Targeted protein degradation (TPD) represents a novel paradigm in drug discovery that could lead to more efficient medicines to treat diseases such as cancer. 'Molecular glue degrader'are an emerging but understudied class of small molecules that have been shown to induce degradation of proteins commonly considered 'undruggable'. Researchers have described a strategy that, for the first time, enables the rational and highly scalable discovery of novel molecular glue degraders.
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New research has found that adolescents who promised to be truthful were less likely to 'cheat' than those who did not, even when they could not be found out.
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In a reversal of trends, American baby boomers scored lower on a test of cognitive functioning than did members of previous generations, according to a new nationwide study.
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They go by different names: goosebumps, goose pimples, goose flesh, and my personal favorite, goose bumples. The medical term is cutis anserine (cutis means skin and anser means goose). I guess the similarity in texture is just too close to goose skin to ignore. Other medical terms for goosebumps are horripilation, piloerection, or the pilomotor reflex.
Each of these terms describes a temporary change in the skin from smooth to bumpy, most commonly developing after exposure to cold.
Many people associate goosebumps with fear, or perhaps more accurately, with horror. Perhaps that’s why a popular series of children’s horror stories by R.L. Stine published in the 1990s was called Goosebumps.
Ever wonder why you get them? Do they serve a purpose? Why do they develop when we’re frightened?
What are goosebumps?
Goosebumps are the result of tiny muscles flexing in the skin, making hair follicles rise up a bit. This causes hairs to stand up. Goosebumps are an involuntary reaction: nerves from the sympathetic nervous system — the nerves that control the fight or flight response — control these skin muscles.
In the animal kingdom, a threatened animal has a similar reaction, causing fur to be puffed out a bit. This makes the animal appear bigger and more dangerous. Perhaps the most dramatic example is the porcupine, which puffs out its quills when sensing danger. This can make a threatening adversary think twice before attacking. That may explain why the sympathetic nervous system controls goosebumps — the reflex is tied into the fight or flight response.
This just in
Researchers studying mice recently linked goosebumps to the regeneration of hair and hair follicles. It seems that the nerves connected to the tiny muscles responsible for goosebumps also connect to hair follicle stem cells, which are the cells responsible for hair growth. So, in response to cold, the nerve tells the tiny muscles in the skin to contract (causing goosebumps) and the same nerve activates hair follicle stem cells for new hair growth.
What purpose do goosebumps serve?
Goosebumps may help you conserve heat when you’re exposed to cold. They may do this in several ways.
As with larger muscles, contraction of the muscles in the skin (called arrectores pilorum) generates heat.
The raised hair follicles cause skin pores to close.
Hairs standing up trap a layer of air near the skin, holding onto body heat.
Each of these might be more important for furry animals than for humans. In fact, it’s not clear how important goosebumps are in humans. For example, if you couldn’t form goosebumps at all, it wouldn’t necessarily mean that you’d have problems with temperature control. Goosebumps may be one of those leftovers from our evolutionary ancestors (like the coccyx, or tailbone) that serve no important purpose.
The new discovery linking goosebumps with hair follicle stem cells might be explained as a longer-term response to cold, at least for animals with fur: they get goosebumps (or the animal equivalent) in the short run to conserve heat, and thicker fur to keep warmer in the long term.
Goosebumps: More than just being cold
Most people associate goosebumps with unpleasant situations, such as feeling particularly cold or feeling afraid. Yet there is more to it than that. The arrectores pilorum are hooked up to the sympathetic nervous system, and the sympathetic nervous system has input from many parts of the brain, including those involved with motivation, arousal, and emotion. So other stimuli may cause goosebumps, for instance:
hearing music or seeing art that is particularly moving or completely engrosses you (which is why you might say “it gave me chills”)
awe
pride
excitement
fear.
Goosebumps and disease
Though rare, goosebumps can be a sign of a seizure disorder called temporal lobe epilepsy, a disorder of the sympathetic nervous system, or other brain disorders. They are also common during heroin or other opiate withdrawal. In fact, one explanation for the origin of the expression “quitting cold turkey” is that goose bumps that develop during withdrawal from heroin mimic cold turkey flesh.
