Health & Fitness

This article was previously published October 24, 2019, and has been updated with new information.

Foods have an immense impact on your body and your brain, and eating whole foods as described in my nutrition plan is a good way to simultaneously support your mental and physical health. Avoiding sugar and artificial sweeteners is in my view, based on the evidence, a crucial aspect of preventing and/or treating depression.

Both contribute to chronic inflammation and can wreak havoc with your brain function. Recent research also shows how swapping processed junk food for a healthier diet can significantly improve depression symptoms, which really shouldn't come as a great surprise.

The Sugar Trap

Research¹ published in 2014 linked sweetened beverages — both sugar- and artificially-sweetened — with an increased risk of depression. Those who drank more than four cans or glasses of soda a day had a 30% higher risk of depression compared to those who did not consume sweetened beverages of any kind.

Interestingly, fruit juices were even more hazardous. The same amount of sweetened fruit drinks (four glasses) was associated with a 38% higher risk of depression.

Overall, artificially sweetened so-called "diet" drinks were associated with the highest risks of depression, compared to beverages sweetened with sugar or high-fructose corn syrup. More specifically, compared to those who did not drink sweetened beverages:

• Those who drank primarily diet soda were 31% more likely to suffer with depression, whereas regular soda was associated with a 22% increased risk
• Those who drank primarily diet fruit drinks had a 51% higher risk for depression, while consuming regular fruit drinks was associated with a more modest 8% increased risk
• Drinking primarily diet iced tea was associated with a 25% increased risk for depression, whereas those who drank regular sweetened iced tea actually had a 6% reduced risk

Similarly, other research² found adolescents who had elevated levels of sodium and low levels of potassium in their urine — two factors indicative of a diet high in junk food and processed food — had more frequent symptoms of depression.

According to the authors,³ "Given the substantial brain development that occurs during adolescence, individuals in this developmental period may be particularly vulnerable to the effects of diet on the neural mechanisms underlying emotion regulation and depression."

Why Sugar Takes a Toll on Mental Health

There are at least four potential mechanisms through which refined sugar intake could exert a toxic effect on mental health:

1. Sugar (particularly fructose) and grains contribute to insulin and leptin resistance and impaired signaling, which play a significant role in your mental health
2. Sugar suppresses activity of a key growth hormone called brain derived neurotrophic factor (BDNF), which promotes healthy brain neurons. BDNF levels are critically low in both depression and schizophrenia, which animal models suggest might actually be causative
3. Sugar consumption also triggers a cascade of chemical reactions in your body that promote chronic inflammation. In the long term, inflammation disrupts the normal functioning of your immune system, which is linked to a greater risk of depression⁴
4. Sugar impairs the microbiome and its influence on the modulation of stress response, immune function, neurotransmission and neurogenesis

In 2004, British psychiatric researcher Malcolm Peet published a provocative cross-cultural analysis⁵ of the relationship between diet and mental illness. His primary finding was a strong link between high sugar consumption and the risk of both depression and schizophrenia. According to Peet:

"A higher national dietary intake of refined sugar and dairy products predicted a worse 2-year outcome of schizophrenia. A high national prevalence of depression was predicted by a low dietary intake of fish and seafood.

The dietary predictors of ... prevalence of depression are similar to those that predict illnesses such as coronary heart disease and diabetes, which are more common in people with mental health problems and in which nutritional approaches are widely recommended."

One of the key predictors of heart disease and diabetes is in fact chronic inflammation which, as Peet mentions, is also associated with poor mental health. Sugar is a primary driver of chronic inflammation in your body, so consuming excessive amounts of sugar can truly set off an avalanche of negative health events — both mental and physical.

Three-Week Dietary Intervention Lifts Depression

More recently, a study^6,7,8 published in the October 2019 issue of PLOS ONE said to be the first of its kind, found dietary intervention can effectively treat depression in young adults. The researchers enrolled 101 individuals aged 17 to 35, whose stress and depression scores indicated moderate to high levels of depression.

Participants were divided into two groups. One received dietary intervention while the other (controls) received no intervention. Dietary instructions were provided to the treatment group by a registered dietician via a 13-minute video, which could be revisited at will.

The dietary recommendations were based on the 2003 Australian Guide to Healthy Eating protocol "with additional recommendations to increase concordance with Mediterranean-style diets … and diet components (e.g., omega-3 fatty acids, cinnamon, turmeric) that have beneficial effects on neurological function."⁹ More specifically, the treatment group was instructed to eat:

Five servings of vegetables per day

Two to three servings of fruit per day

Three servings of wholegrain cereal per day

Three servings of protein (such as lean meat, poultry, eggs or legumes) per day

Three servings of unsweetened dairy per day

Three servings of fish per week

3 tablespoons of nuts and seeds per day

2 tablespoons of olive oil per day

1 teaspoon of turmeric and cinnamon on most days

Refined carbohydrates, sugar, processed meats and soft drinks were to be avoided as much as possible. According to the authors:¹⁰

"There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced risk of depression …

There was good compliance with the diet intervention recommendations assessed using self-report and spectrophotometry. The Diet group had significantly lower self-reported depression symptoms than the Control Group …

Reduced DASS-21 depression subscale scores were maintained on follow up phone call 3 months later. These results are the first to show that young adults with elevated depression symptoms can engage in and adhere to a diet intervention, and that this can reduce symptoms of depression."

Dietary Intervention Significantly Lowers Depression Scores

The first graph below illustrates the difference in primary depression scores (based on Centre for Epidemiological Studies Depression Scale or CESD-R) between the two groups. The second graph illustrates the difference between the two groups based on DASS-21 depression subscale scores.

The researchers also report that the dietary intervention resulted in lower levels of anger. In the Discussion section of the paper, the authors make the following observations:¹³

"The results of this RCT provide support for improving diet as a useful adjunct treatment to reduce depressive symptoms … One of the most interesting findings is the fact that diet change was feasible in this population.

As the participants were young adults and university undergraduate students, we anticipated several potential barriers such as the perceived cost of the diet, the time demands of preparing food and/or reliance on others for food preparation (particularly if they lived at home).

Additionally, the participants were recruited based on self-reported symptoms of depression. We anticipated that the symptoms of depression, including low energy, reduced motivation and apathy, would present as barriers to eating well.

Despite these factors, there was a significant increase in the recommended foods and decrease in processed foods for the diet change group but not the habitual diet group.

Furthermore, within the diet change group, increase in recommended foods was associated with spectrophotometer readings. This provides objective evidence to support the participants' self-reported compliance with the diet …

Even in the general population, adherence to diet advice is typically very poor, with over 80% of Australians reporting that they do not comply with dietary recommendations.

As a result, there is substantial nihilism regarding the ability to change people's diets. The current study simply provided a brief 13-minute video, paper resources and minimal phone support.

The fact that this relatively low-cost intervention can result in a population of young adults adhering to diet recommendations is very promising. Furthermore, it is important to consider that participants in the current study did not need to adhere strictly to the diet recommendations to derive benefit."

Other Studies Support Dietary Intervention for Mental Health

Another recent paper found similar results. The meta-analysis,¹⁴ published in the April 2019 issue of Psychosomatic Medicine, looked at 16 randomized controlled trials with outcome data — based on a variety of depression scores — for 45,826 participants ranging in age from 21 to 85. Interventions ranged from 10 days to three years.

While all but one examined nonclinical depression, dietary interventions were still found to significantly reduce symptoms of depression. Interestingly, women appeared to reap the greatest benefits, not only for depression but also anxiety. According to the authors, "Dietary interventions hold promise as a novel intervention for reducing symptoms of depression across the population."

Interestingly, studies specifying the involvement of a nutritional professional had significantly better results than those in which the dietary advice was delivered without a professional's involvement.

However, as shown in the featured PLOS ONE study, this doesn't necessarily have to be a complicated affair. There, participants simply viewed a video in which a dietician gave the instructions.

Mechanisms of Action

In the Implications and Recommendations section of the Psychosomatic Medicine meta-analysis, the authors point out a number of possible mechanisms of action allowing depressed patients to benefit from nutritional intervention:¹⁵

"… diet may act via several pathways that are implicated in mental health. These include pathways related to oxidative stress, inflammation, and mitochondrial dysfunction, which are disrupted in people with mental disorders.

