per day, and perhaps as little as 5 grams — regardless of their source — you may radically worsen your metabolic health. From a historical perspective, 150 years ago, the average consumption of LA was 2 to 3 grams. Today, many get more than 30 grams a day from their diet. In my view, an LA-restricted diet may be the single most important dietary intervention available. DiNicolantonio adds:

“That's a great point, and I think from a COVID-19 perspective, the biggest thing you want to do is increase the resilience of your cells to oxidative stress. Unfortunately, if you're consuming a diet high in LA, and if it doesn't get burned for fuel and it gets stored in tissues, the half-life of LA is 680 days, and it can start oxidizing the cellular membranes, including on your immune cells as well.

If you increase your omega-6 intake, that affects the levels in your immune cells. And if you saturate your immune cells with this oxidized LA, you're probably at a much higher risk of secreting more proinflammatory cytokines in your own cells, and your lungs and your arteries are probably much more susceptible to the damage that occurs when our body tries to kill off viruses.

I'm sure if we were to actually look at the blood levels of oxidized LA in severe COVID-19 patients, they would be sky high … So yeah, it's likely a huge driver of overall inflammation.”

Simple Strategies to Improve Your NAD+ Level

Another important molecule is nicotinamide adenine dinucleotide (NAD+), which can be increased using precursors such as nicotinamide mononucleotide (NMN) and/or nicotinamide riboside (NR).

NMN appears to be the superior of the two, as it activates a salvage pathway. However, you don’t need to take an expensive supplement to improve your NAD+ level. Strategies such as exercise, hot or cold exposure and time-restricted eating — which costs you nothing — can get the job done. Land explains:

“A lot of the NAD that your body produces is recycled through the salvage pathway. Very little (less than 1%) of it is going to come from food, especially tryptophan or niacin.

The easiest way to prevent losing your NAD as you get older or as you get immunocompromised is to promote the salvage pathway, and one of the activators of this NAMPT enzyme that governs the salvage pathway is AMP protein kinase (AMPK), and AMPK gets primarily turned on by catabolic stressors in the body, such as exercise, sauna, cold, as well as fasting.

What I've concluded is that doing this regular intermittent fasting or timed eating is a very efficient way of keeping our energy levels high and preventing the lowering of the other things that lower NAD, like inflammation and oxidative stress.

The problem is that NAMPT is controlled by sirtuins and sirt1 especially. Sirtuins are longevity genes. Sirtuins also control your circadian rhythms. So, what I think is that if your circadian rhythms are misaligned, if you’re doing shift work or you're jet lagged or something, then sirtuins are not going to be expressed, and you will also then inhibit NAMPT, which will then shut down the NAD salvage pathway.”

In other words, when sirtuins are suppressed from mismatched circadian rhythms, you also suppress NAMPT, as the NAMPT requires sirtuins to work. Sirtuins also consume NAD, so if your NAD level is low, you’re not going to get the benefits sirtuins provide.

“I think the supplemental NR and NMN are very useful if you're in an NAD-deficient state because the problem is that if you're already low in NAD, then it's hard to raise that bar because you're already so low and depleted,” Land says.

“If your NAD is high, then you experience the less negative side effects from inflammation oxidative stress because your body can repair and deal with it, whereas if you're immunocompromised, you're very old or you are just nutrient deficient and have low NAD, then it's a vicious feedback loop. So, using something like a NAD precursor or a booster can be a quick fix to get yourself back on the right track.”

If you use an NAD or NMN supplement, consider getting it in suppository form. Other alternatives include subcutaneous or intranasal administration, all of which are more effective than oral supplements. That said, as noted by DiNicolantonio, if your NAD is low, your best bet is to address the underlying cause rather than simply adding supplements.

“Ultimately, any type of oxidative stress is going to deplete NAD. So, fix your metabolic dysfunction and improve your nutrient deficiencies first, and ultimately your NAD need is going to go down. Fix the things that are causing you to burn through your NAD.”

One of the most common sources of oxidative stress is electromagnetic field (EMF) exposure, which is the topic of my book “EMF*D.” Two primary enzymes consume NAD. One is poly ADP-ribose polymerases (PARP), which is also known as adenosine ribosyl transferase (ARTD). PARP is used to repair DNA damage, and every time PARP is activated, it uses up 150 molecules of NAD.

The good news is that strategies such as sauna, exercise and fasting not only will improve the production of NAD, but also will reduce the consumption of it. These strategies also lower inflammation, which in and of itself will lower your NAD consumption.

Other Benefits of Sauna Bathing

In addition to preserving your NAD, sauna bathing also mimics a fever, which is your body’s first-line defense against infections. DiNicolantonio explains:

“The reason why we induce a fever to fight an infection is because that allows our cells to secrete heat shock proteins. In order for a virus to replicate, it has to infect your cell, hijack your machinery, and it has to export its ribonucleoprotein complex out of the cell to replicate. In order for that complex to get exported, the M1 protein has to dock onto it.

