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May 2023

Researchers suggest a simple tweak to the first meal of the day might help people living with Type 2 diabetes (T2D) better control their blood sugar levels. Switching from a traditional western-style low-fat breakfast, like oatmeal, toast and fruit, to a low-carb meal higher in protein and fat, like eggs with bacon or cheese, can help people with T2D better manage their blood sugar for most of the day.

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Engineers have developed a simple 3D-printed attachment that clips over a smartphone's camera and flash to measure blood pressure at the user's fingertip. The clip works with a custom smartphone app and currently costs about 80 cents to make. Researchers say it could help make regular blood pressure monitoring easy, affordable and accessible to people in resource-poor communities.

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New research has demonstrated that a wearable brain scanner can measure brain function whilst people are standing and walking around. This breakthrough could help better understand and diagnose a range of neurological problems that affect movement, including Parkinson's Disease, stroke and concussion.

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Researchers induced a hibernation-like state in mice by using ultrasound to stimulate the hypothalamus preoptic area in the brain, which helps to regulate body temperature and metabolism. The findings show the first noninvasive and safe method to induce such a state; a similar condition has been previously proposed for spaceflight or for patients with life-threatening health conditions.

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A new study uses data from the Look AHEAD (Action for Health in Diabetes) study, a randomized controlled trial that compared an intensive lifestyle intervention with diabetes support and education in patients diagnosed with type 2 diabetes and overweight or obesity to track the development of cardiovascular disease over time.

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Researchers developed a new cell culture system for expanding human hematopoietic stem cells (HSCs) in the laboratory. The new system's culture medium is free of cytokines and albumin, once believed to be essential components for HSC growth. Using various molecular techniques, the team identified several chemicals that could activate necessary signaling pathways, stimulate cell proliferation, and support long-term HSC expansion. This work may help advance various HSC-related therapeutics in clinical development.

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Analysing up to 100 years' worth of residents' records from various almshouses in England, new research suggests that living in these communities can reduce the negative impact on health and social wellbeing which is commonly experienced by the older population in lower socioeconomic groups, particularly those individuals who are living in isolation.

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Scientists have developed a groundbreaking new technique for engineering biosensors that respond sensitively to specific biomolecules, enhancing cell migration and targeting in cancer treatment. The findings could lead to more precise control over cellular processes for a wide range of therapeutic applications.

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We are quite good at spotting unexpected objects while focused on another activity if they are moving fast, reveals a new study. The findings cast doubt on a long-standing view that our ability to see the unexpected is necessarily impaired when our attention is already directed elsewhere.

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CT scans are better at predicting a middle-aged person's risk for a heart disease, such as a heart attack, than genetics, reports a new study. Conventional measures of risk factor levels include blood pressure and cholesterol. Scientists had hoped genetics could better predict risk than conventional measure, but only when considering CT scan, half the study participants moved into the high-risk group.

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Researchers were able to identify changes in the accessibility (that is, the 'readability') of transposable elements. To do this, the researchers used an approach combining various sets of multiomics data, which characterize and quantify collections of biomolecules in cells or organisms. One was the transcriptome, which consists of all copies of RNA transcribed from DNA in the cell. The other was the epigenome, which is the collection of chemical changes to DNA that modify gene expression. An advantage of this multiomics approach is that they were able to identify families of transposable elements with changes in accessibility, which would have likely been missed by previous approaches.

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Ants' brains are amazingly sophisticated organs that enable them to coordinate complex behavior patterns such as the organization of colonies. Now, researchers have developed a method that allows them to study ants' brain chemistry and gain insights into the insects' neurobiological processes. The findings could help to explain the evolution of social behavior in the animal kingdom, and shed light on the biochemistry of certain hormone systems that have developed similarly in both ants and humans.

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Researchers have shown that within immune structures called the germinal centre, the mislocation of Tfh cells causes reduced capacity to respond well to vaccination with age. The research also identified that Tfh cells have a previously unappreciated role in supporting stromal cell responses to vaccines. The research demonstrates that age-dependent defects in the germinal centre response are reversible. These findings add to our understanding of the mechanisms behind a reduced immune response with age, allowing strategies to be developed to overcome or correct these to ensure the generation of robust immunological memory after vaccination.

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The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.

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As cities are densified at a fast pace, there is now construction very close to roads and thoroughfares. It is already known that noise can have a negative impact on human health, but new research shows that as little as 40 decibels of traffic noise -- the typical level of background noise in an office environment or kitchen -- has a detrimental effect on cognitive performance.

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Drawing on 36 years of data, a new study of 199 baboons in southern Kenya finds that adversity early in life can take years off the lifespan, but strong social bonds with other baboons in adulthood can help get them back. Baboons who formed stronger social bonds -- measured as how often they groomed with their closest friends -- added 2.2 years to their lives, no matter what hardships they faced when they were younger.

