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April 2023

Your native language could impact your musical ability. A global study that compared the melodic and rhythmic abilities of almost half a million people speaking 54 different languages found that tonal speakers are better able to discern between subtly different melodies, while non-tonal speakers are better able to tell whether a rhythm is beating in time with the music.

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What the human genome is lacking compared with the genomes of other primates might have been as crucial to the development of humankind as what has been added during our evolutionary history, according to a new study led by researchers at Yale and the Broad Institute of MIT and Harvard. The new findings, published April 28 in the journal Science, fill an important gap in what is known about historical changes to the human genome.

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Engineers have shown that by using an ingestible capsule that delivers an electrical current to the cells they can stimulate the release of the hormone ghrelin. This approach could prove useful for treating diseases that involve nausea or loss of appetite, such as anorexia or cachexia.

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Scientists carried out an analysis of hundreds of popular song recordings from 1946 to 2020 to determine the lead vocal to accompaniment ratio, or LAR. The study considered the four highest-ranked songs from the Billboard Hot 100 chart for each year and the results show that, contrary to expectations, the LAR for popular music decreased over the decades in question. This means that, relative to their bands, lead singers are getting quieter.

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A new study has shown that overuse of antimicrobials in livestock production can drive the evolution of bacteria more resistant to the first line of the human immune response. Bacteria that had evolved resistance to colistin, an antimicrobial widely used in farming, also showed resistance to compounds that are key components of human and animal immune systems. The results indicate that farmed pigs and chickens could harbour large reservoirs of cross-resistant bacteria, capable of fuelling future epidemics.

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Supply chain networks can be incredibly complex, with multiple manufacturing and distribution points -- and the location of each node in those networks has a significant effect on everything from profitability to product cost to environmental impact. New research shows that efficient mathematical tools serve almost as well as more computationally demanding optimization models for determining the best places to locate elements in a supply chain, and can provide businesses with the relevant information far more quickly.

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New research shows that poor air quality could be causing cognitive problems in babies and toddlers. A new study reveals an association between poor air quality in India and impaired cognition in infants under two. Without action, the negative impact on children's long-term brain development could have consequences for life.

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Researchers have developed a novel and highly efficient method for rapid antibiotic susceptibility testing using optical microscopy. The technique, called Optical Nanomotion Detection, is extremely rapid, single-cell sensitive, label-free, and requires only a basic traditional optical microscope, equipped with a camera or a mobile phone.

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A new observational study has found that RSV infection in the first year of life is associated with a significantly increased risk of asthma in children. The study looks at the effects of RSV infections of all different severities on childhood asthma risk at a population level.

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Problems with the brain's ability to 'prune' itself of unnecessary connections may underlie a wide range of mental health disorders that begin during adolescence, according to research published today. The findings may help explain why people are often affected by more than one mental health disorder, and may in future help identify those at greatest risk.

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Drinking cranberry juice has long been a mythical prevention strategy for women who develop a urinary tract infection -- and new medical evidence shows consuming cranberry products is an effective way to prevent a UTI before it gets started. A global study looking at the benefits of cranberry products has determined cranberry juice, and its supplements, reduce the risk of repeat symptomatic UTIs in women by more than a quarter, in children by more than half, and in people susceptible to UTI following medical interventions by about 53%.

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An international team of researchers lays the foundation to examine how extracellular RNA and its carrier proteins found in bodily fluids function in a healthy as well as a diseased setting, potentially providing a means to accurately implement early detection and monitor disease processes.

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Two doses of an FDA-approved sleeping pill reduced levels of Alzheimer's proteins in a small study of healthy volunteers. The study hints at the potential of sleep medications to slow or stop the progression of Alzheimer's disease, although much more work needs to be done to confirm the viability of such an approach.

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Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.

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Power often boosts an employee's creativity because being powerful liberates the individual from constraints, such as worrying that their ideas will be rejected. However, new research shows that employees who are not in positions of power can become more creative when given time to 'warm up' to a task by engaging in the creative task more than once.

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Research with a unique, perhaps one-of-a-kind individual, shows that you can comprehend and use tactile language and metaphors without relying on previous sensory experiences. These findings challenge notions of embodied cognition that insist that language comprehension and abstract thought require direct memory of such sensations.

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On November 15, 2022, the 8 billionth person on the planet was born. With concerns about food security on the rise, experts are asking: how will we feed everyone? Climate change, natural resource depletion, soil erosion, and fossil fuel use in farming make the task even more challenging. We need to do something differently, but what?  Barath Raghavan, an associate professor of computer science at USC Viterbi, is rethinking traditional farming practices by developing computational tools to help farmers design, develop, and manage sustainable farming methods.  Raghavan, a member of the California Rare Fruit Growers organization, currently grows more than 150 different edible plants in his yard. A decade ago, he started to combine his interests by researching how computing could make agriculture more sustainable.

