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2024

The hormone estrogen regulates binge drinking in females, causing them to 'pregame' -- consume large quantities of alcohol in the first 30 minutes after it's offered, according to a preclinical study. The study establishes -- for what is thought to be the first time -- that circulating estrogen increases binge alcohol consumption in females and contributes to known sex differences in this behavior.

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A study of nearly 10,000 adolescents has identified distinct differences in the brain structures of those who used substances before age 15 compared to those who did not. Many of these structural brain differences appeared to exist in childhood before any substance use, suggesting they may play a role in the risk of substance use initiation later in life, in tandem with genetic, environmental, and other neurological factors.

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Researchers have developed nanodiamond sensors with nitrogen-vacancy (NV) centers, offering exceptional brightness and spin properties for quantum sensing and bioimaging. These nanodiamonds outperform commercial options, requiring 20 times less energy and maintaining quantum states 11 times longer. Enhanced sensitivity to magnetic fields and temperature enables precise applications, including disease detection, battery analysis, and thermal management of electronics, marking a significant advancement in nanotechnology-driven quantum sensing for biological and industrial innovations.

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A choice was made to include each word in this sentence. Every message, even the most mundane, is crafted with a specific frame in mind that impacts how the message is perceived. The study of framing effects is a multidisciplinary line of research that investigates when, how, and why language influences those who receive a message and how it impacts their response.

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Researchers have revealed some of the precise mechanisms by which erroneous cells are recognized, marked for removal, and eliminated via apoptosis in developing zebrafish. Notably, they found that the protein Foxo3 may be a universal marker of cell competition in zebrafish and mice. These findings have important implications for congenital disorders, cancer, and aging, and may lead to novel treatments.

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A new study raises the possibility that jobs that require frequent spatial processing -- such as figuring out a taxi route or the best way to navigate to a hospital -- could lead to lower rates of death from Alzheimer's disease. Researchers investigated this possibility by using national data on the occupations of people who had died to evaluate risk of death from Alzheimer's disease across 443 professions. They found that taxi driving and ambulance driving were associated with a lower rate of death from Alzheimer's disease compared to other professions.

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Detection of nitric oxide (NO) is important for monitoring air quality because the NO released in the combustion of fossil fuels contributes to acid rain and smog. In medicine, NO is an important messenger molecule and serves as a biomarker for asthma. A research team reports a material that can detect NO reversibly, with low power, and with high sensitivity and selectivity: a copper-containing, electrically conducting, two-dimensional metal--organic framework.

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Wildfire smoke has long been known to exacerbate health problems like heart disease, lung conditions, and asthma, but now a new study finds that smoke from these fires can lead to poor health thousands of miles away. Researchers found that medical visits for heart and lung problems rose by nearly 20 percent during six days in June, 2023, when smoke from Western Canadian wildfires drifted across the country, leading to very poor air quality days in Baltimore and the surrounding region.

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A new study of plant-based drinks reveals a common issue: they are lacking in proteins and essential amino acids compared to cow's milk. The explanation lies in their extensive processing, causing chemical reactions that degrade protein quality in the product and, in some cases, produce new substances of concern.

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Researchers have published two studies in which they surveyed readers on their thoughts about AI in journalism. When provided a sample of bylines stating AI was involved in producing news in some way or not at all, readers regularly stated they trusted the credibility of the news less if AI had a role. Even when they didn't understand exactly what AI contributed, they reported less trust and that 'humanness' was an important factor in producing reliable news.

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Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real-world patient data to identify FDA-approved drugs that may be repurposed to target disease-associated microglia in Alzheimer's disease without affecting the healthy type.

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Many recent studies assume that elderly people are at particular risk of dying from extreme heat as the planet warms. A new study of mortality in Mexico turns this assumption on its head: it shows that 75% of heat-related deaths are occurring among people under 35 -- a large percentage of them ages 18 to 35, or the very group that one might expect to be most resistant to heat.

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The U.S. is forecasted to fall in its global rankings below nearly all high-income and some middle-income countries. Drug use disorders, high body mass index, high blood sugar, and high blood pressure are driving mortality and disability higher across the U.S. Future scenarios for health outcomes identify the states that are forecasted to gain ground, face stagnation, or grow worse. Scientific evidence underscores the urgent need to prioritize public health to prevent the economic consequences of sickness, disabilities, and premature mortality in the U.S.