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Bacteria can rapidly evolve resistance to antibiotics by adapting special pumps to flush them out of their cells, according to new research. Antimicrobial resistance is a growing problem of global significance. The rise of resistant 'superbugs' threatens our ability to use antimicrobials like antibiotics to treat and prevent the spread of infections caused by microorganisms. It is hoped that the findings will improve how antibiotics are used to help prevent further spread of antimicrobial resistance.

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Much of what is now considered modern medicine originated as folk remedies or traditional, Indigenous practices. These customs are still alive today, and they could help address a variety of conditions. Now, researchers have identified compounds in the leaves of a particular medicinal Labrador tea plant used throughout the First Nations of Nunavik, Canada, and demonstrated that one of them has activity against the parasite responsible for malaria.

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Researchers described the structure of a special type of amyloid beta plaque protein associated with Alzheimer's disease (AD) progression. Scientists showed the small aggregates of the amyloid beta protein could float through the brain tissue fluid, reaching many brain regions and disrupting local neuron functioning. The research also provided evidence that a newly approved AD treatment could neutralize these small, diffusible aggregates.

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One of the basic and crucial embryonic processes to unfold in virtually every living organism is the formation of hollow, tubular structures that go on to form blood vessels or a digestive tract, and through branching and differentiation, complex organs including the heart and kidneys. This study illuminates fundamental design principles of tubulogenesis for all chordates, including mammals.

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A new study found that air pollution from the oil and gas sector in the United States has substantial adverse impacts on air quality, human health, and health costs. The findings show that the pollutants nitrogen oxide (NO2), fine particulate matter (PM2.5) and ozone (O3) from U.S. oil and gas production contributed to 7,500 excess deaths, 410,000 asthma attacks, and 2,200 new cases of childhood asthma across the U.S. in 2016.

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Researchers explore the role of uneven coffee extraction using a simple mathematical model. They split the coffee into two regions to examine whether uneven flow does in fact make weaker espresso. One of the regions in the model system hosted more tightly packed coffee than the other, which caused an initial disparity in flow resistance. The extraction of coffee decreased the flow resistance further. Understanding the origin of uneven extraction and avoiding or preventing it could enable better brews and substantial financial savings by using coffee more efficiently.

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Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.

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Scientists have identified new genetic risk factors for two types of non-Alzheimer's dementia. These findings detail how researchers identified large-scale DNA changes, known as structural variants, by analyzing thousands of DNA samples. The team discovered several structural variants that could be risk factors Lewy body dementia (LBD) and frontotemporal dementia (FTD).

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A new study finds that incoming students who participated in an online belonging exercise completed their first year as full-time college students at a higher rate than their peers, but only when their institution had strong strategies and resources in place to support diverse students' belonging.

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Researchers have developed a zebrafish model that provides new insight into how the brain acquires essential omega-3 fatty acids, including docosahexaenoic acid (DHA) and linolenic acid (ALA), with the potential to improve understanding of lipid transport across the blood-brain barrier and of disruptions in this process that can lead to birth defects or neurological conditions.

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Automation uncovers combinations of amino acids that feed two bacterial species and could tell us much more about the 90% of bacteria that humans have hardly studied. An artificial intelligence system enables robots to conduct autonomous scientific experiments -- as many as 10,000 per day -- potentially driving a drastic leap forward in the pace of discovery in areas from medicine to agriculture to environmental science.

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Proteins that act like air traffic controllers, managing the flow of signals in and out of human cells, have been observed for the first time with unprecedented detail using advanced microscopy techniques. New findings could inform the development of better drugs for pain relief, diabetes or heart failure.

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Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. Researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity.

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Gene-editing therapy aimed at two targets -- HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells -- can effectively eliminate HIV infection, new research shows. The study combines a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.

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Immunotherapy has redefined cancer treatment, but not all patients experience the same benefit when treated. New research in mice identifies how gut bacteria alter the body's response to a common form of cancer immunotherapy. The animals' gut microbiota lowered the expression of two immune molecules, one previously unknown to play a role in cancer. • Using antibodies to block the activity of either molecule, or the interplay between them, enhanced response to cancer immunotherapy. • The findings can inform the design of treatments that boost the efficacy of cancer immunotherapy among patients with suboptimal response.

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Engineers have developed a stretchable ultrasonic array capable of serial, non-invasive, three-dimensional imaging of tissues as deep as four centimeters below the surface of human skin, at a spatial resolution of 0.5 millimeters. This new method provides a non-invasive, longer-term alternative to current methods, with improved penetration depth.

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A new study provides an early glimpse into the role that AI assistants could play in medicine. The research compared written responses from physicians with those from ChatGPT to real-world health questions. A panel of licensed healthcare professionals preferred ChatGPT's responses 79% of the time.

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CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses. A new study reveals a previously unrecognized player in one such system -- a membrane protein that enhances anti-viral defense. According to study authors, the finding upends the idea that CRISPR systems mount their defense only by degrading RNA and DNA in cells.

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