The bottom line
You’ll see goosebumps most often when you’re cold. But don’t be surprised (or afraid or awed) if they appear at other times. They are a universal but poorly understood phenomenon, but our understanding is improving. And the recent discovery linking goosebumps with hair follicle regeneration could lead to more than just a better understanding of goosebumps; it could lead to new ways to fight baldness or improve tissue healing.
In humans, it’s possible that goosebumps will gradually disappear over the coming centuries as with other remnants of evolution, like the tailbone or wisdom teeth. Or they may serve a more important role than we currently understand and continue to puzzle us for years to come.
Children who suffer trauma from abuse or violence early in life show biological signs of aging faster than children who have never experienced adversity, according to new research. The study examined three different signs of biological aging -- early puberty, cellular aging and changes in brain structure -- and found that trauma exposure was associated with all three.
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If you want to know how to eat for ideal health, look no further than the plates of the pros. Dietitian Susie Burrell deep dives into the diets of her colleagues to reveal their top tips for a healthy diet - and as it turns out, vegetables are the common thread.
According to the director general of the World Health Organization, Tedros Adhanom Ghebreyesus, life will not be returning to your old normal anytime soon. What's more, things will only get worse unless the public follow health advice such as wearing masks and social distancing. The somber announcement came during a July 13, 2020, press conference (above).
This, despite the fact that the WHO's June 5, 2020, guidance memo1 on face mask use states there's no direct evidence that universal masking of healthy people is an effective intervention against respiratory illnesses.
What's more, people are being urged to use cloth masks or bandanas (ostensibly to prevent shortages among health care staff), none of which conform to any kind of quality standards, and according to what little scientific evidence is available have been shown to provide only about half of what little protection you may get from a surgical mask.
No Direct Evidence to Support Universal Mask Usage
SARS-CoV-2 is a beta-coronavirus with a diameter between 60 nanometers (nm) and 140 nm, or 0.06 to 0.14 microns (micrometers).2 This is about half the size of most viruses, which tend to measure between 0.02 microns to 0.3 microns.3
Virus-laden saliva or respiratory droplets expelled when talking or coughing measure between 5 and 10 microns,4 and it is these droplets that surgical masks and respirators can block.
For example, N95 masks can filter particles as small as 0.3 microns,5 so they may prevent a majority of respiratory droplets from escaping. They cannot block aerosolized viruses, however, that are in the air itself. Additionally, many N95 masks only protect the wearer, as they have exhalation ports that allow you to exhale unfiltered air.
Lab testing6 has shown 3M surgical masks can block up to 75% of particles measuring between 0.02 microns and 1 micron, while cloth masks block between 30% and 60% of respiratory particles of this size. As noted in the WHO's guidance memo:7
"Meta-analyses in systematic literature reviews have reported that the use of N95 respirators compared with the use of medical masks is not associated with any statistically significant lower risk of the clinical respiratory illness outcomes or laboratory-confirmed influenza or viral infections …
The use of cloth masks (referred to as fabric masks in this document) as an alternative to medical masks is not considered appropriate for protection of health workers based on limited available evidence …
At present, there is no direct evidence (from studies on COVID- 19 and in healthy people in the community) on the effectiveness of universal masking of healthy people in the community to prevent infection with respiratory viruses, including COVID-19."
Curiously, while cloth masks and face coverings are far less effective for blocking respiratory droplets, the WHO recommends that cloth or nonmedical masks "should only be considered for source control (used by infected persons) in community settings and not for prevention."8
CDC Policy Review Found No Evidence of Usefulness Either
A policy review paper9 published in Emerging Infectious Diseases in May 2020 — the Center for Disease Control and Prevention's own journal — has also reviewed "the evidence base on the effectiveness of nonpharmaceutical personal protective measures … in non-healthcare settings," and they too found no evidence of benefit:
"Although mechanistic studies support the potential effect of hand hygiene or face masks, evidence from 14 randomized controlled trials of these measures did not support a substantial effect on transmission of laboratory-confirmed influenza."
