Health & Fitness

The FDA has approved the first drug that directly targets Alexander disease, a devastating neurological disorder affecting fewer than one in a million people. Developed through decades of research, Zanvastro showed promising results in clinical trials, stabilizing motor function and even improving movement in some patients.

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Scientists have developed an experimental injection that destroys fat cells and significantly reduces dangerous belly fat, potentially opening a new path to treating obesity. Early research also suggests it could help prevent the weight regain that often follows stopping popular weight loss drugs like Ozempic and Wegovy.

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A large study suggests loneliness and social isolation can cost people years of healthy life, especially when it comes to mental health. Men experiencing both lost about 5.8 years free from depression and anxiety, while women lost roughly 3.7 years.

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Nicotine e-cigarettes appear to help more smokers quit than patches, gum, and several other common approaches, according to a major review of 80 clinical trials. Researchers say regulated vaping products are not risk-free, but may be a significantly less harmful alternative for people who would otherwise continue smoking.

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A Stanford-designed molecule turns a major lymphoma-promoting protein against cancer cells, activating their own self-destruct machinery instead of simply blocking tumor growth. In mice, the treatment completely eliminated aggressive human lymphoma tumors within 11 days, although much more testing is needed before it could reach patients.

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Blocking a receptor called P2X7 significantly reduced inflammation in human brain tissue, revealing a potential new treatment strategy for neurological and psychiatric disorders. The discovery could help researchers repurpose existing drugs for conditions including traumatic brain injury, Alzheimer’s, Parkinson’s, depression, and schizophrenia.

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Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations. In mice, shutting down those neurons sharply reduced cannabinoid-related anxious behavior.

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