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Using the power of single-cell analysis, researchers have assessed the effects of age on egg cells (oocytes) in mice, particularly looking to identify genomic and epigenetic factors that relate to reduced developmental competence. The knowledge uncovered by this research provides new insights into the mechanisms underlying egg quality and is relevant to the development of techniques to assess the quality of human egg cells, an area of growing importance as the use of fertility treatments increases.

from Top Health News -- ScienceDaily https://ift.tt/38Yr1Pm

The polio vaccines heralded the elimination of polio from the U.S., saving countless children from sudden paralysis and death. In the developing world, however, outbreaks of poliovirus still occur sporadically, an ironic consequence of the polio vaccine itself. A new genetic study of the vaccine poliovirus reveals how this happens in real time.

from Top Health News -- ScienceDaily https://ift.tt/2Kd43K3

An experimental Alzheimer's disease treatment is proving effective at treating some of the most persistent, life-threatening antibiotic-resistant bacteria. Researchers have discovered that the drug called PBT2 is effective at disrupting and killing a class of bacteria - known as Gram-negative bacteria - that cause infections such as pneumonia, bloodstream infections and meningitis.

from Top Health News -- ScienceDaily https://ift.tt/2Hfz6Uu

Similar to genetic mutations, epigenetic changes, i.e. gene modifications that do not occur on the primary DNA sequence, sometimes arise accidentally in plants and can be transmitted across generations. Using trees as a model, researchers have now shown for the first time that these so-called epimutations accumulate continuously throughout plant development, and that they can be employed as a molecular clock to estimate the age of a tree.

from Top Health News -- ScienceDaily https://ift.tt/2ISAzjU

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