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New research identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. This study tracks both the presence and impact of glyphosate's byproducts in the brain long after exposure ends, showing an array of persistent, damaging effects on brain health. The findings suggest the brain may be much more susceptible to the damaging effects of the herbicide than previously thought. Glyphosate is one of the most pervasive herbicides used in the U.S. and worldwide.

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Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause.

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Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study. The researchers emphasized that lifestyle modifications targeted at reducing this fat could influence the development of Alzheimer's disease.

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The consumption of milk products, eggs and fish has a positive effect on childhood development in Africa. This has been demonstrated in a recent study. The researchers used representative data from five African countries with over 32,000 child observations. If the children had a diet containing animal products, they suffered less from malnutrition and related developmental deficiencies.

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For pregnant women, exposure to fine particulate air pollution (PM2.5) was associated with altered immune responses that can lead to adverse birth outcomes, according to a new study. The study is among the first to examine the relationship between PM2.5 and maternal and fetal health on a single-cell level and highlights the health risk of PM2.5 exposure for pregnant women.

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Researchers have created the smallest walking robot yet. Its mission: to be tiny enough to interact with waves of visible light and still move independently, so that it can maneuver to specific locations -- in a tissue sample, for instance -- to take images and measure forces at the scale of some of the body's smallest structures.

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Each brain is unique, not only in its connections but also in the molecular composition of its neurons, particularly ion channels. Despite their variability, the brain functions reliably -- a paradox known as 'neuronal degeneration' (distinct from pathological degeneration). Researchers used mathematical tools to uncover two distinct mechanisms enabling this robustness. These mechanisms ensure reliable neuromodulation, even with variations in ion channels, offering insights into how the brain adapts its activity to internal and external signals.

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A new study found that a novel mRNA-based therapy that targets a protein called RUNX1 may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR), a disease caused by a traumatic eye injury or surgery like a retinal detachment repair that currently lacks effective treatments other than additional surgical procedures. Since RUNX1 is active in other diseases, the researchers also hope in the future to apply their mRNA technique to treat other retinal conditions like wet age-related macular degeneration and diabetic retinopathy.

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A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report. Dubbed the NanoGripper, the nanorobotic hand also could be programmed to interact with other viruses or to recognize cell surface markers for targeted drug delivery, such as for cancer treatment.

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Colorectal cancer screening is an effective tool for catching the disease early when it's most treatable, yet it is underutilized at federally qualified health centers (FQHC). A new study demonstrated that a targeted intervention that paired mailing at-home colorectal cancer screening kits with coordinated follow-up tripled screening completion rates compared to usual care at FQHCs.

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Engineered proteins are critical industrial and medical applications, ranging from vaccine development to making crops or food proteins more resilient. Scientists can engineer proteins to improve upon nature, but such experiments are time- and labor-intensive. Researchers have developed an AI-based protein design tool known as EVOLVEPro, which is already showing promise for several applications and could be used to help solve other medical challenges.

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Researchers have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to the new study.

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Historical policies shaping educational attainment have enduring benefits for later life memory and risk of dementia, according to a new study. The study compared the differences in years of education based on variations in state schooling mandates with cognitive performance outcomes in residents decades later.

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Salk scientists have tracked the flow of trans fats using mouse models to describe the molecular mechanisms that cause trans fats to promote atherosclerotic cardiovascular disease (ASCVD), explaining how industrially produced trans-unsaturated fatty acids in our food significantly promote ASCVD and encouraging lawmakers to impose regulations on the use of these fats in food. This new insight into the flow of fats through the body points to new therapeutic targets for mitigating diseases like ASCVD, non-alcoholic fatty liver disease, obesity, diabetes, peripheral neuropathy, and neurodegeneration.

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Experts have identified five elements of a brain-based condition that has emerged as a leading cause of vision impairment starting in childhood in the United States and other industrialized nations. Known as cerebral (or cortical) visual impairment (CVI), some estimates suggest that at least 3% of primary school children exhibit CVI-related visual problems, which vary, but may include difficulty visually searching for an object or person or understanding a scene involving complex motion.

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The Wistar Institute and the University of Buea in Cameroon has uncovered the mechanisms for a medicinal plant with anti-HIV potential in Croton oligandrus Pierre & Hutch, a species of African tree that has been used in traditional healing in Cameroon to treat a variety of diseases and conditions including cancers and diabetes.

