Health & Fitness

Medieval medicine is undergoing a reputation makeover. New research reveals that far from being stuck in superstition, early Europeans actively explored healing practices based on nature, observation, and practical experience—some of which uncannily echo today’s wellness trends on TikTok.

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Stroke kills millions, but Osaka researchers have unveiled GAI-17, a drug that halts toxic GAPDH clumping, slashes brain damage and paralysis in mice—even when given six hours post-stroke—and shows no major side effects, hinting at a single therapy that could also tackle Alzheimer’s and other tough neurological disorders.

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Obesity-related cancer deaths in the U.S. have tripled in just two decades, with women, older adults, and minority groups most affected. New research presented at ENDO 2025 highlights how obesity—linked to 13 different cancers—is now a major contributor to cancer mortality, especially in underserved and rural populations. Despite the growing awareness of obesity’s broader health impacts, this surge in cancer fatalities reveals an urgent need for targeted public health interventions and equitable access to care.

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Kids who consume artificial and natural sweeteners like aspartame, sucralose, and glycyrrhizin may face an increased risk of early puberty, especially if they carry specific genetic markers. This large-scale Taiwanese study links sweeteners to hormonal changes and gut bacteria imbalances that can speed up puberty, with effects differing between boys and girls. Early onset puberty has been tied to serious health consequences later in life, including emotional stress and metabolic disorders. The findings could reshape dietary recommendations and encourage genetic screening to mitigate long-term risks.

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Postmenopausal women struggling with weight loss may find a powerful solution by combining the diabetes drug tirzepatide with menopause hormone therapy. A Mayo Clinic study revealed that this dual treatment led to significantly greater weight loss than tirzepatide alone. Women using both treatments lost 17% of their body weight on average, compared to 14% in those not using hormone therapy—and nearly half achieved dramatic 20%+ weight loss.

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In a striking new study, the anti-obesity drug tirzepatide, known as Mounjaro and Zepbound, not only triggered significant weight loss in obese mice but also slashed breast cancer tumor growth. The research, presented at ENDO 2025, links body fat reduction to better cancer outcomes, suggesting that these next-generation weight-loss drugs might offer unexpected benefits beyond metabolic health. With traditional dieting often falling short, this dual-action approach could reshape how doctors tackle obesity-related cancers.

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For centuries, we’ve imagined Neanderthals as distant cousins — a separate species that vanished long ago. But thanks to AI-powered genetic research, scientists have revealed a far more entangled history. Modern humans and Neanderthals didn’t just cross paths; they repeatedly interbred, shared genes, and even merged populations over nearly 250,000 years. These revelations suggest that Neanderthals never truly disappeared — they were absorbed. Their legacy lives on in our DNA, reshaping our understanding of what it means to be human.

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A team at Scripps Research has created a microchip that can rapidly reveal how a person's antibodies respond to viruses using only a drop of blood. This game-changing technology, called mEM, condenses a week’s worth of lab work into 90 minutes, offering a powerful tool for tracking immune responses and fast-tracking vaccine development. Unlike earlier methods, it needs far less blood and delivers more detailed insights, even revealing previously undetected antibody targets on viruses like SARS-CoV-2 and influenza.

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Scientists have uncovered DNA from 214 ancient pathogens in prehistoric humans, including the oldest known evidence of plague. The findings show zoonotic diseases began spreading around 6,500 years ago, likely triggered by farming and animal domestication. These ancient infections may still influence us today, and help guide the vaccines of tomorrow.

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What if your brain is the reason some pain feels unbearable? Scientists at the Salk Institute have discovered a hidden brain circuit that gives pain its emotional punch—essentially transforming ordinary discomfort into lasting misery. This breakthrough sheds light on why some people suffer more intensely than others from conditions like fibromyalgia, migraines, and PTSD. By identifying the exact group of neurons that link physical pain to emotional suffering, the researchers may have found a new target for treating chronic pain—without relying on addictive medications.

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Climate change is silently sapping the nutrients from our food. A pioneering study finds that rising CO2 and higher temperatures are not only reshaping how crops grow but are also degrading their nutritional value—especially in vital leafy greens like kale and spinach. This shift could spell trouble for global health, particularly in communities already facing nutritional stress. Researchers warn that while crops may grow faster, they may also become less nourishing, with fewer minerals, proteins, and antioxidants—raising concerns about obesity, weakened immunity, and chronic diseases.

