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August 2023

First-time fathers seem to experience a steeper decline in relationship satisfaction in the first two years post-partum than second-time fathers, who appear to recover lost relationship satisfaction by the time their second child is 14 months old, according to a new study.

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While self-driving vehicles (SDVs) are being hailed as a solution for safer, more efficient roads, new research suggests some are not quite ready to embrace self-driving cars wholeheartedly -- and will need a period of gradual transition before adoption.

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The use of active mechanical circulatory support is growing rapidly around the world. The hope is that these systems will improve survival after the most severe form of acute heart failure, cardiogenic shock. A recent clinical trial has shown that extracorporeal life support (ECLS) does not reduce 30-day mortality after cardiogenic shock. The finding is likely to influence future guidelines.

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Researchers used wireless neural recording and imaging devices to 'listen in' on the hippocampal brain activity of groups of Egyptian fruit bats as they flew freely within a large flight room. The researchers were surprised to find that, in this social setting, the bat's 'place' neurons encoded not only the animal's location, but also information about the presence or absence of other bats, and even the identity of bats in their path.

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Scientists have developed a specially formulated bioink, which contains microparticles engineered for sustained delivery of insulin-like growth factor-1 (IGF-1). This delivery enhances the formation of mature skeletal muscle tissue from muscle precursor cells and facilitates their structural alignment, leading to more efficient regeneration of functional skeletal muscle tissue. This, in turn, can lead to successful therapies for people suffering from muscle loss or injury.

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In response to the low-fat craze of the 1990s, many food companies removed saturated fats from their products, only to replace them with sugars to maintain their palatability. Unfortunately, the resulting products were no healthier than the originals, and the average person today consumes too much saturated fat. Now, a team of researchers has figured out how to remove some saturated fat, sugar and salt from popular American foods while maintaining their tastiness. The trick? Replacing these over-consumed nutrients with a dose of healthy herbs and spices.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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Alcohol use and subsequent handgun carrying were positively associated during adolescence and young adulthood among individuals who grew up in rural areas, similar to findings in urban areas. Reducing alcohol use may be an important strategy to prevent handgun carrying and firearm-related harm among young people in rural areas.

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In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.

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Hours of inactivity during childhood could be setting the stage for heart attacks and strokes later in life, according to new research. The study found that sedentary time accumulated from childhood to young adulthood was associated with heart damage -- even in those with normal weight and blood pressure.

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New Yorkers can apparently breathe a sigh of relief, at least for now. Their exposure to the smoke in June 2023 from Canadian wildfires led to only a slightly higher bump in visits to New York City hospital emergency departments for breathing problems or asthma attacks than what is seen on days when pollen counts are high. However, authors of a new study say other possible health effects, such as possible heart attacks and stroke, still need to be investigated.

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A study in more than 15,000 people has found that physical fitness is linked with a lower likelihood of developing atrial fibrillation and stroke. Atrial fibrillation is the most common heart rhythm disorder, affecting more than 40 million people worldwide. It is estimated that one in three Europeans will develop atrial fibrillation in their lifetime. Patients with the condition have a five-fold higher risk of stroke than their peers. This study examined whether fitness was related to the likelihood of developing atrial fibrillation.

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A research team has developed a new approach that integrates a minimally invasive, painless microneedle platform capable of absorbing the cell-surrounding, biomarker-containing fluid from deeper layers of the skin with an ultra-sensitive, single-molecule detection method (Simoa) that detects often rare, yet relevant biomarkers with higher sensitivity than conventional methods.

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Various medical circumstances, including heart attacks and extreme cases of COVID-19, necessitate the use of anticoagulants, medicines that prevent blood clots. But the most commonly used, heparin, can induce potentially fatal side effects by making the blood clots worse rather than better. This only happens in a minority of patients so effective treatments are not commonly explored. Researchers have now proposed a side effect-free anticoagulating treatment that has so far proved effective in test mice and could be ready for human trials in just a few years.

