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November 2022

Antibiotic treatment disrupts the balance of beneficial and harmful bacteria in a person's gut. That disruption can lead to the overgrowth of fungal species in the gut mycobiota, including the common intestinal yeast Candida albicans. However, researchers only have a limited understanding of the underlying mechanisms. Researchers now report on how treatment with a common beta-lactam antibiotic led to significant changes in C. albicans in patients.

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Soon after cholesterol and fat start depositing on the lining of the blood vessels that supply your heart, the smooth muscle cells that give the blood vessels strength and flexibility start to get bigger and multiply. While scientists studying the phenomenon suspect these vascular smooth muscle cells are trying to help, this atypical behavior for these strong cells instead contributes to coronary artery disease, the most common type of heart disease in the United States.

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Past social trauma is encoded by a population of stress/threat-responsive brain cells that become hyperactivated during subsequent interaction with non-threatening social targets. As a consequence, previously rewarding social targets are now perceived as social threats, which promotes generalized social avoidance and impaired social reward processing that can contribute to psychiatric disorders.

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In 2018, researchers developed the 'Hikikomori Questionnaire (HQ-25)' to assess and identify hikikomori, a condition of pathological social withdrawal lasting more than six months. Now, the team has developed a new questionnaire they call HQ-25M in hopes of identifying the condition within just one month. Their initial analysis showed validation of the questionnaire as a possible tool for early detection of hikikomori.

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A new study has identified a less invasive way to treat a subset of head and neck cancers that could potentially change the standard of care for patients. Combining radiation and immunotherapy primes patients for more successful surgeries, better responses to treatment and better quality of life.

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Researchers have shown that astrocytes in the mouse brain exhibit an acid response with intensified epileptic seizures. The astrocytes' acid response could lead to the amplification of excitatory neuronal signals and be the underlying drive for generating plasticity for epileptogenesis.

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A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, new research indicates. The study found that male rats who received the drug ifosfamide during adolescence had offspring and grand-offspring with increased incidence of disease. While other research has shown that cancer treatments can increase patients' chance of developing disease later in life, this is one of the first-known studies showing that susceptibility can be passed down to a third generation of unexposed offspring.

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Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy worldwide. Although symptomatic medications are available, one-third of TLE patients remain unresponsive to current treatment, so new drug targets are critically needed. Neuroscientist have recently identified and developed a new drug candidate that has potential for effectively treating TLE by suppressing neuroinflammation.

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In a step likely to advance personalized cancer treatment, scientists have for the first time shown in patients that levels of biomarkers are not enough to tell which patients are likely to respond best to immunotherapy. Instead, clinicians need to understand how immune cells and tumors are interacting within a patient, rather than simply the levels of each associated proteins present, to prescribe the best treatment.

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According to a new study, fossils of a tiny sea creature with a delicately preserved nervous system solve a century-old debate over how the brain evolved in arthropods, the most species-rich group in the animal kingdom. Combining detailed anatomical studies of the fossilized nervous system with analyses of gene expression patterns in living descendants, they conclude that a shared blueprint of brain organization has been maintained from the Cambrian until today.

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A new study of thousands of people reveals a wide range in the amount of water people consume around the globe and over their lifespans, definitively spilling the oft-repeated idea that eight, 8-ounce glasses meet the human body's daily needs. Differences in environment, body composition and activity level contribute to daily water turnover of as little as 1 liter and as much as 10 liters.

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Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now. Researchers say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses -- from the 2002 SARS-CoV outbreak to Omicron, the current variant of SARS-CoV-2, as well as dangerous variants that may emerge in future.

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In severe epilepsies, surgical intervention is often the only remedy -- usually with great success. While neuropsychological performance can recover in the long term after successful surgery, on rare occasions, unexpected declines in cognitive performance occur. Researchers have now been able to show which patients are at particularly high risk for this.

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Though antiretroviral therapy has made HIV a manageable disease, people living with HIV often suffer from chronic inflammation. This can put them at an increased risk of developing comorbidities such as cardiovascular disease and neurocognitive dysfunction, impacting the longevity and quality of their lives. Now, a new study explains why chronic inflammation may be happening and how suppression or even eradication of HIV in the body may not resolve it.

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A daily cup of tea could help you to enjoy better health late in life -- however if you're not a tea drinker, there are other things you can add to your diet. The key is flavonoids, which are naturally occurring substances found in many common foods and beverages such as black and green tea, apples, nuts, citrus fruit, berries and more.