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Losing weight isn’t always winning at health, say experts challenging the long-standing obsession with BMI and dieting. New evidence shows that most people with higher body weight can’t sustain long-term weight loss through lifestyle changes—and the pressure to do so may actually cause harm. From disordered eating to reinforced stigma, the consequences go beyond the physical. A growing movement urges doctors to shift away from the scale and toward personalized, compassionate care that values overall well-being, not just shrinking waistlines.

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UCLA scientists mined millions of electronic health records and uncovered four distinct “roadways” that funnel people toward Alzheimer’s—ranging from mental-health struggles to vascular troubles. Following these breadcrumb trails proved far better at predicting who will develop dementia than single risk factors. The findings hint that spotting—and halting—specific sequences early could rewrite how we prevent the disease.

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Feeling jittery as the week kicks off isn’t just a mood—it leaves a biochemical footprint. Researchers tracked thousands of older adults and found those who dread Mondays carry elevated cortisol in their hair for months, a stress echo that may help explain the well-known Monday heart-attack spike. Even retirees aren’t spared, hinting that society’s calendar, not the workplace alone, wires Monday anxiety deep into the HPA axis and, ultimately, cardiovascular risk.

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People who treat hearing loss with hearing aids or cochlear implants regain rich conversations, escape isolation, and may even protect their brains and lifespans—proof that better hearing translates into fuller living.

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A promising path to fighting COVID and other coronaviruses may have been based on a serious mistake. Scientists had zeroed in on a part of the virus called the NiRAN domain, believed to be a powerful target for new antiviral drugs. But when a Rockefeller team revisited a highly cited 2022 study, they found the evidence didn’t hold up. Key molecules shown in the original virus model were actually missing. Their discovery could help prevent wasted time and resources in the race to develop better treatments—and highlights how even one bad blueprint can throw off years of research.

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Scientists have discovered that the bacteria behind Lyme disease and anaplasmosis have a sneaky way of surviving inside ticks—they hijack the tick’s own cell functions to steal cholesterol they need to grow. By tapping into a built-in protein pathway, the bacteria keep themselves alive until they can infect a new host. The research opens the door to new methods of stopping these diseases before ticks ever get the chance to bite. A new web tool also reveals that this trick might be used by other blood-feeding bugs too.

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Stanford researchers discovered that dialing down an overactive enzyme, LRRK2, can regrow lost cellular “antennae” in key brain cells, restoring vital dopamine communication and neuroprotective signals in a mouse model of genetic Parkinson’s. After three months on the LRRK2-blocking drug MLi-2, damaged circuits revived and early signs of neuronal recovery emerged, hinting that timely treatment could not only halt but reverse disease progression—and perhaps benefit other Parkinson’s forms.

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In a leap toward sustainable desalination, researchers have created a solar-powered sponge-like aerogel that turns seawater into drinkable water using just sunlight and a plastic cover. Unlike previous materials, this new 3D-printed aerogel maintains its efficiency at larger sizes, solving a key scalability issue. In outdoor tests, it produced clean water directly from the ocean without any electricity, pointing to a future of low-cost, energy-free freshwater production.

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Scientists at UC Davis discovered a small genetic difference that could explain why humans are more prone to certain cancers than our primate cousins. The change affects a protein used by immune cells to kill tumors—except in humans, it’s vulnerable to being shut down by an enzyme that tumors release. This flaw may be one reason treatments like CAR-T don’t work as well on solid tumors. The surprising twist? That mutation might have helped our brains grow larger over time. Now, researchers are exploring ways to block the enzyme and give our immune system its power back.

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A sweeping review of more than a century’s research upends the popular notion that left-handers are naturally more creative. Cornell psychologist Daniel Casasanto’s team sifted nearly a thousand studies, ultimately finding no consistent advantage for lefties on standard divergent-thinking tests—and even a slight edge for right-handers in some. The myth appears to thrive on coincidence: left-handedness is rare and so is creative genius, plus lefties’ overrepresentation in art and music gets cherry-picked while other professions are ignored.