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New animal research suggests that little-studied brain cells known as astrocytes are major players in controlling sleep need and may someday help humans go without sleep for longer without negative consequences such as mental fatigue and impaired physical health. The study found that activating these cells kept mice awake for hours when they would normally be resting, without making them any sleepier. The researchers said their findings open up the possibility of future interventions that could target astrocytes to mitigate the negative consequences of prolonged wakefulness. which would benefit the productivity, safety, and health of shift workers and others who work long or odd hours.

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Neuroscientists report the first results from experimental tests designed to explore the idea that 'forgetting' might not be a bad thing, and that it may represent a form of learning -- and outline results that support their core idea. Seemingly lost memories can be retrieved and updated by environmental cues, which means this research has implications for a range of diseases such as Alzheimer's.

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Thanks to continuous advances in human stem cell research, studies that make use of embryo models are progressing quickly. This research offers both a scientific and ethical alternative to the use of embryos resulting from fertilized human eggs, and the appropriate ethical guidelines have been developed in parallel with the advances being made. A group of biologists and ethicists suggest additions to the current ethical framework that refine thinking about human embryology using embryo models to maximize benefits to society.

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People who adhere to a Mediterranean lifestyle -- which includes a diet rich in fruits, vegetables, and whole grains; healthy eating habits like limiting added salts and sugars; and habits promoting adequate rest, physical activity, and socialization -- have a lower risk of all-cause and cancer mortality, according to a new study. People who adhered to the lifestyle's emphasis on rest, exercise, and socializing with friends had a lower risk of cardiovascular disease mortality.

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Young vegetables known as microgreens are reputed to be particularly good for health. But are microgreens the superfood they're claimed to be, and how do they compare to mature veggies? Scientists have found that their nutritional profiles differ, as do their effects on gut bacteria. Yet, tests in mice suggest that both microgreen and mature vegetables can limit weight gain.

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In a development that could accelerate the discovery of new diagnostics and treatments, researchers have developed a versatile and low-cost technology for targeted sequencing of full-length RNA molecules. The technology, called TEQUILA-seq, is highly cost-effective compared to commercially available solutions for targeted RNA sequencing and can be adapted for different research and clinical purposes.

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A popular weight loss medication may prevent up to 1.5 million heart attacks and strokes over 10 years, and could result in 43 million fewer obese people. The study estimated a reduction in cardiovascular disease risk of 1.8% (from 10.15% to 8.34%), projecting up to 1.5 million cardiovascular events could be potentially prevented in 10 years.

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One of the biggest obstacles to the uptake of plant-based alternatives to meat is their very dry and astringent feel when they are eaten. Scientists are now revolutionizing the sensation of plant proteins, transforming them from a substance that can be experienced as gloopy and dry to one that is juicy and plump. And the only substance they are adding to the plant proteins is water.

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A breakthrough project mapping brain changes in nearly 1,300 people diagnosed with six different types of mental illness has revealed the extraordinary diversity of brain changes found in people with conditions like major depression and schizophrenia. The study used brain imaging to measure the size, or volume, of over 1000 different brain regions.

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More mock seafood options are needed because of unsustainable fishing and aquaculture practices, which can harm the environment. Now, researchers have a new approach for creating desirable vegan seafood mimics that taste good, while maintaining the healthful profile of real fish. They 3D-printed an ink made from microalgae protein and mung bean protein, and their proof-of-concept calamari rings were air-fried into a snack.

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Patients with localized prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of the condition remain high. Until now, the precise mechanism behind the spread of the tumor has not been fully explained. But an international research team has succeeded in decoding the underlying cellular signal pathway and has carried out research using a common diabetes medication that could provide a new treatment option.

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Researchers have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. The team uncovered differences in the innate immune and regulated proinflammatory responses, the timing and strength of which are associated with disease severity.

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A research team has developed a novel technique to self-assemble a thin layer of amino acids with ordered orientation over a large area that demonstrates high piezoelectric strength, making the manufacturing of biocompatible and biodegradable medical microdevices, such as pacemaker and implantable biosensor, in the near future possible.

