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September 2024

People who have been fully vaccinated against COVID-19 have a significantly lower risk of developing more severe cardiovascular conditions linked to COVID-19 infection, according to a new Swedish study. At the same time, some cardiovascular effects are seen after individual doses of the vaccine.

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With the global population ageing rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue. Scientists have now identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life.

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A new study has revealed that despite the recent pandemic, outbreak detection efforts remain under-resourced in South and Southeast Asia, with only about half the countries reviewed having integrated pathogen genomic surveillance initiatives in their national plans. The study also identifies key priorities to enhance the preparedness of the region against future pandemics.

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Neuronal pathways originating from the orbitofrontal cortex (OFC) of the brain participate in different adaptive behaviors, but which pathways are used for distinct adaptive strategies remains unclear. In a recent study, researchers from Japan conducted behavioral experiments on monkeys whose OFC pathways could be selectively silenced chemically. Findings demonstrate how these independent pathways are linked to experience-based adaptation and knowledge-based adaptation in primates.

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Researchers report significant strides in enhancing early diagnosis of bipolar disorder in adolescents. They demonstrate the efficacy of integrating multimodal MRI with behavioral assessments for greater diagnostic precision. Bipolar disorder is a severe neuropsychiatric condition that often emerges during adolescence and is characterized by extreme mood swings.

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A survey reveals that a significant proportion of UK general practitioners (GPs) are integrating generative AI tools, such as ChatGPT, into their clinical workflows. The results highlight the rapidly growing role of artificial intelligence in healthcare -- a development that has the potential to revolutionize patient care but also raises significant ethical and safety concerns.

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Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins -- without having to synthesize them one by one, researchers report. Using a naturally occurring process, laboratories can harness the existing molecule-building capacities of bacteria to generate vast libraries of potentially therapeutic DNA-protein hybrid molecules.

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Researchers have identified five independent factors that predict cancer patients' response to checkpoint inhibitors (CPIs). The study validates these factors in more than 1,400 patients and diverse types of cancer. These findings provide a framework to interpret biomarkers of response to CPIs and suggest a future pathway to improve personalized cancer medicine.

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West African genetic ancestry was associated with increased prostate cancer among men living in disadvantaged neighborhoods but not among men living in more affluent neighborhoods, according to a new study. The findings suggest that neighborhood environment may play a role in determining how genetic ancestry influences prostate cancer risk.

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In a world where organizing a simple meeting can feel like herding cats, new research reveals just how challenging finding a suitable meeting time becomes as the number of participants grows. The study dives into the mathematical complexities of this common task, offering new insights into why scheduling often feels so impossible.

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Scientists have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using fruit flies, they found that these changes led to stem cell exhaustion, which prevents stem cells from multiplying. The findings provide the first evidence of an independent exhaustion signal and enhance our understanding of how the delicate balance between stem cell exhaustion and proliferation is disrupted in normal aging.

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A research team has developed an analysis pipeline to identify unexploited genes for a given disease against five databases that provide gene-disease associations. They used their pipeline to study oxidative stress and its related disease, Parkinson's disease, as a case study.

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The heavy metal cadmium, which is found in the air, water, food and soil, is known to cause health problems. A new study has examined if thinking and memory skills were associated with cadmium exposure. They found no association when they looked at the group as a whole. However, when looking at Black and white people separately, it found cadmium may be tied to problems with thinking and memory skills in white people. The study found no such association in Black people. The study does not prove that cadmium causes memory problems in white people; it only shows an association.

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New research has uncovered an extraordinary mechanism of cell division in Corynebacterium matruchotii, one of the most common bacteria living in dental plaque. The filamentous bacterium doesn't just divide, it splits into multiple cells at once, a rare process called multiple fission.

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We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges. But what if we could rewind the clock on this age-related decline? A new study offers a tantalizing glimpse into this possibility.

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A UK survey has found huge variation in treatment for ADHD, highlighting the struggle many young adults face once they turn 18. Researchers have warned that the current system is failing many young adults as they transition from children's to adult's services -- suddenly finding themselves unable to access treatment because services do not link up effectively.

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