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Scientists have achieved an unprecedented look into how the human immune system attacks a transplanted pig kidney, using spatial molecular imaging to map immune activity down to the cellular level. They discovered early signs of rejection within 10 days and pinpointed key immune players—like macrophages—driving the response. Even more exciting: when targeted therapies were applied, the immune assault weakened. As U.S. clinical trials of pig kidney transplants begin, this breakthrough offers hope for overcoming the immune barrier that has long stood in the way of xenotransplantation.

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Scientists have discovered a stealthy mechanism that cytomegalovirus (CMV)—the leading infectious cause of birth defects in the U.S.—uses to infiltrate blood vessel cells while evading immune detection. The virus forms a hidden protein complex that acts like a molecular “backdoor,” allowing it to bypass the immune system’s defenses. This newly identified pathway may explain why vaccine efforts have failed for decades and opens the door to targeted therapies that could finally prevent CMV-linked birth defects in newborns and protect vulnerable patients.

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USC researchers have found a promising new brain scan marker that could better detect Alzheimer’s risk — but only for some. The tau-based benchmark works in Hispanic and White populations when paired with another Alzheimer’s protein, amyloid, but falls short for Black participants, revealing critical gaps in current diagnostics.

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Biological drugs have been a game-changer for people with severe asthma, helping them breathe easier and live more comfortably. But researchers at Karolinska Institutet have uncovered a surprising twist: while these treatments ease symptoms, they may not fully eliminate the immune cells that drive inflammation. In fact, some of these cells actually increase during treatment, suggesting the medication is managing symptoms without targeting the root cause. This could explain why asthma often returns when the drugs are stopped, raising questions about how long-term these treatments should be and whether we're truly solving the underlying problem.

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Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early surge could double as an alarm bell and a target for stop-it-early treatments.

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Researchers in Japan created an AI that can detect fatty liver disease from ordinary chest X-rays—an unexpected and low-cost method that could transform early diagnosis. The model proved highly accurate and may offer a fast, affordable way to flag this silent but serious condition.

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Swap steaks for spinach and you might watch the scale plummet. In a 16-week crossover study, overweight adults who ditched animal products for a low-fat vegan menu saw their bodies become less acidic and dropped an average of 13 pounds—while the Mediterranean diet left weight unchanged. Researchers link the shift to lower “dietary acid load,” a hidden inflammation trigger driven by meat, eggs, and cheese.

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Hot tubs don't just feel great, they may actually outperform saunas when it comes to health perks. A study found that soaking in hot water raises core body temperature more than dry or infrared saunas, triggering stronger heart, blood vessel, and immune responses.

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Caffeine appears to do more than perk you up—it activates AMPK, a key cellular fuel sensor that helps cells cope with stress and energy shortages. This could explain why coffee is linked to better health and longer life.

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Keeping sex on the schedule may be its own menopause medicine: among 900 women aged 40-79, those active in the last three months reported far less dryness, pain, and irritation, while orgasm and overall satisfaction stayed rock-solid despite dips in desire and lubrication. The results hint that intimacy itself can curb genitourinary syndrome of menopause, a cluster of estrogen-related symptoms that erode quality of life.

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Washington University researchers found that raising a molecule called ApoM helps eye cells sweep away harmful cholesterol deposits linked to age-related macular degeneration, potentially preventing vision loss, and the same trick might aid failing hearts too.

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Scientists have uncovered a stealthy tactic used by the SARS-CoV-2 virus: one of its proteins can leap from infected cells to healthy ones, effectively tricking the immune system into attacking the body’s own tissues.

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Recycled plastic pellets can release a hidden mix of over 80 chemicals into water, disrupting hormones and fat metabolism in zebrafish larvae. Researchers warn that unknown and toxic additives make current recycling practices dangerously unpredictable.

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Colistin, a last-resort antibiotic, is losing its power due to rising resistance—and the culprits might be hiding in your seafood dinner. A University of Georgia research team discovered colistin-resistance genes in bacteria found in imported shrimp and scallops from markets in Atlanta. These genes can hop between bacteria via plasmids, potentially turning once-curable infections into deadly threats.