Gut microbiota dysbiosis has also been implicated because of emerging research demonstrating involvement of the microbiome in the modulation of stress response, immune function, neurotransmission, and neurogenesis. A healthy diet typically contains a wide variety of bioactive compounds that can beneficially interact with these pathways.

For example, vegetables and fruits contain, in addition to beneficial vitamins, minerals and fiber, a high concentration of various polyphenols that seem to be associated with reduced rates of depression … potentially because of their anti-inflammatory, neuroprotective, and prebiotic properties.

Furthermore, vitamins (e.g., B vitamins), fatty acids (e.g., omega 3 fatty acids), minerals (e.g., zinc, magnesium), and fiber (e.g., resistant starch) as well as other bioactive components (e.g., probiotics), which are typically abundant in healthy dietary patterns, may also be protective from mental illness.

Along with increasing the intake of beneficial nutrients, dietary interventions may also impact on mental well-being by reducing the consumption of unhealthy food associated with increased risk for depression, such as processed meats, refined carbohydrates, and other inflammatory foods.

Unhealthy diets are also high in other compounds that may negatively affect these pathways. For example, elements commonly found in processed foods such as saturated fatty acids, artificial sweeteners, and emulsifiers may alter the gut microbiome, which may activate inflammatory pathways."

Nutritional Advice for Mental Health

Keeping inflammation in check is an important part of any effective mental health treatment plan. If you're gluten sensitive, you will need to remove all gluten from your diet. A food sensitivity test can help ascertain this. Reducing lectins may also be a good idea.

As a general guideline, eating a whole food diet as described in my optimal nutrition plan can go a long way toward lowering your inflammation level. A cornerstone of a healthy diet is limiting sugar of all kinds, ideally to no more than 25 grams a day.

In one study,¹⁶ men consuming more than 67 grams of sugar per day were 23% more likely to develop anxiety or depression over the course of five years than those whose sugar consumption was less than 39.5 grams per day. Certain nutritional deficiencies are also notorious contributors to depression, especially:

Keeping your gut microbiome healthy also has a significant effect on your moods, emotions and brain.

Helpful Supplements

A number of herbs and supplements can also be used in lieu of drugs to reduce symptoms of anxiety and depression, including the following:

• St. John's Wort (Hypericum perforatum) — This medicinal plant has a long historical use for depression, and is thought to work similarly to antidepressants, raising brain chemicals associated with mood such as serotonin, dopamine and noradrenaline.²⁸
• S-Adenosyl methionine (SAMe) — SAMe is an amino acid derivative that occurs naturally in all cells. It plays a role in many biological reactions by transferring its methyl group to DNA, proteins, phospholipids and biogenic amines. Several scientific studies indicate that SAMe may be useful in the treatment of depression.
• 5-Hydroxytryptophan (5-HTP) — 5-HTP is another natural alternative to traditional antidepressants. When your body sets about manufacturing serotonin, it first makes 5-HTP. Taking 5-HTP as a supplement may raise serotonin levels. Evidence suggests 5-HTP outperforms a placebo when it comes to alleviating depression,²⁹ which is more than can be said about antidepressants.
• XingPiJieYu — This Chinese herb, available from doctors of traditional Chinese medicine, has been found to reduce the effects of "chronic, unpredictable stress," thereby lowering your risk of depression.³⁰

Other Helpful Treatment Options

Evidence clearly shows antidepressants are not an ideal choice for most people with depression. Aside from diet, which I believe is foundational, the depression treatment with the most solid scientific backing is exercise. Other treatment suggestions include phototherapy, regular exercise, cognitive behavioral therapy, the Emotional Freedom Techniques and the importance of limiting your electromagnetic field exposure.

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In this interview, Russel Reiter, Ph.D. — a world-class expert on melatonin — discusses some of the biological activities and health benefits of this important molecule. With some 1,600 papers to his credit, as well as three honorary doctor of medicine¹ degrees, he’s published more studies on melatonin than anyone else alive.

Melatonin 101

Melatonin is one of the most important antioxidant molecules and certainly the most ancient, as it has been part of biological life for over 3 billion years. It's present in prokaryotes, which are bacteria, and even in plants. In the human body — aside from having direct antioxidant effects — it also stimulates the synthesis of glutathione and other important antioxidants like superoxide dismutase and catalase. Reiter continues:

“Melatonin has been here forever ... and its functions have evolved. It has learned to work successfully with other molecules during this three-billion-year evolution. One of the molecules with which it collaborates is glutathione ... But the antioxidant activity of melatonin is extremely diverse.

It in fact is a very good radical scavenger. There are other radical scavengers — vitamin C, vitamin E and so forth — but melatonin is superior to those. But beyond that, it stimulates antioxidative enzymes, especially in mitochondria. Mitochondria are small organelles in the cell that generate the bulk of the free radicals.

So, it's very important to have a good antioxidant at the level of the mitochondria and melatonin happens to be located and is, in fact, synthesized in the mitochondria. Melatonin scavenges radicals that are generated, but it also stimulates something called sirtuin-3, which activates or deacetylates super oxide dismutase (SOD), which is a very important antioxidative enzyme.

It also removes free radicals and prevents the degeneration of the mitochondria, and why this is so important is because mitochondria are really the center of the action within a cell. In other words, there's strong evidence that aging, frailty of aging, senescence of cells as we age, relate to molecular damage at the level of the mitochondria, and melatonin seems to be very efficient at protecting mitochondria from that damage.”

Melatonin increases glutathione through a genomic effect on the enzyme that regulates the synthesis of gamma glutamylcysteine synthase, the rate limiting enzyme in glutathione synthesis. Melatonin activates that enzyme.

Glutathione tends to be found in high concentrations in cells, although some is also found, to a lesser degree, in the extracellular space and the mitochondria. Meanwhile, 95% of the melatonin in your body is concentrated within the mitochondria inside the cells.

Its antioxidant effects are quite diverse, but include preventing free radical generation by enhancing the efficiency of the electron transport chain so fewer electrons leach onto oxygen molecules to generate super oxide antiradical.

How Mitochondrial Melatonin Is Generated

Mitochondrial melatonin production is one of the reasons why regular sun exposure is so crucial. Most people understand that sun exposure on bare skin generates vitamin D, courtesy of UVB (ultraviolet B radiation). Few, however, understand that the near-infrared spectrum, when hitting your skin, triggers the generation of melatonin in your mitochondria. Reiter explains:

“Near-infrared radiation penetrates relatively easily the skin and subcutaneous tissues. Every one of those cells contains mitochondria and it appears that near-infrared radiation that is detected in fact induces melatonin production. That is important, because we now think that melatonin within mitochondria is inducible under a lot of stressful conditions.

That is not definitively proven, but it appears that under stress, all cells may upregulate their ability to produce melatonin because it's so highly productive. And typically, under stress, free radicals are generated. That is emphasized by the [fact] that in plants ... that happens.

In other words, if you expose plants to drought, heat, cold, to metal toxicity, the first thing they do is upregulate their melatonin, because all of those situations generate free radicals. And we suspect, although that has not yet been definitely proven, in animal cells as well, including human [cells].”

Identifying the specific wavelengths that trigger melatonin production can be tricky, but generally speaking, it’s likely to be the range between 800 to 1,000 nanometers (nm). This range of near-infrared is invisible, and has the ability to penetrate tissue. Visible wavelengths generally do not penetrate the skin, and therefore cannot stimulate your mitochondria.

Anytime your skin is exposed to natural sunlight, however, you can be sure you’re receiving the necessary wavelengths of near-infrared to generate melatonin in your mitochondria. Conversely, when indoors under artificial lighting, you can be certain you’re not getting any. This is because most window glass is low-e and filters out a good portion of the near-infrared, so even sitting near a window is not going to provide you with this benefit.

To compensate for time spent indoors, I use a 250-watt Photo Beam near-infrared bulb from SaunaSpace in my office. I keep it lit when I'm in my office and have my shirt off. Considering most people spend most of their days indoors, mitochondrial melatonin deficiency is likely rampant. And, since many also do not get enough sleep, they also have a deficiency in the melatonin synthesized in the pineal gland in response to darkness.