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Identification of risk factors for Parkinson's disease (PD) is essential for early diagnosis. Dating back to the 1920s, Parkinson's disease and parkinsonism -- an umbrella term that refers to motor symptoms found in Parkinson's disease and also other conditions -- have long been described in boxers. Repetitive head impacts from tackle football can also have long-term neurological consequences like chronic traumatic encephalopathy (CTE). But research on the association between participation in tackle football and PD is limited.

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Alzheimer's disease, one of the most common neurodegenerative diseases, leads to progressive loss of memory and autonomy. It is characterized by the accumulation of neurotoxic proteins in the brain, namely amyloid plaques and tau tangles. Due to the silent development of pathology over decades, very early diagnosis is of utmost importance to be able to take action as early as possible in the disease process.

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When it comes to college-aged adults who are glued to their smartphones, experts argue over whether texting while walking increases the risk of an accident. Some studies have shown that texting pedestrians are more likely to walk into oncoming traffic, while other studies suggest that young adults have mastered the art of multitasking and are able to text accurately while navigating obstacles. However, few studies have measured how texters respond to unpredictable hazard conditions. By simulating an environment with random slipping threats, researchers report that texting increases the risk of falling in response to walkway hazards.

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Some HIV-1 carriers who have received an early antiretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated. Scientists have now investigated and revealed how neutralizing antibodies, including those described as broadly neutralizing, contribute to virus control. A clinical trial involving the use of broadly neutralizing antibodies should begin in France before the end of 2023.

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A study has shown that prenatal diagnosis, or diagnosis before a baby is born, is associated with earlier surgery for babies with congenital heart defects, the most common birth defects affecting nearly 1% of all live births. The association was demonstrated for critical defects (when heart surgery is required before the infant leaves the hospital) and certain types of noncritical defects, which constitute about 75% of all congenital heart defects.

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The projected cost of caring for millions of individuals who have Alzheimer's disease (AD) worldwide will exceed a $1 trillion in a few years. In addition to the enormous health burden, patients and their caregivers experience financial, physical and psychological strain. A theory regarding repeated drug failure in AD is that patients undergoing experimental therapies are selected too late in the disease process. Therefore, it is important to identify patients at a high risk of progression to AD in early stages of the disease. To help identify persons who could benefit from early interventions, researchers from Boston University have developed a deep learning framework that can stratify individuals with mild cognitive impairment (MCI) based on their risk of advancing to AD.

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The antibiotic cefazolin is an essential drug according to the World Health Organization (WHO). It is usually produced via batch manufacturing, but this multistep process is time-consuming, wasteful and requires very specialized facilities. Now, researchers have manufactured cefazolin using the continuous-flow method. This method is cheaper, quicker, less wasteful and more flexible in terms of how much drug can be produced when it's needed. Improving access to cefazolin is vital for global health and particularly relevant for countries such as Japan, which experienced a shortage in 2019.

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CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study suggests. The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now.

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A population genetics team recently identified the genetic relationship between over 40,000 23andMe users and a population of enslaved and free African Americans that lived in Catoctin Furnace, Maryland between 1776--1850. Over the course of this study, the researchers considered how best to inform descendants and other genetic relatives of their genetic connection to the site.

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From influencing how our body stores fat to how our brain regulates appetite, hundreds of genes, along with environmental factors, collectively determine our weight and body size. Now, researchers add several genes, which appear to affect obesity risk in certain sexes and ages, to that list. The study may shed light on new biological pathways that underlie obesity and highlight how sex and age contribute to health and disease.

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The public funding of science is responsible for many of the biomedical and other scientific breakthroughs on which our lives depend. However, the process through which funding decisions are made, the peer review of grant proposals, has been historically understudied, and current approaches can lead to undesirable outcomes.

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When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study reaped a 226% increase in cognitive capacity compared to the control group. The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia.

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