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Fresh concerns have emerged about the platelet studies underpinning the FDA approval of ticagrelor, AstraZeneca's multibillion-dollar heart drug. A new BMJ investigation reveals data discrepancies, missing lab readings, and questions about the integrity of the trial process. Notably, key results reported in a major cardiology journal were inaccurately presented, and some study contributors were omitted or denied involvement. With generics on the horizon, critics say these revelations highlight potential dangers, including severe rebound effects and bleeding risks, that were never properly disclosed.

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A new study is turning heads by challenging the popular belief that seed oils are harmful to health. Researchers analyzed blood markers from nearly 1,900 people and found that higher levels of linoleic acid — an omega-6 fat commonly found in seed oils — were linked to lower inflammation and better cardiometabolic health. The study used direct biomarkers instead of diet surveys, making its findings more robust. These results support a growing body of evidence that seed oils, far from fueling disease, may actually help protect against heart disease and type 2 diabetes.

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USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions.

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Cold sore-causing HSV-1 doesn't just hijack cells it reconfigures the entire architecture of our DNA to aid its invasion. Researchers discovered that it actively reshapes the 3D structure of the human genome within hours of infection, using host enzymes like topoisomerase I to gain access to crucial genetic machinery. Stunningly, blocking this single enzyme shuts the virus down completely.

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Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies. This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases. It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine.

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When faced with a tricky maze task involving hidden information, humans instinctively toggle between two clever mental strategies: simplifying in steps or mentally rewinding. MIT researchers showed that people shift methods based on how reliable their memory is echoed by AI models mimicking the same constraints.

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Coffee might be doing more than fueling your morning routine it could be extending your life. A large-scale study by Tufts University suggests that drinking one to three cups of caffeinated coffee daily is associated with lower overall mortality, particularly from cardiovascular causes. But there s a catch: the benefits drop when sugar and saturated fats like cream are added in excess.

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A new survey shows most Americans wrongly think testicular cancer is an older man's issue, despite it most commonly affecting men aged 20 40. Early detection is key but misconceptions about symptoms and screening remain widespread.

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When we focus, switch tasks, or face tough mental challenges, the brain starts to sync its internal rhythms, especially in the midfrontal region. A new study has found that smarter individuals show more precise and flexible coordination of slow theta waves during key decision-making moments. Using EEG recordings and cognitive testing, researchers discovered that it s not constant brainwave synchronization that matters most, but the brain s ability to dynamically adapt its rhythms like a well-tuned orchestra. This flexible neural harmony seems to be a hidden engine behind attention, reasoning, and intelligence.

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Psilocybin, the active ingredient in magic mushrooms, might just revolutionize how depression and anxiety are treated in cancer patients. In a groundbreaking trial, a single dose combined with therapy significantly reduced emotional suffering, and these effects often lasted over two years. As follow-up studies expand the research to multiple doses and larger samples, scientists are eyeing a possible new standard of care that merges psychedelics with psychological support.

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Rutgers scientists have uncovered a tug-of-war inside the brain between hunger and satiety, revealing two newly mapped neural circuits that battle over when to eat and when to stop. These findings offer an unprecedented glimpse into how hormones and brain signals interact, with implications for fine-tuning today's weight-loss drugs like Ozempic.

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Scientists have discovered that your breathing pattern is as unique as a fingerprint and it may reveal more than just your identity. Using a 24-hour wearable device, researchers achieved nearly 97% accuracy in identifying people based solely on how they breathe through their nose. Even more intriguingly, these respiratory signatures correlated with traits like anxiety levels, sleep cycles, and body mass index. The findings suggest that breathing isn t just a passive process it might actively shape our mental and emotional well-being, opening up the possibility of using breath training for diagnosis and treatment.

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A team of scientists has discovered a direct link between the smell of food and feelings of fullness at least in lean mice. This brain circuit, located in the medial septum and triggered by food odors, helps animals eat less by making them feel satiated even before taking a bite. But intriguingly, obese mice lacked this response, highlighting how excess weight may interfere with this satiety mechanism. The finding could have major implications for how we think about the role of smell in appetite and offer new strategies to combat overeating.