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New research found confined and isolating environments changed the way people smelled and responded emotionally to certain food aromas. The team in this study compared 44 people's emotional responses and perception of eight food aromas in two environmental scenarios: sitting in reclined chairs that mimic astronauts' posture in microgravity; and then in the confined setting of the International Space Station (ISS), which was simulated for participants with virtual reality goggles. The research builds on previous work by the team and aims to help explain why astronauts report meals taste different in space and struggle to eat their normal nutritional intake over long missions, which has been reported in the news recently.

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When pain signals are passed along the nervous system, proteins called calcium channels play a key role. Researchers have now pinpointed the exact location of a specific calcium channel fine-tuning the strength of pain signals. This knowledge can be used to develop drugs for chronic pain that are more effective and have fewer side effects.

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Researchers have used machine learning and supercomputer simulations to investigate how tiny gold nanoparticles bind to blood proteins. The studies discovered that favorable nanoparticle-protein interactions can be predicted from machine learning models that are trained from atom-scale molecular dynamics simulations. The new methodology opens ways to simulate efficacy of gold nanoparticles as targeted drug delivery systems in precision nanomedicine.

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A randomized, phase 2 clinical trial shows that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months. The finding adds to mounting evidence of the benefits of high-dose, IV vitamin C in treating cancer.

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A new study shows that the past 30 years of globalization have brought fundamental shifts in some aspects of family interaction among Indigenous people in Guatemala. But families have still maintained a unique level of harmony in their interactions.

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Many bacterial-linked illnesses, such as inflammatory bowel disease or colorectal cancer, are associated with an overgrowth of gut bacteria thought to be bad actors. But when researchers used a machine learning algorithm to predict the density of microbes -- called microbial load, from their gut microbiomes, they found that changes in microbial load, rather than the disease, could be a driver behind the presence of disease-associated microbial species.

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Scientists detect a heightened 'threat vigilance' reaction in adolescents after a few hours of isolation, which socializing online doesn't appear to ameliorate. They say the findings might shed light on the link between loneliness and mental health conditions such as anxiety disorders, which are on the rise in young people.

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One of the first studies to investigate the prevalence of unrecognized cognitive impairment among patients seen at Federally Qualified Health Centers, has found that it is ubiquitous, especially among minoritized older adults. These facilities provide primary care and preventive services regardless of ability to pay or health insurance status to more than 30 million patients, including a growing number of older adults.

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Scientists believe individuals of the most recently discovered 'hominin' group (the Denisovans) that interbred with modern day humans passed on some of their genes via multiple, distinct interbreeding events that helped shape early human history. Scientists outline evidence suggesting that several Denisovan populations, who likely had an extensive geographical range from Siberia to Southeast Asia and from Oceania to South America, were adapted to distinct environments. They further outline a number of genes of Denisovan origin that gave modern day humans advantages in their different environments.

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Children too young to know words like 'impossible' and 'improbable' nonetheless understand how possibility works, finds new work with two- and three-year-olds. The findings demonstrate that young children distinguish between improbable and impossible events, and learn significantly better after 'impossible' occurrences.

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Researchers have uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer. These targets were identified through a screen for genetic vulnerabilities in patient-derived cancer stem cells that represent the variability found in tumors.

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Being a scientist has its challenges. Knowing how to communicate your scientific research in a socially responsible manner can be even more difficult. Thankfully, researchers have identified some of the trade-offs and communication strategies that environmental health scientists can use to communicate more effectively.

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Researchers used an electrophysiological computer model of the heart's electrical circuits to examine the effect of the applied voltage field in multiple fibrillation-defibrillation scenarios. They discovered far less energy is needed than is currently used in state-of-the-art defibrillation techniques. The authors applied an adjoint optimization method and discovered adjusting the duration and the smooth variation in time of the voltage supplied by defibrillation devices is a more efficient mechanism that reduces the energy needed to stop fibrillation by three orders of magnitude.

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Researchers employed analysis tools and machine learning algorithms to identify two genes linked to rheumatoid arthritis and osteoporosis that could serve as diagnostic tools and potential targets for treatments. Drawing from a large database of genetic information, they gathered dozens of sequenced genomes from people with rheumatoid arthritis and osteoporosis to look for any similarities, using recently developed computational methods to narrow down their search. They identified genes ATXN2L and MMP14 as significantly associated with the progression of both rheumatoid arthritis and osteoporosis.

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Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis. Now, they have reason to believe it could be true. Scientists have discovered that the diet makes the gut and its microbes produce two factors that attenuated symptoms of MS in mice.

