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March 2023

Artificial intelligence technologies like ChatGPT are seemingly doing everything these days: writing code, composing music, and even creating images so realistic you'll think they were taken by professional photographers. Add thinking and responding like a human to the conga line of capabilities. A recent study proves that artificial intelligence can respond to complex survey questions just like a real human.

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A newly published literature review sheds light on how nuclear medicine brain imaging can help evaluate the biological changes that cause chemotherapy-related cognitive impairment (CRCI), commonly known as chemo-brain. Armed with this information, patients can understand better the changes in their cognitive status during and after treatment.

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To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team of scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.

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While the donor cells in a bone marrow transplant can help cure the patient's blood cancer, they can also cause graft-versus-host disease -- in which donor T cells, a specialized immune cell in the blood, attack the patient's healthy cells. Before this study, there was no finite T cell population identified as the cause of GVHD. Now, researchers have identified the specific type of T cells that cause GVHD in immunodeficient mice. To further confirm their findings, the researchers directly investigated human patient samples.

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Your circadian rhythm doesn't just govern your sleeping schedule; it can also impact cancer development, diagnosis, and treatment. Researchers discuss the role of circadian rhythms in tumor progression and spread and describe how we could better time when patients are tested for cancer and when they receive therapies to improve diagnostic accuracy and improve treatment success.

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Putting less sugar in sodas and reducing the package size of sodas sold in supermarkets may help reduce our collective sugar intake and thus lower the associated health risks. Good news for consumers, but how does it affect manufacturers? Research conducted in the US has shown that marketing diet or sugar-free varieties does not lead to an increase in the overall turnover of soda manufacturers. This is because consumers tend to switch from sugary to sugar-free versions of the same brand. However, reducing the package size of soda does have a positive effect on the sales figures of the brand as a whole.

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Focus on age, not weight, to capture the greatest number of people in all racial and ethnic groups with prediabetes and diabetes, reports a new study. Screening all adults aged 35 to 70 years, regardless of weight, identifies the greatest proportion of adults with prediabetes and diabetes in the U.S. This approach will also maximize the ability to diagnose prediabetes and diabetes across all racial and ethnic groups, Racial/ethnic minority groups develop diabetes at lower weights than white adults.

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Researchers have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB. If this natural process can be harnessed with new treatments, it could present an alternative to, or improve use of antibiotics, especially where bacteria have become resistant to existing drugs.

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Using artificial intelligence, researchers have discovered how to screen for genetic mutations in cancerous brain tumors in under 90 seconds -- and possibly streamline the diagnosis and treatment of gliomas, a study suggests. The newly developed system, DeepGlioma, identified mutations used by the World Health Organization to define molecular subgroups of diffuse glioma with an average accuracy over 90%.

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Many people who have dieted are familiar with the yo-yo effect: after the diet, the kilos are quickly put back on. Researchers have now shown in mice that communication in the brain changes during a diet: The nerve cells that mediate the feeling of hunger receive stronger signals, so that the mice eat significantly more after the diet and gain weight more quickly. In the long term, these findings could help developing drugs to prevent this amplification and help to maintain a reduced body weight after dieting.

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Continued warming of the climate would see a rise in the number and spread of potentially fatal infections caused by bacteria found along parts of the coast of the United States. Vibrio vulnificus bacteria grow in warm shallow coastal waters and can infect a cut or insect bite during contact with seawater. The researchers predict that by 2041--2060 infections may spread to encompass major population centers around New York. Combined with a growing and increasingly elderly population, who are more susceptible to infection, annual case numbers could double.

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Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products. There is growing evidence that metabolic pathways coupled with external stress factors influence the health of cells and tissues. Many human diseases, including retinal or neurodegenerative diseases, are associated with imbalances in metabolic pathways.

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There is a relative increase of 20% to 30% in breast cancer risk associated with both combined and progesterone-only contraceptives, whatever the mode of delivery, though with five years of use, the 15-year absolute excess incidence is at most 265 cases per 100,000 users, according to a new study.

