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Researchers provide essential insights on the molecular activation of the MAP kinase p38?, the final switch triggering the inflammatory response. Inflammation is a cellular coping mechanism when confronted with stress, such as an infection. However, too much inflammation can damage the functioning of cells and organs. This is the case with cytokine storms, inflammatory cascades that can lead to severe disease and death, recently highlighted during the COVID-19 pandemic. These results open up new directions to develop drugs to prevent cytokine storms and to study similar processes in two other families of MAP kinases, involved in cancer and Alzheimer's disease respectively.

from Top Health News -- ScienceDaily https://ift.tt/2pWtFG6

Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form.

from Top Health News -- ScienceDaily https://ift.tt/vZJG1eA

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