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03/28/22
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13:44 ,
Researchers have shown a new compound delivered in a nasal spray is highly effective in preventing and treating COVID-19 caused by the Delta variant in mice. The researchers believe this is the first treatment of its kind proven to be effective against all COVID-19 variants of concern reported to date, including alpha, beta, gamma and delta.

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11:44 ,
In a potential paradigm change for sepsis diagnostics, a new test predicted sepsis soon after infection in mice -- well before blood clotting and organ failure -- enabling early antibiotic treatment and markedly increased survival. The findings provide a platform to develop rapid and easy-to-perform clinical tests for early sepsis detection and clinical intervention in human patients.

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07:44 ,
As we age, our immune system works less well. We become more susceptible to infections and vaccinations no longer work as effectively. A research team has investigated whether short-lived killifish also undergo aging of the immune system. Indeed, they found that as early as four months of age, killifish have less diverse circulating antibodies compared to younger fish, which may contribute to a generalized decrease in the immune function.

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07:44 ,
With help from the best tweezers in the world a team of researchers has shed new light on a fundamental mechanism in all living cells that helps them explore their surroundings and even invade tissue. Their discovery could have implications for research into cancer, neurological disorders and much else.

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07:44 ,
Girls and boys might be more vulnerable to the negative effects of social media use at different times during their adolescence, say an international team of scientists. The researchers show that, in UK data, girls experience a negative link between social media use and life satisfaction when they are 11-13 years old and boys when they are 14-15 years old. Increased social media use again predicts lower life satisfaction at age 19 years. At other times the link was not statistically significant.

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00:20 , ,

Since early 2020, when the World Health Organization announced a global pandemic and fearmongering by government health experts and mainstream media began, it has become more and more apparent the lengths to which Big Tech will go to censor information you receive.

One lone bastion had been DuckDuckGo, a search engine that ensured users their privacy and search results that were relatively unbiased. However, March 9, 2022,1 the CEO of DuckDuckGo, Gabriel Weinberg, announced on Twitter that:

“Like so many others I am sickened by Russia's invasion of Ukraine and the gigantic humanitarian crisis it continues to create at DuckDuckGo, we've been rolling out search engine updates that down rank-size associated with Russian disinformation.”

The move by DuckDuckGo was only one in many made by social media platforms to reportedly clampdown on “disinformation” campaigns stemming from Russia.2 And yet, you had to have been living under a rock to not have noticed the number of individuals complaining of censorship and reported removal of “misinformation” and “disinformation” from social media platforms in the last two years.

In fact, Google's move to remove content they didn't agree with cracked down in June 2019 when their algorithm replaced crowdsourcing with crowd control and removed nearly every article published on Mercola.com from the search engines. The move by DuckDuckGo is yet another in a long list of censorship actions designed to keep you in the dark.

Privacy-Focused Search Engine No Longer Unbiased

In this short video, author and comedian Jimmy Dore makes short work of the new DuckDuckGo censorship changes, pointedly asking what is so different about the Ukraine/Russian conflict that prompted policy change, which did not happen during other global issues. Dore notes it is funny that no tech companies acted when the U.S.:3

  • Invaded Iraq illegally and killed millions of people
  • Invaded Syria because we're now occupying one-third of Syria
  • Bombed Libya
  • Executed a bombing campaign in Somalia
  • Took actions in Afghanistan against the people of the country

Dore also mentions the shelling by the neo-Nazis in the Donbas area for eight years, the Yemen genocide carried out by Saudi Arabia and Israel's attacks on Syria and Palestine. Referring to the obvious lack of concern for other invasions, Dore comments — "Like so many others, I am sickened only by this one thing [Russia] ever, and I ignore everything else bad that happens in the world."4

Commenting on an article in Mashable, Dore notes that Google and Bing didn't take action against disinformation, saying:5 "You're taking action on the behest of the state, the security state to shape the narrative. You're only going to give one side of the story. This isn't fighting disinformation."

Mashable6 spoke with several social media platforms, including Meta, Twitter, YouTube, Snapchat and Tik-Tok, to ask what actions they are taking against “misinformation.” Meta runs Facebook and Instagram, which Mashable points out attempted to sway the election by manipulating content. Meta has blocked Russian state-run media and refused a request to stop labeling content.

Twitter says they're monitoring high-profile “vulnerable” users to stop account takeovers. Russia Today has over 4.5 million subscribers on YouTube and received more than 10 billion views across its YouTube channels. On the last weekend in February, YouTube demonetized all Russian state-run media. Snapchat stopped advertising in Ukraine, Belarus and Russia and Tik-Tok announced they would take action against users who spread misinformation.