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Scientists found mitochondria size does not coincide with energy demand in the brain as it ages, potentially causing age-related working memory impairment. Their findings point to mitochondria dysfunction rather than synapse loss as cause for age-related cognitive impairment, illuminating research on aging and age-related illness, like Alzheimer's.

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High levels of the body's own cannabinoid substances protect against developing addiction in individuals previously exposed to childhood maltreatment, according to a new study. The brains of those who had not developed an addiction following childhood maltreatment seem to process emotion-related social signals better.

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A new study has found that older persons with mild cognitive impairment (MCI), a common type of memory loss, were 30% more likely to regain normal cognition if they had taken in positive beliefs about aging from their culture, compared to those who had taken in negative beliefs. Researchers also found that these positive beliefs also enabled participants to recover their cognition up to two years earlier than those with negative age beliefs. This cognitive recovery advantage was found regardless of baseline MCI severity.

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Researchers have found that time-restricted fasting could cause fertility problems. Time-restricted fasting is an eating pattern where people limit their food consumption to certain hours of the day. It's a popular health and fitness trend and people are doing it to lose weight and improve their health. But the new study shows that time-restricted fasting affects reproduction differently in male and female zebrafish. Importantly, some of the negative effects on eggs and sperm quality can be seen after the fish returned to their normal levels of food consumption. The research team say that while the study was conducted in fish, their findings highlight the importance of considering not just the effect of fasting on weight and health, but also on fertility.

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When it comes to height, our fate is sealed along with our growth plates -- cartilage near the ends of bones that hardens as a child develops. New research shows that cells in these plates determine the length and shape of our bones and can hint at our stature. The study identified potential 'height genes' and found that genetic changes affecting cartilage cell maturation may strongly influence adult height.

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Among Indigenous, rural non-industrial populations inhabiting the tropical forests of lowland Bolivia, researchers report, there appears to be an optimal balance between levels of food consumption and exercise that maximizes healthy brain aging and reduces the risk of disease.

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A potential drug successfully treats the severe form of nonalcoholic fatty liver disease in non-human primates -- bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests. Nonalcoholic steatohepatitis (NASH) causes scarring and inflammation in the liver and is estimated to affect up to 6.5% of the global population.

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In adolescents, sedentary time may increase heart size three times more than moderate-to-vigorous physical activity, a recent article concludes. The researchers explored the associations of sedentary time, light physical activity, and moderate-to-vigorous physical activity with cardiac structure and function.

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The exact mechanism of cartilage breakdown in osteoarthritis is unknown, but damage from mechanical stress with insufficient self-repair is believed to be the main culprit. The composition of synovial fluid, or joint lubricant, changes significantly: The concentration and molecular weight of hyaluronic acid tends to decrease. Researchers explore the disease-driven breakdown of hyaluronan and the mechanistic implications of these changes on the lubrication and subsequent wear of joints.

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Babies tumble about with more than 200 previously unknown viral families within their intestines. This large number comes as a surprise to researchers, who closely studied the diapers of 647 Danish babies and made this mapping. These viruses most likely play an important role in protecting children from chronic diseases.

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A new study's finding that urban light pollution may disrupt the winter dormancy period for mosquitoes that transmit West Nile virus could be considered both good news and bad news. The good news is that the disease-carrying pests may not survive the winter if their plans to fatten up are foiled. The bad news is their dormancy period, known as diapause, may simply be delayed -- meaning they're biting humans and animals longer into the fall.

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Gossip influences if people receive advantages whether they work in an office in the U.S. or in India -- or even in a remote village in Africa, a new study found. In a set of experiments, anthropologists found that positive and negative gossip influenced whether participants were willing to give a person a resource, such as a raise or a family heirloom, especially when the gossip was specific to the circumstance.

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Researchers examined the interplay of environmental change and the internal and external conditions governing a venture's founding. For businesses founded in dynamic environments, they found that assembling more functionally diverse founding teams lead to longer survival when facing increasingly uncertain environments, while functionally homogeneous teams -- those with relatively few distinct roles and viewpoints -- do better when environments become more predictable.

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Brain development does not occur uniformly across the brain, but follows a newly identified developmental sequence, according to a new study. Brain regions that support cognitive, social, and emotional functions appear to remain malleable -- or capable of changing, adapting, and remodeling -- longer than other brain regions, rendering youth sensitive to socioeconomic environments through adolescence.

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As teacher shortages continue to worsen across the United States, a new study gives insight into why so many stressed and burnt-out teachers are leaving the profession. The study found teachers who struggle to cope with the stress of their job report far lower job satisfaction compared to teachers who find ways to manage the pressure.

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Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

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Nanocages are tiny artificial containers that can be used to deliver therapeutics to a target destination in the body. But some drug molecules are like gifts that are too big for a standard-sized nanocage 'box'. Now researchers describe how they have built a super-sized nanocage that could be used to deliver larger drug cargoes. They have built a bigger box.