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Physicists have built a new technology on a microchip by combining two Nobel Prize-winning techniques. This microchip could measure distances in materials at high precision, for example underwater or for medical imaging. Because the technology uses sound vibrations instead of light, it is useful for high-precision position measurements in opaque materials. There's no need for complex feedback loops or for tuning certain parameters to get it to operate properly. This makes it a very simple and low-power technology, that is much easier to miniaturize on a microchip. What makes it special is that it doesn't need any precision hardware and is therefore easy to produce. It only requires inserting a laser, and nothing else. The instrument could lead to new techniques to monitor the Earth's climate and human health.

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New research has debunked the idea that there is an 'obesity paradox', whereby patients with heart failure who are overweight or obese are thought to be less likely to end up in hospital or die than people of normal weight. The study, which is published in the European Heart Journal, shows that if doctors measure the ratio of waist to height of their patients, rather than looking at their body mass index (BMI), the supposed survival advantage for people with a BMI of 25kg/m2 or more disappears.

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Malaria control programs in Amazonian Peru helped reduce the incidence of the deadly parasitic disease by 78 percent. That is, until the programs ceased to operate. Within four years of the programs being de-funded, malaria rates where right back where they started. The rebound was driven not only by the removal of prevention programs, but also by climate change. Average temperatures in Peru have risen a half-degree Centigrade in the last 20 years.

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Shigellosis, a highly contagious diarrheal disease, is caused by Shigella bacteria circulating in industrializing countries but also in industrialized countries. Scientists who have been monitoring Shigella in France for several years have detected the emergence of extensively drug-resistant (XDR) strains of Shigella sonnei.

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Most people who ranked high in 'joy of missing out' or JOMO also reported high levels of social anxiety in a recent study. The term JOMO has been popularized as a healthy enjoyment of solitude in almost direct opposition to the negative FOMO, the 'fear of missing out' people may have when seeing others having fun experiences without them. In an analysis of two samples of adults, researchers found mixed results when it comes to JOMO with evidence that there is some anxiety behind the joy.

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Scientists developing new biomaterials often try to mimic the body's natural proteins, but a chemist shows that simpler polymers -- based on a handful of plastic building blocks -- also work well. Using AI, her team was able to design polymer mixtures that replicate simple protein functions within biological fluids. The random heteropolymers dissolve and stabilize proteins and can support cells' normal protein-making machinery. The technique could speed the design of materials for biomedical applications.

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Gene therapy has been heralded as the new frontier of medicine, but there are still many limitations to current technologies; among them, how to deliver therapeutic genes to specific cells, and only activate them in the right context. A team has created a new RNA-based tool called DART VADAR to bring gene editing out of the 'dark side' of those problems and into the light. Using an engineered form of a naturally occurring enzyme, their sensors can automatically sense the presence of a trigger molecule and initiate the translation of payload genes within cells. The advance broadens the scope of conditions that can be treated with RNA-based therapeutics and enables the development of highly specific treatments for a variety of diseases.

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35-year-old, recruitment consultant, *Gabby has vaped for three years now. While she once vaped alongside other friends on nights out, recently though, due to the increase of judgment around vaping and most of her friends quitting, she has found herself doing it in secret.  Here, she shares her experience with Body + Soul.

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The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell. It also allows the replacement of used cells from a limited number of 'stem' cells, which then proliferate and specialize. In cancer, however, cell proliferation is no longer controlled and becomes chaotic. Researchers have discovered that, in a healthy individual, certain blood immune cells, the monocytes, also have this ability to proliferate, with the aim to replace tissue macrophages, which are essential for the proper functioning of our body.

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The androgen receptor is a key transcriptional factor for the proper sex development -- especially in males -- and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several pathologies and syndromes, such as the spinal and bulbar muscular atrophy or androgen insensitivity syndrome, among others, for which there is no specific treatment. Regarded as the main initial and progression factor in prostate cancer -- the second most common malignant disease in men in industrialized countries -- this receptor has been, for decades, the main therapeutical target for the treatment against this disease.

