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February 2023

Researchers describe how gut-on-a-chip devices can bridge lab models and human biology. Modeling the microbiome is particularly difficult because of its unique environmental conditions, but through creative design, gut-on-a-chip devices can simulate many of these properties, such as the gut's anaerobic atmosphere, fluid flow, and pulses of contraction/relaxation. Growing intestinal cells in this environment means that they more closely resemble human biology compared to standard laboratory cell cultures.

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Face blindness, a mystifying condition that can trick us into believing we recognize people we've never met or make us fail to recognize those we have, has been previously estimated to affect between 2 and 2.5 percent of people in the world. Now, a new study is providing fresh insights into the disorder, suggesting it may be more common than currently believed.

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While apprehensions about employment and schools dominate headlines, the truth is that the effects of large-scale language models such as ChatGPT will touch virtually every corner of our lives. These new tools raise society-wide concerns about artificial intelligence's role in reinforcing social biases, committing fraud and identity theft, generating fake news, spreading misinformation and more. A team of researchers is seeking to empower tech users to mitigate these risks. The authors demonstrate that people can learn to spot the difference between machine-generated and human-written text.

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Teens and young adults who reduced their social media use by 50% for just a few weeks saw significant improvement in how they felt about both their weight and their overall appearance compared with peers who maintained consistent levels of social media use, according to new research.

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New research finds that overweight populations have a 22% higher mortality risk than those of healthy weight, while obese populations have as much as double the risk. The study counters prevailing wisdom that excess weight impacts mortality only in extreme cases and sheds light on the pitfalls of using Body Mass Index (BMI) to measure health outcomes.

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Previous studies have suggested a possible link between head injury and increased rates of brain tumors but evidence has been limited and often inconclusive. A team has now identified a possible mechanism to explain this link, implicating genetic mutations acting in concert with brain tissue inflammation to change the behavior of cells, making them more likely to become cancerous. Although this study was largely carried out in mice, it suggests that it would be important to explore the relevance of these findings to human gliomas.

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Sensing a hug from each other via the internet may be a possibility in the near future. A research team recently developed a wireless, soft e-skin that can both detect and deliver the sense of touch, and form a touch network allowing one-to-multiuser interaction. It offers great potential for enhancing the immersion of distance touch communication.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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People who regularly use laxatives, a common treatment for constipation, may have more than a 50% increased risk of developing dementia than people who do not use laxatives, according to a new study. Researchers also found people who used only osmotic laxatives, a type of laxative that attracts water to the colon to soften stool, had an even greater risk. Other types of laxatives are bulk-forming, stool-softening, and stimulating. The study does not prove that laxatives cause dementia. It only shows an association.

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Researchers have engineered an electrostatic face mask that can 'self-charge' through the user's breathing and continuously replenish its electrostatic charge as the user wears and breathes through the mask. This significantly increase the filtering performance in prolonged use of the mask for up to 60 hours, compared to four hours for a conventional surgical mask. This also benefits the environment.

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Neuroimaging techniques, like functional magnetic resonance imaging (fMRI), are not able to directly measure neuronal activity. To address this knowledge gap, a team has created a novel experimental platform that is able to optically record local neuronal activity during brain-wide fMRI in rodents.

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Multiple births, a short interval between pregnancies and mothers with a maternal physical or mental health condition are more at risk of having a low birth rate baby. Every year 20 million children are born with a birth weight below 2,500 grams, and considered low birthweight (LBW) babies The study looked to understand the risk factors for LBW so that resources and interventions could be scheduled effectively.

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Ginger has a reputation for stimulating the immune system. New results now support this thesis. In laboratory tests, small amounts of a pungent ginger constituent put white blood cells on heightened alert. The study also shows that this process involves a type of receptor that plays a role in the perception of painful heat stimuli and the sensation of spiciness in food.

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Traditionally, it has been assumed that cultivating food leads to a loss of biodiversity and negative impacts on an ecosystem. A new study defies this assumption, showing that community gardens and urban farms positively affect biodiversity, local ecosystems and the well-being of humans that work in them.

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As anyone who’s worked in an office, a factory, or any other workplace can attest, sometimes bosses play favorites. Whether it’s assigning the most comfortable cubicles or the best parking spots, or deciding whose opinions take precedence during planning sessions, leaders inevitably wind up treating some employees better than others.

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Millions of endurance runners use footwear that has an embedded carbon fiber plate (CFP) in the midsole. While the performance benefits that carbon fiber plate footwear offers have been well documented, little has been published about running injuries related to use of this footwear. In a current opinion piece, authors describe five cases in which runners using carbon fiber plate footwear sustained bone stress injuries.

