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August 2024

The extensive training and the sacrifices athletes make to compete at the Olympic games take center stage. For Paralympians and high-performance athletes with spinal cord injuries (SCI), assessing chronic pain plays a key role in their training and readiness to compete. However, the source of chronic pain is often misattributed to acute trauma or overuse injuries. While the International Olympic Committee acknowledges pain management data among Paralympians and athletes with disabilities is limited, few studies have been launched investigating this dilemma.

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Diagnostic labels for people experiencing what some consider to be relatively milder forms of mental-ill health may affect how others perceive them for better and worse, according to a new study.

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New research may enable potential solutions to metabolic disease by turning to evolution and to bats. 'Our study reports blood sugar levels that are the highest we have ever seen in nature -- what would be lethal, coma-inducing levels for mammals, but not for bats,' said one of the researchers. 'We are seeing a new trait we didn't know was possible.'

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Neuroscientists have sought to better understand brain function but lacked the capability to observe neuronal activity deep within the brain. Scientists have applied rational molecular engineering to develop photoacoustic probes that can be used deep within brain tissue to label and visualize neurons. This imaging approach expands significantly on what neuroscientists have been able to see with conventional light microscopy, offering the potential to report on deep neuron activity and better understand brain function.

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Scientists have learned that children find it hard to focus on a task, and often take in information that won't help them complete their assignment. But the question is, why? In a new study, researchers found that this 'distributed attention' wasn't because children's brains weren't mature enough to understand the task or pay attention, and it wasn't because they were easily distracted and lacked the control to focus. It now appears that kids distribute their attention broadly either out of simple curiosity or because their working memory isn't developed enough to complete a task without 'over exploring.'

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Researchers discovered that treating pancreatic cancer with a common chemotherapy drug makes immunotherapy more effective. Folinic acid elevates levels of two anti-cancer immune molecules within pancreatic tumors: natural killer T cells and type-I interferons. In mice, this led to a more effective immune response, slower tumor growth, and longer survival.

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New research has uncovered a series of mutations in the SARS-CoV-2 spike protein that enhanced the virus' ability to infect the brains of mice. The findings may help scientists understand its neurological symptoms and the mystery of 'long COVID,' and they could one day even lead to specific treatments to protect and clear the virus from the brain.

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Abdominal pain associated with gallstones does not always subside after the gallbladder is removed (cholecystectomy). Even five years after surgery, one-third of patients still experience persisting abdominal pain. Additionally, some patients who do not undergo a cholecystectomy continue to have pain. These symptoms may be caused not only by the presence of gallstones but also by dyspepsia issues or irritable bowel syndrome.

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A recent study explored one possible cause -- hyperoxia or high concentrations of oxygen given to such patients during surgery -- as opposed to doses more similar to air. The study concluded that hyperoxia increased oxidative stress during surgery, but this effect did not persist after surgery and did not lead to more acute kidney injury.

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Researchers have shown how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies. The research team identified a specific cascade of events that lead to allergies and asthma, opening many new avenues for exploring potential preventions and treatments.

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The study highlights the remarkable resilience of older adults (median age 86) during the COVID-19 pandemic. Disruptions to their routines led many to discover new hobbies like gardening and painting and explore virtual activities such as online yoga. While 51% experienced psychosocial issues such as anxiety and depression, 86% did not see worsening of their medical conditions and supported pandemic precautions. Despite the hardships, including the loss of residents and increased use of antidepressants and telehealth, many found joy and growth in their altered circumstances.

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Detecting diseases early requires the rapid, continuous and convenient monitoring of vital biomarkers. Researchers have now developed a novel sensor that enables the continuous, and real-time detection of solid-state epidermal biomarkers, a new category of health indicators. The team's wearable, stretchable, hydrogel-based sensor overcomes the limitations of current methods that rely on biofluid samples, such as blood, urine and sweat. This makes it a promising alternative for wearable, continuous, and real-time health monitoring, facilitating the early detection of conditions such as cardiovascular diseases and stroke.

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The latest research indicates that 16% to 85% of people recovering from a stroke experience at least one psychosocial symptom, including depression, anxiety, stress, fatigue and/or decreased quality of life. Critical nursing interventions, such as regular mental health screenings, education, symptom management and follow-up care, are key to reducing the negative effects on a patient's mental well-being after a stroke, yet only a small proportion of patients receive treatment.

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As global warming intensifies, people increasingly suffer from extreme heat. For those working in a high-temperature environment indoors or outdoors, keeping thermally comfortable becomes particularly crucial. A team has now developed thermally-insulated and breathable soft robotic clothing that can automatically adapt to changing ambient temperatures, thereby helping to ensure worker safety in hot environments.

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Researchers established a suite of parameters that can be determined using ultrasound to quantitatively measure different physical characteristics of the lung. The researchers also demonstrated that the parameters can be used to accurately diagnose and assess the severity of lung diseases in an animal model.

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An assistant clinical professor developed a specialized dance and movement therapy (DMT) program to meet the unique needs of youth from diverse racial and ethnic backgrounds to foster a sense of community and connection.

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Investigators identified a chemokine/chemokine receptor mismatch for osteosarcoma (i.e., osteosarcomas secrete chemokines for which CAR T cells do not express receptors). The researchers modified CAR T cells targeting the osteosarcoma antigen B7-H3 to express CXCR2 or CXCR6 receptors, which recognize chemokines (CXCL8 or CXCL16) secreted by osteosarcoma.

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Researchers investigated the environmental costs of AI, including energy consumption of AI systems in the medical field, carbon emissions of data centers, and electronic waste issues. Specific solutions to mitigate these environmental impacts were discussed, including the development of energy-efficient AI models, the implementation of green computing, and the use of renewable energy.

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Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy symptoms such as tissue swelling and inflammation. Now, researchers have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils. This surprising discovery sheds new light on how our immune system works, particularly during allergic reactions.

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A new study places the origin of the Imazighen in the Epipaleolithic, more than twenty thousand years ago. The research concludes that the genetic origin of the current Arab population of north Africa is far more recent than previously believed, placing it in the seventh century AD. The team has designed an innovative demographic model that uses artificial intelligence to analyze the complete genomes of the two populations.

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