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Researchers have found that an outbreak of highly pathogenic avian influenza (HPAI) was associated with the deaths of more than 330 New England harbor and gray seals along the North Atlantic coast in June and July 2022, and the outbreak was connected to a wave of avian influenza in birds in the region.

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For a functioning brain to develop from its embryonic beginnings, so much has to happen and go exactly right with exquisite precision, according to a just-so sequence in space and time. It's like starting with a brick that somehow replicates and differentiates into a hundred types of building materials that also replicate, while simultaneously self-assembling into a handsome skyscraper replete with functioning thermal, plumbing, security and electrical systems.

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Learning, remembering something, and recalling memories is supported by multiple separate groups of neurons connected inside and across key regions in the brain. If these neural assemblies fail to sync together at the right time, the memories are lost, a new study has found.

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It may be better to let a mild fever run its course instead of automatically reaching for medication, new University of Alberta research suggests. Researchers found that untreated moderate fever helped fish clear their bodies of infection rapidly, controlled inflammation and repaired damaged tissue. Moderate fever is self-resolving, meaning that the body can both induce it and shut it down naturally without medication. The health advantages of natural fever to humans still have to be confirmed through research, but the researchers say because the mechanisms driving and sustaining fever are shared among animals, it is reasonable to expect similar benefits are going to happen in humans.

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A global maternal immunization program for group B Streptococcus -- strep B -- would save millions in healthcare costs by reducing death and disability, but without tiered pricing, equitable access would likely not be achieved. Several vaccines are currently under development, and an assessment of the impact and value of a global program has now been published.

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We all know how important sleep is for mental health, but a meta-analysis found that getting good shut-eye also helps our immune systems respond to vaccination. The authors found that people who slept less than six hours per night produced significantly fewer antibodies than people who slept seven hours or more, and the deficit was equivalent to two months of antibody waning.

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Scientists successfully quantified the total reactive polysulfide content of 22 different types of vegetables, including onions and garlic. They also revealed that reactive polysulfides are not only found in the leek genus (Allium), such as onions and garlic but also in the cruciferous family of vegetables (Brassicaceae), such as broccoli and cabbage.

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A team of investigators has identified metabolic strategies used by Clostridioides difficile to rapidly colonize the gut. The findings identify methods to better prevent and treat the most common cause of antibiotic-associated diarrhea and healthcare-acquired infections (HAIs). The team's approach has implications for understanding broader aspects of microbial metabolism, including responses to antibiotics, and production of important metabolites.

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The skeleton, tendons, and glands of a functional jaw all derive from the same population of stem cells, which arise from a cell population known as neural crest. To discover how these neural crest-derived cells know to make the right type of cell in the right location, researchers focused on a particular gene, Nr5a2, that was active in a region of the face that makes tendons and glands, but not skeleton. To understand the role of Nr5a2, the scientists created zebrafish lacking this gene. These mutant zebrafish generated excess cartilage and were missing tendons in their jaws.

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Sometimes the best things in life come by chance, when we happen to be in the right place at the right time. Now, researchers have found a way to ensure that new medications are delivered to the right place in the body and at the right point in time during disease progression, so that they have the best effect.

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The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains.

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F-Type ATP synthase, a catalytic complex of proteins, synthesizes adenosine triphosphate (ATP), the energy currency of living cells. A lot of ambiguity exists over the rotational mechanism of this spinning enzyme. Now, researchers from Japan have demonstrated how each chemical event of ATP metabolism is linked to the 'stepwise' rotational movement of the F1 component of ATPase. Especially, they clarified the angle of shaft rotation before ATP-cleavage, a long-standing enigma, to be 200°.

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A new study suggests the rise in mental health disorders in children and teens is attributed to a decline over decades in opportunities for them to play, roam and engage in activities independent of direct oversight and control by adults. Although well intended, adults' drive to guide and protect children has deprived them of the independence they need for mental health, contributing to record levels of anxiety, depression, and suicide among young people.

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A pilot trial tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody. Investigators found evidence that the drug dampened the inflammatory T cell response and decreased lung inflammation in patients with COVID-19. Further analysis showed the same gene expression modulation in patients with multiple sclerosis, who experienced decreased brain inflammation, suggesting that Foralumab could be used to treat other diseases.