The Two Types of Melatonin

As hinted at above, there are two types of melatonin in your body: The melatonin produced in your pineal gland, which traverses into your blood, and subcellular melatonin produced inside your mitochondria.

Importantly, the melatonin that your mitochondria produces does not escape your mitochondria. It doesn't go into your blood. So, you're not going to directly increase your blood or serum level of melatonin by sun exposure. But, bright sun exposure around solar noon will indirectly help your pineal gland to produce melatonin during the night.

It is important to understand that your blood level of melatonin is indicative of the melatonin produced in your pineal gland, and/or oral supplementation. Conversely, the melatonin produced by your pineal gland cannot enter into the mitochondria, which is why it is so important to get regular sun exposure. Reiter explains:

“In other words, if you surgically remove the pineal gland from an animal or human, blood levels of melatonin are essentially zero. Not totally zero — I think what happens is that the mitochondria in other cells continue to produce melatonin and some of that leaks out into the blood and gives you a residual — but you have no circadian rhythm.

Melatonin production in the pineal gland is highly rhythmic, depending on the light-dark cycle. This is not true for melatonin in mitochondria. It's not cyclic. It's not impacted by the light dark environment. It may be affected by certain wavelengths of energy, but it's not affected by the light dark environment.

So, blood levels are derived from the pineal gland, and this rhythm is very important for setting circadian rhythms. In other words, the function of that melatonin is quite different from the function of the mitochondrial produced melatonin. It sets the rhythm. Of course, there's always some scavenging by that melatonin as well, but the real scavenging s involved with mitochondrial-produced melatonin.”

Oral Supplementation Neutralizes Free Radicals

Oral supplementation, however, can enter your cells and mitochondria. This is a detail I was wrong about before, and which Reiter clarifies in this interview:

“If you supplement with melatonin, it can also enter cells and get into the mitochondria as well. And that is also very important ... As you age, mitochondrial melatonin diminishes. If you supplement with melatonin, it will get into your mitochondria and, in fact, do what melatonin does — neutralize free radicals and protect the mitochondria's function.”

Melatonin Is Vital to Heart Attack and Stroke Recovery

Considering melatonin’s function within your mitochondria, and the fact that mitochondrial dysfunction is a hallmark of most chronic disease, it makes sense that melatonin would be helpful against a number of different diseases, including the two most common — heart disease and cancer.

As explained by Reiter, one of the situations that is most devastating for the heart and brain is temporary interruption of the blood supply as a result of a cardiac arrest or stroke. This deprives the tissues of oxygen, and without oxygen, they rapidly deteriorate.

When the blood vessel reopens, which is called reperfusion, and oxygen flows back into those oxygen-deprived cells, this tends to be the time of maximum damage, as loads of free radicals are generated once the blood starts flowing again.

“There's a large host of studies, including some in humans, where if you give melatonin to induced heart attack in animals or an accidental heart attack in humans, you can preserve or reduce the amount of cardiac infarct, the amount of damage that occurs in the heart,” Reiter says.

“There's a very famous cardiologist in the Canary Islands, professor Dominguez-Rodriguez, whom I worked with. And we, about three years ago, published a paper where we infused melatonin directly into the heart after the vessel was opened. That reduced cardiac damage by roughly 40%.

The other thing that happens in a heart attack is that cardiac cells do not regenerate. Once you lose a cardiac cell, they're done ... and are replaced by fibrous tissue. Of course, fibrous tissue is not contractile, so you get heart failure.

We just published a paper, again with this same cardiologist, showing that if people who are potentially suffering with heart failure because of a damaged heart, they survive better and longer if they are given melatonin on a regular basis. It's a small study ... but I think that would be a worthwhile field to exploit.”

Dosage Suggestions for Acute Heart Attack

In terms of dosage, it’s difficult to translate doses used in animal studies onto human subjects. In animals, doses between 5 to 10 milligrams per kilogram of bodyweight are used. In humans, however, the dose is calculated on the basis of surface area rather than on body size, and that significantly reduces the amount of melatonin that you have to give.

That said, Reiter stresses that melatonin has no known toxic threshold, so even though we don’t know what the ideal dose is, we do know it’s safe even at high doses. Additionally, the timing of the dose will be important. The first dose should be taken immediately, but subsequent melatonin dosing should follow circadian biology, so around 10 a.m., 4 p.m., and before bed.

“If I had a heart attack and I had melatonin on my person, I would take melatonin,” Reiter says. “The question is how much? ... This is not a recommendation to any of your patients, but I would not be hesitant about taking 50 milligrams at the time, and some subsequently for the next 24 hours, even during the day. Because you don't want to lose any more heart cells than is absolutely necessary ...

I have suggested this a number of times. In other words, an emergency medical technician goes out, picks up a patient who has clearly a heart attack. I think on site, immediately, melatonin should be given intravenously rather than orally. It'd be difficult to give it orally. That would be my recommendation.”

Emergency Medical Kit for Acute Heart Attack or Stroke

In cases of an acute heart attack or stroke (which have virtually identical tissue damage mechanisms, just one affects the heart and the other your brain), I would also add methylene blue. Methylene blue is well-documented to be highly beneficial for reperfusion injuries,² especially if you do it right at the beginning of the event, because it augments cytochromes to allow the continued production of ATP even without the use of oxygen.

So, together, methylene blue and melatonin could act as a one-two punch if you've got a stroke or heart attack. They really should be part of every emergency kit.

As an interesting side note, melatonin can also be useful in people with Type 2 diabetes. Reiter notes he has diabetic colleagues who take 1 gram of melatonin daily to counteract the free radical damage caused by hyperglycemia. Keep in mind that melatonin does not treat the cause of the diabetes. It only helps to counteract the damage being caused.

Half Life and Bioavailability of Melatonin

The half life of melatonin in the blood is only about 40 minutes. Within cells, the half life varies according to the level of oxidative stress present. If oxidative stress is high, the melatonin is destroyed much faster, and oxidative stress is low, it remains within the cell much longer.

Reiter also notes that in addition to being a free radical scavenger, all of melatonin’s metabolic kin — its active metabolites, such as N-acetyl-5-methoxytryptamine — are also excellent scavengers. While quickly used up in the presence of high oxidative stress, melatonin is also rapidly taken up when used orally, hence the suggestion to take multiple doses spread out.

Ideally, you’d want to use sublingual or intravenous melatonin, because it’ll enter your bloodstream much faster. Another option is to make your own rectal suppositories. If you swallow it, it needs to pass through and be metabolized by your liver.

Melatonin Is Also a Potent Antiviral

In addition to its antioxidant potency, melatonin also has antiviral capacity. These two features combined is thought to be why it’s been so useful against COVID-19.

“I'm going to give you a very specific example,” Reiter says. “Here's a local physician, Dr. Richard Neil, whom I have known for a number of years. When COVID-19 became common, he called me, we discussed it, he started giving 1 mg per kilogram of body weight (once a day) for about five days, at the time of diagnosis. He has now treated more than 2,000 patients, very successfully, with melatonin.

The importance of melatonin in reference to COVID is that it is not specifically for [the original Wuhan strain]. The variants, Delta, Omicron, they're viruses we think will respond. We currently have a paper in press where we showed that in animals, Zika virus toxicity is also prevented by melatonin, and we've checked four different coronaviruses in pigs.

That paper also shows that melatonin prevents the damage — the consequence — of those viruses. I think [melatonin] is generally a quite good antiviral agent and should be considered as useful. When President Trump was hospitalized with COVID, one of the molecules he was given was melatonin. Obviously, the physicians treating him knew this literature.”

So, to summarize, if you have symptoms of COVID, you could consider taking oral or sublingual melatonin 30 to 45 minutes before bedtime, first thing in the morning, at 10 a.m. and again at 4 p.m. You clearly want to avoid it a few hours before and after solar noon, as taking supplementation during that time will likely impair pineal nighttime melatonin secretion.