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A scientific team has unlocked a new way to treat serious lung conditions by using specially designed nanoparticles to deliver genetic therapies straight to lung cells. This innovation could transform care for patients with cystic fibrosis or lung cancer. With a powerful combination of gene editing and RNA delivery, the system has already shown promise in animal trials. The streamlined approach not only enhances precision but also avoids harmful side effects, making it a bold leap forward in respiratory medicine.

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Female earwigs may be evolving exaggerated weaponry just like males. A study from Toho University found that female forceps, once assumed to be passive tools, show the same kind of outsized growth linked to sexual selection as the male's iconic pincers. This means that female earwigs might be fighting for mates too specifically for access to non-aggressive males challenging long-standing assumptions in evolutionary biology.

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Sea cucumbers, long known for cleaning the ocean floor, may also harbor a powerful cancer-fighting secret. Scientists discovered a unique sugar in these marine creatures that can block Sulf-2, an enzyme that cancer cells use to spread. Unlike traditional medications, this compound doesn t cause dangerous blood clotting issues and offers a cleaner, potentially more sustainable way to develop carbohydrate-based drugs if scientists can find a way to synthesize it in the lab.

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Scientists in Japan have discovered that a natural compound found in a type of ginger called kencur can throw cancer cells into disarray by disrupting how they generate energy. While healthy cells use oxygen to make energy efficiently, cancer cells often rely on a backup method. This ginger-derived molecule doesn t attack that method directly it shuts down the cells' fat-making machinery instead, which surprisingly causes the cells to ramp up their backup system even more. The finding opens new doors in the fight against cancer, showing how natural substances might help target cancer s hidden energy tricks.

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Creatine is gaining recognition far beyond its roots in athletic performance. Once seen as a gym-only supplement, it's now understood to play a vital role in cellular energy, cognitive function, and healthy aging. From boosting memory and reducing fatigue to preserving muscle mass over time, creatine is emerging as a powerful tool for everyday wellness. Despite persistent myths about bloating or safety risks, a vast body of research shows it's both safe and effective for nearly everyone especially those who don t get enough from diet alone.

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Scientists at Weill Cornell Medicine have developed a new algorithm, the Krakencoder, that merges multiple types of brain imaging data to better understand how the brain s wiring underpins behavior, thought, and recovery after injury. This cutting-edge tool can predict brain function from structure with unprecedented accuracy 20 times better than past models and even estimate traits like age, sex, and cognitive ability.

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A revolutionary STI test developed by UK-based Linear Diagnostics is on track to dramatically reduce the time it takes to detect infections like gonorrhea and chlamydia. Built on ultra-fast EXPAR DNA amplification technology, the platform can deliver lab-accurate results in as little as five minutes, without sending samples to centralized labs.

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Genetic research in Sweden has unveiled three new gene variants that dramatically increase the risk of venous blood clots, sometimes by up to 180%. These discoveries build on existing knowledge of Factor V Leiden and suggest that genetics plays a bigger role than previously thought, especially for clots in the legs that can lead to life-threatening pulmonary embolisms.

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Cannabis use among older Americans has climbed dramatically, with 7% of adults 65 and older now reporting recent use. This rise isn't just in numbers but also in diversity older users today are more likely to be women, college-educated, and higher-income. Researchers suggest legalization and growing social acceptance are contributing factors, especially in states with medical marijuana laws. The trend is especially notable among those with chronic illnesses, raising both opportunities and concerns for medical professionals trying to balance symptom relief with the complexities of aging.

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A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital role in safeguarding the most vulnerable areas of DNA. By forming droplet-like 'bubbles' around damaged DNA within dense regions called heterochromatin, Nup98 safely escorts the damaged segments to repair zones and times the involvement of risky repair proteins. This precise choreography prevents genetic errors that could trigger cancer or speed up aging.

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New research reveals a surprising downside to calorie-cutting diets: a link to higher levels of depressive symptoms, especially in men and those who are overweight. Despite popular beliefs that healthy eating boosts mental wellness, real-life restrictive diets may be nutritionally unbalanced, potentially harming emotional and cognitive health.