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Organs in the human body have complex networks of fluid-filled tubes and loops. They come in different shapes and their three-dimensional structures are differently connected to each other, depending on the organ. During the development of an embryo, organs develop their shape and tissue architecture out of a simple group of cells. Due to a lack of concepts and tools, it is challenging to understand how shape and the complex tissue network arise during organ development. Metrics for organ development have now been defined.

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Researchers have developed a new method of protecting organs during heart and aortic surgery when blood circulation has to be blocked. Rather than relying on cold temperatures to induce hypometabolism and reduce the need for oxygen, the technique works by stimulating Q neurons in the brain, which slows metabolism down to a hibernation-like state. The findings could lead to new ways of performing similar surgeries in people.

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Tick-borne pathogens, known for causing illnesses such as Lyme disease, are on the rise in Central Canada -- presenting new risks in areas where they were never previously detected. The findings demonstrate the need for more comprehensive testing and tracking to detect the spread and potential risk of tick-borne pathogens to human and wildlife populations throughout Canada.

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The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To this end, researchers characterized the functional significance of DDX41 in great detail. Their findings reveal that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and overall genomic integrity maintenance. The findings may hold significance in treating hematopoietic malignancies.

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Researchers have shown that patients with acute COVID-19 infection have increased levels of the cytokine IL-26 in their blood. Moreover, high IL-26 levels correlate with an exaggerated inflammatory response that signifies severe cases of the disease. The findings indicate that IL-26 is a potential biomarker for severe COVID-19.

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Don't spank your kids. That's the conventional wisdom that has emerged from decades of research linking corporal punishment to a decline in adolescent health and negative effects on behavior, including an increased risk for anxiety and depression. Now, a new study explores how corporal punishment might impact neural systems to produce those adverse effects.

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Two new studies reveal how bacteria infiltrate tumors and could be helping tumors progress and spread and suggest a link between oral health and cancer, as microbes in the mouth are associated with cancers elsewhere in the body. The two articles focus on an oral bacterium called Fusobacterium nucleatum, which has been linked to colorectal cancer.

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The method by which a baby was delivered is associated with how its immune system will respond to two key childhood vaccines, research suggests. Babies born naturally were found to have higher antibody levels, compared with those born via Caesarian section after receiving their jabs that protect against bacteria that cause lung infections and meningitis. Experts say the findings could help to inform conversations about C-sections between expectant mothers and their doctors, and shape the design of more tailored vaccination programs.

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Leprosy is one of the world's oldest and most persistent diseases but the bacteria that cause it may also have the surprising ability to grow and regenerate a vital organ. Scientists have discovered that parasites associated with leprosy can reprogram cells to increase the size of a liver in adult animals without causing damage, scarring or tumors. The findings suggest the possibility of adapting this natural process to renew aging livers and increase healthspan -- the length of time living disease-free -- in humans.

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Scientists have developed a novel concept of a nose-to-brain system for the clinical application of neuropeptides. They developed a derivative of glucagon-like peptide-2 and found that when administered intranasally, it is efficiently delivered through the trigeminal nerve to the site of action and exhibits antidepressant-like effects. This is the first demonstration in the world that intranasally administered neuropeptides reach the brain (hippocampus and hypothalamus) via neurons.

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Healthier plant-based dietary patterns were associated with better environmental health, while less healthy plant-based dietary patterns, which are higher in foods like refined grains and sugar-sweetened beverages, required more cropland and fertilizer, according to a new study.

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Scientists have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings have promising implications for guiding targeted therapies designed to alter the composition of the blood metabolome to improve human health.

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Countless tiny hairs (cilia) are found on the outer wall of some cells, for example in our lungs or in our brain. When these micrometer-sized hairs coordinate their movement and produce wave-like movements together, they can cause currents on a microscale and thus pump fluid from one place to another. Until now, this could only be studied in large computer simulations. However, more than a few thousand hairs cannot be simulated in this way. Now a continuum theory of micro-hairs has been developed -- a powerful and completely new approach.

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A linguistic analysis of Nazi propaganda suggests that dehumanization of Jews shifted over time, with propaganda after the onset of the Holocaust portraying Jews as having a greater capacity for agency, relative to earlier propaganda focused on disengaging moral concern.

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In Alzheimer's disease, the degeneration of brain cells is linked to formation of toxic protein aggregates and deposits known as amyloid plaques. Similar processes play an important role also in type 2 diabetes. A research team has now developed 'mini-proteins', so-called peptides, which are able to bind the proteins that form amyloids and prevent their aggregation into cytotoxic amyloids.