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A concerning increase in global rates of severe invasive infections becoming resistant to key antibiotics has a team of infectious disease researchers studying a recently emerged strain of bacteria called Streptococcus dysgalactiae subspecies equisimilis. These infections range in severity from strep throat to flesh-eating disease.

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Patients with Huntington's disease have a genetic mutation that triggers proteins to misfold and clump together in the brain. These clumps interfere with cell function and eventually lead to cell death. The new treatment leverages peptide-brush polymers, which act as a shield to prevent proteins from binding to one another. In studies in mice, the treatment successfully rescued neurons to reverse symptoms.

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A team has developed a large-scale drug screening technique that can track target molecule behavior within cells. The researchers verified their technique by testing the epidermal growth factor receptor (EGFR), a known target for cancer drugs. Their drug screening resulted in the identification of the known drugs, as well as others that were not previously known to affect EGFR. This new method can potentially help develop new drugs and repurpose existing drugs.

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Scientists have developed a new method of genetic analysis, which extracts more precise data than previously used methods when looking at DNA, and will improve our understanding of the genetic basis of rare and complex diseases. The findings explain a new method of analyzing genetics, which determines the extent to which genes are involved in phenotype formation. The previously used method extracted information using averages from different datasets, meaning that it had limitations in terms of the type of information it could provide, and what scientists could learn from it.

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Medical scientists involved in a large international study have identified new signs of kidney transplant rejection that could lead to more precise diagnosis and treatment for transplant recipients. The research examined more than 16,000 kidney transplant biopsies and found that certain results previously thought to be of questionable significance actually indicate an increased risk of transplant failure.

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Propofol is used in the operating room to induce anesthesia. To maintain anesthesia, a continuous infusion of the agent via a separate syringe pump is the standard procedure for total intravenous anesthesia. However, this is not entirely sustainable: propofol produces about 45 percent of the drug waste in the operating room, and a quarter of the agent remains unused. Researchers have now shown that an alternative method reduces the amount of waste.

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Researchers have developed a miniature soft lithium-ion battery that could be used as a defibrillator to control heart rhythm during surgery. The flexible lithium-ion battery is constructed by assembling biocompatible hydrogel droplets. The state-of-the-art device is the smallest soft lithium-ion battery with the highest energy density. The research opens the way to developing tiny bio-integrated devices, with a range of applications in robotics, biology, and medicine.

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A new analysis shows that political polarization also poses significant health risks -- by obstructing the implementation of legislation and policies aimed at keeping Americans healthy, by discouraging individual action to address health needs, such as getting a flu shot, and by boosting the spread of misinformation that can reduce trust in health professionals.

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Researchers have successfully developed an ultra-sensitive pressure sensor for electronic skin modeled after the nervous system in the human brain. This technology is applicable to future devices, including AI-based digital healthcare devices, and is expected to be utilized across various fields, such as transparent displays and wearable devices, due to its transparency and physical flexibility.

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A new study reveals that setting reminders can eliminate some age-related declines in memory. The findings offer a significant breakthrough in addressing the cognitive challenges faced by older adults, particularly in the context of prospective memory, which is the ability to remember to perform an intended action at the right moment, like taking medication or attending appointments.

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A new paper explains why there needs to be a shift in cannabis policies to a public health approach as opposed to the prevailing, more punitive approach that pushes abstinence instead of public education. With cannabis now legal to some extent in most U.S. states, the authors say the case for such a shift is all the more urgent.

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Workplace bullying poses a serious threat to employees' health and well-being. A study sheds new light on the impact of social relationships on workplace bullying. Focusing on the dynamics of social relationships, the study shows how workplace culture, interaction and social relationships play a role in bullying.

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While artificial intelligence (AI) systems, such as home assistants, search engines or large language models like ChatGPT, may seem nearly omniscient, their outputs are only as good as the data on which they are trained. However, ease of use often leads users to adopt AI systems without understanding what training data was used or who prepared the data, including potential biases in the data or held by trainers. A new study suggests that making this information available could shape appropriate expectations of AI systems and further help users make more informed decisions about whether and how to use these systems.

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SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing viruses. The discovery may point the way to the development of more effective drugs against this and possibly similar, future diseases.

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New research quantified the association between loneliness and dementia by analyzing data from more than 600,000 people around the world. The meta-analysis of 21 longitudinal studies showed that experiencing feelings of loneliness increased the risk of developing dementia by 31%.