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A diabetes drug may soon double as a treatment for liver disease. Dapagliflozin, an SGLT-2 inhibitor typically used for type 2 diabetes, significantly improved liver inflammation and scarring in patients with metabolic dysfunction-associated steatohepatitis (MASH) during a clinical trial in China. Participants on the drug saw better liver outcomes and fewer side effects than those on a placebo. Although more research is needed, especially in diverse populations, this finding hints at a transformative role for existing medications in tackling liver diseases.

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Researchers have synthesized a new compound called infuzide that shows activity against resistant strains of pathogens.

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As psychedelics gain traction as potential treatments for mental health disorders, an international study stands to improve the rigor and reliability of clinical research.

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A team led by Virginia Tech graduate student Samuel Daramola developed a deep learning model called LSTM-SAM that predicts extreme water levels from tropical cyclones more efficiently and accurately, especially in data-scarce coastal regions, to offer a faster, low-cost tool for flood forecasting.

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Parasitic worms that infect humans are not interbreeding with those that infect cattle as previously thought. This is good news for when it comes to controlling schistosomiasis, a disease caused by these worms that affects more than 200 million people globally.

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Long considered a disease brought to the Americas by European colonizers, leprosy may actually have a much older history on the American continent. Scientists reveal that a recently identified second species of bacteria responsible for leprosy, Mycobacterium lepromatosis, has been infecting humans in the Americas for at least 1,000 years, several centuries before the Europeans arrived.

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Researchers find high-fat diets set off metabolic dysfunction in cells, leading to weight gain, but these effects can be reversed by treatment with an antioxidant.

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Researchers compared the whole genome sequence of two genetically distinct lineages of bed bug, and their findings indicate bed bugs may well be the first true urban pest.

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Researchers reveal unprecedented insights into insulin resistance that could pave the way for better treatments and earlier detection of type 2 diabetes.

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Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events. Despite clinicians recommending that many patients with diabetes take statins, nearly one-fifth of them opt to delay treatment. In a new study, researchers found that patients who started statin therapy right away reduced the rate of heart attack and stroke by one third compared to those who chose to delay taking the medication.

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A specific group of nerve cells in the brain stem appears to control how semaglutide affects appetite and weight -- without causing nausea.

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People who have been taking antidepressants for more than two years are substantially more likely to experience withdrawal symptoms compared to short-term users when they come off the medication, finds a new study.

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Keeping a human in the loop significantly enhances emotional engagement during online psychological interviews.

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Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help sustain the inflammatory fibroblasts, which also secrete the growth factor epiregulin, thereby promoting tumor growth. This newly proposed mechanism for tumor growth offers a promising new target for cancer therapies and possibly other conditions linked to inflammation, such as inflammatory bowel disease.

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A study has found that implementing robust air pollution control measures could mean Southeast Asian countries prevent as many as 36,000 ozone-related premature deaths each year by 2050.

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Hydrogen boride (HB) nanosheets can inactivate viruses, bacteria, and fungi within minutes in the dark conditions. By coating surfaces with HB nanosheets, it rapidly inactivates SARS-CoV-2, influenza virus, and other pathogens. The nanosheets work by denaturing microbial proteins, offering a safe, effective, and versatile antimicrobial coating for everyday items.

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Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies.

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Using a novel lab method they developed, researchers have identified nine molecules in the blood that were elevated in teens diagnosed with depression. These molecules also predicted how symptoms might progress over time. The findings of the clinical study could pave the way for earlier detection, before symptoms worsen and become hard to treat.

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A new risk calculator accurately identified participants who had calcium buildup in their heart arteries and those who had a higher future heart attack risk, in an analysis of about 7,000 adults in New York City referred for heart disease screening.

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A new study provides new insight into height differences between adult men and women, demonstrating that Y chromosome genes contribute more to height than their X chromosome counterparts.

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With its fascinating ability to regrow entire limbs and internal organs, the Mexican axolotl is the ideal model for studying regeneration. Scientists have now found a factor that tells cells which part of the arm to regenerate -- and used it to reprogram the identity of cells as they develop. This breakthrough for the regeneration research field has implications for tissue engineering, including in human tissues.

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Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results could pave the way for the development of new therapies against viral diseases.

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Unique Danish longitudinal study with over 136,000 measurements reveals the connection between pubertal development and weight throughout adolescence.