Reiter points out that slow-release melatonin has not been widely studied, and he generally doesn’t recommend it for that reason.

Melatonin for Cancer

Melatonin can also be useful in the prevention and treatment of cancer. Reiter explains:

“Cancer cells are clever. They do everything they can to permit their continued survival. It seems counterintuitive, but what they do is they prevent pyruvate from entering the mitochondria, and that reduces ATP production. But as a consequence of doing that, they accelerate something called glycolysis and that's very inefficient in producing ATP, but it does it very rapidly. So, then they have sufficient energy.

The importance of preventing pyruvate from entering the mitochondria, we now think is the fact that pyruvate is a precursor to something called acetyl coenzyme A. Acetyl coenzyme A is a cofactor for the enzyme that regulates melatonin production in the mitochondria.

So, by eliminating or preventing pyruvate from getting into the mitochondria, [the cancer cells] prevent or reduce melatonin production, because they don't allow the necessary cofactor to be produced. In other words, we predicted about four years ago that, in fact, the mitochondria of cancer cells would produce less melatonin.

We have subsequently shown that in two studies, both uterine cancers. Clearly, melatonin levels and the activity of the enzymes in the mitochondria of these types of cancer cells are at least about half what they would normally be. The prevention of pyruvate into the mitochondria, that's Warburg type metabolism.

The other thing is the pyruvate is metabolized into lactic acid. It escapes the cell and produces an acidic environment for the cancer cell, and cancer cells like that acidic environment. So, if you can reduce the Warburg type metabolism, you may be able to limit the growth of cancer cells and perhaps also the metastasis ...

Some cancer cells may only be part-time cancerous because [during nighttime] when they have high melatonin, then they avoid Warburg type metabolism. The interesting thing about Warburg type metabolism [is that] ... many pathological cells, inflammatory cells, cells that are affected by amyloid beta in the brain, exhibit this specific type metabolism ...

And we know that inflammatory cells — M2 and M1 inflammatory cells — can be converted back and forth by melatonin. The inflammatory cells can be prevented by giving them melatonin [because of] its effect on Warburg type metabolism. So, Warburg type metabolism is common in many, many pathological cells.”

The Link Between Metabolic Flexibility, Melatonin and Cancer

One of the reasons for why cancer is so prevalent likely has to do with the fact that 93% of Americans are metabolically inflexible and cannot seamlessly transition between burning carbs and fats for fuel.³ Glucose (sugar) is one of the primary fuels that most people have. Glucose has six carbons and is metabolized into pyruvate, which is a three-carbon molecule. Pyruvate, in turn, is metabolized in the mitochondria to acetyl-CoA.

The reason the Warburg Effect works is b pecauseyruvate dehydrogenase kinase (PDK) inhibits the inflow of pyruvate into the mitochondria so it cannot be converted into acetyl-CoA, and acetyl-CoA is not only needed in the production of melatonin, but is also used to efficiently produce ATP in the mitochondria and is how glucose is used in the mitochondria.

Another source of acetyl-CoA is beta oxidation of fats, which breaks down the fat to the two carbon molecule acetyl-CoA, which enters the mitochondria an active transport molecule, courtesy of MCT (mono carboxylase transporter). My point here is that when you are metabolically inflexible, the Warburg Effect becomes massive. But if you're cardiometabolically healthy and can burn fat, you can effectively bypass that defect.

Prior to my interview with Reiter, I certainly knew that limiting carbs and preventing the Warburg effect was important in cancer treatment, but I hadn’t realized that one of the metabolic byproducts of acetyl-CoA was needed to produce melatonin. So, being metabolically flexible not only impairs the Warburg effect, but also supplies melatonin to combat the excessive oxidative stress in cancer.

This is why I would strongly encourage each and every one of you to regularly engage in two activities the rest of your life. First, expose as much of your skin as you can to an hour of sunshine a day around solar noon.

Second, you have to eliminate all seed oils from your diet, as excess seed oils are the primary reason why most people are metabolically inflexible. While the average person’s consumption of these oils is around 25% to 30% of total daily calories, it should only be about 1% to 2% (mine is 1.5%).

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This article was previously published December 8, 2019, and has been updated with new information.

Thomas Seyfried, Ph.D., professor in the biology department at Boston College, is a leading expert and researcher in the field of cancer metabolism and nutritional ketosis. His book, "Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer" is a foundational textbook on this topic, and in August 2016, he received the Mercola.com Game Changer Award for his work.

Here, we discuss the mechanisms of cancer and the influence of mitochondrial function, which plays a crucial role in the development and treatment of this disease. His landmark cancer theory is available as a free PDF.

Many of his views are now encapsulated in his most paper,¹ "Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis," published online December 27, 2018. He's also published a number of other papers^2,3,4 on the metabolic underpinnings of cancer.

"The paper … is a review and hypothesis paper identifying the missing link in Otto Warburg's central theory," Seyfried explains. "[Warburg] defined the origin of cancer very accurately back in the 1920s, '30s, '40s and '50s in his work in Germany. Basically, he argued and provided data showing that all cancer cells, regardless of tissue origin, were fermenters. They fermented lactic acid from glucose as a substrate.

Even in the presence of oxygen, these cells were fermenting. This is clearly a defect in oxidative phosphorylation. The problem is that for decades, people said Warburg was wrong — mainly because we see a lot of cancer cells take up oxygen and make adenosine triphosphate (ATP) from within the mitochondria … People began to question, 'If cancer cells have normal respiration, why would they want to use glucose as a fermentable fuel?'

The whole concept became distorted … The cancer cells simply choose to ferment rather than respire. Now, of course, if you look under the electron microscope at majority of cancers, you'll see that the mitochondria are defective in a number of different ways. Their structures are abnormal. The numbers are abnormal. There are many abnormalities of mitochondria seen directly under electron microscopy. Clearly, Warburg was not wrong."

Why Biopsies Are Risky

Before we delve into the meat of how cancer actually occurs it would be good to review a diagnostic strategy that nearly all of us are offered when confronted with a cancer diagnosis. It is vital to understand that this may not be your best strategy and that for many it would be wise to avoid the biopsy.

Seyfried warns against doing biopsies, as this procedure may actually cause the cancer to spread. A tumor is basically a group of proliferating cells in a particular part of your body. For purposes of diagnosis, a small biopsy sample will often be taken to ascertain whether the tumor is benign or malignant.

The problem is that when you stab into the cancer microenvironment to remove a part of the tissue, it creates a wound in that microenvironment that in turn elicits the invasion by macrophages and other immune cells.

If you already have an acidic microenvironment, you run the risk of causing a fusion hybridization event in that microenvironment between your macrophages and cancer stem cells (as discussed below). This could turn a potentially benign situation into a malignant one, and if the tumor is malignant, stabbing into it could make a bad situation worse.

"The question is, what is the value of doing a biopsy in the first place? We take biopsies of breast tissue to get a genomic readout of the different kinds of mutations that might be in the cells. Now, if cancer is not a genetic disease and the mutations are largely irrelevant, then it makes no sense to do that in the first place. If the tumor is benign, why would you want to stab it? If the tumor is malignant, why would you ever want to stab it?

I came to this view by reading so many articles in the literature based on brain cancer, breast cancer, colon cancer, liver cancer showing how needle biopsies have led to the dissemination of these tumor cells, putting these people at risk for metastatic cancer and death," Seyfried says.

In metabolic therapy you would not touch the tumor; you would not disturb the microenvironment. By leaving it alone, you allow the tumor to shrink and go away.

"When you start to look at this as a biological problem, many of the things that we do in cancer make no sense. We have, in brain cancer, people say, 'You have a very low-grade tumor. Let's go in and get it out.' What happens is you go in and get it out, and then the following year it turns into a glioblastoma.

How did that happen? Well, you disturbed the microenvironment. You allowed these cells that are marginally aggressive to become highly aggressive. Then you lead to the demise of the patient," Seyfried says.

"That happens significantly because it's called secondary glioblastoma arising from therapeutic attempt to manage a low-grade tumor. The same thing can happen with all these different organs. You stab breast tumors, you stab colon tumors, you run the risk of spreading the cells …

My argument is the following: If the patient has a lump, whether it's in the breast, in the colon, lung or wherever or a lesion of some sort, that should be the cue to do metabolic therapy.

