Health & Fitness

Ancient sediments from caves have already proven to preserve DNA for thousands of years. The amount of recovered sequences from environmental sediments, however, is generally low, which complicates analyses. A study has now successfully retrieved three mammalian environmental genomes from a single soil sample of 25,000 years BP obtained from the cave of Satsurblia in the Caucasus (Georgia).

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An international study of parks and gardens finds even the humble roadside verge plays an important role in the environment and for our health.

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Human Usher syndrome is the most common form of hereditary deaf-blindness. Researchers have now identified a novel pathomechanism leading to Usher syndrome. They have discovered that the Usher syndrome type 1G protein SANS plays a crucial role in regulating splicing process. Furthermore, they have been able to demonstrate that defects in the SANS protein can lead to errors in the splicing of genes related to the Usher syndrome, which may provoke the disease.

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When it comes to post-menopausal hormone therapy, the type, route and duration all play a role in reducing the risk of neurodegenerative diseases.

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A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities. The study offers new hope to those living with incurable genetic and neurodegenerative diseases.

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Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a 'stealthy' role in the progression of infection by reducing the immune response. Blueprints such as these allow drug designers to uncover potential weaknesses in bacterial arsenals as they seek to develop new therapeutics that may help us win the war against antibiotic resistance.

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The blood-brain barrier protects the brain and is notoriously hard to get past for drug delivery, making it difficult to treat disorders in the central nervous system. In a mice study, a team of researchers used a novel approach to study the barrier and in detail characterized a Trojan horse technique to help to solve the challenge.

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