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Researchers have discovered that microscopic structural changes in the aging heart may help prevent irregular heartbeats. The discovery challenges the idea that all age-related heart changes are harmful.

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Small clinical study with obese dieters who had chronic health problems found that eating balanced meals and including craved foods with those meals helped dieters manage cravings, even into the yearlong maintenance phase of the program.

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Controlling blood pressure is not the only way to treat hypertension. A new study identified eight associated risk factors. Each risk factor addressed was associated with a 13% lower risk of premature death. Patients who addressed at least four of these risk factors had no greater risk of an early death than those without high blood pressure.

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Researchers found that consumers tend to overestimate fractional star ratings and underestimate fractional numerals. In either case, the ratings can be misleading, potentially causing a company to unknowingly overpromise and underdeliver -- or sell its own product short.

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A new study suggests that it might be possible to personalize care for people with bipolar disorder, using the results of detailed personality tests. It finds that such tests might help identify people who have certain combinations of personality traits that could raise or lower their risk of repeated depressive episodes or poor functioning in everyday life.

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A study shows a non-opioid pain reliever blocks pain at its source -- calming specific nerve signals that send pain messages to the brain. In mice, the compound SBI-810 eased pain from surgery, bone fractures, and nerve injury without causing sedation or constipation.

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As a group, carriers of recessive disorders are slightly less healthy and have a reduced chance of having offspring. This disadvantage is greatest for carriers of a recessive gene for intellectual disability, and reflected in a shorter school career and increased childlessness, according to new research. Time to rewrite the textbooks?

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New polymer microparticles can be used to deliver vaccines at different times. The work could lead to childhood vaccines given just once, eliminating the need for booster doses.

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That 'aha' moment when you come back to a puzzle and immediately figure it out? Something fascinating is going on in your brain. A new study using functional magnetic resonance imaging shows that these flashes of insight aren't just satisfying -- they create strong memories that can help etch learning into the brain.

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Researchers have revealed insight into why embryos erase a key epigenetic mark during early development, suggesting this may have evolved to help form a placenta.

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Magnetic resonance imaging (MRI) scans of the heart could help to detect a life-threatening heart disease and enable clinicians to better predict which patients are most at risk, according to a new study.

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Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level. This advance could help clinicians identify certain diseases, streamline the process of drug discovery, and give biologists new insights into the effects of protein mutations.

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In many neurodegenerative diseases, proteins misfold and clump together in brain tissue. Scientists developed a new therapy made of peptides and a sugar that naturally occurs in plants. The therapeutic molecules self-assemble into nanofibers, which bond to the neuron-killing proteins. Now trapped, the toxic proteins can no longer enter neurons and instead harmlessly degrade.

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Evidence of a unique T cell may explain why urban children are more prone to allergies than rural children. Differences in the development of the gut microbiome may be an underlying cause.

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People with multiple long-term physical health conditions are at a significantly greater risk of developing depression, a study shows.

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A new study finds that an easily measurable brain wave shift of phase may be a universal marker of unconsciousness under general anesthesia.

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Why does the brain split visual spatial perception between its hemispheres? A new review by neuroscientists examines the advantages and trade-offs, and how the brain ultimately makes vision feel seamless.

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What makes people think an AI system is creative? New research shows that it depends on how much they see of the creative act. The findings have implications for how we research and design creative AI systems, and they also raise fundamental questions about how we perceive creativity in other people.

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New research has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body's immune response in advanced ovarian cancer. The findings offer new insights into immune suppression in ovarian cancer and open promising avenues for future immunotherapy approaches. Over 70% of patients with ovarian cancer are diagnosed at an advanced stage, often presenting with large volumes of ascites. This ascites fluid not only supports the spread of cancer throughout the abdominal cavity but also significantly impairs the body's immune defenses. Understanding how ascites affects the immune system is important for developing better treatments that use the immune system to fight cancer.

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A new study puts the spotlight on the rising burden of ischemic heart disease across Southeast Asia, East Asia and Oceania, and calls for localized, equity-focused interventions in these regions. The researchers identified region-specific, modifiable risk factors that influence the increasing prevalence of ischemic heart disease, such as toxic air pollution in East Asia and ultra-processed dietary dependence in Oceania.