As Dore asks, "Is DuckDuckGo turning on its users or did they misunderstand the search engine to begin with? Is it your job to decide what's information and what's disinformation? I would say no. I would say I'm a grown-up and I can figure that out."7

DuckDuckGo has based their advertising and promotion around delivering “unbiased results,”8 which they now claim was based on user privacy policy and not necessarily the results you get in the search engine. However, that’s not what they wrote on Twitter, “When you search, you expect unbiased results, but that's not what you get on Google."9

Google Extended Their Censorship Reach in June 2019

As Dore quips, “We know Google is biasing their Google results. And they do it whenever they feel like it.”10 Just months before the pandemic, Google began to extend their censorship reach by changing their algorithm and removing many Mercola.com articles from the search results.

Traffic to Mercola.com from Google plummeted nearly 99% after the Google Broad Core Algorithm Update that took effect June 3, 2019.11 According to Google’s blog August 1, 2019, these core updates were not supposed to target or punish particular sites.12

“In fact, there's nothing in a core update that targets specific pages or site … One way to think of how a core update operates is to imagine you made a list of the top 100 movies in 2015. A few years later in 2019, you refresh the list. It's going to naturally change.”

If this were true, then Mercola.com and other authoritative websites would not have lost significant traffic. According to a Search Engine Journal (SEJ) article13 published June 10, 2019, Google uses three factors when determining how websites are ranked. These are expertise, authoritativeness and trustworthiness (E-A-T). Yet, SEJ reported several websites that were leaders in their space had lost up to 90% of their traffic from the update on June 3, 2019.

The U.K. news site, Daily Mail, also suffered a major decline in traffic, ostensibly because they published unreliable news and clickbait articles. SEJ fact-checked the fact-checkers at MediaBiasFactCheck.com, that wrote:14

“In review, the Daily Mail tends to publish stories utilizing sensationalized headlines with emotionally loaded wordings such as “Woman, 63, ‘becomes PREGNANT in the mouth’ with baby squid after eating calamari”, which is a misleading headline.”

While the headline may have been clickbait, the article was indeed based in fact and cited the National Institutes of Health as a true story. Additionally, MediaBiasFactCheck.com uses Wikipedia as a source of finding fake news. As Sharyl Attkisson revealed on Full Measure, Wikipedia is full of falsehoods and twisted narratives used to convince the public of a specific narrative.15

Google’s extended censorship happened just 10 months before the World Health Organization declared a pandemic in March 2020. Could that have been to prepare searchers to read only the content Big Tech was doling out and not truly independent investigative journalism that invites debate and reporting on both sides of the issue?

Is It a Conspiracy When It Turns Out To Be True?

Mashable reports16 that for those who are not familiar with DuckDuckGo, the move to downrank websites based on the company's idea of "misinformation" or "disinformation" would not sound too far out of the ordinary. After all, Google, Bing, Facebook, Instagram and Twitter have all updated their policies in the past two years to ensure their readers see only what the company wants them to see.

While the current Mashable article is about the Ukraine/Russia conflict, I've written about the pandemic censorship on these platforms for nearly two years. DuckDuckGo users took to Twitter, announcing their displeasure and intent to switch search engines. DuckDuckGo has roughly 3% of the U.S. market share, which DuckDuckGo claims is a user base of 30 million people.

Mashable writes that the search engine was not built to "placate users with a certain political ideology."17 Yet, the search engine was used as an alternative platform because the search results were not biased. Mashable then writes, "So, whether DuckDuckGo likes it or not, many of those types of users have adopted the search engine."

Exactly who are "those types of users"? Dore asks, "How do we get rid of half the country? I wish there was a bio lab to come up with a solution."18 The types of users that Mashable is referring to are likely the same who are routinely in Facebook jail or have had their accounts removed or deleted for sharing “misinformation.”

To date during the pandemic, people who published research data or questioned the government narrative about the virus or the shot were called conspiracy theorists or accused of publishing misinformation to lead people away from the “science.”

Yet, much of the information that was once called a conspiracy or misinformation is now accepted as fact. Although I’ve written about other examples in the past, these are two among many that have had a significant impact on health, the environment and the economy.

• SARS-CoV-2 was a lab leaked virus — An investigation by the House Foreign Affairs Committee published in August 2021,19 demonstrated using public and intelligence reports that the virus was manipulated using gain of function and leaked in September, well before the 2021 Military Games were held in Wuhan and close to the date of Event 20120 that simulated the response to a dangerous coronavirus pandemic.

A study21,22 published February 21, 2022, in Frontiers in Virology claims to have discovered that a sequence of the virus’ spike protein is a 100% match to a modified messenger RNA (mmRNA) sequence patented23 by Moderna — in 2016.