Pages 970 to 972 of the review include the following quotes:10
"In our systematic review, we identified 10 RCTs [randomized controlled trials] that reported estimates of the effectiveness of face masks in reducing laboratory-confirmed influenza virus infections in the community from literature published during 1946–July 27, 2018. In pooled analysis, we found no significant reduction in influenza transmission with the use of face masks …
Disposable medical masks (also known as surgical masks) are loose-fitting devices that were designed to be worn by medical personnel to protect accidental contamination of patient wounds, and to protect the wearer against splashes or sprays of bodily fluids …
There is limited evidence for their effectiveness in preventing influenza virus transmission either when worn by the infected person for source control or when worn by uninfected persons to reduce exposure.
Our systematic review found no significant effect of face masks on transmission of laboratory-confirmed influenza … In this review, we did not find evidence to support a protective effect of personal protective measures or environmental measures in reducing influenza transmission."
These Mistakes Undermine the Protection Masks May Provide
If and when you do use a mask, you have to follow proper protocols, or else you can nullify what little protection they do offer against potentially infectious respiratory droplets. As detailed in WHO's guidance memo, you need to make sure your medical mask is:11
Changed when wet, soiled or damaged
Untouched. Do not adjust or displace it from your face for any reason. "If this happens, the mask should be safely removed and replaced; and hand hygiene performed"
Discarded and changed after caring for any patient on contact/droplet precautions for other pathogens
The memo also points out that "Staff who do not work in clinical areas do not need to use a medical mask during routine activities (e.g., administrative staff)." Now, if administrative hospital staff do not need to wear masks, why would healthy individuals need to wear them when walking around, especially in open-air areas?
Broward county, Florida, has gone so far as to issue an emergency order12 mandating masks to be worn inside your own residence. But why, if administrative hospital staff aren't even advised to wear them at work?
In summary, it is likely that masks are not entirely useless in all circumstances. However, the literature rather strongly suggests the usefulness of masks depends on a significant number of factors — type, fit, length of use, purpose and circumstances — which are effectively impossible to account for in public universal-masking policies.
The science, contrary to the ignorant platitudes we are bombarded with, has NOT proven that universal masking is effective for viral containment, and has instead provided substantial grounds for skepticism of such a policy.
Benefits of Mask Wearing Do Not Include Infection Control
Despite the lack of scientific evidence showing masks do much of anything to prevent the spread of viral infections, the WHO still manages to make a case for universal mask wearing. The "potential benefits" listed, however, have little to do with health, and much more to do with learning submission. According to the WHO, potential benefits of mask wearing include:13
• "Reduced potential stigmatization of individuals wearing masks to prevent infecting others or of people caring for COVID-19 patients in nonclinical settings" — In other words, we should all wear masks to make people caring for COVID-19 patients feel more accepted, as if that's actually a significant problem.
• "Making people feel they can play a role in contributing to stopping spread of the virus" — I.e., masks, while providing a false sense of security, make people feel like they're "doing something" to help. Put another way, it makes people feel virtuous and "good."
• "Reminding people to be compliant with other measures" — In other words, mask wearing is a sign of overall compliance.
• "Potential social and economic benefits" — This is perhaps the most ludicrously strained reason of all. According to the WHO:
"Encouraging the public to create their own fabric masks may promote individual enterprise and community integration … The production of non-medical masks may offer a source of income for those able to manufacture masks within their communities. Fabric masks can also be a form of cultural expression, encouraging public acceptance of protection measures in general."
Potential Harms and Risks of Mask Wearing
The WHO also lists a number of potential harms and risks of mask wearing, which "should be carefully taken into account when adopting this approach of targeted continuous medical mask use." These include:14
Self-contamination due to the manipulation of the mask by contaminated hands or not changing the mask when wet, soiled or damaged
General discomfort, as well as facial skin lesions, irritant dermatitis or worsening acne
False sense of security that may reduce adherence to other well recognized preventive measures such as hand hygiene
Disadvantages for or difficulty wearing them by specific vulnerable populations such as those with mental health disorders, developmental disabilities, the deaf and hard of hearing community, and children
Difficulty wearing them in hot and humid environments
Aside from these, several people have demonstrated that masks can rapidly result in the buildup of toxic carbon dioxide, which can have a markedly detrimental impact on health.