Do metabolic therapy first. In all likelihood, it will shrink down and become less aggressive. Then the option becomes, 'Should we debulk completely rather than doing some sort of a biopsy?' We want to reduce the risk, because if we can catch the whole tumor completely, then we don't run the risk of spreading it …

In our procedure, you bring the body back into a very high state of metabolic balance, and then you strategically go and degrade the tumors slowly without harming the rest of the body.

Radiation, chemo and the strategies that we're using today don't do this. They're based on the gene theory of cancer that genetic mutations are causing the cell cycle to grow out of control. Well, this is not the case. Again, a lot of these toxic procedures need to be rethought, reanalyzed in my mind."

Solving the Warburg Theory's Dilemma

In biology, structure determines function. This is an evolutionarily conserved concept. So, how can mitochondria be structurally abnormal in tissue, yet have normal respiration? As Seyfried notes, this doesn't make sense. Confusion has arisen in part because many study cancer in culture, and "make profound statements and comments regarding what happens in culture," Seyfried says.

"If you look at cancer cells in culture, many of them do take in oxygen and make ATP, but at the same time, they're fermenting. This was the conundrum. They called it the Warburg Effect. They're fermenting, but many people at the same time thought their respiration was normal.

This was the main problem with Warburg's theory. But Warburg clearly said in his papers [that] it's not the fact that they take in oxygen; it's how much ATP they can generate from oxidative phosphorylation, which is the normal respiratory capacity of the mitochondria."

As explained by Seyfried, if you measure ATP and look at oxygen consumption in tumor cells, it appears they're making ATP and taking in oxygen, therefore, their respiration is assumed to be normal. However, when you look at the tissues in cancer patients, the mitochondria are abnormal.

"What I and Dr. Christos Chinopoulos from Semmelweis University in Budapest, Hungary, who is the world-leading expert on mitochondrial physiology and biochemistry … realized [was] that the mitochondria of tumor cells are actually fermenting amino acids, glutamine in particular. They're not respiring. They're fermenting an alternative fuel, which is glutamine," Seyfried says.

Warburg's Cancer Theory Proves Correct

With this understanding, Warburg's theory can be proven correct — cancer arises from damage to the mitochondria's ability to produce energy through respiration in their electron transport chain.

The compensatory fermentation involves not only lactic acid fermentation, but also succinic acid fermentation using glutamine as a fermentable fuel. It's been known for decades that glutamine is a main fuel for many different kinds of cancers, but most people thought it was being respired, not fermented.

Seyfried and Chinopoulos' discovery confirms that cancer cells in fact have damaged respiration, and to survive, the cancer cells must use fermentation. The two most available fermentable fuels in the cancer microenvironment are glucose and glutamine. Hence, targeting glucose and glutamine is a crucial component of cancer treatment.

Without glucose and glutamine, the cancer cells will starve, as they cannot use ketones. The simplest approach to cancer then is to bring patients into therapeutic ketosis, and then strategically target the availability of glucose and glutamine.

"Basically, what we're saying [is] that mitochondrial substrate-level phosphorylation is a non-oxidative metabolism mechanism inside the mitochondria that would generate significant amounts of energy without oxidative phosphorylation," Seyfried says.

Genetic Mutations Are Not the Cause of Cancer

According to Seyfried, mitochondrial dysfunction is at the heart of nearly every type of cancer. Unfortunately, few oncologists have this understanding and many still believe cancer is the result of genetic defects. However, nuclear transfer experiments clearly show cancer cannot be a genetic disease.

"There's been no rational scientific argument that I have seen, to discredit the multitude of evidence showing that the [genetic] mutations are not the drivers but the effects [of mitochondrial dysfunction]," Seyfried says.

"As a matter of fact, there's new information now where people are finding so-called genetic drivers of cancer expressed and present in normal cells, normal skin and also esophagus … This is another [issue] — how you get these so-called driver mutations in normal tissues. We're also finding some cancers that have no mutations, yet, they're fermenting and growing out of control.

There are a number of new observations coming out that challenge the concept that cancer is a genetic disease. And once you realize that it's not a genetic disease, then you have to seriously question the majority of therapies being used to manage the disease. This [helps] explain [why] we have 1,600 people a day dying from cancer in the United States.

Why do we have such an epidemic of suffering and death when we have been studying this disease for decades? Well, if you look at the massive amounts of scientific papers being written on cancer, you'll often find that they're structured around gene defects.

What I'm saying is that if cancer is not a genetic disease and the mutations are downstream epiphenomena, why would the field continue to focus on things that are mostly irrelevant to the nature of the disease? What I'm saying is very devastating, because I'm telling the majority of the people in the field that they're basically wasting their time …

I think we can drop the death rate of this disease by about 50% in 10 years if cancer is treated as a mitochondrial metabolic disease, targeting fermentable fuels rather than using toxic therapies that are focused on downstream effects.

Radiation is designed to stop DNA replication. DNA replication requires energy. If you pull the plug on their fermentable fuels, they're not going to be able to replicate anyway … All of the things that we're doing to treat cancer is basically approaching the disease from a misunderstanding of the biology …

We know viruses can cause cancer. We know radiation causes cancer. We know carcinogens cause cancer. We know intermittent hypoxia causes cancer. We know systemic inflammation causes cancer. We know just getting older puts you at risk for more cancer.

We know there are inherited mutations in the genome that can cause cancer. But how are all these things linked through a common pathophysiological mechanism? The common pathophysiological mechanism is damaged through the structure and function of the mitochondria.

Every one of the issues … including inherited mutations, damage the respiration of a particular population of cells in a tissue. You look at the breast cancer gene (BRCA 1), for example. People will say, 'Cancer must be a genetic disease because you inherit a mutation that causes the disease.'

You only get the disease if that mutation disrupts the function of the mitochondria. Fifty percent of women who carry the mutation never get cancer or breast cancer because the mutation, for some reason, did not damage the mitochondria in that person."

So, to summarize, the true origin of cancer is damage to the respiratory function of the mitochondria, triggering compensatory fermentation, which is run by oncogenes. Oncogenes play a role by facilitating the entry of glucose and glutamine into the cell to replace oxidative phosphorylation.

Why and How Cancer Spreads

Seyfried also has a very different view on the biology of metastasis (the spread of cancer). He explains:

"We've looked at cancer stem cells in a number of our preclinical models … These guys grow like crazy in place. The tumor just keeps expanding, but it doesn't spread. It doesn't spread into the bloodstream or metastasize to various organs.

We discovered a very unusual cancer 20 years ago. It took us 10 to 15 years to figure out what it was. You can put a few of these cells anywhere in the mouse's body and within three to four weeks, this mouse is full of metastatic cancer. It made the cover of the International Journal of Cancer, when we published this back in 2008, but we had worked on the problem for years.

We couldn't figure out what it was that made these cells so incredibly metastatic. We found out that once we identified the biology of the cell, it turned out [it has] many characteristics in common with the macrophage, which is one of the most powerful immune cells in our body.

We said, 'Wow. Is this unique only to this kind of cell or do metastatic cancers in humans also express characteristics of macrophages?' We looked and we found that almost every major cancer that metastasizes has characteristics of macrophages. Then we said, 'Well, how could this possibly happen? Is it coming from the macrophage?'

A number of scientists ... have all clearly shown that there is some fusion hybridization character going on. In other words, macrophages, our wound-healing cells, they come into a microenvironment where you might find many proliferating neoplastic stem cells, but they don't have the capacity to metastasize.

It's only when the macrophages fuse with these stem cells that you have a dysregulated energy metabolism coming in this hybrid cell. This hybrid cell now has characteristics of both stem cells and macrophages.

The stem cell is not genetically equipped to enter and exit tissue. The macrophage, as a normal cell of your body, is genetically equipped to enter and exit tissue and live in the bloodstream. They're very strongly immunosuppressive. These are all characteristics of metastatic cancer."