• Limited vaccine efficacy and health damage — Among those banned from social media for claiming the vaccine would not work was former New York Times reporter Alex Berenson, who was banned from Twitter for questioning vaccine mandates and wrote:24

“Think of it — at best — as a therapeutic with a limited window of efficacy and terrible side effect profile that must be dosed IN ADVANCE OF ILLNESS. And we want to mandate it? Insanity”

Since then:

◦Pfizer25 and Moderna26 have said people will likely need a fourth shot to maintain whatever protection they may have from the injection.

◦CDC director Dr. Rochelle Walensky told Washington University she wasn’t aware the vaccine efficacy would wane,27 which means she now knows that it does.

◦The U.K. finds roughly 90% of cases, hospitalizations and deaths are in vaccinated individuals.28

◦The Vaccine Adverse Events Reporting System (VAERS) has been inundated with reports of adverse events, permanent health damage and death totaling 1,168,892 reports in 15 months as of March 4, 2022.29

Crowdsourcing Replaced by Crowd Control

Science thrives in an atmosphere of debate, not censorship. Many would call evidence-based public debate essential to understanding and developing public health policy. Yet, DuckDuckGo has followed in the footsteps of other search engines and social media platforms by identifying its own brand of misinformation.

When voices are censored, humanity loses and fascism wins. In 2019, Pinterest banned me, and Google had erased most of my information from the search results. In the following two years, I was forced to take down all my articles after they were online for just 48 hours. What makes me so dangerous?

According to Search Engine Journal, in the late 2000s Google began using social shares and signals to impact their search engine ranking.30 This utilized crowdsourcing so the websites that provided the best answers to your questions made it to the top of the search results.

This was a democratic system that rewarded publishers for sharing quality information. During this time, my information was frequently at the top of health searches because many people found it to be the most valuable. As Google's power grew, their goal of providing a service to you changed.

Instead of serving you quality search results, the new goal is to unite industry and government, forcing their beliefs on readers and manipulating your behavior and your future. Instead of crowdsourcing, Google began using crowd control.

The search engine has changed from looking at users as customers to making users custodians of their will and essentially making you a host to carry out their agenda. It sounds dystopian and like science fiction, but Google has become a puppet master and has learned how to manipulate their readers without them even knowing it.

Google’s Centralized Power Controls What You See and Believe

Lawrence Sanger, who co-founded Wikipedia in 2001, bailed ship the very next year,31 saying "trolls sort of took over" the site, that "The inmates started running the asylum,"32 and that "In some fields and some topics, there are groups who 'squat' on articles and insist on making them reflect their own specific biases."33 In this short Ted Talk, Attkisson shares how to recognize those biases and what it means to society.

Considering Wikipedia's history of bias, it's not surprising that the online “encyclopedia” is Google's chosen arbiter of expertise and credibility. As reported by TechCrunch34 in January 2019, Google donated $2 million to Wikimedia Endowment, Wikipedia's parent organization, and another $1.1 million to the Wikimedia Foundation.

To help sway public opinion and policy, Google has also recruited law professors to back up and promote its views. According to a 2017 Campaign for Accountability report,35 Google has paid academics in both the U.S. and Europe millions of dollars to influence public opinion and policymakers alike.36,37

When you consider power assessment by looking at lobbying expenditures, Google is leading the pack on corporate spending on lobbying — efforts primarily aimed at eliminating competitors and gaining power over others. According to a June 5, 2019, article38 in The New York Times, "… four of the biggest technology companies are amassing an army of lobbyists as they prepare for what could be an epic fight over their futures."

The four companies — Google, Facebook, Amazon and Apple — spent $55 million on lobbying in 2018, which is just under double what they spent in 2016. Google could potentially also garner some protection or aid from the U.S. National Security Agency (NSA). According to an Aljazeera report39 published in 2014, emails reveal a cozy relationship between Google and the NSA, with coordination occurring at the highest levels.

Two years later, in March 2016, Wired reported40 the executive chairman of Google's parent company Alphabet and former Google CEO, Eric Schmidt, had been chosen by the Pentagon to chair its new Defense Innovation Advisory Board.41

Google holds enormous power over what people read, see and therefore likely believe. Any dissenting view can be effectively stripped from the search results, so content is no longer crowdsourced by social signals, but instead is controlled by an alphabet soup of corporations bent on ensuring society follows their lead.

DuckDuckGo used to have a tenuous hold over unbiased results but has publicly announced their decision to relinquish it and cross over to join Google in the unrelenting effort to control your thoughts, behaviors and pocketbook. Without access to independent journalism through search, it’s more important than ever to stay connected and share information across your network of friends and family.