Heat shock protein 70, which gets released during sauna sessions, can combine to the viral ribonucleoprotein complex preventing M1 protein from docking. [By] inhibiting the export of that viral ribonucleoprotein complex, [heat shock protein] essentially inhibits viral replication.”

According to Land, regular sauna bathing and exercise are among the best things you can do to strengthen your immune system and increase your body’s resilience. The two are also complementary.

Exercise causes preconditioning hormesis, so if you exercise before your sauna, then you significantly bolster your body’s ability to handle infection and other stresses. The heat will also promote recovery from the exercise by boosting growth hormone, repairing damaged proteins and reducing inflammation.

More Information

This interview merely touches on a small number of highlights of the information found in “The Immunity Fix,” so to learn more, be sure to pick up a copy. To connect with DiNicolantonio and Land, see their websites, DrJamesDinic.com and SiimLand.com. Both can also be found on Twitter and Instagram by searching for DrJamesDinic (@drjamesdinic) and Siim Land.

The Immunity Fix


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Thomas Lewis, author of “The End of Alzheimer’s: The Brain and Beyond,” is a microbiologist with a Ph.D. from MIT. He’s done a lot of work on diagnostic testing, and in this interview, we explore how retinal assessment and other laboratory tests can be used to stratify your risk factors for chronic disease and COVID-19. Lewis recently published an excellent paper on this.

We first met almost two years ago at the Academy for Comprehensive Integrative Medicine in Orlando, Florida, where he gave a presentation on how assessment of the retina can be used as a diagnostic tool to evaluate your risk for a wide variety of diseases.

The Eye-Brain Connection

As just one example, glaucoma and Alzheimer’s disease are often linked together, with glaucoma occurring first, as they did in Lewis’ father’s case. His dad developed glaucoma several years before he developed Alzheimer's.

Lewis goes so far as to refer to glaucoma as “Alzheimer's disease of the eye,” and Alzheimer's as “glaucoma of the brain.” Similarly, cataracts are a manifestation of your innate immune response against acute and chronic infection. If you are, say, 50 years old and you have early nuclear cataracts, it's a bad sign, as it’s an indication of a chronic infection.

The infection is what’s causing this unfolded protein response to slowly matriculate in the lens of the eye. According to Lewis, “If you have an early cataract, that's a bad sign for longevity. Most people with cataracts die of some vascular event fairly young.”

Your Eye Is a Window Into Your Overall Health

Lewis explains the general theory for using the eye as a biomarker for systemic disease:

“When you look at disease, in the allopathic system, you're either healthy or you're sick. But we really lie on a continuum of health. I say we live on four different continuums, determinants of health, lifestyle, risks, things like that. For physiological health, we measure blood, stool and urine …

For pathology, which is largely ignored, we do ultrasounds, MRIs and CT scans that assess tissue changes. The eye happens to be particularly good at that because the eye is transparent, and the methodology used to measure the eye is low-cost and noninvasive but highly precise and accurate.

For example, optical coherence tomography (OCT) is much more precise at looking at micro vessels, capillaries, compared to MRI because the wavelength of light they use to create the interference is a much shorter wave length. In other words, it gives much more detail than an MRI.”

OCT is a type of tomography that uses safe, nonionizing light waves. At a cash price of about $50, it’s also an affordable diagnostic tool that can tell you a lot about what’s going on in your body.

I was intrigued with the test and found a local optometrist to perform it for me. I hadn’t had an eye exam for a few decades so thought it would be a good checkup. Well, I had no glaucoma, 20/20 vision, near and far without glasses, and my OCT was totally normal, like that of a young adult. It’s great to know that lifestyle changes work. Next month I will share an article on what they have done for my physical body.

Again, because the eye is transparent, OCT allows you to see all the micro vessels, and whatever is happening in this carotid tissue — the vasculature in your eye — is also happening in the rest of your body, as the carotid is the most vascular tissue in your entire body.

“Whereas the brain uses 10 times more oxygen than most tissue on a per mass basis, the retina, which is constantly converting photons to electrons, uses even more oxygen on a per mass basis. If you're vulnerable, the eye is potentially a canary for that vulnerability,” he explains.

“That's why we use this test. It's so simple to see if there are life risks that are translating into physiological risk and then changing into pathological risks. When you're changing into pathological risk, a bad ending is getting closer because you have tissue damage, basically.”

The COVID Connection

Many common lab tests can also tell you a lot about your health and the state of your immune system. When COVID-19 broke out, Chinese researchers reported patients had elevated ferritin and erythrocyte sedimentation (SED) rate, among other things. Lewis compared the COVID-19 lab panels with the work he’d been doing for the past 15 years, and found they matched up nicely.