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U.S. babies died at a higher rate in the months following the Supreme Court's 2022 Dobbs v. Jackson Women's Health decision, and infant mortality was highest among those born with chromosomal or genetic abnormalities, new research has found. The findings mirror previous research analyzing the experience in Texas after a ban on abortions in early pregnancy and illuminate the consequences of restricting access to abortion care, said researchers who conducted the national analysis.

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How do complex mixtures of chemicals affect our health? New research has shown that chemicals that occur in complex mixtures and in concentration ratios as found in humans act together. Even if the concentrations of the individual substances were each below the effect threshold, the chemicals in the mixture showed a cumulative neurotoxic effect.

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For people with ischemic stroke, treatment with the clot-busting drug tenecteplase is associated with a slightly higher likelihood of an excellent recovery and reduced disability three months later than the drug alteplase, according to a meta-analysis. Researchers found that the likelihood of good recovery was similar between the two treatments.

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Bacteria-based therapies represent an exciting breakthrough in cancer treatment, harnessing their remarkable ability to specifically target and attack tumors. To fully harness the potential of this approach, an efficient and safe method for producing natural anticancer bacteria is needed. Now, researchers from Japan have developed a novel scaffold-based method to culture antitumor bacteria. This method not only enhances the tumor-killing properties and safety of the bacteria but also presents a simple approach for large-scale cultivation.

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A new study suggests that large-scale adoption of electric vehicles (EVs) could lead to significant population-level health benefits. The research team used computer simulations to show that aggressive electrification of the U.S. vehicle fleet, coupled with an ambitious rollout of renewable electricity generation, could result in health benefits worth between US$84 billion and 188 billion by 2050. Even scenarios with less aggressive grid decarbonization mostly predicted health benefits running into the tens of billions of dollars.

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Researchers have developed an innovative approach to epidemic modeling that could transform how scientists and policymakers predict the spread of infectious diseases. The study introduces a new framework that incorporates socioeconomic status (SES) factors -- such as income, education, and ethnicity -- into epidemic models. The study underscores an urgent need for more comprehensive epidemic modeling frameworks as societies continue to grapple with the lingering impacts of COVID-19 and prepare for future pandemics. By expanding beyond the conventional focus on age and context, this new approach opens the door to a more detailed understanding of disease transmission and offers a powerful tool for addressing health inequities.

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Alzheimer's disease may damage the brain in two distinct phases, based on new research using sophisticated brain mapping tools. According to researchers who discovered this new view, the first, early phase happens slowly and silently -- before people experience memory problems -- harming just a few vulnerable cell types. In contrast, the second, late phase causes damage that is more widely destructive and coincides with the appearance of symptoms and the rapid accumulation of plaques, tangles, and other Alzheimer's hallmarks.

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Preeclampsia is a life-threatening pregnancy complication marked by persistent high blood pressure that is even more serious when it occurs early in the first trimester. The exact cause of early-onset preeclampsia is unknown, and it is difficult to predict, prevent and diagnose. Now researchers report on six proteins that could be used as targets to diagnose and treat the condition.

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Medicare could save up to 74% of the money lost from discarded Alzheimer's drug lecanemab by the simple introduction of a new vial size that would reduce the amount of unused medication that is thrown away. As it is, nearly 6% of the medication is discarded, costing Medicare $1,600 per patient per year.

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Results of the first phase of a Ceramide Ring Trial have just been published, representing a significant landmark in the field of lipidomics. This achievement represents a groundbreaking advance in the establishment of ceramide reference values, plasma lipids involved in such as cardiovascular diseases.

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Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression. Their illegal use contributes to nearly half a million deaths worldwide each year. Researchers have discovered a molecule, called nanobody NbE, which binds tightly and durably to the cell receptors that usually bind to opioids, thereby blocking the drugs' activity. Moreover, the scientists were able to create even smaller molecules that retain the same properties, which could prove far more effective than current treatments in mitigating the harmful effects of opioids.

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Smiling during conversations often elevates the experience of knowing someone, but this understanding has been subjective. A new study investigated the reciprocal relationship between people who indulge in smiling during face-to-face conversations. The researchers found that speakers smile more when listeners smile more, particularly in paired individuals of the same biological sex. These findings provide evidence of synchronized smiling behavior, highlighting the influence of facial expressions on interpersonal relationships.

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Just as a musician can train to more sharply distinguish subtle differences in pitch, mammals can improve their ability to interpret hearing, vision, and other senses with practice. This process, which is called perceptual learning, may be enhanced by activating a major nerve that connects the brain to nearly every organ in the body, a new study in mice shows.