Metastatic Cancer Is a Hybrid Cell Combination

According to Seyfried, metastatic cancer cells are essentially a hybrid, a mix of an immune system cell and a dysregulated stem cell, the latter of which could originate from a disorganized epithelial cell or something similar. In short, it's a hybrid cell with macrophage characteristics.

Macrophages are essential for wound healing and part of our primary defense system against bacterial infections. They live both in the bloodstream and in tissues, and can go anywhere in the body. When an injury or infection occurs, they immediately move in to protect the tissue.

"The metastatic cancer cell has many of those same properties," Seyfried explains, "But the energy and the function of the cell is completely dysregulated, so it proliferates like crazy but has the capacity to move and spread through the body, so it's a corrupted macrophage. We call it a rogue macrophage."

Like macrophages, metastatic cancer cells can also survive in hypoxic environments, which is why most angiogenic therapies are ineffective against metastatic cancer.

So, what do these metastatic hybrid cells need to survive? Both macrophages and immune cells are major glutamine consumers, and according to Seyfried, you can effectively kill metastatic cells by targeting glutamine.

Conventional Cancer Treatments Are Unnecessarily Deadly

However, it must be done in such a way so as to not harm the normal macrophages and the normal immune cells. In other words, it must be strategic. For this reason, Seyfried developed a "press-pulse therapy" for cancer, which allows the patient to maintain normal immune system function, while at the same time targeting the corrupted immune cells — the macrophage fusion hybrid metastatic cells — as well as inflammation.

"The therapies we are using to attempt to kill these [metastatic] cells put us at risk for having the cells survive and kill us. You can control these cells for a short period of time, but they can hunker down and enter into some sort of a slightly dormant state, but they reappear.

People say, 'Oh, these tumor cells are so nifty and smart they can come back at you.' The problem is you've never really challenged them on their very existence, which is they depend on fermentation to survive. If you don't target their fermentation, they're going to continue to survive and come back at you.

Many of the therapies that we use — radiation, chemo and some of these other procedures — are not really going after the heart of the problem. That oftentimes puts you at risk for the recurrence of the disease. Your body is already seriously weakened by the toxic treatments. And in the battle, you lose. If you are fortunate enough to survive … your body is still beat up.

You have now put your [body] at risk for other kinds of maladies … Why are we using such toxic therapies to kill a cell when we know what its weaknesses are? These are the paradigm changes that will have to occur as we move into the new era of managing cancer in a logical way."

A Strategic Approach to Killing Cancer Cells

To properly address cancer, then, you need to clean up the microenvironment, because the microenvironment will strategically kill cells that are dependent on fermentation while enhancing cells that aren't. At the same time, the microenvironment will also reduce inflammation.

"You also have to be very careful not to kill your normal and healthy immune cells, because they need glutamine too," Seyfried says. "What we find is that when we strategically attack the tumor this way, it turns out that our immune cells are paralyzed.

The cancer cells are killed, but the normal immune cells are paralyzed. They're not dying, they're just not doing their job. What we do is we back off the therapy a little; allow the normal immune cells to regain their biological capacity, pick up dead corpses, heal the microenvironment, and then we go after the cancer cells again.

It's a graded response, knowing the biology of the normal cells and the abnormal biology of the tumor cells. This is a beautiful strategy. Once people know how you can play one group of cells off another, and how you can strategically kill one group of cells without harming the other cells, it really becomes a precision mechanism for eliminating tumor cells without harming the rest of the body.

You don't need to be poisoned and irradiated. You just have to know how to use these procedures to strategically kill the cells. Protecting normal macrophages is part of the strategic process. Killing the corrupted ones is part of the strategic process. Again, you have to put all of these together in a very logical path. Otherwise, you're not going to get the level of success that we should be getting."

The Press-Pulse Strategy

This strategy is what Seyfried calls "press-pulse treatment," and essentially involves restricting the fermentable fuels — glucose and glutamine — in a cyclical fashion to avoid causing damage to normal cells and tissues. Glucose is effectively restricted through a ketogenic diet. Restricting glutamine is slightly trickier.

The press-pulse strategy was developed from the concept of press-pulse in the field of the paleobiology. A "press" was some chronic stress on populations, killing off large numbers, but not everything, because some organisms can adapt to stress. The "pulse" refers to some catastrophic event.

The simultaneous occurrence of these two unlikely events led to the mass extinction of almost all organisms that existed on the planet. This was a cyclic event over many hundreds of millions of years. The geological records show evidence for this press-pulse extinction phenomenon.

"What we simply did was take that concept and say, 'Let's chronically stress the tumor cells.' They need glucose. You can probably kill a significant number of tumor cells by just stressing their glucose. That's the press. The press is different ways to lower blood sugar. You put that chronic stress on top of the population either by restricted ketogenic diets [or] therapeutic fasting. There are a lot of ways that you can do this.

Also, emotional stress reduction. People are freaked out because they have cancer, therefore their corticoid steroids are elevated, which elevates blood sugar. Using various forms of stress management, moderate exercise — all of these will lower blood sugar and contribute to a chronic press and stress on the cancer cells.

However, you're not going to kill all cancer cells if you just take away glucose. Because the other fuel that's keeping the beast alive is the glutamine. We have to pulse, because we can't use a press for glutamine targeting, because then you're going to kill your normal immune cells or impair them, and they are needed for the eventual resolution of the disease.

What we're going to do is we're going to pulse various drugs. We don't have a diet system that will target glutamine. Glutamine is everywhere. It's the most abundant amino acid in your body … But you have to use [the drugs] very strategically; otherwise they can harm our normal immune system and then be counterproductive ...

I think that once we understand how we can target effectively glutamine without harming our normal immune cells … this is the strategy that will make most of these other therapies obsolete ... It's cost-effective and non-toxic and it will work very well.

But we're still at the very beginning of this. We need to continue to develop the doses, timing and scheduling of those drugs that are most effective in targeting glutamine that can be done without harming the rest of the cells in our body."

If you would like to support Dr. Seyfried's research, please consider making a donation to the "Foundation For Metabolic Cancer Therapies." The donation tag is on the top row of the of the foundation site. This Foundation is dedicated to supporting Dr. Seyfried's studies using metabolic therapy for cancer management with 100% of the donated funds going directly to research on metabolic therapy for cancer.

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By now, many of you will be familiar with Dr. Robert Malone, inventor of the core mRNA and DNA vaccine platform technology¹ that the various COVID shots are based upon. (To be clear, he’s not the inventor of the COVID shots themselves but rather the foundational platform that underlies them, for which Malone holds several patents.)

Malone rose to prominence after his appearance on the DarkHorse podcast² in June 2021, where he, Steve Kirsch and DarkHorse host Bret Weinstein, Ph.D., spent three hours dissecting the COVID fraud. Interestingly, Malone and Kirsch were both double-jabbed before realizing there were problems with the shots, but once they did, they boldly stepped into the limelight to warn and inform others.

Malone also appeared on the Joe Rogan podcast³ December 30, 2021, which ended up being the most-viewed podcast of all time with some 50 million views. The transcript of that interview was even entered into the Congressional Record⁴ January 3, 2022, by Congressman Troy Nehls, R-Texas, after Twitter and YouTube removed it from their platforms.

Malone also helped promote the work of Dr. Matthias Desmet, a clinical psychologist at the University of Gantt in Belgium and author of “The Psychology of Totalitarianism.” Desmet was the first to introduce the concept of “mass formation” to explain how and why people were going along with a narrative that was clearly false and evidently destructive. 

Like so many others who have tried to share truth and opinions that differ from the official COVID narrative, myself included, Malone has been viciously attacked by media and relentlessly “fact checked.” Alas, with the passage of time, his wisdom and knowledge are now being validated on a near-daily basis.

“I would say we've been gaslighted, ridiculed, defamed — but I don't think we've been discredited,” he says. “I think we could both hold our heads up high. We've called it amazingly well.

I'm just in the middle of reviewing and building the chapters for the book that has to do with what's gone wrong with the HHS [Health and Human Services] and what we need to fix, which includes a litany of things that have been miscalled by the CDC [Centers for Disease Control and Prevention].

The list is enormous. And we continue to see on a daily basis the weaponization of fear porn, the two most recent examples being the monkeypox and the Omicron BA.4 [and] BA.5.”