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00:20 , ,

This article was previously published February 4, 2019, and has been updated with new information.

As you probably know, inflammation and oxidative damage are primary drivers of most chronic diseases. What you may not be aware of is the importance of nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) and NADPH oxidase, typically abbreviated as NOX, in these processes.

In a recent paper,1James DiNicolantonio, who co-wrote my book, "Superfuel," details the importance of collagen and glycine for the inhibition of NADPH breakdown. DiNicolantonio, also co-wrote a book with Jason Fung, called "The Longevity Solution," which takes a deep dive into how collagen and glycine may help promote longevity.

The Longevity Solution

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Without sufficient amounts of NADPH, your body cannot recharge glutathione once it becomes oxidized. As you know, glutathione is crucial for detoxification, and both collagen and glycine effectively raises your NADPH level by inhibiting the enzyme that breaks down NADPH.

Considering the importance of NADPH for optimal health and chronic disease prevention, this is really important information that could make a big difference for many, as collagen and glycine are both easily obtainable and relatively inexpensive. But before we delve into the specifics of how glycine affects NOX and NADPH, let's review some of the basics.

What Is NADPH and NOX?

NADPH is the reduced form of NADP+. It's a reducing agent necessary for anabolic reactions, including lipid and nucleic acid synthesis. NOX is an enzyme complex that is bound to the cellular membrane, facing the extracellular space. Inhibiting NOX is a useful strategy to increase NADPH and your cells' ability to counter oxidative stress.

NOX is activated in a large number of pathological conditions that generate a great deal of oxidative stress. In fact, according to DiNicolantonio, NOX overactivity appears to play a significant role in a wide range of health conditions, including but not limited to:

Vascular diseases and vascular complications of other diseases (diabetes, kidney failure, blindness and heart disease for example)

Insulin resistance

Neurodegenerative disorders such as Alzheimer's and Parkinson's

Cancer

Glaucoma

Pulmonary fibrosis

Erectile dysfunction

As explained by DiNicolantonio in a paper2 detailing bilirubin's ability to inhibit NOX complexes and downregulate NOX activity, and the benefits of spirulina for this purpose:

"Activation of NADPH oxidase [NOX] is a key mediator of proinflammatory microglial activation … Oxidative stress in adipocytes, stemming largely from NADPH oxidase activity, appears to play a key role in the induction of insulin resistance and the skewing of adipokine and cytokine production in hypertrophied adipocytes."

Six Ways to Inhibit NOX and Increase NADPH

NADPH is used as a reductive reservoir of electrons for antioxidants that become oxidized and nonfunctional. NADPH is also necessary to make your steroid hormones and fats. When you have low levels, you are in deep trouble.

That said, NADPH appears to be a biological molecule that can be helpful or harmful depending on how much of it is circulating at the time, so it needs to be carefully regulated by your body. For example, although NOX lowers NADPH, it also plays an important role in helping your immune system fight bacteria, and helps your T-cells to function properly.

It follows then, that preventing many chronic diseases would require finding a means of inhibiting or modulating NOX. The good news is there are several ways of doing this that are neither costly nor cumbersome, including the following:

• Niacinamide — Taking nicotinamide can also help increase your NADPH level.3

• Lowering your glucose level and avoiding fructose — Excess glucose is converted to fructose and lowers your NAD+,4 so keeping your glucose low and avoiding fructose is part of the equation.

• Nutritional ketosis — Ketone metabolism increases the negative redox potential of your family of NAD coenzyme redox molecules, which helps control oxidative damage by increasing NADPH and promoting transcription of enzymes of the antioxidant pathways though activation of FOXO3a.5

• Glycine and collagen — As detailed in the featured paper, glycine and collagen (which also contains glycine) also have NOX-inhibiting effects, thereby raising your NADPH level.

The way glycine inhibits NOX superoxide production is by bringing chloride into the cell, which reduces the cell's ability to push out chloride ions (since it's pushing against a higher chloride gradient). Chloride ions are required to bring in electrons to generate superoxide, so by minimizing chloride ions, glycine helps minimize oxidative stress.

Glycine Upregulates NADPH and Has Anticancer Activity

According to the featured paper,6 supplemental glycine may be useful for the "prevention and control of atherosclerosis, heart failure, angiogenesis associated with cancer or retinal disorders and a range of inflammation-driven syndromes, including metabolic syndrome." Glycine may also be an excellent complement to spirulina, as both suppress NOX.