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We often only realize how important our sense of smell is when it is no longer there: food is not as tasty as it once was, or we no longer react to dangers such as the smell of smoke. Researchers have investigated the neuronal mechanisms of human odor perception for the first time. Individual nerve cells in the brain recognize odors and react specifically to the smell, the image and the written word of an object, for example a banana. The results of this study close a long-standing knowledge gap between animal and human odor research.

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Doctors have long believed the cancer drug 5-fluorouracil works by damaging the building blocks of DNA, but researchers have now found that in certain cancers, it kills cells by interfering with RNA synthesis. The findings could help researchers design better drug combinations for colon and gastrointestinal cancers.

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Toddlers in the UK obtain nearly half (47%) of their calories from ultra-processed foods (UPFs), and this rises to 59% by the age of seven, according to a new study. The most common UPFs consumed by the toddlers -- who were 21 months when their parents recorded their diets -- were flavored yogurts and wholegrain breakfast cereals, products typically seen as healthy. By the age of seven, the most common UPFs were sweet cereals, white bread and puddings.

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Auditory hallucinations are likely the result of abnormalities in two brain processes: a 'broken' corollary discharge that fails to suppress self-generated sounds, and a 'noisy' efference copy that makes the brain hear these sounds more intensely than it should, according to a new study.

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A new study estimates that thousands of lives could have been saved during the first year of the COVID-19 pandemic if convalescent plasma had been used more broadly, particularly in outpatients at high risk for severe disease and in hospitalized patients during their first few days of admission.

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The genetic confirmation of a suspected diagnosis of 'hereditary colorectal cancer' is of great importance for the medical care of affected families. However, many of the variants identified in the known genes cannot yet be reliably classified in terms of their causal role in tumor formation. Scientists have reassessed the medical relevance of a significant number of unclear variants and thus significantly reduced their number.

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Farming is a notoriously hard profession with long hours spent operating dangerous equipment and performing other arduous tasks. New research finds that indigenous farm employees -- many of whom have legal status in the U.S. after moving from Latin America -- may experience more physical pain on the job than undocumented workers.

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People who have been fully vaccinated against COVID-19 have a significantly lower risk of developing more severe cardiovascular conditions linked to COVID-19 infection, according to a new Swedish study. At the same time, some cardiovascular effects are seen after individual doses of the vaccine.

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With the global population ageing rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue. Scientists have now identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life.

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A new study has revealed that despite the recent pandemic, outbreak detection efforts remain under-resourced in South and Southeast Asia, with only about half the countries reviewed having integrated pathogen genomic surveillance initiatives in their national plans. The study also identifies key priorities to enhance the preparedness of the region against future pandemics.

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Neuronal pathways originating from the orbitofrontal cortex (OFC) of the brain participate in different adaptive behaviors, but which pathways are used for distinct adaptive strategies remains unclear. In a recent study, researchers from Japan conducted behavioral experiments on monkeys whose OFC pathways could be selectively silenced chemically. Findings demonstrate how these independent pathways are linked to experience-based adaptation and knowledge-based adaptation in primates.

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Researchers report significant strides in enhancing early diagnosis of bipolar disorder in adolescents. They demonstrate the efficacy of integrating multimodal MRI with behavioral assessments for greater diagnostic precision. Bipolar disorder is a severe neuropsychiatric condition that often emerges during adolescence and is characterized by extreme mood swings.

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A survey reveals that a significant proportion of UK general practitioners (GPs) are integrating generative AI tools, such as ChatGPT, into their clinical workflows. The results highlight the rapidly growing role of artificial intelligence in healthcare -- a development that has the potential to revolutionize patient care but also raises significant ethical and safety concerns.

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Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins -- without having to synthesize them one by one, researchers report. Using a naturally occurring process, laboratories can harness the existing molecule-building capacities of bacteria to generate vast libraries of potentially therapeutic DNA-protein hybrid molecules.

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Researchers have identified five independent factors that predict cancer patients' response to checkpoint inhibitors (CPIs). The study validates these factors in more than 1,400 patients and diverse types of cancer. These findings provide a framework to interpret biomarkers of response to CPIs and suggest a future pathway to improve personalized cancer medicine.

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West African genetic ancestry was associated with increased prostate cancer among men living in disadvantaged neighborhoods but not among men living in more affluent neighborhoods, according to a new study. The findings suggest that neighborhood environment may play a role in determining how genetic ancestry influences prostate cancer risk.