“It's not about treating COVID-19, it's about measuring how full your vessel is towards these markers that create the cytokine storm, high inflammation, and kill you, and try to modulate that,” Lewis says.

"Why does the Z-Pak treat COVID-19? It doesn't. It treats bacterial infection, but we all have a subclinical bacterial infectious burden, and that burden is taking up immune system bandwidth, which makes you less able to fight something as virial as COVID-19. That's why Z-Pak works …

There's nothing really special about COVID-19 and our immune response, because our immune response is innate and adaptive. It's [about] being able to more accurately measure your immune compromised status. And almost everything we measure is reversible through very simple processes, supplementation, lifestyle activities, treating the infection, treating the pre-existing virus.”

Understanding Cytokines

One of the most lethal aspects of COVID-19 is the cytokine or bradykinin storm that can develop. A cytokine is a short-lived signaling protein that has regulatory properties on nearby cells. It could be beneficial or it could be detrimental. It could be proinflammatory, or it could be anti-inflammatory.

So, it's not so much that cytokines are bad — they're absolutely necessary and you'd be dead in a few heartbeats without them — but when they get out of control, they can kill you. That's what’s known as a cytokine storm, which I have discussed extensively in previous newsletters. It is one of the reasons why vitamin D works so well; it aborts most cytokine storms through its modulation of your immune response.

Risk Score Versus Diagnosis

What the retinal assessment and various lab assays can do is identify a brewing problem, which can then be addressed using strategies such as nutritional supplementation and lifestyle changes.

“For the average person, knowing where you are on that continuum would be extraordinarily valuable,” Lewis says, “and that's the testing we're doing and trying to promote more broadly.”

The key, however, is not to be within the “normal” reference ranges for disease markers, examples of which include fibrinogen, D-dimer, SED rate or C-reactive protein. What Lewis has done is determine the point at which there’s a statistical increase in early mortality. “That sets a completely different set of normal ranges for biomarkers, which is what we use. These ranges are much tighter compared to normal reference ranges, so you are amplifying the signal your body is projecting about your health. We're not diagnosing people, we're risk scoring people,” he explains.

Helpful Lab Tests

Screening tests that can help assess the state of your health and immune system include:

1-25 Dihydroxy vitamin D — This is the activated form of vitamin D. Vitamin D increases antimicrobial peptides (AMPs) and improves the activity of neutrophils (white blood cells that fight bacteria).

RBC magnesium — Magnesium is an important cofactor for the activation of vitamin D. Taking magnesium can actually reduce the amount of oral vitamin D you require to optimize your vitamin D level.

Neutrophil to lymphocyte ratio (NLR) — This marker alone determines prognosis in most solid tumor cancers. Neutrophils go up when there’s a bacterial infection, while lymphocytes are suppressed by viruses. As explained by Lewis, “The NLR is sort of an amplified barometer for your stealth infectious burden. The absolute count should be 1.5 or below.” Anything above 55% neutrophils is indicative of a chronic, likely bacterial, infection.

Red blood cell distribution width (RDW) — Red blood cells are born small and die large. If your RDW is wide, you likely have plaques and inflamed carotid arteries. Above 16 or 17, RDW could be a sign of anemia, but between 12.5 and 16, it’s a pure sign of inflammation.

C-reactive protein — A marker of inflammation. This should be 0.6 or below.

Fibrinogen — As a signaling molecule for tissue repair, fibrinogen is a good marker for how well your body is able to repair itself. If your fibrinogen is between 150 and 285, your repair and recovery is probably meeting or outpacing wear and tear, allowing you to properly heal and recover.

Above 285, you are probably deteriorating more rapidly than you're repairing. Fibrinogen is also a clotting factor marker, so in COVID-19 and sepsis, for example, high fibrinogen is indicative of a cytokine storm. Pre-cytokine storm levels are also indicative of several chronic diseases, including heart attack and cancer.

Ferritin — Ferritin is an iron transport protein that becomes elevated in COVID-19 and other serious illnesses. Iron catalyzes growth of bacterial pathogens. Typically, when your blood cells are under attack by a pathogen, your body responds by hiding the iron from the antigen (the infection) in the ferritin protein, thereby resulting in anemia (low iron) and high ferritin.

If you have elevated ferritin, the iron may not be available to the pathogen, but it is still available to the cells of your body.

Iron is a powerful oxidant stressor that will radically increase oxidized species, reactive oxygen species (ROS) and reactive nitrogen species, which activates the NRLP3 inflammasome and radically increases inflammatory mediators and cytokines. The solution for high ferritin is to donate blood. If your ferritin is above 100, consider giving blood periodically.

Fasting insulin — Insulin resistance is a foundational contributor to most chronic disease and significantly increases your risk of complications and death from SARS-CoV-2 infection. Fasting glucose is also a useful test that you can easily do at home.