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A definitive diagnosis of Alzheimer's disease (AD) was once only possible after someone had died, but recent biomarker studies have led to the development of imaging and spinal fluid tests for those still living. However, the tests can only monitor severe disease, differentiating advanced AD from related disorders. Researchers have now identified a biomarker that could help physicians diagnose AD earlier, as a patient transitions into mild cognitive impairment (MCI).

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In the battle of the sexes, women beat men in their ability to recover from kidney injury, but the reasons are not well understood. A study provides some insights: Females, it turns out, have an advantage at the molecular level that protects them from a form of cell death that occurs in injured kidneys. This protection could be exploited as a potential therapeutic.

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Schwannomas are the most common nerve sheath tumor. They can occur in anyone but are also linked to a hereditary condition known as Neurofibromatosis Type II (NF2). With an urgent need for new treatments, an international team of scientists showed that after just 21 days of two experimental drugs being administered, tumor growth can be strongly and significantly reduced.

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Most languages lack a specialized vocabulary to describe smell experiences. People instead use words from other domains, such as 'heavy', 'good' or 'fruity', when talking about smells. But which words are really used and how do they relate to each other? This has been answered for English by researchers by using a fully automatic method that is based on texts from the Internet.

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To find out how different aspects of music influence the body, researchers turned a live electronic music concert into a lab study. By introducing levels of bass over speakers that were too low to hear and monitoring the crowd's movements, scientists found that people danced 11.8 percent more when the very low frequency bass was present.

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Between maintaining a career, carving out time for a social life and raising a family, wellness is often the first thing to slip when life throws you a curveball. But as TV presenter Tara Rushton tells Body+Soul, it doesn’t have to be that way if you add in some self-care wherever you can. Here, Rushton explains how she prioritises her healthy lifestyle – and also makes it a family affair.

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Life on land may have quieted down during the height of the pandemic, but far offshore the Atlantic Ocean was just as active as ever according to a new study. Researchers found that there was no significant change in the continental shelf's underwater soundscape during the year 2020 -- a surprising contrast to earlier reports of quieter coastal waters during that same timeframe.

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Patients with cancer and a weakened immune system who are treated with immunotherapies tend to fare far worse from COVID-19 than those who haven't received such therapies in the three months before their COVID diagnosis, show findings in a new study. Researchers found worse outcomes in both the disease itself as well as the fierce immune response that sometimes accompanies it.

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Schizophrenia patients have fewer connections between nerve cells. This is believed to be caused by genetic risk variants leading to an excessive elimination of nerve cell connections by the immune cells of the brain. Researchers now report that the levels of protein from the relevant risk gene are elevated in first-episode patients and that inflammation further increases the expression of the risk gene.

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Cancer cells have a series of features that allow the immune system to identify and attack them. However, these same cells create an environment that blocks immune cells and protects the tumor. This means that immune cells cannot reach the cancer cells to remove them. The scientific community has been working for years to increase the effectiveness of the immune system against cancer by using vaccines based on dead tumor cells.

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In the 20 years obesity among adults has risen significantly. Data show that one third of U.S. adults 20 years of age and older have obesity. Obesity continues to be a common, serious and costly disease. Scientists discuss the many different theories explaining why obesity continues to increase despite best efforts at controlling weight gain in this environment, including increased availability and marketing of high-calorie and high-glycemic-index foods and drinks, larger food portions, leisure time physical activities being replaced with sedentary activities such as watching television and use of electronic devices, inadequate sleep, and the use of medications that increase weight.

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A new study has revealed men and women experience change while travelling in similar ways. Consumers are increasingly seeking activities that help them achieve new levels of enrichment and since the lift of COVID-19 travel restrictions, they are more conscious of the value they want to gain from their holidays.

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Peering inside common atmospheric particles is providing important clues to their climate and health effects, according to a new study by chemists. Secondary organic aerosol (SOA) particles are ubiquitous in the atmosphere and play an important role in air quality and climate. They can add to air pollution and damage the lungs, as well as help deflect solar radiation or aid cloud formation. Different types of SOA can mix together in a single particle and their environmental impacts are governed by the new particles' physical and chemical properties, particularly the number of phases --or states-- it can exist in. In a new research letter published in the European Geosciences Union's open access journal Atmospheric Chemistry and Physics, an international team of researchers found that particles with two phases can form when different types of SOA mix. The finding could help improve current models that predict SOA climate and health effects.

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In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment. Their target is SAMHD1, a protein which can protect us from viral infections by destroying an essential building block of DNA that viruses and cancer need to replicate.

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