The featured paper also details the anti-angiogenic activity of glycine, which refers to its ability to inhibit the growth of blood vessels that feed tumors. Animal studies, for example, have shown mice with cancer that are fed glycine exhibit suppressed angiogenesis and tumor growth, even though glycine does not affect the proliferation of cancer cells directly.

DiNicolantonio and his team hypothesize that one of the reasons for this antitumor effect has to do with the fact that glycine increases the chloride level in endothelial cells, thereby limiting the export of chloride from the endosome. This in turn inhibits activation of NOX, which has pro-angiogenic activity (meaning it promotes the growth of blood vessels to tumors). According to this paper:7

"This might explain the well-documented anti-angiogenic effects of boosting plasma glycine to the high physiological range. The possibility that supplemental glycine may have clinical utility as an anti-angiogenic agent for cancer control merits evaluation — albeit the concurrent effects of glycine on anticancer immune surveillance should be considered.

The anti-angiogenic effects of glycine might also find application in prevention or treatment of the choroidal neovascularization associated with diabetic retinopathy and age-related macular degeneration. It will be of interest to determine whether retinal pigment epithelium expresses glycine receptors."

Glycine Also Supports Vascular Health

NOX activation also plays an important role in heart disease, and by inhibiting NOX (which raises NADPH), glycine may also offer protection against cardiovascular problems. DiNicolantonio and his team explain:

"The role of [NOX] complex activation in promoting pro-inflammatory behavior of vascular endothelium is well documented; in particular, endothelial [NOX] plays a mediating role in atherogenesis. It is reasonable to postulate that a high proportion of this [NOX] activation occurs in endosomes, and is susceptible to modulation by cytosolic chloride level.

If so, then we could expect elevated plasma glycine, via stimulation of glycine-activated chloride channels, to suppress endothelial inflammation by opposing endosomal [NOX] activity. Moreover, the hyperpolarizing impact of glycine on endothelium might also promote vascular health by boosting calcium influx into endothelial cells, thereby enhancing the protective activity of the endothelial nitric oxide synthase.

It also seems not unlikely, given the documented impact of glycine on macrophages, that supplemental glycine could oppose atherogenesis and plaque instability via anti-inflammatory effects on intimal macrophages and foam cells … Glycine may also provide antioxidant protection to heart muscle … Moreover, in mice subjected to cardiac pressure overload or angiotensin II administration, glycine supplementation lessens the ensuing cardiac hypertrophy."

Glycine Supplementation May Improve Your Health

Considering how important it is to minimize inflammation and oxidative stress, and the role NOX and NADPH play in these processes, glycine supplementation holds great promise as a simple and inexpensive aid. I personally take one-quarter teaspoon (about 1 gram) twice a day.

Since glycine is mildly sweet, you could even use it as a healthy sugar substitute in tea or coffee. As noted by DiNicolantonio, "Intakes as high as 31 grams daily have proved safe. It is therefore ideal for incorporation into functional foods and beverages." The paper also cites a number of studies showing glycine supplementation may be beneficial for the prevention and/or treatment of:8

  • Metabolic syndrome — As noted in DiNicolantonio's paper, "In humans with metabolic syndrome supplemented with 15 grams glycine per day (5 grams thrice daily), plasma markers of oxidative stress declined by 25 percent relative to placebo"
  • Complications from diabetes
  • Alcoholic and nonalcoholic liver disorders
  • Cardiac hypertrophy

Glycine supplementation may also:9

Help improve sleep

Maintain cartilage integrity

Moderate the adverse metabolic effects of high-fructose diet

Boost glutathione synthesis, especially when used in combination with a N-acetylcysteine (NAC) supplement

Improve oxidant-scavenging activity by converting to pyruvate, which is a direct scavenger of hydrogen peroxide and inhibits formation of age-advanced glycation end-products

Have antioxidant effects by increasing synthesis of heme and bilirubin, although evidence of this is still lacking, and the effect is likely to be modest

Help detoxify glyphosate — Glyphosate is an analog of the amino acid glycine.10 It attaches in places where you need glycine. Importantly, glycine is used up in the detoxification process, hence many of us do not have enough glycine for efficient detoxification.

To eliminate glyphosate, you need to saturate your body with glycine. Dr. Dietrich Klinghardt, who is a specialist in metal toxicity and its connection to chronic infections, recommends taking 1 teaspoon (4 grams) of glycine powder twice a day for a few weeks and then lowering the dose to one-fourth teaspoon (1 gram) twice a day. This forces the glyphosate out of your system, allowing it to be eliminated through your urine

While glycine powder is an inexpensive option, collagen is another alternative that is extremely rich in glycine. If going this route, I recommend looking for organic grass fed collagen.



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