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Your optimal amount of sleep may depend on where you live, new research has found. An analysis of sleep data and health outcomes for nearly 5,000 people in 20 countries revealed that the hours of sleep required for good health varies significantly across different cultures, challenging the common belief that everyone needs the same amount. The study was the first to investigate whether people from countries with shorter sleep durations suffer from worse health, and it found no evidence that this is so.

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Bacterial resistance negates the effect of antibiotics in the treatment of infection. Using mouse models, researchers now show that if antibiotics are administered with an enzyme called endolysin, the combined effect protects against infection by resistant bacteria in all bodily organs -- including the brain, which antibiotics alone have difficulty reaching.

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A study of starlings in Africa shows that they form long-term social bonds similar to human friendships.

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A new study examines the choices healthy research volunteers make when given the opportunity to learn their risk of developing Alzheimer's disease dementia. The researchers found a large discrepancy between the percentage of participants who said they would like to learn their risk if such estimates became available and the percentage who followed through to learn those results when given the actual opportunity.

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Scientists have identified essential genetic code for a method called plasmid curing, which aims to 'displace' antibiotic resistance genes from bacteria.

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A new study suggests that artificial intelligence (AI) could help detect interval breast cancers before they become more advanced and harder to treat.

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Scientists inserted DNA-encoding methylmercury detoxification enzymes into the genome of an abundant human gut bacterium. The engineered bacterium detoxified methylmercury in the gut of mice and dramatically reduced the amount that reached other tissues, such as the brain and liver. Mice given an oral probiotic containing the engineered microbe and fed a diet high in bluefin tuna had much lower methylmercury levels than expected, suggesting that a probiotic might eventually make it safer for people to consume fish. Researchers performed the tests using pregnant mice and found lower levels of methylmercury in both maternal and fetal tissues, and lower signs of mercury toxicity in the fetal brain.

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Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease. The study showed that reliable antiviral predictions can be made even when only a modest amount of experimental data are available.

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What is the secret to happiness? Does happiness come from within, or is it shaped by external influences such as our jobs, health, relationships and material circumstances? A new study shows that happiness can come from either within or from external influences, from both, or neither -- and which is true differs across people.

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Researchers have identified the neural mechanisms in the brain that regulate both positive and negative impressions of a social encounter, as well as how an imbalance between the two could lead to common neuropsychiatric disorders.

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Persistently high blood sugar and insulin resistance significantly increased the risk of worsening functional and structural heart damage during growth from adolescence to young adulthood, a new study shows.

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Protein sources appear to have major effects on both the population and function of the mouse gut microbiome.

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Social singing and dance are often assumed to be hard-wired into the human condition; studies have supported the conclusion that these are common across cultures. But new research from an anthropologist challenges the idea that dance and lullabies are universal among humans. The study draws on 43 years of research with an Indigenous population in Paraguay.

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A brisk walk, a splash of water aerobics, or even a light jog around the block -- if your heart rate goes up then so too will your brain health according to new research.

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Breast cancer deaths among women ages 20-49 declined significantly between 2010 and 2020, according to a new study.

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Scientists believe they have found a way to improve warning systems for vulnerable communities threatened by humid heatwaves, which are on the rise due to climate change and can be damaging and even fatal to human health. The study analysed how patterns of recent rainfall can interact with dry or moist land conditions to influence the risk of extreme humid heat in the global tropics and subtropics.

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A study analyzing data from nationally representative dietary surveys and mortality data from eight countries (Australia, Brazil, Canada, Chile, Colombia, Mexico, United Kingdom, and United States) shows that premature deaths attributable to consumption of ultraprocessed foods (UPFs) increase significantly according to their share in individuals' total energy intake. The new study reinforces the call for global action to reduce UPF consumption, supported by regulatory and fiscal policies that foster healthier environments.

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Scientists have uncovered why vaccines can elicit a stronger immune response if they are administered in the same arm.

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Why do some people do more for the community than others? A new study now shows that personality traits such as extraversion and agreeableness correlate with volunteering and charitable giving.

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A lab develops brain wave decoder that may help in spinal cord injury rehabilitation.

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