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When patients receive care after cardiac arrest, doctors can now -- by entering patient data in a web-based app -- find out how thousands of similar patients have fared. Researchers have developed three such systems of decision support for cardiac arrest that may, in the future, make a major difference to doctors' work.

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In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later.

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Viruses use the molecular repertoire of the host cell to replicate. Researchers want to exploit this for the treatment of influenza. The team identified a compound that inhibits the body's own methyltransferase MTr1, thereby limiting the replication of influenza viruses. The compound proved effective in lung tissue preparations and mouse studies and showed synergistic effects with already approved influenza drugs.

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Scientists have demonstrated that personalizing CAR-T cell stimulation during manufacturing can significantly enhance the consistency and potency of the resulting CAR-T cell products. By using artificial antigen-presenting cell mimicking scaffolds (APC-ms), the team was able to fine-tune the levels of T cell stimulation to match the phenotype of T cells obtained from leukemia patients, and significantly enhanced their ex vivo and in vivo tumor-clearing abilities.

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DNA can help to stimulate bone healing in a localized and targeted manner, for example after a complicated fracture or after severe tissue loss following surgery. Scientists have developed a new process in which they coat implant materials with a gene-activated biomaterial that induces stem cells to produce bone tissue.

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Over 600 CTE cases have been published in the literature from multiple international research groups. And of those over 600 cases, 97 percent have confirmed exposure to RHI, primarily through contact and collision sports. CTE has been diagnosed in amateur and professional athletes, including athletes from American, Canadian, and Australian football, rugby union, rugby league, soccer, ice hockey, bull-riding, wrestling, mixed-martial arts, and boxing.

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Researchers have investigated in detail how BPTA syndrome, an extremely rare hereditary condition, arises. A change in the charge of a protein disrupts cellular self-organization, resulting in a developmental disorder. The team also identified hundreds of comparable genetic changes associated with various conditions, such as brain development disorders and predisposition to cancer. This mechanism could be the cause of numerous unexplained diseases and health conditions.

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Characterized by antisocial behaviors and low academic achievement, conduct disorder (CD) impacts an estimated 9.5% of individuals in the United States. Childhood maltreatment is a major risk factor for CD. Past CD studies have identified structural alterations in various brain regions, such as those implicated in emotion processing, learning, and social cognition. A new study has now assessed whether youths with CD who experienced childhood maltreatment differ at the brain level from those with CD without a history of maltreatment.

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A new study demonstrates that a portable electrochemical sensing technology known as eRapid could be an ideal instrument to enable the inexpensive, multiplexed detection of different SARS-CoV-2-directed antibodies at the point-of-care. Researchers showed that specifically engineered eRapid sensors can detect antibodies targeting the virus' so-called nucleocapsid (N) protein from ultra-small samples of blood plasma and dried blood spots with 100% sensitivity and specificity within less than 10 minutes.

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How long people live is less predictable and life expectancy for young people can be as much as 14 years shorter in violent countries, compared to peaceful countries, according to a new study. It reveals a direct link between the uncertainty of living in a violent setting, even for those not directly involved in the violence, and a 'double burden' of shorter and less predictable lives.

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Researchers have used single carbon atom doping to form four chemical bonds in one step. Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression). The team chemically modified an anti-seizure medication in 96% yield, highlighting the work's utility to otherwise synthetically complex aspects of pharmaceutical development. The results of this work could become foundational to drug discovery and development.

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Scientists have identified a previously unknown species of circovirus, provisionally named human circovirus 1 (HCirV-1). Circoviruses are a family of small, highly resistant DNA viruses that were initially identified in 1974 in various animal species, where they can cause respiratory, renal, dermatological and reproductive problems. HCirV-1 is a novel virus that is distant from known animal circoviruses. It was shown to be implicated in damage to the liver of a patient undergoing immunosuppressive treatment.

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Engineers have developed a new way to make sharper, defect-free displays, which could improve augmented and virtual reality devices. Instead of replacing red, green, and blue light-emitting diodes side by side in a horizontal patchwork, the team stacks the diodes to create vertical, multicolored pixels.

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Smart voice assistants are a popular way for people to get quick answers or play their favorite music. That same technology could make the laboratory safer for scientists and technicians who handle potentially infectious samples. Researchers now report a small, voice-activated device that can extract and pretreat bacterial DNA, helping protect those on the front lines of disease outbreaks. The system could also help scientists with disabilities conduct studies more easily.

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