Immune Imprinting Is Making the Vaxxed Sicker

As noted by Malone, media are again trying to drum up fear porn, despite data clearly showing hospitalization rates remain steady even though the infection rate is rising. They’re also ignoring what Malone and others warned about from the start, which is that vaccinating during a pandemic is a beyond foolish strategy as it is virtually guaranteed to drive the evolution of resistant strains.

This is precisely what we’re now seeing with BA.4 and BA.5, which circumvent both natural immunity and COVID jab-induced antibodies. The CDC and the Food and Drug Administration are also ignoring the reality of immune imprinting, which Malone says is backed by more than 10 high-end, highly visible peer reviewed journals.

“We're literally driving the highly vaccinated to an immune compromised state in which they're more susceptible to infection by Omicron — as a consequence of their prior vaccination — and they are becoming chronically or multiply infected,” Malone says.

“This is precisely the situation that's been shown in peer reviewed literature to be driving the development of the further development of the escape mutants. So, our public policies are completely contrary to the need here. I'm speechless concerning the mismatch between what our government promotes and what the true public health need is.”

Is Malone Controlled Opposition?

In scanning through the comments on my newsletter, I’ve noticed that some people are convinced Malone is controlled opposition. Considering that he’s the developer of the mRNA technology that underlies the jabs, and the fact that he’s been double-jabbed himself, and has worked extensively with the Deep State intelligence community, Malone believes his current actions speak for themselves:

“I have historically worked with people who have been truly Deep State intelligence community. I have decades of experience in biodefense. I have been deep in the belly of the beast. I have won literally billions of dollars for my clients in grants and contracts. I have managed hundreds of millions of dollars in grants and contracts in the vaccine space.

[I’ve been] ... study section chair or key study section member on many hundred-plus million-dollar contract reviews, typically for the NIH [National Institutes of Health] ... but also DOD [Department of Defense]. I historically been deeply embedded in this whole enterprise. I know it upside down.

I understand this system. So, I think the concerns that I could be controlled opposition are valid. I think that it's appropriate to acknowledge the basis for those concerns. Now, [those] concerns, I think, are refuted by my behaviors and actions.

Let's start with the inventions. I have many patents. I've contributed to the development of many technologies. My wife and I helped found Inovia, the post electrical field gene delivery company that is promoting its own vaccine technology, which is a DNA-based platform and could well be adapted to RNA-based vaccines.

I certainly have those nine initial issued patents and others that relate to virtually any delivery system used to administer polynucleotides to the nasal pharynx, to mucosal tissues, to elicit a mucosal immune response ... I have many patents on various [nano] lipids, these positively charged fats that are used to deliver the polynucleotides, but I'm also an objective scientist.

As a consequence of the decades of experience in basic discovery research in this area, we've turned away from this technology because we could never overcome the inflammatory problems, this acute immune response and the recruitment of inflammatory cells into the injected tissues. We ran into this again and again and again, both in mice and then in monkeys, and could never overcome it. We abandoned the technology.”

Malone Explains the Patent Controversy

Malone goes on to explain the origin of the patent controversy — why some claim he didn’t actually invent the mRNA platform the COVID jabs are using, and why the technology was used at all if it had already been abandoned due to excessive hazards:

“Kati Karikó called me up in the mid-‘90s and wanted some advice. I told her about the problems with the RNA and the problems with the inflammatory response and, together with Drew Weissman, she applied the pseudouridine discoveries that were just emerging and put pseudouridine all the way through the RNA, which is both immunosuppressive and increases the half life of the RNA.

So, these RNAs that are now being used are really nothing like the natural RNA. They're synthetic product. The basis for their assertion that they're the true inventors and I am not — despite all the prior art and multiple patents — is that they made this improvement on the art that was enabling.

[However], the CureVac technology demonstrates that's not enabling, that, in fact, you can get good immune responses with mRNA that does not include pseudouridine. But I had turned away from the tech. There were better ways to provide an immune response, I believed. Those are still investigational.

Talking about eyes wide open, I have intimate understanding of the good, the bad and the ugly of this approach and this technology. That's always been my position — that of an objective scientist. Then, on the last point on this, I never received substantial revenue of any kind from my inventions.

The patents were filed from a company that's now called Vical that had partnered with Merck years ago. Over a billion dollars were spent to advance the technology. Merck and Vical only focused on the DNA and they failed.

But as a consequence of the terms of my employment, I received — in addition to my technician salary, which was about $20,000 a year — $1 for all those patents. I've had no patent royalty. So, I have no financial conflict of interest here. It doesn't matter to me one way or the other.

What matters is integrity and honesty and truthfulness ... Let me put it this way ... I was in a dark room, I backed into the light switch, and what I saw was such that I could never unsee it.”

On Malone’s CIA Connections

Malone was also, once upon a time, in business with a former CIA agent named Michael Callahan, who held a senior position in the Defense Threat Reduction Agency (DTRA). Callahan was in Wuhan, China, in the fourth quarter of 2019 and called Malone in early January 2020, asking him to get a team together to address a novel virus that had broken out in China.

“I had a series of interactions with him subsequently, until I became completely disillusioned and aware that he was lying to me almost constantly, including about things like whether or not the pathogen was engineered. So, I think I can certainly empathize, and understand why some might have these concerns ...

[But] I don't ask people to accept what I say, I ask people to think for themselves. I've tried to be truthful, honest, act with integrity, provide access to information, try to help people to think through things by themselves, and I've made a number of predictions and comments and analyses and, like you, I stand by what I've said.

So even if I was controlled opposition, that's kind of irrelevant. The question is not who I am; the question is what is the information? Is it useful to you? Is it helping you to manage your own affairs, make conformed choices about vaccinating your children? If so, I think that even if I was controlled opposition, I suspect that I'm fairly useful controlled opposition for those of us that are in this boat together of seeking truth ...

Frankly, all of my contacts with the government now are destroyed. The colleagues that I used to communicate with regularly at the FDA will no longer take my call ... I've dropped my contract with Defense Threat Reduction Agency.

Largely I just became disillusioned with them, particularly after I found out that another branch of DTRA is continuing to support the Wuhan Institute of Virology and disclose that.

I shared a number of fragments of information about what I know that's been going on within DTRA, as well as within NIAID [National Institutes of Allergy and Infectious Diseases] and the NIH. In doing so, I compromised that part of my career. I've thrown away, for the second time by the way, a big career path that I've developed over decades.”

Malone’s COVID Jab Experience

Malone also discusses his reasoning for taking the COVID shots. He needed to travel, and thought the shot might be helpful for his “long-COVID,” which he developed after contracting the infection early on in the pandemic.

Unfortunately, like so many others, he suffered a series of complications, particularly after the second dose, including cardiac damage resulting in hypertension with a frequent systolic pressure of up to 230, narcolepsy, central nervous brain fog, restless leg and several other symptoms now known to be associated with the shot.

When he later looked up his batch number on HowBadIsMyBatch.com,⁵ he discovered his second dose was from a batch associated with a high rate of complications. “So that's that. We all make mistakes. I acknowledge now [that taking the vaccine] was absolutely not the proper way to approach this,” he says.

Dr. Meryl Nass, who has since lost her medical license for the crime of talking about COVID treatments, was instrumental in actually curing Malone’s long-COVID. She prescribed ivermectin, which gave him near-immediate relief. “So, tip of the hat to Meryl Nass, a true truth warrior and another inspirational figure in all of this,” Malone says.

Pseudouridine-Enhanced RNA Can Cause Immunosuppression

In the interview, Malone delves into some of the mRNA jab quality control problems that have arisen, and whether or not the addition of pseudouridine actually reduces the inflammatory reaction associated with mRNA gene therapy as claimed.

As explained earlier, Karikó — a former Hungarian spy — had sought Malone’s help, and he told her about the problems with the RNA he was finding. Karikó and Weissman — a post-doc of Dr. Anthony Fauci — then went on to experiment with the addition of pseudouridine, which we now know influences things like RNA stability, folding, processing and splicing. It's highly regulated, but that wasn't known at the time.