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In a world where organizing a simple meeting can feel like herding cats, new research reveals just how challenging finding a suitable meeting time becomes as the number of participants grows. The study dives into the mathematical complexities of this common task, offering new insights into why scheduling often feels so impossible.

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Scientists have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using fruit flies, they found that these changes led to stem cell exhaustion, which prevents stem cells from multiplying. The findings provide the first evidence of an independent exhaustion signal and enhance our understanding of how the delicate balance between stem cell exhaustion and proliferation is disrupted in normal aging.

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A research team has developed an analysis pipeline to identify unexploited genes for a given disease against five databases that provide gene-disease associations. They used their pipeline to study oxidative stress and its related disease, Parkinson's disease, as a case study.

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The heavy metal cadmium, which is found in the air, water, food and soil, is known to cause health problems. A new study has examined if thinking and memory skills were associated with cadmium exposure. They found no association when they looked at the group as a whole. However, when looking at Black and white people separately, it found cadmium may be tied to problems with thinking and memory skills in white people. The study found no such association in Black people. The study does not prove that cadmium causes memory problems in white people; it only shows an association.

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New research has uncovered an extraordinary mechanism of cell division in Corynebacterium matruchotii, one of the most common bacteria living in dental plaque. The filamentous bacterium doesn't just divide, it splits into multiple cells at once, a rare process called multiple fission.

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We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges. But what if we could rewind the clock on this age-related decline? A new study offers a tantalizing glimpse into this possibility.

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A UK survey has found huge variation in treatment for ADHD, highlighting the struggle many young adults face once they turn 18. Researchers have warned that the current system is failing many young adults as they transition from children's to adult's services -- suddenly finding themselves unable to access treatment because services do not link up effectively.

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The extensive training and the sacrifices athletes make to compete at the Olympic games take center stage. For Paralympians and high-performance athletes with spinal cord injuries (SCI), assessing chronic pain plays a key role in their training and readiness to compete. However, the source of chronic pain is often misattributed to acute trauma or overuse injuries. While the International Olympic Committee acknowledges pain management data among Paralympians and athletes with disabilities is limited, few studies have been launched investigating this dilemma.

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Diagnostic labels for people experiencing what some consider to be relatively milder forms of mental-ill health may affect how others perceive them for better and worse, according to a new study.

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New research may enable potential solutions to metabolic disease by turning to evolution and to bats. 'Our study reports blood sugar levels that are the highest we have ever seen in nature -- what would be lethal, coma-inducing levels for mammals, but not for bats,' said one of the researchers. 'We are seeing a new trait we didn't know was possible.'

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Neuroscientists have sought to better understand brain function but lacked the capability to observe neuronal activity deep within the brain. Scientists have applied rational molecular engineering to develop photoacoustic probes that can be used deep within brain tissue to label and visualize neurons. This imaging approach expands significantly on what neuroscientists have been able to see with conventional light microscopy, offering the potential to report on deep neuron activity and better understand brain function.

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Scientists have learned that children find it hard to focus on a task, and often take in information that won't help them complete their assignment. But the question is, why? In a new study, researchers found that this 'distributed attention' wasn't because children's brains weren't mature enough to understand the task or pay attention, and it wasn't because they were easily distracted and lacked the control to focus. It now appears that kids distribute their attention broadly either out of simple curiosity or because their working memory isn't developed enough to complete a task without 'over exploring.'

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Researchers discovered that treating pancreatic cancer with a common chemotherapy drug makes immunotherapy more effective. Folinic acid elevates levels of two anti-cancer immune molecules within pancreatic tumors: natural killer T cells and type-I interferons. In mice, this led to a more effective immune response, slower tumor growth, and longer survival.

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New research has uncovered a series of mutations in the SARS-CoV-2 spike protein that enhanced the virus' ability to infect the brains of mice. The findings may help scientists understand its neurological symptoms and the mystery of 'long COVID,' and they could one day even lead to specific treatments to protect and clear the virus from the brain.

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Abdominal pain associated with gallstones does not always subside after the gallbladder is removed (cholecystectomy). Even five years after surgery, one-third of patients still experience persisting abdominal pain. Additionally, some patients who do not undergo a cholecystectomy continue to have pain. These symptoms may be caused not only by the presence of gallstones but also by dyspepsia issues or irritable bowel syndrome.

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A recent study explored one possible cause -- hyperoxia or high concentrations of oxygen given to such patients during surgery -- as opposed to doses more similar to air. The study concluded that hyperoxia increased oxidative stress during surgery, but this effect did not persist after surgery and did not lead to more acute kidney injury.