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A new global study, which takes a gender-sensitive approach, has found that a mother's educational status plays an increasingly important role in shaping their children's educational status, while the importance of the father's educational status has declined. Education expansion was expected to create greater social mobility around the world, but new global evidence from Lancaster University and the University of British Columbia challenges this assumption and shows how gender really matters.

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In Alzheimer's and related neurodegenerative diseases, the brain protein tau is closely linked to brain damage and cognitive decline. A new study indicates that T cells play a key role in tau-related neurodegeneration, a finding that suggests new treatment strategies for Alzheimer's and related diseases.

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Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer's disease.

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Researchers reveal that cardiomyocytes and skeletal muscle cells replace their existing stock of ribosomes with a different type which can make physical contact with mitochondria, the batteries of the cells, and significantly boost the production of ATP. In the heart, the natural mechanism is triggered in response to myocardial infarction, as well as cardiac hypertrophy. The findings establish ribosomes as a new frontier for therapeutic strategies that prevent or heal damage to the heart.

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Space travel has always tested the human body by the effects of the new conditions of altered gravity on biological systems. It has long been known that continuous exposure to microgravity conditions human physiology and causes effects that compromise muscular, sensory, endocrine and cardiovascular functions. But is it also risky to be exposed to altered gravity for short periods of time?

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The thousands of languages spoken throughout the world draw on many of the same fundamental linguistic abilities and reflect universal aspects of how humans categorize events. Some aspects of language may also be universal to people who create their own sign languages, according to new research.

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People who had higher scores for sleep health -- based on regularity, satisfaction, alertness, timing, efficiency and duration -- during a 12-month weight loss program were more likely to follow the caloric intake and exercise components of the program in comparison to peers who scored lower for sleep health.

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More than 350 former NFL players were studied on average 29 years after their playing careers ended. Retirees who experienced concussion symptoms during their playing careers were found to perform worse on a battery of cognitive tests. When comparing the retired players to more than 5,000 men who did not play football, cognitive performance was generally worse for former players, with older players performing worse.

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Changes in our REM sleep patterns could potentially be used to diagnose the severity of epilepsy, a new study has suggested. Researchers showed that astrocytes -- star-shaped glial cells that control the local ionic and metabotropic environment of the brain -- exhibit an acid response with REM sleep in mice. They theorize that the acid response could be the underlying drive for specific information processing and generating plasticity during sleep.

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Helium -- essential for many medical and industrial processes -- is in critically short supply worldwide. Production is also associated with significant carbon emissions, contributing to climate change. This study provides a new concept in gas field formation to explain why, in rare places, helium accumulates naturally in high concentrations just beneath the Earth's surface. The findings could help locate new reservoirs of carbon-free helium -- and potentially also hydrogen.

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Researchers have identified a new mutation that leads to the cardiac disease arrhythmogenic cardiomyopathy (ACM). They assessed the effect of this mutation on heart muscle cells and obtained new insights into the underlying mechanism that causes the disease. The results of this study could contribute to the development of new treatments for ACM.

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New research in mice shows bacteria hijack communication between nerve and immune cells in the meninges -- the protective layers that shield the brain from infection. The experiments detail step by step how bacteria activate pain receptors and initiate a signaling cascade that disables immune cells and culminates in bacterial invasion of the brain. The findings provide much-needed understanding into a critical window during the early stages of bacterial invasion when intervention could halt the spread of infection. The results point to therapeutic pathways for new treatments of bacterial meningitis, an often-fatal disease that can leave survivors with serious neurologic damage.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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Certain diseases, including Alzheimer's, are currently considered 'undruggable' because traditional small molecule drugs can't interfere with the proteins responsible for the illnesses. But a new technique that specifically targets and breaks apart certain proteins -- rather than just interfering with them -- may offer a pathway toward treatment. Researchers have now designed a compound that targets and breaks down a post-translationally modified protein closely associated with Alzheimer's disease.

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