Health & Fitness

The STEP UP trials revealed that a 7.2 mg dose of semaglutide led to greater weight loss than the currently approved 2.4 mg dose. Nearly half of participants lost 20% or more of their body weight, while also improving metabolic health. Side effects were mostly mild and temporary. Researchers say this could reshape obesity treatment if confirmed in longer-term studies.

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Researchers uncovered a key cellular regulator, PP2A-B55alpha, that controls both the cleanup of damaged mitochondria and the creation of new ones. In Parkinson’s disease models, reducing this regulator improved symptoms and mitochondrial health. The findings could inspire new drugs for Parkinson’s, mitochondrial disorders, and even cancer.

from Top Health News -- ScienceDaily https://ift.tt/nh5cjAY

Scientists discovered that vitamin D2 supplements can lower levels of vitamin D3, the form the body uses most effectively. Unlike D2, vitamin D3 enhances the immune system’s first line of defense against infections. This raises questions about which type of supplement should be prioritized.

from Top Health News -- ScienceDaily https://ift.tt/wfcVnKt

A Weill Cornell Medicine team has found that triple-negative breast cancer depends on the enzyme EZH2 to spread. By silencing key genes, EZH2 drives chaotic cell divisions and fuels metastasis. Blocking EZH2 restored stability and prevented cancer cells from traveling to distant organs. This discovery opens the door to new therapies that may finally tame this aggressive disease.

from Top Health News -- ScienceDaily https://ift.tt/sBkHKdQ