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A brimming inbox on Monday morning sets your head spinning. You take a moment to breathe and your mind clears enough to survey the emails one by one. This calming effect occurs thanks to a newly discovered brain circuit involving a lesser-known type of brain cell, the astrocyte. According to new research, astrocytes tune into and moderate the chatter between overactive neurons.

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People with Alzheimer's disease develop defects in cognitive functions like memory as well as problems with noncognitive functions that can lead to anxiety and depression. Investigators used mice to study a process through which new neurons are generated in adulthood, called adult hippocampus neurogenesis (AHN). The research showed that deep brain stimulation of new neurons helped restore both cognitive and noncognitive functions in mouse models of Alzheimer's disease.

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In a twist on the question, 'Which came first, the chicken or the egg?', scientists have long faced a similar question about how human adenovirus replicates: 'Which comes first, assembly of the viral particle, or packaging of the viral genome?' Now, in a new study, scientists have answered that question, showing that viral proteins use a process called phase separation to coordinate production of viral progeny.

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Humans use mental shortcuts to estimate the likelihood of events and tend to make a logical error called a conjunction fallacy, in which two events occurring simultaneously is thought to be more likely than one occurring alone. This logical error has long been thought unique to humans, but a new study shows that rats make the same mistakes. This could make rats good research models for studying psychopathological conditions characterized by false beliefs or the perception of nonexistent events, like schizophrenia and certain anxiety disorders.

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Women are more likely than men to develop Alzheimer's disease (AD), with women making up two-thirds of the population living with AD. A new study sheds light on the relationship between the risk of Alzheimer's disease and age of menopause and use of hormone therapy (HT).

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An illusion involving a hidden thumb confounds capuchin and squirrel monkeys for the same reason it does humans -- it misdirects expected outcomes of actions they can carry out. However, marmosets have five equidistant digits, and were rarely fooled by the magician. The research adds to evidence that animals struggle to predict movements outside of their own 'biomechanical ability'.

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For more than 50 years, it has been suspected that fat cells constantly remodel the lipids they store. Researchers have now demonstrated this process directly for the first time using culture cells. Among other things, the study shows that the cells quickly eliminate harmful fatty acids. They refine others into molecules that can be used more effectively. In the long term, this turns the components of palm fat into the building blocks of high-quality olive oil, for example.

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The largest-yet analysis of ancient DNA in Africa, which includes the first ancient DNA recovered from members of the medieval Swahili civilization, has now broken the stalemate about the extent to which people from outside Africa contributed to Swahili culture and ancestry.

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New research shows how countries have contributed to global warming through their emissions of key greenhouse gases since 1850 -- marking a new effort to track impacts in a critical decade for climate policy. Involving several members of the team behind the annual Global Carbon Budget, the work builds on published records of historical emissions of carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) -- gases that have made significant contributions to warming -- from the pre-industrial period to 2021.

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Harsh discipline from parents puts young children at greater risk of developing lasting mental health problems, new research shows. A study with over 7,500 children in Ireland found those exposed to 'hostile' parenting at age three were 1.5 times likelier to have 'high risk' mental health symptoms at age nine. Hostile parenting involves frequent harsh treatment: for example, shouting at children regularly, isolating them as a punishment, or unpredictable treatment depending on the parent's mood. While parenting is only one factor influencing mental health, the study recommends that mental health professionals and teachers should be alert to its potential impact.

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Scientists have employed inventive chemistry to produce an injectable biomaterial with significantly improved adhesive strength, stretchability, and toughness. This chemically modified, gelatin-based hydrogel had attractive features, including rapid gelation at room temperature and tunable levels of adhesion. This custom-engineered biomaterial is ideal as a surgical wound sealant, with its controllable adhesion and injectability and its superior adherence to a variety of tissue and organ surfaces.

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Is the eye a window into aging? New research has shown how imaging of the fundus, the blood vessel-rich tissue in the retina, can be used to track human aging, in a way that is noninvasive, less expensive and more accurate than other aging clocks that are currently available. Researchers also did a genome-wide association study (GWAS) to establish the genetic basis for such a clock, which they call eyeAge.

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Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. It has also been reported that vesicles called exosomes produced by these CAFs play an important role in cancer progression. A research group investigated the effect of CAF-derived exosomes on the growth of malignant melanoma cells. They found that CAF-derived exosomes express CD9 and CD63 transmembrane proteins, and that the CD9-positive exosomes may inhibit the growth of malignant melanoma cells.

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In interventions designed to encourage more sustainable and climate-smart behavior, examples of what other people are doing and financial 'carrots' are more important than providing knowledge and facts. This has been shown in an international second-order meta-analysis of more than four hundred primary studies. However, all types of climate mitigation interventions have a relatively small effect on how people behave.

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