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A team of investigators has identified metabolic strategies used by Clostridioides difficile to rapidly colonize the gut. The findings identify methods to better prevent and treat the most common cause of antibiotic-associated diarrhea and healthcare-acquired infections (HAIs). The team's approach has implications for understanding broader aspects of microbial metabolism, including responses to antibiotics, and production of important metabolites.

from Top Health News -- ScienceDaily https://ift.tt/nSuNJcR

The skeleton, tendons, and glands of a functional jaw all derive from the same population of stem cells, which arise from a cell population known as neural crest. To discover how these neural crest-derived cells know to make the right type of cell in the right location, researchers focused on a particular gene, Nr5a2, that was active in a region of the face that makes tendons and glands, but not skeleton. To understand the role of Nr5a2, the scientists created zebrafish lacking this gene. These mutant zebrafish generated excess cartilage and were missing tendons in their jaws.

from Top Health News -- ScienceDaily https://ift.tt/p1RN9Qz

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