In one video, a science teacher tried to evade YouTube censorship by saying children should wear face masks to school — all while holding up handwritten signs informing viewers the tactic was for censorship evasion, and to pay attention to the carbon dioxide metering results, which show carbon dioxide levels behind the mask shoot up above 10,000 parts per million (ppm) after just 10 breaths.
After garnering several hundred thousand views, the video was removed for "violating YouTube community guidelines."
Del Bigtree of The Highwire has performed an identical demonstration15 (see bitchute video below). With an N95 mask on, the carbon dioxide level spikes above 8,480 ppm within seconds. Above 5,000 ppm, OSHA warns that "toxicity or oxygen deprivation could occur."
Carbon dioxide levels between 2,000 ppm and 5,000 ppm are associated with headaches, sleepiness, poor concentration, loss of attention, increased heart rate and slight nausea. The maximum permissible daily exposure limit is 5,000 ppm.
Wearing a standard surgical mask, carbon dioxide levels again reached above 8,000 ppm, although it took longer. Shockingly, wearing a cloth bandana resulted in carbon dioxide buildup near the nose and mouth exceeding 8,000 ppm.
Even wearing a clear plastic face shield (without a mask) resulted in carbon dioxide levels in the 1,500-ppm range, which is associated with drowsiness and poor air quality. The video at the top of this section also addresses many of the potential harms and risks of masks wearing.
Toxic ingredients that can worsen breathing problems are yet another potential hazard of certain masks. For example, surgical masks are made of plastics like polypropylene, a known asthma trigger.16
The 2018 study,17,18 "Hypoxia Downregulates Protein S Expression," also describes how hypoxia (low oxygen concentration) increases your risk of blood clots by reducing protein S, which is a natural anticoagulant. Wearing a mask, especially for long periods of time, may reduce your oxygen concentration, and considering COVID-19 is already associated with abnormal blood clotting, inducing hypoxia may be ill advised.
PPE Waste Is Becoming an Environmental Hazard
Last but not least, environmentalists are now warning that personal protective equipment (PPE) such as medical face masks may turn into a devastating environmental problem. As reported by The Guardian, June 8, 2020:19
"The French non-profit Opération Mer Propre, whose activities include regularly picking up litter along the Côte d'Azur, began sounding the alarm late last month.
Divers had found what Joffrey Peltier of the organization described as 'COVID waste' — dozens of gloves, masks and bottles of hand sanitizer beneath the waves of the Mediterranean, mixed in with the usual litter of disposable cups and aluminum cans … 'It's the promise of pollution to come if nothing is done,' said Peltier.
In France alone, authorities have ordered two billion disposable masks, said Laurent Lombard of Opération Mer Propre. 'Knowing that … soon we'll run the risk of having more masks than jellyfish in the Mediterranean,' he wrote on social media alongside video of a dive showing algae-entangled masks and soiled gloves in the sea near Antibes.
The group hopes the images will prompt people to embrace reusable masks and swap latex gloves for more frequent handwashing. 'With all the alternatives, plastic isn't the solution to protect us from COVID. That's the message,' said Peltier."
Consider Peaceful Civil Disobedience
Clearly, most people are being bombarded with mainstream media propaganda that seeks to convince you that masks are necessary to prevent the spread of COVID-19. So, it is entirely understandable that you would want everyone to wear masks because you believe they will save lives.
However, if you carefully evaluate the evidence, independent of the mainstream narrative, it is likely you will conclude that this recommendation has nothing to do with decreasing the spread of the virus but more to indoctrinate you into submission.
Most objections to mask-wearing requirements are not to the masks themselves, but to the mandate, and well-documented consequences such as oxygen deprivation should give anybody pause when considering a legal requirement of wearing masks in public. We already see that most people wear masks in public regardless of mandates.20 But it is entirely irresponsible and unethical for governments to mandate such a practice on anybody.
In my recent interview with Patrick Wood, he provides compelling evidence that this has been a carefully crafted technocratic strategy that has been in place for the last 50 years or so.
By submitting to these orders, we are likely setting the stage for inevitable mandatory vaccinations. If you're still on the fence, please watch my interview with Wood, embedded above for your convenience, and consider not complying with mask mandates.