Uric acid — Uric acid is a multifactorial inflammatory marker. It also helps protect against hypoxia.

Homocysteine — Homocysteine is a vascular toxin associated with heart disease that is influenced by your vitamin B levels. As explained by Lewis:

“LabCorp keeps changing their reference normals, and now they're as high as 17. But the Framingham's study shows that with a baseline of 9, every five points higher homocysteine leads to a 40% increase in dementia because it's a vascular toxicity.”

SED rate — The SED rate is a measurement of how fast your red blood cells settle in a test tube. Red blood cells have a repulsive charge on the outside of their membranes (zeta potential) that allow them to remain buoyant. When this repulsive charge is lacking, they settle faster. As explained by Lewis:

“SED rate is a surrogate for how good your electrical system is working, which I then use as a surrogate for your gut and how well it's doing at digesting and making minerals bioavailable, because it's the sodium potassium pump that drives the electric potential of cells, among other minerals.”

Ideally, if your zeta potential is good and high, your SED rate should be close to zero. The lower, the better. The higher your SED rate, the worse off you are, as this means the “battery” of your red blood cells are discharged, which will result in systemic problems and overall low energy levels. Typically, your SED rate will improve once you start to heal and rebalance your gut.

Where to Get These Tests

Your primary care doctor can order any and all of these lab tests for you. However, they may not be able to thoroughly guide your treatment based on your results, which is what Lewis and his team specialize in. So, for testing and a comprehensive analysis, consider turning to www.healthrevivalpartners.com.

“Come through us and we'll help you solve your problem,” Lewis says. “Under our services tab, we have a COVID-19 service, and there we have five different levels of panels, from just a population screening to a very deep dive. Basically, every marker we talked about today, and more.

Looking at the lipids, the chemistry, liver function, metabolic, all that stuff, is included. We don't take insurance, but I can order these labs. My team can order these labs anywhere in the country …

We couple the lab test with a highly functional intake survey. What we've done, and we were publishing a paper on this, is we've created a risk score for every single question and answer that is typically on a functional intake questionnaire, and made it digitized, so it's online. You take it.

We give you a letter grade, which is sort of a reflection of your total risk portfolio, and then subsections of grades. Then we give you a very detailed color-code report, which really turns into your treatment plan, if you will. We want to ameliorate these different things. And we have health coaches to help you organize them because some things you want to do in series, other things you want to do in parallel. We call this the hierarchy of health.

Anybody who does a blood test gets that. And then our team is trained on how to help you understand your labs from a very detailed chronic perspective, but also look back at the risk factors and show you what risk factors could potentially have led to an elevation in that lab. So, you see a very clear one-to-one correlation.

We give you a letter grade, but there's a score underneath it. And then we give you what we call our chronic disease temperature, which is the amalgamation of 20 of these important biomarkers into a single score. We have a plot of our chronic disease temperature versus our chronic disease assessment.

It's a fairly linear thing, showing you that your risks are tied to your physiological health. And then we've shown, in populations that we work with, that when we lower their risk grade — just the lifestyle things, cleaning up the teeth, improving the gut, cleaning the diet up, detoxification — as their risk rate goes down, their physiological score goes down, which is a good thing because we want your score as low as possible.

That's the essence of what we do. We have functional doctors, regular doctors, health coaches.”

Managing Your Expectations

While most health problems can be successfully addressed with nutritional and other lifestyle changes, it’s important to manage your expectations of how long it’s going to take. As noted by Lewis:

“I have a very simple explanation to set expectations up. If it took you 10 years to get into something chronic, it's going to take you at least 10 months to get out of it. And that's with diligence, consistency and the proper treatment. When we have really compliant people [working on healing] rheumatoid arthritis, psoriasis, brain fog, we get this major inflection of health improvement at five months.

Why is that? Because everything in nature is log linear. We are wired to understand that implicitly, but society has taught us instantaneous gratification. We think if we do one thing, we'll get one result. But really everything is an asymptote, going into disease is an asymptote, so you're incubating, incubating, incubating, and then suddenly things go wrong.

While getting out of that state is the reverse of that, it takes you a long time to move the needle and start feeling better. Then all of a sudden, you reach that inflection point and you feel better.

Everything in nature, including health, it’s a log linear relationship to get to where you want to be … When people understand that and buy into that concept, then they can stay the course and we can actually make them better. It's not an overnight thing. That's the only point I'm trying to make.”

More Information

Again, HealthRevivalPartners.com is where you can sign up for your biomarker panel and receive the guidance you need to address whatever problems you may be having. For more information about the eye-brain connection and what your eye health can tell you about your Alzheimer’s risk, which we touched on at the beginning of this interview, see RealHealthClinics.com.



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