Health & Fitness

Data is not only the answer to numerous questions in the business world; the same applies to biomedical research. In order to develop new therapies or prevention strategies for diseases, scientists need more and better data, faster and faster. However, the quality is often very variable and the integration of different data sets often almost impossible.

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Castalagin, a polyphenol from the Amazonian fruit camu-camu, increases the efficacy of immunotherapy in mice by modifying their microbiome, researchers find.

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Using cellphone mobility data and COVID-19 hospital admissions data, researchers have reliably forecast regional hospital demands for almost two years, according to a new study. The forecasting system, which municipal authorities credit with helping Austin maintain the lowest COVID-19 death rate among all large Texas cities, has been built out for use by 22 municipal areas in Texas and can be used by any city to guide COVID-19 responses as the virus continues to spread.

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Researchers have found that three different autism risk genes actually affect similar aspects of neuron development and the same neuron types, although each gene acted through unique molecular mechanisms. Additionally, a person's specific genomic background fine-tuned the genes' effects. The study was conducted using miniature 3D models, or 'organoids,' of the human cerebral cortex, the part of the brain responsible for cognition, perception, and language. The results advance our understanding of autism spectrum disorder and are a first step toward finding treatments for the condition.

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A genome study to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.

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A hormone produced by the liver called fibroblast growth factor 21 (FGF21) suppresses alcohol consumption in primates, finds a new study. Vervet monkeys with a strong preference for ethanol that were given an FGF21 analogue consumed 50% less alcohol. The study also studied the brain circuits involved in mice and found that the protein, known to also reduce sugar intake, acts on different circuits to reduce alcohol and sugar consumption.

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A Phase 1 clinical trial has demonstrated the safety and efficacy of a novel immunotherapy drug in the treatment of HIV.

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