What was known was that if RNAs include pseudouridine, they will last much longer and be far less inflammatory. Basically, immune responses against cells that have pseudouridine-modified mRNA in them are suppressed. On the basis of that, Karikó and Weissman incorporated pseudouridine throughout the entire mRNA molecule, which were synthesized using the methods Malone developed, and then purified.

When this product was injected, they got a better adaptive immune response and less inflammatory response. This is the science that the COVID shots are based on. However, recent investigations, using needle biopsies, have shown RNA persists in axillar lymph nodes for at least 60 days. They didn’t test any longer than that, so it could be far longer. The levels of spike protein produced was also found to be far higher than expected and lasted for at least 60 days.

“So, what we now know is that pseudouridinee can cause RNA to behave in ways that are absolutely not like natural RNA, as I had originally proposed,” Malone says. “The RNA is typically degraded within a couple of hours, so if people were to have adverse events, the inciting molecule would be gone and physicians could elect not to readminister it.

But in the current formulation with the pseudouridine incorporated throughout the entire backbone of the RNA, which is something that never happens in a natural situation, they do suppress the acute inflammatory response, but they also seem to suppress overall adaptive immune responses or immune function.

This may be something that's contributing to the immunosuppression that's observed after dosing with these products. That's unresolved, but there's no question that adverse event exists, that nonspecific immunosuppression.

So, we have now ... lots of evidence that the discovery of Karikó and Weissman had negative aspects to it, which were not well characterized by Pfizer, Moderna, BioNTech, et cetera.”

Malone also reviews other ingredients and quality control issues that can contribute to a “hot,” or more lethal batch, so to learn more, be sure to listen to the interview in its entirety. For example, he reviews the problem of aggregation, the toxicity of PEG, and how fatigue may be related to the fact that spike protein is not merely attached to cell surfaces but actually poison the mitochondria.

He also admits there may be some truth to claims that graphene oxide is being used, although he still hasn’t seen any conclusive proof. “Initially, I thought that was crazy talk, but the unwillingness of the pharmaceutical companies to disclose their ingredients, which is just mind boggling — that's completely contrary to anything I've ever encountered in any teaching I've ever had about regulated products — so, there's something amiss here. There's no question,” he says.

Upcoming Fall Trivalent Jab Will Likely Be More Dangerous

The FDA recently approved a new trivalent COVID jab for fall 2022, which won’t be going through any additional testing, even though it will be a brand-new composition to cover some of the newer strains. I fear this will radically increase side effects, as does Malone.

“The trivalent story goes back to the logic of influenza vaccines ... Reasoning by analogy, apparently, the FDA and the CDC have now concurred that a similar strategy shall be taken for these unlicensed experimental use authorized products that have produced an adverse event signal like no vaccine in history — which they deny — and are clearly not stopping infection replication and spread of the viruses.

What they've decided is they're going to now use the flu model, which will enable them to continue the manufacturing process, which, as we've just discussed, is poorly characterized, not really adequately provided with oversight, and [has poor] lot consistency.

We know from the ‘How Bad Is My Batch’ analysis, the lot consistency is horrid. But that's all apparently OK. And, one antigen is good so let's go to three. The problem is multifaceted.

Typically, when you do this, you maintain approximately the same dose of each antigen, so that would be, in the case of Pfizer, we're going to go from 50 to 150 micrograms of RNA in a jab. Let's hope they don't do that. But even if they only double the dose, then we know that the adverse events are going to go up considerably.”

‘Mass Psychosis at Its Worst’

Malone also questions the underlying thesis and science of this endeavor. The idea is that by continuing to administer the Wuhan-1 spike and adding BA.4 and BA.5, which evolved to evade antibodies to the Wuhan-1 strain, they’re ignoring the peer reviewed literature, which is extensive, showing that immune imprinting (aka “antigenic sin”) is occurring.

In fact, immune imprinting is part of why flu shots have such poor efficacy. In a nutshell, if you had COVID, or got the jab, your immune system is biased toward the original Wuhan strain, to the exclusion of others. Omicron and later variants have evolved to exploit that bias, which is why jabbed individuals are now getting sick with COVID more often than the unjabbed, and suffer repeated reinfections.

“We have created a situation in which they have to keep getting vaccinated, I guess. That's the logic being promoted by the CDC. We have to keep vaccinating them at frequent intervals because the vaccination is damaging their ability to control infection of these escape [strains].

And now the CDC and the FDA have signed off on the idea of a trivalent vaccine that I couldn't have imagined a better design if I wanted to, to drive this immune imprinting phenomena and make people less able to resist Omicron infection, because it includes Wuhan-1 plus two Omicron strains.

It is exactly the opposite of what's needed. It is Geert Vanden Bossche’s worst nightmare, and they are doing it blindly without even bothering to read the peer reviewed literature that describes this. This is insanity. It is mass psychosis at its worst,” Malone says.

“There is a lot of very deep, complex immunology associated with what we've been doing to people all over the world, and it involves every single facet of this product, the lipids themselves, the formulations, the structure of the RNA and the payload that's being expressed.

Each of them is associated with their own profile of adverse events. That is clearly seen in the early Moderna data ... In the Phase 1 data of their influenza vaccine product using the same tech, at the 100-mcg dose, 80% of the subjects had Grade 2 or Grade 3 adverse events. That's the formulations and the same RNA chemistry but no spike protein. That shows it's not just the spike [that causes adverse events].

This has got to go down in history as one of the most profound failures of regulatory science in the 20th and 21st century, and the craven cowardice of the FDA regulatory authority to address this has, I think, all over the world, led to a recognition that the FDA has been captured by the pharmaceutical industry.

It is profoundly corrupt and has to be completely rebuilt. The damage that's been done to the reputation of the American regulatory process, globally, is profound. As I had suggested, almost two years ago, if they continue on this path they are going to destroy the entire regulatory process, as well as any faith that anyone ever had in the vaccine enterprise. And here we are ...

If there's a silver lining here, I think it's that, for many of us, including myself, who had bought into the system, the experience is so powerful that it is opening eyes everywhere. I'm now completely in the same camp as Bobby Kennedy, in that I believe the entire vaccine enterprise needs to be revisited, and it's unequivocal.

We do not have the data to support the safety and efficacy of the current pediatric vaccine schedule, and all of the components of the pediatric vaccine schedule need to be reassessed for risk benefit ratio. Both as individual products and as combined products.”

More Information

Malone has now released his first book, “Lies My Government Told Me.” If you want to know what he knows, or fret about how we will ever rectify the wrongs uncovered, you’ll want to read this book. You can also follow Malone’s work on GETTR, maloneinstitute.org, rwmalonemd.com and Substack.

I firmly believe his GETTR account is the must-follow site if you want to keep current on the pandemic nonsense. I read it nearly every day and nearly always find new and important updates there first.

“It's hard to see a way forward that is not rather bleak in the world that's being envisioned by these unelected corporatist powers, these public-private partnerships, that seek to control our lives in every facet and aspect,” Malone says.

“But having focused on this now for many months, in part out of necessity because I had to finish the book, I'm starting to see a path forward, and recent Supreme Court decisions ... are giving me hope.

I think that partnership between attorneys ... organizations that are more constitutionalist in their framing and background, together with people that are knowledgeable about the inner workings of the administrative state and HHS, offers opportunity ...

Also, I think it's reasonable that all of us need to start thinking about intentional communities, about how we can build local sustainable community capabilities ... Those of us that are awake need to really think hard about preparing ourselves, not overreacting, but being a prepper ...

There are forces at play here that this whole public health thing is just a facade, a ruse. I'm completely convinced the reason why so many of these policies make no sense from a public health standpoint is they're not about public health ...

The evidence that a lot of this is being manipulated, hence the fear porn, is overwhelming in my opinion, and I cannot reconcile the abundant examples of public health mismanagement and misalignment between the need and the policies unless I account for the underlying financial agendas, geopolitical power agendas that are in play right now.

And I think that those of us who are still committed to integrity and dignity and community need to circle the wagons and think through how to prepare for a future in which all of these agendas are coming to fruition. They're coming to a head and we better be ready for them.”

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