Health & Fitness

Researchers have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.

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Researchers recently announced that they have engineered a new class of material, called a 'polyzwitterionic complex,' or 'pZC,' which is able to both withstand the harsh acidic conditions of the stomach and then dissolve predictably in the comparatively gentle environment of the small intestine. This property means that pZCs could help revolutionize the delivery of medicines of all sorts, from familiar oral antibiotics to new classes of delicate protein therapeutics.

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Researchers show that three transcription factors -- GATA4, NKX2-5 and TBX5 -- interact with CHD4 inside the embryonic heart, recruit it for action, and uses CHD4 to play their roles in heart health and disease.

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A previously developed a microbiome 'fingerprint' method that identifies single strains of particular gut bacteria through analysis of metagenomics data from fecal samples, has been refined to include looking for single-nucleotide variants in the KEGG metabolic pathways of a particular strain. This magnified analysis shows a short-term difference in sub-strain dynamics of two Bacteroides species between healthy individuals and hospitalized COVID-19 patients.

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A new microsimulation projects that over the next 20 years, Japanese people will live longer without dementia, but older women with a less than high school education will benefit less than men.

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Researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans.

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