Skeletal muscle development and regeneration mechanisms vary by gender

Researchers have generated mice lacking the estrogen receptor beta gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ER-beta gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration.

from Women's Health News -- ScienceDaily https://ift.tt/35bUvWO