Health & Fitness

Scientists have uncovered a hidden “stop-scratching” signal in the nervous system that tells your brain when enough scratching is enough. The discovery centers on a molecule called TRPV4, which acts like part of an internal braking system for itch relief. In experiments involving chronic itch similar to eczema, mice missing this signal scratched less often—but when they did scratch, they couldn’t stop.

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Researchers have developed a stem cell-based model of the human intestine that may transform how new IBD treatments are discovered. After testing thousands of compounds, they identified glycyrrhizin — a natural substance found in black licorice — as a promising anti-inflammatory candidate. In both lab-grown tissue and mice, the compound reduced intestinal damage and cell death linked to IBD.

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A new study shows that listening to your own favorite workout music can dramatically boost endurance. Cyclists exercising with self-selected songs lasted nearly 20% longer than when riding in silence, yet they didn’t feel more exhausted at the end. Researchers say music may help people stay in the “pain zone” longer without increasing perceived strain.

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Scientists studying axolotls, zebrafish, and mice have uncovered a shared set of genes that may one day help humans regrow lost limbs. By identifying powerful “SP genes” involved in regeneration, researchers discovered that disabling these genes stopped proper bone regrowth in salamanders and mice. They then used a gene therapy inspired by zebrafish biology to partially restore regeneration in mice, marking a major step toward future treatments that could replace damaged limbs with living tissue instead of prosthetics.

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Scientists have uncovered a surprising secret hidden inside fat cells that could reshape how we think about obesity and metabolic disease. A protein called HSL, long believed to simply release stored fat when the body needs energy, turns out to have a second job deep inside the nucleus of fat cells—helping keep those cells healthy and balanced. Even more surprising, people and mice missing this protein don’t become obese as expected; instead, they lose fat tissue in a dangerous condition called lipodystrophy.

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Beneath the beauty of coral reefs lies a hidden universe of microbes unlike anything scientists expected. Each coral species supports its own specialized microbial partners, many of which have never been studied before. These microbes produce a stunning variety of chemical compounds with potential uses in medicine and biotech. The discovery highlights just how much is at stake as coral reefs face growing threats.

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A little-known tree from Brazil’s Atlantic Forest may hold a surprising weapon against COVID-19. Researchers discovered that compounds called galloylquinic acids, extracted from its leaves, can attack SARS-CoV-2 on multiple fronts—blocking the virus from entering cells, disrupting its replication, and even dampening harmful inflammation. Unlike many antivirals that target just one part of the virus, these natural compounds act in several ways at once, potentially making it harder for resistance to develop.

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