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Researchers have shown how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies. The research team identified a specific cascade of events that lead to allergies and asthma, opening many new avenues for exploring potential preventions and treatments.

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The study highlights the remarkable resilience of older adults (median age 86) during the COVID-19 pandemic. Disruptions to their routines led many to discover new hobbies like gardening and painting and explore virtual activities such as online yoga. While 51% experienced psychosocial issues such as anxiety and depression, 86% did not see worsening of their medical conditions and supported pandemic precautions. Despite the hardships, including the loss of residents and increased use of antidepressants and telehealth, many found joy and growth in their altered circumstances.

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Detecting diseases early requires the rapid, continuous and convenient monitoring of vital biomarkers. Researchers have now developed a novel sensor that enables the continuous, and real-time detection of solid-state epidermal biomarkers, a new category of health indicators. The team's wearable, stretchable, hydrogel-based sensor overcomes the limitations of current methods that rely on biofluid samples, such as blood, urine and sweat. This makes it a promising alternative for wearable, continuous, and real-time health monitoring, facilitating the early detection of conditions such as cardiovascular diseases and stroke.

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The latest research indicates that 16% to 85% of people recovering from a stroke experience at least one psychosocial symptom, including depression, anxiety, stress, fatigue and/or decreased quality of life. Critical nursing interventions, such as regular mental health screenings, education, symptom management and follow-up care, are key to reducing the negative effects on a patient's mental well-being after a stroke, yet only a small proportion of patients receive treatment.

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As global warming intensifies, people increasingly suffer from extreme heat. For those working in a high-temperature environment indoors or outdoors, keeping thermally comfortable becomes particularly crucial. A team has now developed thermally-insulated and breathable soft robotic clothing that can automatically adapt to changing ambient temperatures, thereby helping to ensure worker safety in hot environments.

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Researchers established a suite of parameters that can be determined using ultrasound to quantitatively measure different physical characteristics of the lung. The researchers also demonstrated that the parameters can be used to accurately diagnose and assess the severity of lung diseases in an animal model.

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An assistant clinical professor developed a specialized dance and movement therapy (DMT) program to meet the unique needs of youth from diverse racial and ethnic backgrounds to foster a sense of community and connection.

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Investigators identified a chemokine/chemokine receptor mismatch for osteosarcoma (i.e., osteosarcomas secrete chemokines for which CAR T cells do not express receptors). The researchers modified CAR T cells targeting the osteosarcoma antigen B7-H3 to express CXCR2 or CXCR6 receptors, which recognize chemokines (CXCL8 or CXCL16) secreted by osteosarcoma.

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Researchers investigated the environmental costs of AI, including energy consumption of AI systems in the medical field, carbon emissions of data centers, and electronic waste issues. Specific solutions to mitigate these environmental impacts were discussed, including the development of energy-efficient AI models, the implementation of green computing, and the use of renewable energy.

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Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy symptoms such as tissue swelling and inflammation. Now, researchers have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils. This surprising discovery sheds new light on how our immune system works, particularly during allergic reactions.

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A new study places the origin of the Imazighen in the Epipaleolithic, more than twenty thousand years ago. The research concludes that the genetic origin of the current Arab population of north Africa is far more recent than previously believed, placing it in the seventh century AD. The team has designed an innovative demographic model that uses artificial intelligence to analyze the complete genomes of the two populations.

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Two of the closest known relatives to SARS-CoV-2 -- a pair of bat coronaviruses discovered by researchers in Laos -- may transmit poorly in people despite being genetically similar to the COVID-19-causing virus, a new study reveals. The findings provide clues as to why some viruses have greater 'pandemic potential' than others and how researchers might go about identifying those that do before they become widespread.

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Researchers have mapped the spatial distribution of around 700 long non-coding RNAs, otherwise known as lncRNAs, in the testes. The team discovered much higher levels of lncRNAs in the testes than had been previously estimated, indicating that lncRNAs may play a more significant role in male reproduction than previously believed.

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'Holiday' or 'vacation', 'to start' or 'to begin', 'my friend's cat' or 'the cat of my friend' -- in our language, there are different ways of expressing the same things and concepts. But can the choice of a particular variant determine whether we prefer to cooperate with certain people rather than with others? A research team investigated this and showed that people are more likely to co-operate with others if they make similar linguistic choices in a conversation. The experiment suggests that the decisive factor is probably the feeling of belonging to the same social group.

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