Health & Fitness

A new study has found that RAAS inhibitors, a class of blood pressure-lowering medicine, may be better at reducing the risk of brain aneurysm rupture. People with a brain aneurysm -- a weakened area of a blood vessel -- who were being treated for high blood pressure with medication from the class of drugs called RAAS inhibitors had a significantly lower risk of a ruptured aneurysm compared to those who took other blood pressure medications. These results indicate that RAAS inhibitors may be preferable to other blood pressure-lowering medications and could inform treatment decisions for people with high blood pressure who have unruptured intracranial aneurysms.

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A new method to combat malaria which sees the disease turn against itself could offer an effective treatment for the hundreds of millions of people infected globally each year, as the efficacy of current antimalarial drugs weakens. The research has identified an anti-malarial compound, ML901, which inhibits the malaria parasite but does not harm mammalian -- human or other mammals' -- cells.

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An investigation into the evolution of Salmonella bacteria infecting Brazilian poultry shows that the introduction of a Salmonella vaccine, combined with increasing antibiotic usage by Brazilian farmers, has led to the rise of strains that are more antibiotic-resistant, but less likely to cause disease in humans.

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Around one third of all food worldwide ends up in the trash bin instead of on our plate. With the help of digital twins, researchers at Empa and Stellenbosch University are now aiming to reduce food waste, for example in the case of citrus fruits, along the production and supply chains. The hygrothermal measurement data needed to improve the shelf life of oranges and the like would actually be available. So far, however, they have been underutilized, the researchers write in a recent study in the journal Nature Food.

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Combination chemoimmunotherapy with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib demonstrated improved progression-free survival over standard chemoimmunotherapy for previously untreated mantle cell lymphoma (MCL) in patients 65 and over, researchers reported.

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High-resolution microscopy now enabled an international research team to enlarge the knowledge about species-specific differences of the architecture of cortical neurons.

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A compound called ERX-41 targets a previously unrecognized vulnerability in difficult-to-treat types of cancer including triple-negative breast cancer. The compound will be studied as a drug for clinical translation.

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